Abstract:
:Monocyte chemotactic protein (MCP-1) is a specific monocyte chemoattractant and activating factor produced by both immune cells (mononuclear phagocytes and lymphocytes) and non-immune cells (parenchymal and stromal cells). In order to define the conditions under which human monocytes express MCP-1, monocytes were exposed to IFN-gamma, IL- lbeta, TNF-alpha, IL-4 or PHA under serum free conditions. There was no significant MCP-1 production by monocytes following exposure to IL-lbeta, TNF-alpha or IL-4. In contrast, stimulation with IFN-gamma resulted in a dose dependent increase in MCP-1 protein and mRNA expression. Simultaneous stimulation with IFN-gamma and IL-1beta or TNF-alpha resulted in no further increase in MCP-1 production. It is concluded that IFN-gamma, primarily a product of T(H)1 T lymphocytes, stimulates the expression of MCP-1 by monocytes.
journal_name
Mediators Inflammjournal_title
Mediators of inflammationauthors
Liebler JM,Kunkel SL,Allen RM,Burdick MD,Strieter RMdoi
10.1155/S0962935194000050subject
Has Abstractpub_date
1994-01-01 00:00:00pages
27-31issue
1eissn
0962-9351issn
1466-1861journal_volume
3pub_type
杂志文章abstract:BACKGROUND:Empirical observations have shown that ozonated autohemotherapy markedly improves the symptoms of chronic limb ischemia (muscular pain at rest, intermittent claudication, etc) in atherosclerotic patients, but mechanisms of action remain unclear. AIMS:Human endothelial cells (HUVECs) are known to release nit...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1080/09629350020027573
更新日期:2000-01-01 00:00:00
abstract::Paricalcitol, a selective vitamin D receptor (VDR) activator used for treatment of secondary hyperparathyroidism in chronic kidney disease (CKD), has been associated with survival advantages, suggesting that this drug, beyond its ability to suppress parathyroid hormone, may have additional beneficial actions. In this ...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2014/670475
更新日期:2014-01-01 00:00:00
abstract::In the central nervous system (CNS), mastocytes and glial cells (microglia, astrocytes and oligodendrocytes) function as sensors of neuroinflammatory conditions, responding to stress triggers or becoming sensitized to subsequent proinflammatory challenges. The corticotropin-releasing hormone and glucocorticoids are cr...
journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
doi:10.1155/2013/893521
更新日期:2013-01-01 00:00:00
abstract::Acne inversa (AI; also designated as hidradenitis suppurativa) is a chronic inflammatory disease with still unknown pathogenesis that affects the intertriginous skin of perianal, inguinal, and axillary sites. It leads to painful nodules, abscesses, and fistulas with malodorous secretion and is frequently associated wi...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2016/4097574
更新日期:2016-01-01 00:00:00
abstract::Acute respiratory distress syndrome (ARDS) remains a high morbidity and mortality disease entity in critically ill patients, despite decades of numerous investigations into its pathogenesis. To obtain global protein expression changes in acute lung injury (ALI) lung tissues, we employed a high-throughput proteomics me...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2014/469358
更新日期:2014-01-01 00:00:00
abstract::Background. Growth arrest-specific (Gas) 6 is one of the endogenous ligands of TAM receptors (Tyro3, Axl, and Mertk), and its role as an immune modulator has been recently emphasized. Naturally occurring CD4+CD25+ regulatory T cells (Tregs) are essential for the active suppression of autoimmunity. The present study wa...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2017/6848430
更新日期:2017-01-01 00:00:00
abstract:Aim:To analyze changes in peripheral blood monocytes and their clinical significance in patients with early stage of idiopathic membranous nephropathy (IMN). Methods:A total of 27 patients with early stage of IMN and 16 age- and sex-matched healthy controls (HCs) were recruited for the study. The monocyte subset count...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2018/5270657
更新日期:2018-06-21 00:00:00
abstract::Stimulation of phosphoinositide hydrolysis in myocardium from autoimmune myocarditis mice by ThEA and histamine was assayed. Myocardium from autoimmune heart, but not the normal forms, specifically increased phosphoinositide turnover in the presence of histaminergic agonists. This increment was blocked by a specific H...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/S0962935193000444
更新日期:1993-01-01 00:00:00
abstract::The aim is to examine whether the changes in pleural fluid interleukin (IL)-1beta, IL-2, IL-6, and IL-8 levels were significant in differential diagnosis of childhood pleural effusions. IL-1beta, IL-2, IL-6, and IL-8 levels in pleural fluids of all 36 patients were measured. The levels of IL-1beta, IL-2, IL-6, and IL-...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/MI.2005.2
更新日期:2005-02-24 00:00:00
abstract::Human Vγ9Vδ2 T cells recognise pyrophosphate-based antigens (phosphoantigens) and have multiple functions in innate and adaptive immunity, including a unique ability to activate other cells of the immune system. We used flow cytometry and ELISA to define the early cytokine profiles of Vγ9Vδ2 T cells stimulated in vitr...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2010/704941
更新日期:2010-01-01 00:00:00
abstract:BACKGROUND:Severe traumatization induces a complex pathophysiology, driven by the patient's own immune system. The initial activation is a result of damage-associated molecular patterns, which are released from disrupted and dying cells and recognized by immune receptors, for example, RAGE. In this study we aimed to ev...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2015/691491
更新日期:2015-01-01 00:00:00
abstract::The recently discovered IL-33 as an IL-1 cytokine family member has been proved to be specifically released from osteonecrotic bones. We aimed to investigate the potential role of IL-33 in the development of osteonecrosis of femoral head (ONFH). Forty patients diagnosed with ONFH and forty age-, sex-, and body mass in...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2017/1732638
更新日期:2017-01-01 00:00:00
abstract::Activation of macrophages is one of the key processes in generating the immune response against pathogens or misfolded/aggregated otherwise unharmful host's proteins. Antigens and their immune complexes (IC) may shape macrophage phenotype in various directions. Data on the impact of protein structure during inflammati...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2018/7501985
更新日期:2018-11-18 00:00:00
abstract::Inflammatory mediators, including cytokines, histamine, bradykinin, prostaglandins, and leukotrienes, impact the immune system, usually as proinflammatory factors. Other mediators act as regulatory components to establish homeostasis after injury or prevent the inflammatory process. Histamine, a biogenic vasoactive am...
journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
doi:10.1155/2018/9524075
更新日期:2018-08-27 00:00:00
abstract::As one of the ligands of aryl hydrocarbon receptor (AhR), baicalein, isolated from Scutellaria baicalensis Georgi, has been proved to exert potential therapeutic effects on ulcerative colitis (UC), but its therapeutic mechanism remains obscure. Authentically, ulcerative colitis can be alleviated by regulating the diff...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2020/5918587
更新日期:2020-10-05 00:00:00
abstract::This study examined the role of lymphotoxin (LT)-alpha in host defense against airborne infection with Francisella tularensis, a gram-negative facultative intracellular bacterium and the causative agent of tularemia. Following a low-dose aerosol infection with the highly virulent type A strain of F. tularensis, mice d...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2008/239740
更新日期:2008-01-01 00:00:00
abstract::Inflammation is considered to be one of the most critical factors involved in the development of complex metabolic diseases such as type 2 diabetes, cancer, and cardiovascular disease. A few decades ago, the discovery of mitochondria-associated endoplasmic reticulum (ER) membrane (MAM) was followed by the identificati...
journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
doi:10.1155/2016/1851420
更新日期:2016-01-01 00:00:00
abstract::Group A streptococcus (GAS) imposes a great burden on humans. Efforts to minimize the associated morbidity and mortality represent a critical issue. Glycogen synthase kinase-3 β (GSK-3 β) is known to regulate inflammatory response in infectious diseases. However, the regulation of GSK-3 β in GAS infection is still unk...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2013/720689
更新日期:2013-01-01 00:00:00
abstract::Background. Neutrophilic bronchial inflammation is a main feature of bronchiectasis, but not much is known about its relationship with other disease features. Aim. To compare airway inflammatory markers with clinical and functional findings in subjects with stable noncystic fibrosis bronchiectasis (NCFB). Methods. 152...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2015/642503
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND:Rodent models suggest that follistatin-like 3 (fstl3) is associated with diabetes and obesity. In humans, plasma fstl3 is reduced with gestational diabetes. In vitro, TNF-α induces fstl3 secretion, which suggests a link to inflammation. OBJECTIVE:To elucidate the association between plasma fstl3 and obesity...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2014/364209
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND:Human and rodent leukocytes express high levels of the glucocorticoid-inducible protein annexin 1 (ANXA1) (previously referred to as lipocortin 1). Neutrophils and monocytes have abundant ANXA1 levels. AIM:We have investigated, for the first time, ANXA1 ultrastructural expression in rat eosinophils and comp...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1080/09629350210000015683
更新日期:2002-10-01 00:00:00
abstract::The metabolic syndrome is a cluster of cardiometabolic alterations that include the presence of arterial hypertension, insulin resistance, dyslipidemia, and abdominal obesity. Obesity is associated with a chronic inflammatory response, characterized by abnormal adipokine production, and the activation of proinflammato...
journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
doi:10.1155/2013/136584
更新日期:2013-01-01 00:00:00
abstract::Among numerous inflammatory mediators a nitric oxide molecule is supposed to be important in the modulation of neutrophil survival in vivo and in vitro. The effect of exogenous supply of NO donors such as SNP, SIN-1, and GEA-3162 on the course of human neutrophil apoptosis and the role of extracellular antioxidants in...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/MI.2005.81
更新日期:2005-06-09 00:00:00
abstract::Inflammatory processes are known to be involved at least in the early phase of complex regional pain syndrome type 1 (CRPS1). Blister fluid obtained from the involved extremities displayed increased amounts of proinflammatory cytokines IL-6 and TNFalpha compared with the noninvolved extremities. The aim of this paper ...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/MI/2006/28398
更新日期:2006-01-01 00:00:00
abstract::Amyotrophic lateral sclerosis (ALS) is considered a multifactorial, multisystem disease in which inflammation and the immune system play important roles in development and progression. The pleiotropic cytokine TNFα is one of the major players governing the inflammation in the central nervous system and peripheral dist...
journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
doi:10.1155/2017/2985051
更新日期:2017-01-01 00:00:00
abstract::Keishibukuryogan (KBG) is one of the traditional herbal formulations widely administered to patients with blood stagnation for improving blood circulation; currently, it is the most frequently prescribed medicine in Japan. KBG has been reported to improve conjunctional microcirculation. The aim of this study was to ev...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2010/804298
更新日期:2010-01-01 00:00:00
abstract:Background:Endothelial dysfunction and apoptosis resulting from oxidative stress can lead to the development of atherosclerosis. Our group has previously showed that CD137 signaling contributes to the progression of atherosclerosis and the vulnerability of plaques. The aim of this study is to investigate the effects of...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2020/4321912
更新日期:2020-06-06 00:00:00
abstract::Matrix metalloproteinase-14 (MMP-14) promotes vulnerable plaque morphology in mice, whereas tissue inhibitor of metalloproteinases-3 (TIMP-3) overexpression is protective. MMP-14(hi) TIMP-3(lo) rabbit foam cells are more invasive and more prone to apoptosis than MMP-14(lo) TIMP-3(hi) cells. We investigated the implica...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2014/276457
更新日期:2014-01-01 00:00:00
abstract::Thousands of people suffer from severe malaria every year. The innate immune response plays a determinant role in host's defence to malaria. Transient receptor potential vanilloid 1 (TRPV1) modulates macrophage-mediated responses in sepsis, but its role in other pathogenic diseases has never been addressed. We investi...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2014/506450
更新日期:2014-01-01 00:00:00
abstract::Inflammatory response in Chagas disease is related to parasite and host factors. However, immune system regulation has not been fully elucidated. Thus, this study is aimed at evaluating IL-4 influence on acute phase of Trypanosoma cruzi experimental infection through dosage of cytokine levels in cardiac homogenate of ...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2018/3421897
更新日期:2018-11-28 00:00:00