Growth Differentiation Factor 15 May Predict Mortality of Peripheral and Coronary Artery Diseases and Correlate with Their Risk Factors.

abstract：:Psoriasis is a common chronic inflammatory multisystemic disease with a complex pathogenesis consisting of genetic, immunological, and environmental components. It is associated with a number of comorbidities, including diabetes, metabolic syndrome, obesity, and myocardial infarction. In addition, the severity of psor...

journal_title：Mediators of inflammation

authors： Rodríguez-Cerdeira C,Cordeiro-Rodríguez M,Carnero-Gregorio M,López-Barcenas A,Martínez-Herrera E,Fabbrocini G,Sinani A,Arenas-Guzmán R,González-Cespón JL

更新日期：2019-05-28 00:00:00

abstract：Objective:For patients with severe acute pancreatitis (SAP), a high body mass index (BMI) increases the possibility of infection derived from the intestine. In this study, we evaluate whether TAK242 can alleviate severe acute pancreatitis-associated injury of intestinal barrier in high-fat diet-fed rats. Methods:A SAP...

journal_title：Mediators of inflammation

authors： Su YR,Hong YP,Mei FC,Wang CY,Li M,Zhou Y,Zhao KL,Yu J,Wang WX

更新日期：2019-12-17 00:00:00

abstract：BACKGROUND:The proinflammatory chemokine CXCL10, in addition to its chemotactic properties, is also involved in the stimulation of natural killer and T-cell migration in Mycobacterium tuberculosis infection. In this study, our experiments were designed to determine the role of interferon (IFN)-alphabeta in the producti...

journal_title：Mediators of inflammation

authors： Méndez Samperio P,Trejo A,Miranda E

更新日期：2004-12-01 00:00:00

abstract：:Type 2 Diabetes Mellitus (T2DM) is well known to include an inflammatory component that has been considered to be related to diabetic complications. Diabetic nephropathy (DN) is one of the significant complications as it constitutes the most frequent cause of end-stage renal disease. Tumor Necrosis Factor-α (TNF-α) is...

journal_title：Mediators of inflammation

authors： Emara M,El-Edel R,Fathy WM,Aboelkhair NT,Watany MM,Abou-Elela DH

更新日期：2020-07-01 00:00:00

abstract：:To investigate the role of AEG-1 in glycolysis and tumorigenesis, we construct myc-AEG-1 expression vector and demonstrate a novel mechanism that AEG-1 may increase the activity of AMPK by Thr172 phosphorylation. The higher expression levels of AEG-1 in colorectal carcinoma cells were found but showed significant diff...

journal_title：Mediators of inflammation

authors： Song HT,Qin Y,Yao GD,Tian ZN,Fu SB,Geng JS

更新日期：2014-01-01 00:00:00

abstract：:Acne inversa (AI; also designated as hidradenitis suppurativa) is a chronic inflammatory disease with still unknown pathogenesis that affects the intertriginous skin of perianal, inguinal, and axillary sites. It leads to painful nodules, abscesses, and fistulas with malodorous secretion and is frequently associated wi...

journal_title：Mediators of inflammation

authors： Tsaousi A,Witte E,Witte K,Röwert-Huber HJ,Volk HD,Sterry W,Wolk K,Schneider-Burrus S,Sabat R

更新日期：2016-01-01 00:00:00

abstract：:Vascular complications of diabetes mellitus represent a major public health problem. Although many steps forward have been made to define the causes and to find the best possible therapies, the problem remains crucial. In recent years, more and more evidences have defined a link between microbiota and the initiation, ...

journal_title：Mediators of inflammation

authors： Biscetti F,Nardella E,Cecchini AL,Landolfi R,Flex A

更新日期：2019-05-08 00:00:00

abstract：:Osteoarthritis (OA) belongs to a group of degenerative diseases. Synovial inflammation, cartilage abrasion, and subchondral sclerosis are characteristics of OA. Researchers do not fully understand the exact etiology of OA. However, matrix metalloproteinases (MMPs), which are responsible for cartilage matrix degradatio...

journal_title：Mediators of inflammation

authors： Chen YT,Hou CH,Hou SM,Liu JF

更新日期：2014-01-01 00:00:00

abstract：:Recent investigations have indicated that reactive metabolites and AGE-RAGE-mediated inflammation might play an important role in the pathogenesis of ischemia-reperfusion injury in liver transplantation. In this observational clinical study, 150 patients were enrolled following liver transplantation from deceased dono...

journal_title：Mediators of inflammation

authors： Brenner T,Fleming TH,Spranz D,Schemmer P,Bruckner T,Uhle F,Martin EO,Weigand MA,Hofer S

更新日期：2013-01-01 00:00:00

abstract：:Concentrations of acute phase proteins (CRP: C-reactive protein, albumin) change during surgery. We investigated the acute phase response to circumcision and the effects of anaesthesia on this response. The children were divided into four groups; group 1 (intratracheal general anaesthesia, n=40), group 2 (general anae...

journal_title：Mediators of inflammation

authors： Buyukkocak U,Caglayan F,Caglayan O,Basar M,Cakmak M,Batislam E,Ulusoy S

更新日期：2005-10-24 00:00:00

abstract：:Monocyte chemotactic protein (MCP-1) is a specific monocyte chemoattractant and activating factor produced by both immune cells (mononuclear phagocytes and lymphocytes) and non-immune cells (parenchymal and stromal cells). In order to define the conditions under which human monocytes express MCP-1, monocytes were expo...

journal_title：Mediators of inflammation

authors： Liebler JM,Kunkel SL,Allen RM,Burdick MD,Strieter RM

更新日期：1994-01-01 00:00:00

abstract：:Fibroblasts are important to host defence and immunity, can also as initiators of inflammation as well. As the endogenous "braking signal", Lipoxins can regulate anti-inflammation and the resolution of inflammation. We investigated the effect of lipoxinA(4) on the expression of cyclooxygenase-2 in lipopolysaccharide-s...

journal_title：Mediators of inflammation

authors： Zheng S,Wang Q,He Q,Song X,Ye D,Gao F,Jin S,Lian Q

更新日期：2011-01-01 00:00:00

abstract：:Enterovirus 71 (EV71) is one of the most common intestinal virus that causes hand, foot, and mouth disease (HFMD) in infants and young children (mostly ≤5 years of age). Generally, children with EV71-infected HFMD have mild symptoms that resolve spontaneously within 7-14 days without complications. However, some EV71-...

journal_title：Mediators of inflammation

authors： Zhang W,Huang Z,Huang M,Zeng J

更新日期：2020-01-31 00:00:00

abstract：:Cytokine-induced endothelial dysfunction leads to inflammation and vascular adhesion molecule production in retinal pigment epithelium (RPE) cells. Inflammation is a critical mediator in retinal degeneration (RD) diseases, including age-related macular degeneration (AMD), and RD progression may be prevented through an...

journal_title：Mediators of inflammation

authors： Huang WC,Liou CJ,Shen SC,Hu S,Hsiao CY,Wu SJ

更新日期：2020-10-16 00:00:00

abstract：:The present study was carried out to investigate the effects and mechanisms of polydatin (PD) in septic mice. The model of cecal ligation and puncture (CLP-)induced sepsis was employed. Pretreatment of mice with PD (15, 45, and 100 mg/kg) dose-dependently reduced sepsis-induced mortality and lung injury, as indicated ...

journal_title：Mediators of inflammation

authors： Li XH,Gong X,Zhang L,Jiang R,Li HZ,Wu MJ,Wan JY

更新日期：2013-01-01 00:00:00

abstract：:Edelweiss (Leontopodium alpinum Cass.) is traditionally employed in folk medicine as an anti-inflammatory remedy. In nature, the plant is sparsely available and protected; therefore production of callus cultures was established. A concentrated ethanolic extract of culture homogenate, with leontopodic acid representing...

journal_title：Mediators of inflammation

authors： Daniela L,Alla P,Maurelli R,Elena D,Giovanna P,Vladimir K,Roberto DT,Chiara de L,Saveria P,Liudmila K

更新日期：2012-01-01 00:00:00

abstract：:Cardiovascular (CV) disease is the most common cause of premature mortality in patients with rheumatoid arthritis (RA). It is the result of an accelerated atherosclerotic process. Both RA and atherosclerosis are complex polygenic diseases. Besides traditional CV risk factors and chronic inflammation, a number of studi...

journal_title：Mediators of inflammation

authors： Rodríguez-Rodríguez L,López-Mejías R,García-Bermúdez M,González-Juanatey C,González-Gay MA,Martín J

更新日期：2012-01-01 00:00:00

abstract：:Inflammatory mediators, including cytokines, histamine, bradykinin, prostaglandins, and leukotrienes, impact the immune system, usually as proinflammatory factors. Other mediators act as regulatory components to establish homeostasis after injury or prevent the inflammatory process. Histamine, a biogenic vasoactive am...

journal_title：Mediators of inflammation

authors： Branco ACCC,Yoshikawa FSY,Pietrobon AJ,Sato MN

更新日期：2018-08-27 00:00:00

abstract：:This study investigated the protective effects of intravitreal Resolvin D1 (RvD1) against LPS-induced rat endotoxic uveitis (EIU). RvD1 was administered into the right eye at a single injection of 5 μL volume containing 10-100-1000 ng/kg RvD1 1 h post-LPS injection (200 μg, Salmonella minnesota) into thefootpad of Spr...

journal_title：Mediators of inflammation

authors： Rossi S,Di Filippo C,Gesualdo C,Potenza N,Russo A,Trotta MC,Zippo MV,Maisto R,Ferraraccio F,Simonelli F,D'Amico M

更新日期：2015-01-01 00:00:00

abstract：:Vascular adhesion protein-1 (VAP-1) is an ectoenzyme that functions as a copper-containing amine oxidase and is involved in leukocyte adhesion at sites of inflammation. Inhibition of VAP-1 oxidative deamination has become an attractive target for anti-inflammatory therapy with demonstrated efficacy in rodent models of...

journal_title：Mediators of inflammation

authors： Kubota R,Reid MJ,Lieu KL,Orme M,Diamond C,Tulberg N,Henry SH

更新日期：2020-01-20 00:00:00

abstract：AIMS:This retrospective analysis was aimed at evaluating the effectiveness of treatment of persistent diabetic macular edema with intravitreal injections of 0.7 mg dexamethasone implant Ozurdex. The study comprised three male patients (6 eyes). RESULTS:The average thickness of the retina at baseline was 632  μm, the m...

journal_title：Mediators of inflammation

authors： Zalewski D,Raczyńska D,Raczyńska K

更新日期：2014-01-01 00:00:00

abstract：:It is hypothesized that central nervous system inflammation induced by systematic inflammation due to surgical trauma plays a critical role in postoperative cognitive dysfunction. The potential inhibitory effect of nerve blockage with local anesthetics on peripheral inflammatory response has been reported. We hypothes...

journal_title：Mediators of inflammation

authors： He Y,Li Z,Zuo YX

更新日期：2015-01-01 00:00:00

abstract：:Adipose tissue produces a wide range of proteins that may influence the immune system. In this study, we assessed the serum levels of leptin, adiponectin, and ghrelin, in association with the measurements of body composition, in 15 female patients with various autoimmune diseases (systemic lupus erythematosus, primary...

journal_title：Mediators of inflammation

authors： Toussirot E,Gaugler B,Bouhaddi M,Nguyen NU,Saas P,Dumoulin G

更新日期：2010-01-01 00:00:00

abstract：:The pathogenesis of brain inflammation and damage by human immunodeficiency virus (HIV) infection is unclear. Because blood-brain barrier damage and impaired cerebral perfusion are common features of HIV-1 infection, we evaluated the role of tumour necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) in ...

journal_title：Mediators of inflammation

authors： Sharief MK,Ciardi M,Thompson EJ,Sorice F,Rossi F,Vullo V,Cirelli A

更新日期：1992-01-01 00:00:00

abstract：:Behçet's disease (BD) is a multisystemic disorder of unknown etiology characterized by the "triple symptom complex" consisting of recurrent oral aphthosis, genital ulcers, and chronic relapsing bilateral uveitis. Recurrent mucocutaneous lesions are generally considered the hallmark of the disease, being the most commo...

journal_title：Mediators of inflammation

authors： Rotondo C,Lopalco G,Iannone F,Vitale A,Talarico R,Galeazzi M,Lapadula G,Cantarini L

更新日期：2015-01-01 00:00:00

abstract：:Dysfunctions of the L-arginine (L-arg)/nitric-oxide (NO) pathway are suspected to be important for the pathogenesis of multiple organ dysfunction syndrome (MODS) in septic shock. Therefore plasma concentrations of L-arg and asymmetric dimethylarginine (ADMA) were measured in 60 patients with septic shock, 30 surgical ...

journal_title：Mediators of inflammation

authors： Brenner T,Fleming TH,Rosenhagen C,Krauser U,Mieth M,Bruckner T,Martin E,Nawroth PP,Weigand MA,Bierhaus A,Hofer S

更新日期：2012-01-01 00:00:00

abstract：:Perinatal insults and subsequent neuroinflammation are the major mechanisms of neonatal brain injury, but there have been only scarce reports on the associations between hypoxic preconditioning and glial activation. Here we use neonatal hypoxia-ischemia brain injury model in 7-day-old rats and in vitro hypoxia model w...

journal_title：Mediators of inflammation

authors： Chen CY,Sun WZ,Kang KH,Chou HC,Tsao PN,Hsieh WS,Fu WM

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Airway smooth muscle (ASM) is considered to be a target for mediators released during airway inflammation. AIMS:To investigate the expression of c-fos, a constituent of the transcription factor activator protein-1, in human ASM cells. In addition, to measure the release of interleukin (IL)-6 into the condit...

journal_title：Mediators of inflammation

authors： McKay S,Bromhaar MM,de Jongste JC,Hoogsteden HC,Saxena PR,Sharma HS

更新日期：2001-06-01 00:00:00

abstract：:Hydroxysafflor yellow A (HSYA) is an effective therapeutic agent for inflammatory diseases and autoimmune disorders; however, its regulatory effect on NLRP3 inflammasome activation in macrophages has not been investigated. In this study, we predicted the potential interaction between HSYA and xanthine oxidase (XO) via...

journal_title：Mediators of inflammation

authors： Xu X,Guo Y,Zhao J,Wang N,Ding J,Liu Q

更新日期：2016-01-01 00:00:00

abstract：:A TP II analogue, [1-Nal3] TP II, was synthesized by a conventional solution method, followed by deprotection with 1M TFMSA-thioanisole (molar ratio 1:1) in TFA in the presence of Me2Se and m-cresol as scavengers. The synthetic [1-Nal3] TP II, TP II and [Phe (4 F)3] TP II were tested for comparative effect on the impa...

journal_title：Mediators of inflammation

authors： Abiko T,Nakatsubo S

更新日期：2000-01-01 00:00:00