Abstract:
BACKGROUND:Hepatic ischemia-reperfusion (I/R) injury is a pivotal clinical problem occurring in many clinical conditions such as transplantation, trauma, and hepatic failure after hemorrhagic shock. Apoptosis and autophagy have been shown to contribute to cell death in hepatic I/R injury. Ethyl pyruvate, a stable and simple lipophilic ester, has been shown to have anti-inflammatory properties. In this study, the purpose is to explore both the effect of ethyl pyruvate on hepatic I/R injury and regulation of intrinsic pathway of apoptosis and autophagy. METHODS:Three doses of ethyl pyruvate (20 mg/kg, 40 mg/kg, and 80 mg/kg) were administered 1 h before a model of segmental (70%) hepatic warm ischemia was established in Balb/c mice. All serum and liver tissues were obtained at three different time points (4 h, 8 h, and 16 h). RESULTS:Alanine aminotransferase (ALT), aspartate aminotransferase (AST), and pathological features were significantly ameliorated by ethyl pyruvate (80 mg/kg). The expression of Bcl-2, Bax, Beclin-1, and LC3, which play an important role in the regulation of intrinsic pathway of apoptosis and autophagy, was also obviously decreased by ethyl pyruvate (80 mg/kg). Furthermore, ethyl pyruvate inhibited the HMGB1/TLR4/ NF-κb axis and the release of cytokines (TNF-α and IL-6). CONCLUSION:Our results showed that ethyl pyruvate might attenuate to hepatic I/R injury by inhibiting intrinsic pathway of apoptosis and autophagy, mediated partly through downregulation of HMGB1/TLR4/ NF-κb axis and the competitive interaction with Beclin-1 of HMGB1.
journal_name
Mediators Inflammjournal_title
Mediators of inflammationauthors
Shen M,Lu J,Dai W,Wang F,Xu L,Chen K,He L,Cheng P,Zhang Y,Wang C,Wu D,Yang J,Zhu R,Zhang H,Zhou Y,Guo Cdoi
10.1155/2013/461536subject
Has Abstractpub_date
2013-01-01 00:00:00pages
461536eissn
0962-9351issn
1466-1861journal_volume
2013pub_type
杂志文章abstract:AIM:To determine gastric tissue lactoferrin (Lf) levels of Helicobacter pylori- (Hp-) positive and -negative patients and its effect on anemia. METHODS:Cases in which initial presentation was of abdominal pain and that were Hp-positive at endoscopy were included. Hp-positive cases and -negative controls were divided i...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2012/214581
更新日期:2012-01-01 00:00:00
abstract::Syndecan-1 (CD138) is a transmembrane heparin sulfate proteoglycan expressed on distinct stages of differentiation of B-lymphoid cells. Its prognostic value in B-cell chronic lymphocytic leukemia (B-CLL) has not been evaluated so far. The serum concentration of sCD138 and some angiogenesis-involved cytokines: vascular...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/MI/2006/42394
更新日期:2006-01-01 00:00:00
abstract::The production of nitric oxide (NO) was measured in cultures of spleen cells stimulated by lipopolysaccharide (LPS), IL-2 or LPS + IL-2. We observed that NO synthesis is increased by IFN-gamma but inhibited by IFN-alpha/beta. This is not the case when IL-2 is present in the cultures, since interferons play a minor rol...
journal_title:Mediators of inflammation
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doi:10.1155/S0962935196000117
更新日期:1996-01-01 00:00:00
abstract:Objectives:In this study, we assessed the effects of dietary magnesium on leukocyte telomere length (LTL). Designs:The current cross-sectional analysis was based on data collected within a type 2 diabetes project. Settings. Dietary magnesium intake is associated with peripheral blood leukocyte telomere length (LTL). H...
journal_title:Mediators of inflammation
pub_type: 杂志文章
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abstract::Podocyte injury critically contributes to the pathogenesis of obesity-related glomerulopathy (ORG). Recently, lipid accumulation and inflammatory responses have been found to be involved in podocyte injury. This study is to explore their role and relationship in podocyte injury of ORG. In animal experiments, the ORG m...
journal_title:Mediators of inflammation
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doi:10.1155/2019/3172647
更新日期:2019-04-11 00:00:00
abstract::Previous studies showed little CD137 expressed in normal vascular smooth muscle cells (VSMCs) and it is important to find a valid way to elevate it before studying its function. The level of CD137 was detected by RT-PCR, western blot, and flow cytometry, respectively. CD137 signaling activation was activated by agonis...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2017/1382805
更新日期:2017-01-01 00:00:00
abstract::The purpose of this study is to characterize synovial fluid- (SF-) derived exosomes of patients with gonarthrosis comparing two methods of isolation and to investigate their immune regulatory properties. Extracellular vesicles (EVs) have been isolated from inflamed SF by polymer precipitation method and quantified by ...
journal_title:Mediators of inflammation
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更新日期:2017-01-01 00:00:00
abstract:BACKGROUND:Growth arrest specific gene 6 (Gas6) protein enhances survival of oligodendrocytes and neurons, and it is involved in autoimmunity. Therefore, we aimed to verify whether cerebrospinal-fluid (CSF) Gas6 concentration may represent a biomarker of disease activity in multiple sclerosis. METHODS:Sixty-five patie...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2013/406483
更新日期:2013-01-01 00:00:00
abstract::The secretory leukocyte protease inhibitor (SLPI) is a low-molecular-weight inhibitor of proteases, such as elastase and cathepsin G which are released from leukocytes during phagocytosis. The purpose of this study was to determine whether or not SLPI is able to inhibit IgE-mediated histamine release. Nasal mucosa fro...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1080/09629359891162
更新日期:1998-01-01 00:00:00
abstract::The clinical outcome of autologous adipose stem cell (ASC) treatment of patients with multiple sclerosis (MS) was investigated following one year of observation. Methods. The clinical and MRI outcomes of 16 ASC-treated patients with RRMS and SPMS are reported after a one-year follow-up period. Results. At 18 months of...
journal_title:Mediators of inflammation
pub_type: 杂志文章
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更新日期:2016-01-01 00:00:00
abstract::Current studies have identified the multifaceted protective functions of dexmedetomidine on multiple organs. For the first time, we clarify effects of dexmedetomidine on monocyte-endothelial adherence and whether its underlying mechanism is relative to connexin43 (Cx43), a key factor regulating monocyte-endothelial ad...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2020/7039854
更新日期:2020-02-10 00:00:00
abstract::The mechanism of pain reduction involves bidirectional processes of pain blocking (nociception) and reductions in the levels of proinflammatory cytokines in the blood. Does transcutaneous electrical nerve stimulation (TENS) reduce blood levels of proinflammatory cytokines? For this systematic review, we searched in si...
journal_title:Mediators of inflammation
pub_type: 杂志文章,meta分析,评审
doi:10.1155/2018/1094352
更新日期:2018-04-02 00:00:00
abstract::Autism is a neurodevelopmental disorder characterized by problems in communication, social skills, and repetitive behavior. Recent studies suggest that apoptotic and inflammatory mechanisms may contribute to the pathogenesis of this disorder. Nuclear factor-κB (NF-κB) is an important gene transcriptional factor involv...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2011/785265
更新日期:2011-01-01 00:00:00
abstract::The success of peritoneal dialysis (PD) is dependent on the structural and functional integrity of the peritoneal membrane. The mesothelium lines the peritoneal membrane and is the first line of defense against chemical and/or bacterial insult. Peritonitis remains a major complication of PD and is a predominant cause ...
journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
doi:10.1155/2012/484167
更新日期:2012-01-01 00:00:00
abstract::Neonates are extremely susceptible to bacterial infections, and evidences suggest that phagocytosis-induced cell death (PICD) is less frequently triggered in neonatal monocytes than in monocytes from adult donors. An insufficient termination of the inflammatory response, leading to a prolonged survival of neonatal mon...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2019/1603131
更新日期:2019-11-03 00:00:00
abstract::The aim of this study was to evaluate the relationship between serum transforming growth factor β 1 (TGF- β 1) concentrations and the duration of type 1 diabetes mellitus (T1DM) in children and adolescents. One hundred and sixteen patients with T1DM and 19 healthy controls were examined. Serum TGF- β 1 concentrations ...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2013/849457
更新日期:2013-01-01 00:00:00
abstract::Multiple sclerosis is an autoimmune disease with classical traits of demyelination, axonal damage, and neurodegeneration. The migration of autoimmune T cells and macrophages from blood to central nervous system as well as the destruction of blood brain barrier are thought to be the major processes in the development o...
journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
doi:10.1155/2014/659206
更新日期:2014-01-01 00:00:00
abstract::Little is known about the cause and pathophysiology of middermal elastolysis (MDE). In this condition, variable inflammatory infiltrate may be present or not together with loss of elastic fibres in the middermis that spares both papillary and lower reticular dermis. MDE may be a consequence of abnormal extracellular m...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2017/9524594
更新日期:2017-01-01 00:00:00
abstract::Tuberculosis is characterized by the presence of activated mononuclear cells both in the peripheral circulation and in pleural fluid. Expression and up-regulation of adhesion molecules is the basis of cell-cell adhesion in granuloma formation and in leukocyte migration to the inflammatory site. Soluble isoforms of adh...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/S0962935196000403
更新日期:1996-01-01 00:00:00
abstract::Adipokines are cytokines produced mainly by adipose tissue, besides many other tissues such as placenta, ovaries, peripheral-blood mononuclear cells, liver, muscle, kidney, heart, and bone marrow. Adipokines play a significant role in the metabolic syndrome and in cardiovascular diseases, have implications in regulati...
journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
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abstract::Atherosclerosis is characterized by interaction between immune and vascular endothelial cells which is mediated by adhesion molecules occurring on the surface of the vascular endothelium leading to massive release of proinflammatory mediators. Ginkgo biloba L. (Ginkgoaceae) standardized extracts showing beneficial eff...
journal_title:Mediators of inflammation
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doi:10.1155/2019/6173893
更新日期:2019-06-25 00:00:00
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journal_title:Mediators of inflammation
pub_type: 杂志文章
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更新日期:2014-01-01 00:00:00
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journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2009/390951
更新日期:2009-01-01 00:00:00
abstract::To determine the role of mutant SOD1 gene (SOD1(G93A)) on muscle cell differentiation, we derived C2C12 muscle cell lines carrying a stably transfected SOD1(G93A) gene under the control of a myosin light chain (MLC) promoter-enhancer cassette. Expression of MLC/SOD1(G93A) in C2C12 cells resulted in dramatic inhibition...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2015/537853
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND:Rodent models suggest that follistatin-like 3 (fstl3) is associated with diabetes and obesity. In humans, plasma fstl3 is reduced with gestational diabetes. In vitro, TNF-α induces fstl3 secretion, which suggests a link to inflammation. OBJECTIVE:To elucidate the association between plasma fstl3 and obesity...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2014/364209
更新日期:2014-01-01 00:00:00
abstract:INTRODUCTION:Proliferative vitreoretinopathy (PVR) is a severe inflammatory complication of retinal detachment. Pathological epiretinal membranes grow on the retina surface leading to contraction, and surgery fails in 5% to 10% of the cases. We evaluated the expression of VEGF-A, Otx1, Otx2, Otx3, and p53 family member...
journal_title:Mediators of inflammation
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更新日期:2013-01-01 00:00:00
abstract::Peripheral artery disease (PAD) is a common disease affecting 20-25% of population over 60 years old. Early diagnosis is difficult because symptoms only become evident in advanced stages of the disease. Inflammation, impaired metabolism, and mitochondrial dysfunction predispose to PAD, which is normally associated wit...
journal_title:Mediators of inflammation
pub_type: 杂志文章
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更新日期:2018-09-20 00:00:00
abstract::Cysteinyl leukotrienes (CysLTs) are potent lipid inflammatory mediators synthesized from arachidonic acid, through the 5-lipoxygenase (5-LO) pathway. Owing to their properties, CysLTs play a crucial role in the pathogenesis of inflammation; therefore, CysLT modifiers as synthesis inhibitors or receptor antagonists, ce...
journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
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更新日期:2017-01-01 00:00:00
abstract::The effects of chronic mild prenatal stress on leukocyte infiltration into the airways was investigated in rat offspring. The chronic prenatal stress consisted of transitory and variable changes in the rat's living conditions. Offspring at adult age were actively sensitized (day 0) and intratracheally challenged (day ...
journal_title:Mediators of inflammation
pub_type: 杂志文章
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更新日期:1999-01-01 00:00:00
abstract::Nitric oxide has enigmatic qualities in inflammation. In order to appreciate the precise contributions of nitric oxide to a pathophysiological process, one must account for enzyme source, coproduction of oxidants and antioxidant defences, time, rate of nitric oxide production, cellular source, peroxynitrite formation ...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/S0962935195000639
更新日期:1995-01-01 00:00:00