Abstract:
:One of the most globally prevalent supraventricular arrhythmias is atrial fibrillation (AF). Knowledge of the structures and functions of messenger RNA (mRNA) has recently increased. It is no longer viewed as solely an intermediate molecule between DNA and proteins but has come to be seen as a dynamic and modifiable gene regulator. This new perspective on mRNA has led to rising interest in it and its presence in research into new therapeutic schemes. This paper, therefore, focuses on microRNAs (miRNAs), which are small noncoding RNAs that regulate posttranscriptional gene expression and play a vital role in the physiology and normative development of cardiovascular systems. This means they play an equally vital role in the development and progression of cardiovascular diseases. In recent years, multiple studies have pinpointed particular miRNA expression profiles as being associated with varying histological features of AF. These studies have been carried out in both animal models and AF patients. The emergence of miRNAs as biomarkers and their therapeutic potential in AF patients will be discussed in the body of this paper.
journal_name
Mediators Inflammjournal_title
Mediators of inflammationauthors
Xu X,Zhao Z,Li Gdoi
10.1155/2020/3053520subject
Has Abstractpub_date
2020-03-12 00:00:00pages
3053520eissn
0962-9351issn
1466-1861journal_volume
2020pub_type
杂志文章,评审abstract::Gout is a common inflammatory disease characterized by acute arthritis and hyperuricemia. A number of epidemiological studies have suggested the critical role of gout in carcinogenesis. The aim of this study was to estimate the association between gout and cancer risk by meta-analysis of all relevant studies published...
journal_title:Mediators of inflammation
pub_type: 杂志文章,meta分析,评审
doi:10.1155/2015/680853
更新日期:2015-01-01 00:00:00
abstract:Purpose:To explore the potential of monocyte-to-lymphocyte ratio (MLR) at hospital admission for predicting acute traumatic intraparenchymal hematoma (tICH) expansion in patients with cerebral contusion. Patients and Methods. This multicenter, observational study included patients with available at-hospital admission (...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2020/5483981
更新日期:2020-12-28 00:00:00
abstract::Cathepsin G is a serine protease secreted by activated neutrophils that play a role in the inflammatory response. Because neutrophils are known to be invading leukocytes in various tumors, their products may influence the characteristics of tumor cells such as the growth state, motility, and the adhesiveness between c...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2009/850940
更新日期:2009-01-01 00:00:00
abstract::Breast cancer (BC) is potentially life-threatening malignancy that still causes high mortality among women. Scientific research in this field is focused on deeper understanding of pathogenesis and progressing of BC, in order to develop relevant diagnosis and improve therapeutic treatment. Multifunctional cytokine TGF-...
journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
doi:10.1155/2014/141747
更新日期:2014-01-01 00:00:00
abstract::Our understanding of inflammation's role in the pathogenesis of myeloproliferative neoplasm (MPN) is evolving. The impact of chronic inflammation, a characteristic feature of MPN, likely goes far beyond its role as a driver of constitutional symptoms. An inflammatory response to the neoplastic clone may be responsible...
journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
doi:10.1155/2015/606819
更新日期:2015-01-01 00:00:00
abstract::Diabetic retinopathy is considered a neurovascular disorder, hyperglycemia being considered the main risk factor for this pathology. Diabetic retinopathy also presents features of a low-grade chronic inflammatory disease, including increased levels of cytokines in the retina, such as interleukin-1 beta (IL-1β). Howeve...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2017/4316316
更新日期:2017-01-01 00:00:00
abstract::The regulatory functions of glycosaminoglycan hyaluronan (HA) are suggested to be dependent on its molecular weight (MW). Proinflammatory and stimulatory effects are proposed mainly for the low MW HA. However, the complex response of blood phagocytes to HA of different MW is unclear. Herein, the effects of highly puri...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2010/380948
更新日期:2010-01-01 00:00:00
abstract::Postoperative-fluid retention is a severe complication frequently reported in patients undergoing major surgical procedures. The complex network of molecules involved in such a severe surgery-induced condition remains poorly understood. Inflammation has been proposed among the various causes of fluid retention. Since ...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2013/159349
更新日期:2013-01-01 00:00:00
abstract::The aim of the present study was to compare serum levels of soluble forms of interleukin-2 receptor, CD4 and CD8, released by lymphocytes during activation of the immune system, in patients with allergic bronchial asthma, with those in healthy subjects. Significantly higher levels of soluble IL-2R and soluble CD4 were...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/S0962935195000433
更新日期:1995-01-01 00:00:00
abstract:BACKGROUND:In smoking COPD patients the bronchoalveolar lavage (BAL) fluid contains high numbers of inflammatory cells. These cells might produce arachidonic acid (AA) metabolites, which contribute to inflammation and an increased bronchomotor tone. AIMS:To investigate levels of AA metabolites in BAL fluid, before and...
journal_title:Mediators of inflammation
pub_type: 临床试验,杂志文章
doi:10.1080/09629350123056
更新日期:2001-02-01 00:00:00
abstract::Dengue is an acute febrile illness with a wide spectrum of signs and symptoms ranging from mild to severe forms characterized by plasma leakage that can be fatal. NK cells are one of the main effectors in early infection and may play an important role in dengue pathogenesis. We investigated NK cell involvement during ...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2017/5649214
更新日期:2017-01-01 00:00:00
abstract::As one of the ligands of aryl hydrocarbon receptor (AhR), baicalein, isolated from Scutellaria baicalensis Georgi, has been proved to exert potential therapeutic effects on ulcerative colitis (UC), but its therapeutic mechanism remains obscure. Authentically, ulcerative colitis can be alleviated by regulating the diff...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2020/5918587
更新日期:2020-10-05 00:00:00
abstract::The CCN family member 2 (CCN2, also known as connective tissue growth factor) may behave as a risk biomarker and a potential therapeutic target for renal disease. CCN2 participates in the regulation of inflammation and fibrosis. TGF-β is considered the main fibrogenic cytokine; however, in some pathological settings T...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2015/506041
更新日期:2015-01-01 00:00:00
abstract::Collagen triple helix repeat containing-1 (CTHRC1) has been identified as cancer-related protein. CTHRC1 expresses mainly in adventitial fibroblasts and neointimal smooth muscle cells of balloon-injured vessels and promotes cell migration and tissue repair in response to injury. CTHRC1 plays a pivotal role in some pat...
journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
doi:10.1155/2020/9578701
更新日期:2020-08-12 00:00:00
abstract::Macrophages contribute to a continuous increase in blood pressure and kidney damage in hypertension, but their polarization status and the underlying mechanisms have not been clarified. This study revealed an important role for M2 macrophages and the YM1/Chi3l3 protein in hypertensive nephropathy in a mouse model of h...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2019/9086758
更新日期:2019-07-10 00:00:00
abstract::Cardiovascular disease linked to atherosclerosis is the leading cause of death worldwide. Atherosclerosis is mainly linked to dysfunction in vascular endothelial cells and subendothelial accumulation of oxidized forms of LDL. In the present study, we investigated the role of myeloperoxidase oxidized LDL (Mox-LDL) in e...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2014/134635
更新日期:2014-01-01 00:00:00
abstract::Vascular adhesion protein-1 (VAP-1) is an ectoenzyme that functions as a copper-containing amine oxidase and is involved in leukocyte adhesion at sites of inflammation. Inhibition of VAP-1 oxidative deamination has become an attractive target for anti-inflammatory therapy with demonstrated efficacy in rodent models of...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2020/3270513
更新日期:2020-01-20 00:00:00
abstract:AIM:To determine induced sputum cell counts and interleukin-8 (IL-8), tumor necrosis factor alpha (TNF-alpha) and leukotriene B4 (LTB4) levels as markers of neutrophilic inflammation in moderate persistent asthma, and to evaluate the response to inhaled steroid therapy. METHODS:Forty-five moderate asthmatic patients a...
journal_title:Mediators of inflammation
pub_type: 临床试验,杂志文章
doi:10.1080/09629350400003118
更新日期:2004-08-01 00:00:00
abstract::The present study was carried out to investigate the effects and mechanisms of polydatin (PD) in septic mice. The model of cecal ligation and puncture (CLP-)induced sepsis was employed. Pretreatment of mice with PD (15, 45, and 100 mg/kg) dose-dependently reduced sepsis-induced mortality and lung injury, as indicated ...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2013/354087
更新日期:2013-01-01 00:00:00
abstract::Plasma GDF15 concentrations were measured in 612 Taiwanese individuals without overt systemic disease. Clinical parameters, GDF15 genetic variants, and 22 biomarker levels were analyzed. We further enrolled 86 patients with PAD and 481 patients with CAD, who received endovascular intervention and coronary angiography,...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2017/9398401
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND:The role of prolactin (PRL) on tissue injury and repair mechanisms in multiple sclerosis (MS) remains unclear. The aim of this work was to investigate the relationship between PRL plasma levels and brain damage as measured by magnetic resonance imaging (MRI). METHODS:We employed a chemiluminescence immunoas...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2015/732539
更新日期:2015-01-01 00:00:00
abstract::The mixed leukocyte population obtained from the peritoneum of the August rat is a potentially important experimental model of inherent eosinophilia that has not been well characterized. In the present study, isolated cell preparations generated a concentration-dependent release of leukotriene (LT) C(4) when exposed t...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/S0962935196000610
更新日期:1996-01-01 00:00:00
abstract::Exosomes are nanosized vesicles released from every cell in the body including those in the respiratory tract and lungs. They are found in most body fluids and contain a number of different biomolecules including proteins, lipids, and both mRNA and noncoding RNAs. Since they can release their contents, particularly mi...
journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
doi:10.1155/2016/5628404
更新日期:2016-01-01 00:00:00
abstract::Cysteinyl leukotrienes (CysLTs) are potent lipid inflammatory mediators synthesized from arachidonic acid, through the 5-lipoxygenase (5-LO) pathway. Owing to their properties, CysLTs play a crucial role in the pathogenesis of inflammation; therefore, CysLT modifiers as synthesis inhibitors or receptor antagonists, ce...
journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
doi:10.1155/2017/2432958
更新日期:2017-01-01 00:00:00
abstract:OBJECTIVE:Individuals with inflammation have a myriad of pregnancy aberrations including increasing their preterm birth risk. Toll-like receptors (TLRs) and receptor for advanced glycation end products (RAGE) and their ligands were all found to play a key role in inflammation. In the present study, we reviewed TLR and ...
journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
doi:10.1155/2010/490406
更新日期:2010-01-01 00:00:00
abstract::Inflammation is an important component of diabetic retinal damage. We previously reported that a novel β-adrenergic receptor agonist, Compound 49b, reduced Toll-like receptor 4 (TLR4) signaling in retinal endothelial cells (REC) grown in high glucose. Others reported that TLR4 activates high-mobility group box 1 (HMGB...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2017/2860956
更新日期:2017-01-01 00:00:00
abstract::Periodontitis is an inflammatory disease characterized by destruction of the tooth-supporting tissues. Obese individuals have an increased risk of periodontitis, and elevated circulating levels of nicotinamide phosphoribosyltransferase (NAMPT) may be a pathomechanistic link between both diseases. Recently, increased l...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2013/202530
更新日期:2013-01-01 00:00:00
abstract::Matrix metalloproteinase 9 is a proteolytic enzyme which is recently one of the more often studied biomarkers. Its possible use as a biomarker of neuronal damage in stroke, heart diseases, tumors, multiple sclerosis, and epilepsy is being widely indicated. In epilepsy, MMP-9 is suggested to play a role in epileptic fo...
journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
doi:10.1155/2016/7369020
更新日期:2016-01-01 00:00:00
abstract::The therapeutic strategies used in the treatment of hepatitis C are essentially based on the combination of direct-acting antiviral agents (DAAs). This therapy has been shown to be very effective in relation to patient adherence to treatment and has shown high rates of sustained virological response (SVR). However, th...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2019/4738237
更新日期:2019-11-04 00:00:00
abstract:OBJECTIVES:Obesity and related diseases are dramatically increasing problems, particularly in children and adolescents. We determined circulating levels of different interleukin (IL)-1 family members in normal weight and overweight adolescents. METHODS:Seventy male, Caucasian adolescents (13-17 years) were recruited. ...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2010/958403
更新日期:2010-01-01 00:00:00