Abstract:
OBJECTIVE:To investigate the Th17/Treg immune balance in the ulcerative colitis (UC) patients in a Chinese Han population. METHODS:Ninety UC patients and 30 healthy subjects were enrolled. The serum IL-17 and TGF-β1 levels of these participants were measured with ELISA; the percentage of Th17 and Treg cells in peripheral blood was determined with flow cytometry. RESULTS:In UC patients, the levels of IL-17 and Th17 were significantly higher compared with healthy subjects; the percentage of Th17 and IL-17 level in moderate and severe subgroup was significantly higher than in mild subgroup; a positive correlation existed between these two indexes and clinical activity index and endoscopic evaluation. TGF-β1 level and Treg cells in UC patients were lower than healthy subjects. TGF-β1 level in moderate and severe subgroup was lower than in mild subgroup. There was a negative linear correlation between Treg cells and clinical activity index, endoscopic evaluation. A positive correlation was detected between Treg cells and TGF-β1 level. CONCLUSIONS:Th17/Treg immune imbalance might play a crucial role in the development of UC. To induce the production of Treg cells and TGF-β1, inhibit the level of Th17 and IL-17, and thus recover the Th17/Treg immune balance might imply new therapeutic targets in UC management.
journal_name
Mediators Inflammjournal_title
Mediators of inflammationauthors
Gong Y,Lin Y,Zhao N,He X,Lu A,Wei W,Jiang Mdoi
10.1155/2016/7089137subject
Has Abstractpub_date
2016-01-01 00:00:00pages
7089137eissn
0962-9351issn
1466-1861journal_volume
2016pub_type
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journal_title:Mediators of inflammation
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journal_title:Mediators of inflammation
pub_type: 已发布勘误
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