Abstract:
BACKGROUND:Asthma is a disorder characterized by a predominance of Th2 cells and eosinophilic inflammation. Suppressors of cytokine signaling (SOCS) proteins act as negative regulators of cytokine signaling. In particular, SOCS1 and SOCS3 play an important role in immune response by controlling the balance between Th1 and Th2 cells. In a previous study, we demonstrated that treatment of chronic asthmatic mice with gene therapy using plasmid encoding galectin-3 (Gal-3) led to an improvement in Th2 allergic inflammation. METHODS:Using a microarray approach, this study endeavored to evaluate the changes produced by therapeutic Gal-3 delivered by gene therapy in a well-characterized mouse model of chronic airway inflammation. Results were confirmed by real-time RT-PCR, Western blot and immunohistochemical analysis. RESULTS:We identify a set of genes involved in different pathways whose expression is coordinately decreased/increased in mice treated with Gal-3 gene therapy. We report a correlation between Gal-3 treatment and inhibition of SOCS1 and SOCS3 expression in lungs. CONCLUSION:These results suggest that negative regulation of SOCS1 and 3 following Gal-3 treatment could be a valuable therapeutic approach in allergic disease.
journal_name
Mediators Inflammjournal_title
Mediators of inflammationauthors
López E,Zafra MP,Sastre B,Gámez C,Lahoz C,del Pozo Vdoi
10.1155/2011/823279subject
Has Abstractpub_date
2011-01-01 00:00:00pages
823279eissn
0962-9351issn
1466-1861journal_volume
2011pub_type
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journal_title:Mediators of inflammation
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doi:10.1080/09629350120093731
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journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1080/09629359891162
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journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2019/4738237
更新日期:2019-11-04 00:00:00
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journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
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journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1080/09629359791893
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journal_title:Mediators of inflammation
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更新日期:1994-01-01 00:00:00
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journal_title:Mediators of inflammation
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pub_type: 杂志文章,评审
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