Annexin 1 localisation in tissue eosinophils as detected by electron microscopy.

abstract：:The present study was carried out to investigate the effects and mechanisms of polydatin (PD) in septic mice. The model of cecal ligation and puncture (CLP-)induced sepsis was employed. Pretreatment of mice with PD (15, 45, and 100 mg/kg) dose-dependently reduced sepsis-induced mortality and lung injury, as indicated ...

journal_title：Mediators of inflammation

authors： Li XH,Gong X,Zhang L,Jiang R,Li HZ,Wu MJ,Wan JY

更新日期：2013-01-01 00:00:00

abstract：:We report here that the leptomeningeal cells transduce inflammatory signals from peripheral macrophages to brain-resident microglia in response to Porphyromonas gingivalis (P.g.) LPS. The expression of Toll-like receptor 2 (TLR2), TLR4, TNF-α, and inducible NO synthase was mainly detected in the gingival macrophages o...

journal_title：Mediators of inflammation

authors： Liu Y,Wu Z,Zhang X,Ni J,Yu W,Zhou Y,Nakanishi H

更新日期：2013-01-01 00:00:00

abstract：:We have previously shown that immunodominant MBP peptides encapsulated in mannosylated liposomes (Xemys) effectively suppressed experimental allergic encephalomyelitis (EAE). Within the frames of the successfully completed phase I clinical trial, we investigated changes in the serum cytokine profile after Xemys admini...

journal_title：Mediators of inflammation

authors： Lomakin Y,Belogurov A Jr,Glagoleva I,Stepanov A,Zakharov K,Okunola J,Smirnov I,Genkin D,Gabibov A

更新日期：2016-01-01 00:00:00

abstract：:[This corrects the article DOI: 10.1155/2016/3214105.]. ...

journal_title：Mediators of inflammation

authors： Liang Y,Chen Q,Du W,Chen C,Li F,Yang J,Peng J,Kang D,Lin B,Chai X,Zhou K,Zeng J

更新日期：2017-01-01 00:00:00

abstract：:Podocyte injury critically contributes to the pathogenesis of obesity-related glomerulopathy (ORG). Recently, lipid accumulation and inflammatory responses have been found to be involved in podocyte injury. This study is to explore their role and relationship in podocyte injury of ORG. In animal experiments, the ORG m...

journal_title：Mediators of inflammation

authors： Zhao J,Rui HL,Yang M,Sun LJ,Dong HR,Cheng H

更新日期：2019-04-11 00:00:00

abstract：:Silica inhalation can induce chronic lung inflammation and fibrosis. Upon silica stimulation, activated macrophages trigger the T-lymphocyte which can differentiate into many different types of Th cells, including the recently discovered Th17 cells. IL-17A, the typical Th17 cytokine, is reported in some inflammatory d...

journal_title：Mediators of inflammation

authors： Tang W,Liu F,Chen Y,Song L,Dai W,Li C,Weng D,Chen J

更新日期：2014-01-01 00:00:00

abstract：:Hydroxysafflor yellow A (HSYA) is an effective therapeutic agent for inflammatory diseases and autoimmune disorders; however, its regulatory effect on NLRP3 inflammasome activation in macrophages has not been investigated. In this study, we predicted the potential interaction between HSYA and xanthine oxidase (XO) via...

journal_title：Mediators of inflammation

authors： Xu X,Guo Y,Zhao J,Wang N,Ding J,Liu Q

更新日期：2016-01-01 00:00:00

abstract：:Many therapies are now available for patients with rheumatoid arthritis (RA) who have an inadequate response to methotrexate including tumor necrosis factor inhibitors, abatacept, tocilizumab, and rituximab. Clinical response to drugs varies widely between individuals. A part of this variability is due to the characte...

journal_title：Mediators of inflammation

authors： Daïen CI,Morel J

更新日期：2014-01-01 00:00:00

abstract：:Extracellular bacterial ribonucleases such as binase from Bacillus pumilus possess cytotoxic activity against tumor cells with a potential for clinical application. Moreover, they may induce activation of tumor-derived macrophages either into the M1-phenotype with well-documented functions in the regulation of the ant...

journal_title：Mediators of inflammation

authors： Makeeva A,Rodriguez-Montesinos J,Zelenikhin P,Nesmelov A,Preissner KT,Cabrera-Fuentes HA,Ilinskaya ON

更新日期：2017-01-01 00:00:00

abstract：:Development of solid cancer depends on escape from host immunosurveillance. Various types of immune cells contribute to tumor-induced immune suppression, including tumor associated macrophages, regulatory T cells, type 2 NKT cells, and myeloid-derived suppressor cells (MDSCs). Growing body of evidences shows that MDSC...

journal_title：Mediators of inflammation

authors： Katoh H,Watanabe M

更新日期：2015-01-01 00:00:00

abstract：:A complex web of dynamic relationships between innate and adaptive immunity is now evident for many autoinflammatory and autoimmune disorders, the first deriving from abnormal activation of innate immune system without any conventional danger triggers and the latter from self-/non-self-discrimination loss of tolerance...

journal_title：Mediators of inflammation

authors： Lopalco G,Cantarini L,Vitale A,Iannone F,Anelli MG,Andreozzi L,Lapadula G,Galeazzi M,Rigante D

更新日期：2015-01-01 00:00:00

abstract：:Crohn's disease (CD) is a multifactorial chronic inflammatory bowel disease of unknown cause. The aim of the present study was to explore if mRNA over-expression of SSTR5 and CCR7 found in CD patients could be correlated to respective protein expression. When compared to healthy donors, SSTR5 was over-expressed 417 +/...

journal_title：Mediators of inflammation

authors： Taquet N,Dumont S,Vonesch JL,Hentsch D,Reimund JM,Muller CD

更新日期：2009-01-01 00:00:00

abstract：:Myeloproliferative neoplasms (MPNs) are a heterogeneous group of clonal diseases characterized by the excessive and chronic production of mature cells from one or several of the myeloid lineages. Recent advances in the biology of MPNs have greatly facilitated their molecular diagnosis since most patients present with ...

journal_title：Mediators of inflammation

authors： Hermouet S,Bigot-Corbel E,Gardie B

更新日期：2015-01-01 00:00:00

abstract：:H. pylori induces a complicated local and systematic immune response and contributes to the carcinogenesis of gastric cancer. A primary type 1 immune response is evoked by H. pylori since its occurrence. However, it is not unusual that an inhibitory immunity is dominant in H. pylori-associated diseases, which are prom...

journal_title：Mediators of inflammation

authors： Li R,Jiang XX,Zhang LF,Liu XM,Hu TZ,Xia XJ,Li M,Xu CX

更新日期：2017-01-01 00:00:00

abstract：:Tuberculosis is characterized by the presence of activated mononuclear cells both in the peripheral circulation and in pleural fluid. Expression and up-regulation of adhesion molecules is the basis of cell-cell adhesion in granuloma formation and in leukocyte migration to the inflammatory site. Soluble isoforms of adh...

journal_title：Mediators of inflammation

authors： Hamzaoui A,Hamzaoui K,Kahan A,Chabbou A

更新日期：1996-01-01 00:00:00

abstract：BACKGROUND:Growth arrest specific gene 6 (Gas6) protein enhances survival of oligodendrocytes and neurons, and it is involved in autoimmunity. Therefore, we aimed to verify whether cerebrospinal-fluid (CSF) Gas6 concentration may represent a biomarker of disease activity in multiple sclerosis. METHODS:Sixty-five patie...

journal_title：Mediators of inflammation

authors： Sainaghi PP,Collimedaglia L,Alciato F,Molinari R,Sola D,Ranza E,Naldi P,Monaco F,Leone M,Pirisi M,Avanzi GC

更新日期：2013-01-01 00:00:00

abstract：:Human respiratory syncytial virus (RSV) sometimes causes acute and severe lower respiratory tract illness in infants and young children. RSV strongly upregulates proinflammatory cytokines and the platelet-activating factor (PAF) receptor, which is a receptor for Streptococcus pneumoniae, in the pulmonary epithelial ce...

journal_title：Mediators of inflammation

authors： Yokota S,Okabayashi T,Hirakawa S,Tsutsumi H,Himi T,Fujii N

更新日期：2012-01-01 00:00:00

abstract：:Particulate matter with an aerodynamic diameter equal or less than 2.5 micrometers (PM2.5) is associated with the development of chronic obstructive pulmonary disease (COPD). The mechanisms by which PM2.5 accelerates disease progression in COPD are poorly understood. In this study, we aimed to investigate the effect o...

journal_title：Mediators of inflammation

authors： Wang J,Li Y,Zhao P,Tian Y,Liu X,He H,Jia R,Oliver BG,Li J

更新日期：2020-05-08 00:00:00

abstract：:We investigated the influence of 2-chlorodeoxyadenosine (2-CdA) in combination with tumour necrosis factor-alpha (TNFalpha) or its mutein VI, which differs from the native molecule by N-terminal amino acid composition, on the survival time of mice inoculated with leukaemia L1210 or P388. Groups of mice with leukaemia ...

journal_title：Mediators of inflammation

authors： Góra-Tybor J,Warzocha K,Robak T

更新日期：1995-01-01 00:00:00

abstract：:This study tested the hypothesis that shock wave therapy (SW) enhances mitochondrial uptake into the lung epithelial and parenchymal cells to attenuate lung injury from acute respiratory distress syndrome (ARDS). ARDS was induced in rats through continuous inhalation of 100% oxygen for 48 h, while SW entailed applicat...

journal_title：Mediators of inflammation

authors： Lin KC,Wallace CG,Yin TC,Sung PH,Chen KH,Lu HI,Chai HT,Chen CH,Chen YL,Li YC,Shao PL,Lee MS,Sheu JJ,Yip HK

更新日期：2018-10-21 00:00:00

abstract：:Matrix metalloproteinase 9 is a proteolytic enzyme which is recently one of the more often studied biomarkers. Its possible use as a biomarker of neuronal damage in stroke, heart diseases, tumors, multiple sclerosis, and epilepsy is being widely indicated. In epilepsy, MMP-9 is suggested to play a role in epileptic fo...

journal_title：Mediators of inflammation

authors： Bronisz E,Kurkowska-Jastrzębska I

更新日期：2016-01-01 00:00:00

abstract：:As a noninvasive method, exhaled breath condensate (EBC) has gained importance to improve monitoring of lung diseases and to detect biomarkers. The aim of the study was to investigate, whether erythropoietin (EPO) is detectable in EBC. EBC was collected from 22 consecutive patients as well as from healthy individuals....

journal_title：Mediators of inflammation

authors： Schumann C,Triantafilou K,Krueger S,Hombach V,Triantafilou M,Becher G,Lepper PM

更新日期：2006-01-01 00:00:00

abstract：OBJECTIVE:In this work we studied the correlation between platelet count, platelet activation, and systemic inflammation in overweight, obese, and morbidly obese individuals. METHODS AND SUBJECTS:A total of 6319 individuals participated in the study. Complete blood counts, high sensitivity C-reactive protein (hs-CRP) ...

journal_title：Mediators of inflammation

authors： Samocha-Bonet D,Justo D,Rogowski O,Saar N,Abu-Abeid S,Shenkerman G,Shapira I,Berliner S,Tomer A

更新日期：2008-01-01 00:00:00

abstract：:We recently reported the immune-enhancing effects of a high-molecular-weight fraction (HMF) of CW in macrophages and immunosuppressed mice, and this effect was attributed to a crude polysaccharide. As polysaccharides may also have anti-inflammatory functions, we investigated the anti-inflammatory effects and related m...

journal_title：Mediators of inflammation

authors： Cho CW,Ahn S,Lim TG,Hong HD,Rhee YK,Yang DC,Jang M

更新日期：2017-01-01 00:00:00

abstract：:Chlamydophila pneumoniae (CPn) is a common respiratory pathogen that causes a chronic and persistent airway infection. The elderly display an increased susceptibility and severity to this infection. However, the underlying mechanisms are not well understood. Dendritic cells (DCs) are the initiators and regulators of i...

journal_title：Mediators of inflammation

authors： Prakash S,Agrawal S,Ma D,Gupta S,Peterson EM,Agrawal A

更新日期：2014-01-01 00:00:00

abstract：:Prevalence of thyroid dysfunction and its impact on cognition in older people has been demonstrated, but many points remain unclarified. In order to study the effect of aging on the thyroid gland, we compared the thyroid gland of very old mice with that of younger ones. We have first investigated the changes of thyroi...

journal_title：Mediators of inflammation

authors： Traina G,Cataldi S,Siccu P,Loreti E,Ferri I,Sidoni A,Codini M,Gizzi C,Sichetti M,Ambesi-Impiombato FS,Beccari T,Curcio F,Albi E

更新日期：2017-01-01 00:00:00

abstract：:The aim of this study was to evaluate the effects of moderate-intensity exercise on plasma levels of C-reactive protein (CRP) and tumor necrosis factor-alpha (TNF-α) as markers of low-grade inflammation and endothelial function in diabetic (db/db) mice. Control and db/db mice were divided into sedentary and exercised ...

journal_title：Mediators of inflammation

authors： Sallam N,Khazaei M,Laher I

更新日期：2010-01-01 00:00:00

abstract：:Background. Growth arrest-specific (Gas) 6 is one of the endogenous ligands of TAM receptors (Tyro3, Axl, and Mertk), and its role as an immune modulator has been recently emphasized. Naturally occurring CD4+CD25+ regulatory T cells (Tregs) are essential for the active suppression of autoimmunity. The present study wa...

journal_title：Mediators of inflammation

authors： Zhao GJ,Zheng JY,Bian JL,Chen LW,Dong N,Yu Y,Hong GL,Chandoo A,Yao YM,Lu ZQ

更新日期：2017-01-01 00:00:00

abstract：:Postoperative peritoneal adhesion (PPA) is a common postoperative complication caused by any peritoneal inflammatory process. This study aimed to identify the biological function of large intergenic non-coding RNAs (lincRNAs) Cox-2 in the inflammation reaction of adhesion formation. The Cox-2 expression in peritoneal ...

journal_title：Mediators of inflammation

authors： Bian Y,Yang L,Zhang B,Li W,Wang S,Jiang S,Chen X,Li W,Zeng L

更新日期：2019-12-03 00:00:00

abstract：BACKGROUND:In smoking COPD patients the bronchoalveolar lavage (BAL) fluid contains high numbers of inflammatory cells. These cells might produce arachidonic acid (AA) metabolites, which contribute to inflammation and an increased bronchomotor tone. AIMS:To investigate levels of AA metabolites in BAL fluid, before and...

journal_title：Mediators of inflammation

authors： Verhoeven GT,Garrelds IM,Hoogsteden HC,Zijlstra FJ

更新日期：2001-02-01 00:00:00