Abstract:
:The secretory leukocyte protease inhibitor (SLPI) is a low-molecular-weight inhibitor of proteases, such as elastase and cathepsin G which are released from leukocytes during phagocytosis. The purpose of this study was to determine whether or not SLPI is able to inhibit IgE-mediated histamine release. Nasal mucosa from 11 test subjects without atopic disposition was used for this in vitro study. We found that SLPI inhibited histamine release in a dose-dependent way but was without influence on the spontaneous release.
journal_name
Mediators Inflammjournal_title
Mediators of inflammationauthors
Westin U,Lundberg E,Ohlsson Kdoi
10.1080/09629359891162subject
Has Abstractpub_date
1998-01-01 00:00:00pages
217-20issue
3eissn
0962-9351issn
1466-1861journal_volume
7pub_type
杂志文章abstract::Schistosomiasis is a chronic inflammatory disease whose macrophages are involved in immunopathology modulation. Although P2X7 receptor signaling plays an important role in inflammatory responses mediated by macrophages, no reports have examined the role of P2X7 receptors in macrophage function during schistosomiasis. ...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2014/134974
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND:The role of prolactin (PRL) on tissue injury and repair mechanisms in multiple sclerosis (MS) remains unclear. The aim of this work was to investigate the relationship between PRL plasma levels and brain damage as measured by magnetic resonance imaging (MRI). METHODS:We employed a chemiluminescence immunoas...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2015/732539
更新日期:2015-01-01 00:00:00
abstract::Particulate matter with an aerodynamic diameter equal or less than 2.5 micrometers (PM2.5) is associated with the development of chronic obstructive pulmonary disease (COPD). The mechanisms by which PM2.5 accelerates disease progression in COPD are poorly understood. In this study, we aimed to investigate the effect o...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2020/4260204
更新日期:2020-05-08 00:00:00
abstract::Thymosin beta(4) is a polypeptide isolated from thymosin fraction 5. This peptide exhibits important activities in the regulation and differentiation of thymus-dependent lymphocytes. An analogue of thymosin beta(4), [Phe(4F)(12)] deacetyl- thymosin beta(4), was synthesized by a solution method, followed by deprotectio...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/S096293519200019X
更新日期:1992-01-01 00:00:00
abstract::Cytokine-induced endothelial dysfunction leads to inflammation and vascular adhesion molecule production in retinal pigment epithelium (RPE) cells. Inflammation is a critical mediator in retinal degeneration (RD) diseases, including age-related macular degeneration (AMD), and RD progression may be prevented through an...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2020/9421340
更新日期:2020-10-16 00:00:00
abstract::The therapeutic strategies used in the treatment of hepatitis C are essentially based on the combination of direct-acting antiviral agents (DAAs). This therapy has been shown to be very effective in relation to patient adherence to treatment and has shown high rates of sustained virological response (SVR). However, th...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2019/4738237
更新日期:2019-11-04 00:00:00
abstract:Background:Over the last 20 years, the prevalence of hepatitis B virus (HBV) infection in China has decreased gradually due to the application of a national HBV vaccination program. In contrast, the prevalence of alcoholic liver disease (ALD), nonalcoholic fatty liver disease, autoimmune liver disease, and drug-induced...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2017/5605981
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND:Human and rodent leukocytes express high levels of the glucocorticoid-inducible protein annexin 1 (ANXA1) (previously referred to as lipocortin 1). Neutrophils and monocytes have abundant ANXA1 levels. AIM:We have investigated, for the first time, ANXA1 ultrastructural expression in rat eosinophils and comp...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1080/09629350210000015683
更新日期:2002-10-01 00:00:00
abstract::Nephrolithiasis is characterized by calcification of stones in the kidneys from an unknown cause. Animal models demonstrated the functional roles of the transient receptor potential vanilloid member 5 (TRPV5) gene in calcium renal reabsorption and hypercalciuria. Therefore, TRPV5 was suggested to be involved in calciu...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2015/375427
更新日期:2015-01-01 00:00:00
abstract::Current studies have identified the multifaceted protective functions of dexmedetomidine on multiple organs. For the first time, we clarify effects of dexmedetomidine on monocyte-endothelial adherence and whether its underlying mechanism is relative to connexin43 (Cx43), a key factor regulating monocyte-endothelial ad...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2020/7039854
更新日期:2020-02-10 00:00:00
abstract:OBJECTIVE:To evaluate the effects of psychological stress on periodontitis healing in rats and the contribution of basic fibroblast growth factor (bFGF) expression to the healing process. METHODS:Ninety-six rats were randomly distributed into control group, periodontitis group, and periodontitis plus stress group. The...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2012/732902
更新日期:2012-01-01 00:00:00
abstract:Background:Multiple sclerosis (MS) is a chronic debilitating disorder characterized by persisting damage to the brain caused by autoreactive leukocytes. Leukocyte activation is regulated by cytokines, which are readily detected in MS serum and cerebrospinal fluid (CSF). Objective:Serum and CSF levels of forty-five cyt...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2020/2727042
更新日期:2020-10-22 00:00:00
abstract::In addition to the spectrum of biological action already known to be exhibited by acetylsalicylic acid (ASA) as an analgesic, anti-inflammatory and platelet aggregation inhibitor, there is growing evidence of a stimulatory effect on the immune system. ASA has been found to increase the production ofcytokines and to in...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/S0962935194000591
更新日期:1994-01-01 00:00:00
abstract:OBJECTIVE:Progranulin (PGRN) is implicated in the pathogenesis of rheumatoid arthritis (RA). The aim of this study was to assess the relationship between PGRN and disease activity in RA. METHODS:PGRN levels were evaluated in patients with RA (n = 47) and OA (n = 42) and healthy controls (n = 41). Immunohistochemical a...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2015/740357
更新日期:2015-01-01 00:00:00
abstract::Mechanical ventilation (MV) is a major life support technique for the management of trauma-associated hemorrhagic shock (HS). Ventilator-induced diaphragm dysfunction (VIDD), one of the most common complications of MV, has been well demonstrated in animal and human studies. However, few data are available concerning t...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2019/3738409
更新日期:2019-11-14 00:00:00
abstract::Multiple sclerosis (MS) is a chronic demyelinating disease of the human central nervous system (CNS). The condition predominantly affects young adults and is characterised by immunological and inflammatory changes in the periphery and CNS that contribute to neurovascular disruption, haemopoietic cell invasion of targe...
journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
doi:10.1155/MI/2006/93684
更新日期:2006-01-01 00:00:00
abstract::Our understanding of inflammation's role in the pathogenesis of myeloproliferative neoplasm (MPN) is evolving. The impact of chronic inflammation, a characteristic feature of MPN, likely goes far beyond its role as a driver of constitutional symptoms. An inflammatory response to the neoplastic clone may be responsible...
journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
doi:10.1155/2015/606819
更新日期:2015-01-01 00:00:00
abstract::Macrophage migration inhibitory factor (MIF) has recently been forwarded as a critical regulator of inflammatory conditions, and it has been hypothesized that MIF may have a role in the pathogenesis of asthma and chronic obstructive pulmonary disease (COPD). Hence, we examined effects of MIF immunoneutralization on th...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1080/09629350050024339
更新日期:2000-01-01 00:00:00
abstract::The probiotic Enterococcus faecium HDRsEf1 (Ef1) has been shown to have positive effects on piglet diarrhoea, but the mechanism has not yet been elucidated. In this study, using the IPEC-J2 cell line to mimic intestinal epithelial cells and enterotoxigenic Escherichia coli (ETEC) K88ac as a representative intestinal p...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2016/7474306
更新日期:2016-01-01 00:00:00
abstract::This study examined the role of lymphotoxin (LT)-alpha in host defense against airborne infection with Francisella tularensis, a gram-negative facultative intracellular bacterium and the causative agent of tularemia. Following a low-dose aerosol infection with the highly virulent type A strain of F. tularensis, mice d...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2008/239740
更新日期:2008-01-01 00:00:00
abstract::The human virome comprises viruses that infect host cells, virus-derived elements in our chromosomes, and viruses that infect other organisms, including bacteriophages and plant viruses. The development of high-throughput sequencing techniques has shown that the human gut microbiome is a complex community in which the...
journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
doi:10.1155/2015/326032
更新日期:2015-01-01 00:00:00
abstract::Fibrosis of oesophagus, lungs, heart, and kidney in the course of systemic sclerosis (SSc) may lead to dysfunction of the above organs or even patients death. Recent studies point out the role of angiogenesis and fibrosis disturbances in the pathogenesis of SSc. Heart fibrosis is one of the most important prognostic f...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/MI.2005.144
更新日期:2005-08-14 00:00:00
abstract:OBJECTIVE:To investigate the Th17/Treg immune balance in the ulcerative colitis (UC) patients in a Chinese Han population. METHODS:Ninety UC patients and 30 healthy subjects were enrolled. The serum IL-17 and TGF-β1 levels of these participants were measured with ELISA; the percentage of Th17 and Treg cells in periphe...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2016/7089137
更新日期:2016-01-01 00:00:00
abstract::The clinical outcome of autologous adipose stem cell (ASC) treatment of patients with multiple sclerosis (MS) was investigated following one year of observation. Methods. The clinical and MRI outcomes of 16 ASC-treated patients with RRMS and SPMS are reported after a one-year follow-up period. Results. At 18 months of...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2016/5302120
更新日期:2016-01-01 00:00:00
abstract::Infection with dengue virus (DENV) causes an increase in proinflammatory responses, such as nitric oxide (NO) generation and TNF-α expression; however, the molecular mechanism underlying this inflammatory activation remains undefined, although the activation of the transcription factor NF-κB is generally involved. In ...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2015/274025
更新日期:2015-01-01 00:00:00
abstract::Acute kidney injury (AKI), a clinical syndrome, is a sudden onset of kidney failure that severely affects the kidney tubules. One potential treatment is dexmedetomidine (DEX), a highly selective α2-adrenoreceptor agonist that is used as an anesthetic adjuvant. It also has anti-inflammatory, neuroprotective, and sympat...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2020/2120971
更新日期:2020-04-03 00:00:00
abstract::Adipokines are cytokines produced mainly by adipose tissue, besides many other tissues such as placenta, ovaries, peripheral-blood mononuclear cells, liver, muscle, kidney, heart, and bone marrow. Adipokines play a significant role in the metabolic syndrome and in cardiovascular diseases, have implications in regulati...
journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
doi:10.1155/2016/4981916
更新日期:2016-01-01 00:00:00
abstract:INTRODUCTION:Impaired maternal immune tolerance resulting in systemic inflammation plays a pivotal role in the pathogenesis of preeclampsia. Phenotypical changes of monocytes and neutrophil granulocytes have already been studied in preeclampsia, and some studies also included T lymphocyte activation markers; however, t...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2017/8045161
更新日期:2017-01-01 00:00:00
abstract::The aim of this study was to evaluate the effects of moderate-intensity exercise on plasma levels of C-reactive protein (CRP) and tumor necrosis factor-alpha (TNF-α) as markers of low-grade inflammation and endothelial function in diabetic (db/db) mice. Control and db/db mice were divided into sedentary and exercised ...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2010/149678
更新日期:2010-01-01 00:00:00
abstract::Innate lymphoid cells (ILCs) are a group of hematopoietic cells devoid of antigen receptors that have important functions in lymphoid organogenesis, in the defense against extracellular pathogens, and in the maintenance of the epithelial barrier. Three distinct groups of ILCs have been identified on the basis of pheno...
journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
doi:10.1155/2014/235460
更新日期:2014-01-01 00:00:00