Abstract:
:Aging is characterized by the progressive decline of physiological function and tissue homeostasis leading to increased vulnerability, degeneration, and death. Aging-related changes of the innate and adaptive immune system include decline in the preservation and enhancement of many immune functions, such as changes in the number of circulating monocytic and dendritic cells, thymic involution, T cell polyfunctionality, or production of proinflammatory cytokines, and are defined as immunosenescence. Inflammatory functions are increased with age, causing the chronic low-grade inflammation, referred to as inflamm-aging, that contribute, together with immunosenescence, to neurodegenerative diseases. In this review, we discuss the link between the immune and nervous systems and how the immunosenescence and inflamm-aging can contribute to neurodegenerative diseases.
journal_name
Mediators Inflammjournal_title
Mediators of inflammationauthors
Costantini E,D'Angelo C,Reale Mdoi
10.1155/2018/6039171subject
Has Abstractpub_date
2018-03-08 00:00:00pages
6039171eissn
0962-9351issn
1466-1861journal_volume
2018pub_type
杂志文章,评审abstract::It is hypothesized that central nervous system inflammation induced by systematic inflammation due to surgical trauma plays a critical role in postoperative cognitive dysfunction. The potential inhibitory effect of nerve blockage with local anesthetics on peripheral inflammatory response has been reported. We hypothes...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2015/460125
更新日期:2015-01-01 00:00:00
abstract::Human periodontal ligament (hPDL) fibroblasts play a major role during periodontitis and orthodontic tooth movement, mediating periodontal inflammation, osteoclastogenesis, and collagen synthesis. The highly COX-2-selective NSAID etoricoxib has a favorable systemic side effect profile and high analgesic efficacy, part...
journal_title:Mediators of inflammation
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doi:10.1155/2019/2514956
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abstract::A complex web of dynamic relationships between innate and adaptive immunity is now evident for many autoinflammatory and autoimmune disorders, the first deriving from abnormal activation of innate immune system without any conventional danger triggers and the latter from self-/non-self-discrimination loss of tolerance...
journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
doi:10.1155/2015/194864
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abstract:BACKGROUND:Growth arrest specific gene 6 (Gas6) protein enhances survival of oligodendrocytes and neurons, and it is involved in autoimmunity. Therefore, we aimed to verify whether cerebrospinal-fluid (CSF) Gas6 concentration may represent a biomarker of disease activity in multiple sclerosis. METHODS:Sixty-five patie...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2013/406483
更新日期:2013-01-01 00:00:00
abstract::Microscopic colitis (MC), comprising collagenous colitis (CC) and lymphocytic colitis (LC), is a common cause of chronic diarrhea. Various immune cell infiltrations in the epithelium and lamina propria are seen in MC immunopathology. We compared gene and protein expressions of different immune cell attracting chemokin...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2015/132458
更新日期:2015-01-01 00:00:00
abstract::The human virome comprises viruses that infect host cells, virus-derived elements in our chromosomes, and viruses that infect other organisms, including bacteriophages and plant viruses. The development of high-throughput sequencing techniques has shown that the human gut microbiome is a complex community in which the...
journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
doi:10.1155/2015/326032
更新日期:2015-01-01 00:00:00
abstract::Interleukin-37 (IL-37) is unique in the IL-1 family since it broadly suppresses innate immunity and elevates in humans with inflammatory and autoimmune diseases. IL-37 shows definite groups and transcripts for human IL37 gene, but it is still not completely understood the effect and mechanisms of inflammatory response...
journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
doi:10.1155/2019/2650590
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abstract::Obesity-induced skeletal muscle inflammation is characterized by increased macrophage infiltration and inflammatory cytokine production. In this study, we investigated whether 4-1BB, a member of the TNF receptor superfamily (TNFRSF9) that provides inflammatory signals, participates in obesity-induced skeletal muscle i...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2013/865159
更新日期:2013-01-01 00:00:00
abstract::Shinbaro3, a formulation derived from the hydrolysed roots of Harpagophytum procumbens var. sublobatum (Engl.) Stapf, has been clinically used in the pharamacopuncture treatment of arthritis in Korea. In the present study, Shinbaro3 inhibited NO generation in LPS-induced RAW 264.7 cells in a dose-dependent manner. Shi...
journal_title:Mediators of inflammation
pub_type: 杂志文章,收录出版
doi:10.1155/2018/4514329
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abstract::Adipose tissue produces a wide range of proteins that may influence the immune system. In this study, we assessed the serum levels of leptin, adiponectin, and ghrelin, in association with the measurements of body composition, in 15 female patients with various autoimmune diseases (systemic lupus erythematosus, primary...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2010/938408
更新日期:2010-01-01 00:00:00
abstract::Development of solid cancer depends on escape from host immunosurveillance. Various types of immune cells contribute to tumor-induced immune suppression, including tumor associated macrophages, regulatory T cells, type 2 NKT cells, and myeloid-derived suppressor cells (MDSCs). Growing body of evidences shows that MDSC...
journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
doi:10.1155/2015/159269
更新日期:2015-01-01 00:00:00
abstract:OBJECTIVE:Acute ST-segment elevation myocardial infarction (ASTEMI) is accompanied by increased expression of inflammation and decreased expression of anti-inflammation. IL-37 was found to be involved in the atherosclerosis-related diseases and increased in acute coronary syndrome. However, the level of IL-37 in blood ...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2015/626934
更新日期:2015-01-01 00:00:00
abstract::Many therapies are now available for patients with rheumatoid arthritis (RA) who have an inadequate response to methotrexate including tumor necrosis factor inhibitors, abatacept, tocilizumab, and rituximab. Clinical response to drugs varies widely between individuals. A part of this variability is due to the characte...
journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
doi:10.1155/2014/386148
更新日期:2014-01-01 00:00:00
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journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
doi:10.1080/09629350120054518
更新日期:2001-04-01 00:00:00
abstract::Human respiratory syncytial virus (RSV) sometimes causes acute and severe lower respiratory tract illness in infants and young children. RSV strongly upregulates proinflammatory cytokines and the platelet-activating factor (PAF) receptor, which is a receptor for Streptococcus pneumoniae, in the pulmonary epithelial ce...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2012/528568
更新日期:2012-01-01 00:00:00
abstract::Delayed rectifier K(+)-channels (Kv1.3) are predominantly expressed in T lymphocytes. Based on patch-clamp studies, the channels play crucial roles in facilitating the calcium influx necessary to trigger lymphocyte activation and proliferation. Using selective channel inhibitors in experimental animal models, in vivo ...
journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
doi:10.1155/2015/436572
更新日期:2015-01-01 00:00:00
abstract::The aim is to examine whether the changes in pleural fluid interleukin (IL)-1beta, IL-2, IL-6, and IL-8 levels were significant in differential diagnosis of childhood pleural effusions. IL-1beta, IL-2, IL-6, and IL-8 levels in pleural fluids of all 36 patients were measured. The levels of IL-1beta, IL-2, IL-6, and IL-...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/MI.2005.2
更新日期:2005-02-24 00:00:00
abstract::The effects of chronic mild prenatal stress on leukocyte infiltration into the airways was investigated in rat offspring. The chronic prenatal stress consisted of transitory and variable changes in the rat's living conditions. Offspring at adult age were actively sensitized (day 0) and intratracheally challenged (day ...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1080/09629359990621
更新日期:1999-01-01 00:00:00
abstract:OBJECTIVE:To investigate the effects and mechanisms of hydroxytyrosol (HT) during the pathogenesis of myocardial ischemia reperfusion (I/R) in rat hearts. METHODS:The rats were randomized into five groups: sham group, I/R group, HT+I/R group, HT+LY294002+I/R group, and LY+I/R group. Myocardial infarct size, markers of...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2016/1232103
更新日期:2016-01-01 00:00:00
abstract::The mixed leukocyte population obtained from the peritoneum of the August rat is a potentially important experimental model of inherent eosinophilia that has not been well characterized. In the present study, isolated cell preparations generated a concentration-dependent release of leukotriene (LT) C(4) when exposed t...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/S0962935196000610
更新日期:1996-01-01 00:00:00
abstract::One of the most globally prevalent supraventricular arrhythmias is atrial fibrillation (AF). Knowledge of the structures and functions of messenger RNA (mRNA) has recently increased. It is no longer viewed as solely an intermediate molecule between DNA and proteins but has come to be seen as a dynamic and modifiable g...
journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
doi:10.1155/2020/3053520
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abstract::Methyltransferase-like 3 (METTL3), an RNA N6-methyladenosine (m6A) methyltransferase, is essential for the m6A mRNA modification. As a key enzyme of m6A methylation modification, METTL3 has been implicated in immune and inflammation regulation. However, little is known of the role and underlying mechanism of METTL3 in...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2019/3120391
更新日期:2019-10-24 00:00:00
abstract::Autism is a neurodevelopmental disorder characterized by problems in communication, social skills, and repetitive behavior. Recent studies suggest that apoptotic and inflammatory mechanisms may contribute to the pathogenesis of this disorder. Nuclear factor-κB (NF-κB) is an important gene transcriptional factor involv...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2011/785265
更新日期:2011-01-01 00:00:00
abstract::Peripheral artery disease (PAD) is a common disease affecting 20-25% of population over 60 years old. Early diagnosis is difficult because symptoms only become evident in advanced stages of the disease. Inflammation, impaired metabolism, and mitochondrial dysfunction predispose to PAD, which is normally associated wit...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2018/2760272
更新日期:2018-09-20 00:00:00
abstract:OBJECTIVE:The proapoptotic protein, granzyme B (GZB), was identified as a contributor to the atherosclerotic plaque instability and recently as inflammatory activator. We studied the release kinetics of GZB and other markers of inflammation such as high sensitivity C reactive protein (hsCRP), interleukin 18 (IL-18), an...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2013/343268
更新日期:2013-01-01 00:00:00
abstract:BACKGROUND/AIM:Coronary artery ectasia (CAE) was thought of as a variant of atherosclerosis. C-reactive protein (CRP) which is among the most sensitive markers of systemic inflammation, and elevation of systemic and local levels of this inflammatory marker which has been associated with an increased risk for cardiovasc...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2007/89649
更新日期:2007-01-01 00:00:00
abstract::The aim was to investigate whether bone tissue resorption in early RA is related to crepitus of the temporomandibular joint (TMJ) and systemic levels of inflammatory mediators and markers and sex steroid hormones. Twentynine women and 18 men with recently diagnosed RA were examined for TMJ bone erosions with computeri...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2010/627803
更新日期:2010-01-01 00:00:00
abstract:BACKGROUND:Platelet-activating factor (PAF) seems to be implicated in systemic lupus erythematosus (SLE) patients with associated renal diseases. AIMS:In this study, we ensured the role of PAF in SLE patients without renal complications. METHODS:Blood PAF and acetylhydrolase activity, plasma soluble phospholipase A(2...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1080/0962935031000097718
更新日期:2003-04-01 00:00:00
abstract::Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized by chronic inflammation of multiple joints. The central pathogenesis of RA is the proliferation of synovial fibroblasts in response to inflammatory cytokines. However, some of the targeted therapies for inflammation reactions do not display signi...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2015/460310
更新日期:2015-01-01 00:00:00
abstract::Mammalian placentation is a vital facet of the development of a healthy and viable offspring. Throughout gestation the placenta changes to accommodate, provide for, and meet the demands of a growing fetus. Gestational gene expression is a crucial part of placenta development. The endocannabinoid pathway is activated i...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2015/850471
更新日期:2015-01-01 00:00:00