Immunological Dynamics Associated with Direct-Acting Antiviral Therapies in Naive and Experimented HCV Chronic-Infected Patients.

abstract：BACKGROUND:Asthma is a disorder characterized by a predominance of Th2 cells and eosinophilic inflammation. Suppressors of cytokine signaling (SOCS) proteins act as negative regulators of cytokine signaling. In particular, SOCS1 and SOCS3 play an important role in immune response by controlling the balance between Th1 ...

journal_title：Mediators of inflammation

authors： López E,Zafra MP,Sastre B,Gámez C,Lahoz C,del Pozo V

更新日期：2011-01-01 00:00:00

abstract：Aim:To analyze changes in peripheral blood monocytes and their clinical significance in patients with early stage of idiopathic membranous nephropathy (IMN). Methods:A total of 27 patients with early stage of IMN and 16 age- and sex-matched healthy controls (HCs) were recruited for the study. The monocyte subset count...

journal_title：Mediators of inflammation

authors： Hou J,Zhang M,Ding Y,Wang X,Li T,Gao P,Jiang Y

更新日期：2018-06-21 00:00:00

abstract：:The destruction of joints caused by rheumatoid arthritis and osteoarthritis is characterized by an imbalance of enzyme catalysed cartilage breakdown and regeneration. A complex cytokine network perpetuates joint conditions by direct regulation of metalloproteases, by indirect recruitment of cells that secrete degradat...

journal_title：Mediators of inflammation

authors： Sipe JD,Martel-Pelletier J,Otterness IG,Pelletier JP

更新日期：1994-01-01 00:00:00

abstract：:Heart failure is the most frequent cardiac complication of chronic kidney disease (CKD). Biomarkers help identify high-risk patients. Natriuretic peptides (BNP and NT-proBNP) are largely used for monitoring patients with cardiac failure but are highly dependent on glomerular filtration rate (GFR). Soluble suppression ...

journal_title：Mediators of inflammation

authors： Plawecki M,Morena M,Kuster N,Chenine L,Leray-Moragues H,Jover B,Fesler P,Lotierzo M,Dupuy AM,Klouche K,Cristol JP

更新日期：2018-10-08 00:00:00

abstract：Aim:The objective of the current study is to analyze the correlation between cytokine levels and periodontal parameters in aggressive periodontitis patients before and after periodontal treatment that was performed by using two different laser therapies. Materials and Methods:Twenty-six generalized aggressive periodon...

journal_title：Mediators of inflammation

authors： Talmac AC,Calisir M,Eroglu EG,Ertugrul AS

更新日期：2019-06-12 00:00:00

abstract：:The secretory leukocyte protease inhibitor (SLPI) is a low-molecular-weight inhibitor of proteases, such as elastase and cathepsin G which are released from leukocytes during phagocytosis. The purpose of this study was to determine whether or not SLPI is able to inhibit IgE-mediated histamine release. Nasal mucosa fro...

journal_title：Mediators of inflammation

authors： Westin U,Lundberg E,Ohlsson K

更新日期：1998-01-01 00:00:00

abstract：:In this study, we investigated in groups of female BALB/c mice injected with Crotalus durissus terrificus venom (Cdt) the renal function based on creatinine clearance, percentage of fractional excretion cytokines and histological examination of renal tissue. Cdt caused renal alterations that induced proteinuria during...

journal_title：Mediators of inflammation

authors： Hernández Cruz A,Barbosa Navarro L,Mendonça RZ,Petricevich VL

更新日期：2011-01-01 00:00:00

abstract：:[This corrects the article DOI: 10.1155/2020/6947482.]. ...

journal_title：Mediators of inflammation

authors： Zhao Y,Wang J,Zhang M,Li P,Qi S,Lin W

更新日期：2020-11-21 00:00:00

abstract：:CXCL8 displays several tumor-promoting effects. Targeting and/or lowering CXCL8 concentrations within the tumor microenvironment would produce a therapeutic benefit. Aim of this study was to test the effect of IFNγ on the basal and TNFα-stimulated secretion of CXCL8 in TCP-1 and BCPAP thyroid cancer cell lines (harbor...

journal_title：Mediators of inflammation

authors： Rotondi M,Coperchini F,Awwad O,Pignatti P,Di Buduo CA,Abbonante V,Magri F,Balduini A,Chiovato L

更新日期：2016-01-01 00:00:00

abstract：:To investigate the role of AEG-1 in glycolysis and tumorigenesis, we construct myc-AEG-1 expression vector and demonstrate a novel mechanism that AEG-1 may increase the activity of AMPK by Thr172 phosphorylation. The higher expression levels of AEG-1 in colorectal carcinoma cells were found but showed significant diff...

journal_title：Mediators of inflammation

authors： Song HT,Qin Y,Yao GD,Tian ZN,Fu SB,Geng JS

更新日期：2014-01-01 00:00:00

abstract：:Cathepsin G is a serine protease secreted by activated neutrophils that play a role in the inflammatory response. Because neutrophils are known to be invading leukocytes in various tumors, their products may influence the characteristics of tumor cells such as the growth state, motility, and the adhesiveness between c...

journal_title：Mediators of inflammation

authors： Kudo T,Kigoshi H,Hagiwara T,Takino T,Yamazaki M,Yui S

更新日期：2009-01-01 00:00:00

abstract：:Our understanding of inflammation's role in the pathogenesis of myeloproliferative neoplasm (MPN) is evolving. The impact of chronic inflammation, a characteristic feature of MPN, likely goes far beyond its role as a driver of constitutional symptoms. An inflammatory response to the neoplastic clone may be responsible...

journal_title：Mediators of inflammation

authors： Fleischman AG

更新日期：2015-01-01 00:00:00

abstract：:To determine the role of mutant SOD1 gene (SOD1(G93A)) on muscle cell differentiation, we derived C2C12 muscle cell lines carrying a stably transfected SOD1(G93A) gene under the control of a myosin light chain (MLC) promoter-enhancer cassette. Expression of MLC/SOD1(G93A) in C2C12 cells resulted in dramatic inhibition...

journal_title：Mediators of inflammation

authors： Martini M,Dobrowolny G,Aucello M,Musarò A

更新日期：2015-01-01 00:00:00

abstract：:Lactobacillus species can exert health promoting effects in the gastrointestinal tract (GIT) through many mechanisms, which include pathogen inhibition, maintenance of microbial balance, immunomodulation, and enhancement of the epithelial barrier function. Different species of the genus Lactobacillus can evoke differe...

journal_title：Mediators of inflammation

authors： Sengupta R,Altermann E,Anderson RC,McNabb WC,Moughan PJ,Roy NC

更新日期：2013-01-01 00:00:00

abstract：:Causes of mortality from COVID-19 include respiratory failure, heart failure, and sepsis/multiorgan failure. TLR4 is an innate immune receptor on the cell surface that recognizes pathogen-associated molecular patterns (PAMPs) including viral proteins and triggers the production of type I interferons and proinflammator...

journal_title：Mediators of inflammation

authors： Aboudounya MM,Heads RJ

更新日期：2021-01-14 00:00:00

abstract：:Peptide 204-212 of lipocortin (LC) 5 inhibited porcine pancreatic phospholipase A(2) (PLA(2)) induced rat stomach strip contractions and ADP induced rabbit platelet aggregation in a concentration dependent manner (IC(30) of 10 muM and 400 muM, respectively). The first two amino acids are not necessary since the eptape...

journal_title：Mediators of inflammation

authors： Mugridge KG,Becherucci C,Parente L,Perretti M

更新日期：1993-01-01 00:00:00

abstract：:Daily food intake is crucial to maintain health and determine endogenous fuel to practice endurance exercise. We investigated the association between quantity of macronutrient and micronutrient daily intake and inflammation induced by long-distance exercise. Methods. Forty-four Brazilian male amateurs' marathon finish...

journal_title：Mediators of inflammation

authors： Passos BN,Lima MC,Sierra APR,Oliveira RA,Maciel JFS,Manoel R,Rogante JI,Pesquero JB,Cury-Boaventura MF

更新日期：2019-10-07 00:00:00

abstract：:Postoperative-fluid retention is a severe complication frequently reported in patients undergoing major surgical procedures. The complex network of molecules involved in such a severe surgery-induced condition remains poorly understood. Inflammation has been proposed among the various causes of fluid retention. Since ...

journal_title：Mediators of inflammation

authors： Mezzasoma L,Cagini L,Antognelli C,Puma F,Pacifico E,Talesa VN

更新日期：2013-01-01 00:00:00

abstract：:Microcystins (MCs) produced by toxic cyanobacteria cause serious water pollution and public health hazard to humans and animals. However, direct molecular mechanisms of MC-LR in vascular endothelial cells (ECs) have not been understood yet. In this study, we investigated whether MC-LR induces vascular inflammatory pro...

journal_title：Mediators of inflammation

authors： Shi J,Zhou J,Zhang M

更新日期：2015-01-01 00:00:00

abstract：:S. epidermidis is responsible for biofilm-related nonunions. This study compares the response to S. epidermidis-infected fractures in rats systemically or locally injected with vancomycin or bone marrow mesenchymal stem cells (BMSCs) in preventing the nonunion establishment. The 50% of rats receiving BMSCs intravenous...

journal_title：Mediators of inflammation

authors： Lovati AB,Drago L,Bottagisio M,Bongio M,Ferrario M,Perego S,Sansoni V,De Vecchi E,Romanò CL

更新日期：2016-01-01 00:00:00

abstract：:Autism is a neurodevelopmental disorder characterized by problems in communication, social skills, and repetitive behavior. Recent studies suggest that apoptotic and inflammatory mechanisms may contribute to the pathogenesis of this disorder. Nuclear factor-κB (NF-κB) is an important gene transcriptional factor involv...

journal_title：Mediators of inflammation

authors： Malik M,Tauqeer Z,Sheikh AM,Wen G,Nagori A,Yang K,Brown WT,Li X

更新日期：2011-01-01 00:00:00

abstract：:Scorpion venoms consist of a complex of several toxins that exhibit a wide range of biological properties and actions, as well as chemical compositions, toxicity, and pharmacokinetic and pharmacodynamic characteristics. These venoms are associated with high morbility and mortality, especially among children. Victims o...

journal_title：Mediators of inflammation

authors： Petricevich VL

更新日期：2010-01-01 00:00:00

abstract：OBJECTIVES:Obesity and related diseases are dramatically increasing problems, particularly in children and adolescents. We determined circulating levels of different interleukin (IL)-1 family members in normal weight and overweight adolescents. METHODS:Seventy male, Caucasian adolescents (13-17 years) were recruited. ...

journal_title：Mediators of inflammation

authors： Jung C,Gerdes N,Fritzenwanger M,Figulla HR

更新日期：2010-01-01 00:00:00

abstract：:In this study we demonstrated that ΔCaecm33 double mutant showed reduced biofilm formation and causes less damage to gingival mucosa tissues. This was confirmed by the reduced level of necrotic cells and Bax/Bcl2 gene expression as apoptotic markers. In contrast, parental and Caecm33 mutant strains decreased basement ...

journal_title：Mediators of inflammation

authors： Rouabhia M,Semlali A,Chandra J,Mukherjee P,Chmielewski W,Ghannoum MA

更新日期：2012-01-01 00:00:00

abstract：:Enterovirus 71 (EV71) is one of the most common intestinal virus that causes hand, foot, and mouth disease (HFMD) in infants and young children (mostly ≤5 years of age). Generally, children with EV71-infected HFMD have mild symptoms that resolve spontaneously within 7-14 days without complications. However, some EV71-...

journal_title：Mediators of inflammation

authors： Zhang W,Huang Z,Huang M,Zeng J

更新日期：2020-01-31 00:00:00

abstract：:Platelet size has been demonstrated to reflect platelet activity and seems to be a useful predictive and prognostic biomarker of cardiovascular events. It is associated with a variety of prothrombotic and proinflammatory diseases. The aim is a review of literature reports concerning changes in the mean platelet volume...

journal_title：Mediators of inflammation

authors： Korniluk A,Koper-Lenkiewicz OM,Kamińska J,Kemona H,Dymicka-Piekarska V

更新日期：2019-04-17 00:00:00

abstract：Background:Multiple sclerosis (MS) is a chronic debilitating disorder characterized by persisting damage to the brain caused by autoreactive leukocytes. Leukocyte activation is regulated by cytokines, which are readily detected in MS serum and cerebrospinal fluid (CSF). Objective:Serum and CSF levels of forty-five cyt...

journal_title：Mediators of inflammation

authors： Martynova E,Goyal M,Johri S,Kumar V,Khaibullin T,Rizvanov AA,Verma S,Khaiboullina SF,Baranwal M

更新日期：2020-10-22 00:00:00

abstract：:Crohn's disease (CD) is a multifactorial chronic inflammatory bowel disease of unknown cause. The aim of the present study was to explore if mRNA over-expression of SSTR5 and CCR7 found in CD patients could be correlated to respective protein expression. When compared to healthy donors, SSTR5 was over-expressed 417 +/...

journal_title：Mediators of inflammation

authors： Taquet N,Dumont S,Vonesch JL,Hentsch D,Reimund JM,Muller CD

更新日期：2009-01-01 00:00:00

abstract：:Aging is characterized by the progressive decline of physiological function and tissue homeostasis leading to increased vulnerability, degeneration, and death. Aging-related changes of the innate and adaptive immune system include decline in the preservation and enhancement of many immune functions, such as changes in...

journal_title：Mediators of inflammation

authors： Costantini E,D'Angelo C,Reale M

更新日期：2018-03-08 00:00:00

abstract：:Collagen triple helix repeat containing-1 (CTHRC1) has been identified as cancer-related protein. CTHRC1 expresses mainly in adventitial fibroblasts and neointimal smooth muscle cells of balloon-injured vessels and promotes cell migration and tissue repair in response to injury. CTHRC1 plays a pivotal role in some pat...

journal_title：Mediators of inflammation

authors： Mei D,Zhu Y,Zhang L,Wei W

更新日期：2020-08-12 00:00:00