Two faces of TGF-beta1 in breast cancer.

abstract：:The pathogenesis of brain inflammation and damage by human immunodeficiency virus (HIV) infection is unclear. Because blood-brain barrier damage and impaired cerebral perfusion are common features of HIV-1 infection, we evaluated the role of tumour necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) in ...

journal_title：Mediators of inflammation

authors： Sharief MK,Ciardi M,Thompson EJ,Sorice F,Rossi F,Vullo V,Cirelli A

更新日期：1992-01-01 00:00:00

abstract：:The purpose of this study is to assess the role of nitric oxide (NO) in the intestinal lesions of passive anaphylaxis, since this experimental model resembles necrotizing enterocolitis. Sprague-Dawley rats were sensitized with IgE anti-dinitrophenol monoclonal antibody. Extravasation of protein-rich plasma and haemorr...

journal_title：Mediators of inflammation

authors： Tavares JC,Moreno A,Crespo MS

更新日期：1997-01-01 00:00:00

abstract：:The expression of cytochrome P4501A1 (CYP1A1) enzyme is changed in various organs during the host response to inflammation or infection, leading to alterations in the metabolism of endogenous and exogenous compounds. Results of this study showed that CYP1A1 expression was significantly downregulated in the mammary tis...

journal_title：Mediators of inflammation

authors： Zhang WY,Wang H,Qi S,Wang X,Li X,Zhou K,Zhang Y,Gao MQ

更新日期：2018-02-28 00:00:00

abstract：:Enterovirus 71 (EV71) is one of the most common intestinal virus that causes hand, foot, and mouth disease (HFMD) in infants and young children (mostly ≤5 years of age). Generally, children with EV71-infected HFMD have mild symptoms that resolve spontaneously within 7-14 days without complications. However, some EV71-...

journal_title：Mediators of inflammation

authors： Zhang W,Huang Z,Huang M,Zeng J

更新日期：2020-01-31 00:00:00

abstract：:Cytokines play an important role in the regulation of the immune system (adaptive and innate). Given their importance in proinflammatory processes, cytokines have been used for understanding the pathogenesis and as biomarkers in many diseases. IL-31 and IL-33 are still considered novel cytokines. IL-31 controls signal...

journal_title：Mediators of inflammation

authors： Di Salvo E,Ventura-Spagnolo E,Casciaro M,Navarra M,Gangemi S

更新日期：2018-03-11 00:00:00

abstract：:The purpose of the current study was to explore the effect of autologous adipose tissue on cartilage responses to lipopolysaccharide (LPS). We hypothesized that LPS elicits an inflammatory response in cartilage, and that response is augmented in the presence of adipose tissue. Furthermore, we hypothesized that this au...

journal_title：Mediators of inflammation

authors： Pearson W,Garland AEN,Nixon A,Cant JP,Hurtig MB

更新日期：2020-11-12 00:00:00

abstract：:We investigated the serum concentrations of interleukin-6 (IL-6) and two IL-6 family of cytokines (leukaemia inhibitory factor (LIF) and ciliary neurotrophic factor (CNTF) as well as IL-6 soluble receptor (sIL-6R) using an enzyme-linked immunosorbent assay (ELISA) in 66 patients with rheumatoid arthritis (RA) and 24 h...

journal_title：Mediators of inflammation

authors： Robak T,Gladalska A,Stepień H,Robak E

更新日期：1998-01-01 00:00:00

abstract：:The aim of our work was to find if MCP-1 -2518 (A/G) single nucleotide polymorphism (SNP) influences somehow the serum concentrations of high-sensitive CRP (hsCRP) both in patients suffering from ischemic heart disease (IHD), myocardial infarction (MI), angina pectoris (AP), and hypertension (HT) and in control group ...

journal_title：Mediators of inflammation

authors： Bucova M,Lietava J,Penz P,Mrazek F,Petrkova J,Bernadic M,Petrek M

更新日期：2009-01-01 00:00:00

abstract：Background:Sphingosine-1-phosphate (S1P) is a biologically active lysophospholipid mediator involved in modulating inflammatory process. We investigated the effects of FTY720, a structural analogue of S1P after phosphorylation, on lung injury induced by hindlimb ischemia reperfusion (IR) in rats. Methods:Fifty Sprague...

journal_title：Mediators of inflammation

authors： Wang L,Chen F,Pan Y,Lin L,Xiong X

更新日期：2017-01-01 00:00:00

abstract：:Cathepsin G is a serine protease secreted by activated neutrophils that play a role in the inflammatory response. Because neutrophils are known to be invading leukocytes in various tumors, their products may influence the characteristics of tumor cells such as the growth state, motility, and the adhesiveness between c...

journal_title：Mediators of inflammation

authors： Kudo T,Kigoshi H,Hagiwara T,Takino T,Yamazaki M,Yui S

更新日期：2009-01-01 00:00:00

abstract：:Increasing evidence has demonstrated that reactive oxygen species (ROS) induces oxidative stress and plays a crucial role in the pathogenesis of acute pancreatitis (AP). Hydrogen-rich saline (HRS), a well-known ROS scavenger, has been shown to possess therapeutic benefit on AP in many animal experiments. Recent findin...

journal_title：Mediators of inflammation

authors： Ren JD,Ma J,Hou J,Xiao WJ,Jin WH,Wu J,Fan KH

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:Asthma is a disorder characterized by a predominance of Th2 cells and eosinophilic inflammation. Suppressors of cytokine signaling (SOCS) proteins act as negative regulators of cytokine signaling. In particular, SOCS1 and SOCS3 play an important role in immune response by controlling the balance between Th1 ...

journal_title：Mediators of inflammation

authors： López E,Zafra MP,Sastre B,Gámez C,Lahoz C,del Pozo V

更新日期：2011-01-01 00:00:00

abstract：:The etiopathogenesis of endometriosis still remains unknown. Recent data provide new valuable information concerning the role of oxidative stress in the pathophysiology of the disease. It has been proved that levels of different lipid peroxidation end products are increased in both peritoneal fluid (PF) and serum of e...

journal_title：Mediators of inflammation

authors： Polak G,Barczyński B,Kwaśniewski W,Bednarek W,Wertel I,Derewianka-Polak M,Kotarski J

更新日期：2013-01-01 00:00:00

abstract：:Pulmonary fibrosis is a progressive and fatal fibrotic disease of the lungs with unclear etiology. Recent insight has suggested that early injury/inflammation of alveolar epithelial cells could lead to dysregulation of tissue repair driven by multiple cytokines. Although dysregulation of interleukin- (IL-) 22 is invol...

journal_title：Mediators of inflammation

authors： Liang M,Wang J,Chu H,Zhu X,He H,Liu Q,Qiu J,Zhou X,Guan M,Xue Y,Chen X,Zou H

更新日期：2013-01-01 00:00:00

abstract：:Syndecan-1 (CD138) is a transmembrane heparin sulfate proteoglycan expressed on distinct stages of differentiation of B-lymphoid cells. Its prognostic value in B-cell chronic lymphocytic leukemia (B-CLL) has not been evaluated so far. The serum concentration of sCD138 and some angiogenesis-involved cytokines: vascular...

journal_title：Mediators of inflammation

authors： Wołowiec D,Dybko J,Wróbel T,Urbaniak-Kujda D,Jaźwiec B,Tomaszewska-Toporska B,Kapelko-Słowik K,Potoczek S,Kuliczkowski K

更新日期：2006-01-01 00:00:00

abstract：:High levels of serum long chain saturated fatty acids (LCSFAs) have been associated with inflammation in type 2 diabetes. Dietary SFAs can promote inflammation, the secretion of IgG antibodies, and secretion of the proinflammatory cytokine IL-1β. This study characterizes anti-LCSFA IgG antibodies from patients with ty...

journal_title：Mediators of inflammation

authors： Nicholas DA,Salto LM,Boston AM,Kim NS,Larios M,Beeson WL,Firek AF,Casiano CA,Langridge WH,Cordero-MacIntyre Z,De Leon M

更新日期：2015-01-01 00:00:00

abstract：:The effect of lipoprotein apheresis (Direct Adsorption of Lipids, DALI) (LA) on plasma levels of pentraxin 3 (PTX3), an inflammatory marker that reflects coronary plaque vulnerability, and expression of PTX3 mRNA was evaluated in patients with hyperLp(a)lipoproteinemia and angiographically defined atherosclerosis/coro...

journal_title：Mediators of inflammation

authors： Stefanutti C,Mazza F,Steiner M,Watts GF,De Nève J,Pasqualetti D,Paal J

更新日期：2016-01-01 00:00:00

abstract：:We investigated whether TNB alters colonic tissue levels of PAF at the expense of changes in colonic motility in the isolated perfused rabbit left colon. Colonic inflammation was induced by the intracolonic administration of 0.25 ml of 50% ethanol containing 30 mg of trinitrobenzene. Strain gauge transducers were sewn...

journal_title：Mediators of inflammation

authors： Longo WE,Standeven J,Chandel B,Deshpande Y,Vernava AM,Kaminski D

更新日期：1995-01-01 00:00:00

abstract：:The causes of retinal hypoxia are many and varied. Under hypoxic conditions, a variety of soluble factors are secreted into the vitreous cavity including growth factors, cytokines, and chemokines. Cytokines, which usually serve as signals between neighboring cells, are involved in essentially every important biologica...

journal_title：Mediators of inflammation

authors： dell'Omo R,Semeraro F,Bamonte G,Cifariello F,Romano MR,Costagliola C

更新日期：2013-01-01 00:00:00

abstract：Objective:Renal ischemia/reperfusion injury (RI/RI) is the main cause of acute kidney injury. Total glucosides of paeony (TGP) are a traditional Chinese medicine. This study was aimed at exploring the role of TGP in RI/RI and its underlying mechanism of action. Methods:Rat RI/RI models were constructed by surgical ope...

journal_title：Mediators of inflammation

authors： Chen F,Hu Y,Xie Y,Zhao Z,Ma L,Li Z,Tan W

更新日期：2020-11-24 00:00:00

abstract：BACKGROUND:Nonbacterial prostatitis has no established etiology. We hypothesized that proteinase-activated receptor-1 (PAR1) can play a role in prostatitis. We therefore investigated the effects of PAR1 stimulation in the context of a new model of murine nonbacterial prostatitis. METHODS:Using a hapten (ethanol-dinitr...

journal_title：Mediators of inflammation

authors： Stanton MM,Nelson LK,Benediktsson H,Hollenberg MD,Buret AG,Ceri H

更新日期：2013-01-01 00:00:00

abstract：:The number of persons who relocate to regions of high altitude for work, pleasure, sport, or residence increases every year. It is known that the reduced supply of oxygen (O2) induced by acute or chronic increases in altitude stimulates the body to adapt to new metabolic challenges imposed by hypoxia. Sleep can suffer...

journal_title：Mediators of inflammation

authors： Lemos Vde A,dos Santos RV,Lira FS,Rodrigues B,Tufik S,de Mello MT

更新日期：2013-01-01 00:00:00

abstract：:Colitis is a major form of inflammatory bowel disease which involved mucosal immune dysfunction. Aloperine is an alkaloid isolated from the shrub Sophora alopecuroides L. and has been recognized as an effective treatment for inflammatory and allergic diseases. The present study aimed to examine the molecular mechanism...

journal_title：Mediators of inflammation

authors： Fu X,Sun F,Wang F,Zhang J,Zheng B,Zhong J,Yue T,Zheng X,Xu JF,Wang CY

更新日期：2017-01-01 00:00:00

abstract：:The aim of the present study was to compare serum levels of soluble forms of interleukin-2 receptor, CD4 and CD8, released by lymphocytes during activation of the immune system, in patients with allergic bronchial asthma, with those in healthy subjects. Significantly higher levels of soluble IL-2R and soluble CD4 were...

journal_title：Mediators of inflammation

authors： Lorenzo GD,Mansueto P,Melluso M,Morici G,Norrito F,Cigna D,Candore G,Caruso C

更新日期：1995-01-01 00:00:00

abstract：:To elucidate the modulatory role of histamine-degrading enzymes in airway constrictor responses, human bronchial strips were studied under isometric conditions in vitro. Pretreatment of tissues with the histamine N-methyltransferase (HMT) inhibitor SKF 91488 specifically potentiated the contractile responses to histam...

journal_title：Mediators of inflammation

authors： Tamaoki J,Chiyotani A,Tagaya E,Isono K,Konno K

更新日期：1994-01-01 00:00:00

abstract：:Respiratory syncytial virus (RSV) is the most common respiratory virus and is associated with pediatric pneumonia, causing bronchiolitis and significant mortality in infants and young children. MicroRNAs (miRNAs) are endogenous noncoding small RNAs that function in gene regulation and are associated with host immune r...

journal_title：Mediators of inflammation

authors： Zhang X,Huang F,Yang D,Peng T,Lu G

更新日期：2020-05-01 00:00:00

abstract：:Keloids are characterized by excessive collagen deposition and growth beyond the edges of the initial injury, and cytokines may be related to their formation. The objective of this study was to evaluate the collagen fibers, analyze in situ expression of cytokines in keloid lesions, and compare to the control group. Re...

journal_title：Mediators of inflammation

authors： da Silva IR,Tiveron LCRDC,da Silva MV,Peixoto AB,Carneiro CAX,Dos Reis MA,Furtado PC,Rodrigues BR,Rodrigues V Jr,Rodrigues DBR

更新日期：2017-01-01 00:00:00

abstract：:The CCN family member 2 (CCN2, also known as connective tissue growth factor) may behave as a risk biomarker and a potential therapeutic target for renal disease. CCN2 participates in the regulation of inflammation and fibrosis. TGF-β is considered the main fibrogenic cytokine; however, in some pathological settings T...

journal_title：Mediators of inflammation

authors： Rodrigues-Díez R,Rayego-Mateos S,Orejudo M,Aroeira LS,Selgas R,Ortiz A,Egido J,Ruiz-Ortega M

更新日期：2015-01-01 00:00:00

abstract：:The recently discovered IL-33 as an IL-1 cytokine family member has been proved to be specifically released from osteonecrotic bones. We aimed to investigate the potential role of IL-33 in the development of osteonecrosis of femoral head (ONFH). Forty patients diagnosed with ONFH and forty age-, sex-, and body mass in...

journal_title：Mediators of inflammation

authors： Ma J,Guo W,Li Z,Wang B,Li S,Wang P

更新日期：2017-01-01 00:00:00

abstract：:Cathepsin S is a cysteine protease and regulator of autophagy with possible involvement in periodontitis. The objective of this study was to investigate whether cathepsin S is involved in the pathogenesis of periodontal diseases. Human periodontal fibroblasts were cultured under inflammatory and infectious conditions ...

journal_title：Mediators of inflammation

authors： Memmert S,Damanaki A,Nogueira AVB,Eick S,Nokhbehsaim M,Papadopoulou AK,Till A,Rath B,Jepsen S,Götz W,Piperi C,Basdra EK,Cirelli JA,Jäger A,Deschner J

更新日期：2017-01-01 00:00:00