当前位置： SCI文献检索 > MEDIATORS OF INFLAMMATION期刊下所有文献 > Leptomeningeal cells transduce peripheral macrophages inflammatory signal to microglia in reponse to Porphyromonas gingivalis LPS.

Leptomeningeal cells transduce peripheral macrophages inflammatory signal to microglia in reponse to Porphyromonas gingivalis LPS.

Abstract：

:We report here that the leptomeningeal cells transduce inflammatory signals from peripheral macrophages to brain-resident microglia in response to Porphyromonas gingivalis (P.g.) LPS. The expression of Toll-like receptor 2 (TLR2), TLR4, TNF-α, and inducible NO synthase was mainly detected in the gingival macrophages of chronic periodontitis patients. In in vitro studies, P.g. LPS induced the secretion of TNF-α and IL-1β from THP-1 human monocyte-like cell line and RAW264.7 mouse macrophages. Surprisingly, the mean mRNA levels of TNF-α and IL-1β in leptomeningeal cells after treatment with the conditioned medium from P.g. LPS-stimulated RAW264.7 macrophages were significantly higher than those after treatment with P.g. LPS alone. Furthermore, the mean mRNA levels of TNF-α and IL-1β in microglia after treatment with the conditioned medium from P.g. LPS-stimulated leptomeningeal cells were significantly higher than those after P.g. LPS alone. These observations suggest that leptomeninges serve as an important route for transducing inflammatory signals from macrophages to microglia by secretion of proinflammatory mediators during chronic periodontitis. Moreover, propolis significantly reduced the P.g. LPS-induced TNF-α and IL-1β production by leptomeningeal cells through inhibiting the nuclear factor-κB signaling pathway. Together with the inhibitory effect on microglial activation, propolis may be beneficial in preventing neuroinflammation during chronic periodontitis.

journal_name

Mediators Inflamm

journal_title

Mediators of inflammation

authors

Liu Y,Wu Z,Zhang X,Ni J,Yu W,Zhou Y,Nakanishi H

doi

10.1155/2013/407562

subject

Has Abstract

pub_date

2013-01-01 00:00:00

pages

407562

eissn

0962-9351

issn

1466-1861

journal_volume

2013

pub_type

杂志文章

相关文献

MEDIATORS OF INFLAMMATION文献大全
  • Aloperine Protects Mice against DSS-Induced Colitis by PP2A-Mediated PI3K/Akt/mTOR Signaling Suppression.

    abstract：:Colitis is a major form of inflammatory bowel disease which involved mucosal immune dysfunction. Aloperine is an alkaloid isolated from the shrub Sophora alopecuroides L. and has been recognized as an effective treatment for inflammatory and allergic diseases. The present study aimed to examine the molecular mechanism...

    journal_title：Mediators of inflammation

    pub_type： 杂志文章

    doi：10.1155/2017/5706152

    authors： Fu X,Sun F,Wang F,Zhang J,Zheng B,Zhong J,Yue T,Zheng X,Xu JF,Wang CY

    更新日期：2017-01-01 00:00:00

  • IgE-mediated histamine release from nasal mucosa is inhibited by SLPI (secretory leukocyte protease inhibitor) to the level of spontaneous release.

    abstract：:The secretory leukocyte protease inhibitor (SLPI) is a low-molecular-weight inhibitor of proteases, such as elastase and cathepsin G which are released from leukocytes during phagocytosis. The purpose of this study was to determine whether or not SLPI is able to inhibit IgE-mediated histamine release. Nasal mucosa fro...

    journal_title：Mediators of inflammation

    pub_type： 杂志文章

    doi：10.1080/09629359891162

    authors： Westin U,Lundberg E,Ohlsson K

    更新日期：1998-01-01 00:00:00

  • A splice variant of ASC regulates IL-1beta release and aggregates differently from intact ASC.

    abstract：:The apoptosis-associated speck-like protein containing a caspase recruit domain (ASC) is involved in apoptosis and innate immunity and is a major adaptor molecule responsible for procaspase-1 activation. ASC mRNA is encoded by three exons: exons 1 and 3 encode a pyrin domain (PYD) and caspase recruit domain (CARD), re...

    journal_title：Mediators of inflammation

    pub_type： 杂志文章

    doi：10.1155/2009/287387

    authors： Matsushita K,Takeoka M,Sagara J,Itano N,Kurose Y,Nakamura A,Taniguchi S

    更新日期：2009-01-01 00:00:00

  • Immunological Dynamics Associated with Direct-Acting Antiviral Therapies in Naive and Experimented HCV Chronic-Infected Patients.

    abstract：:The therapeutic strategies used in the treatment of hepatitis C are essentially based on the combination of direct-acting antiviral agents (DAAs). This therapy has been shown to be very effective in relation to patient adherence to treatment and has shown high rates of sustained virological response (SVR). However, th...

    journal_title：Mediators of inflammation

    pub_type： 杂志文章

    doi：10.1155/2019/4738237

    authors： Pereira GL,Tarragô AM,Neves WLL,da Silva Neto PV,de Souza PS,Dos Santos Affonso J,de Sousa KS,da Silva JA,Costa AG,da Silva Victoria F,Victoria MB,Malheiro A

    更新日期：2019-11-04 00:00:00

  • Inhibition of the mTOR Pathway Exerts Cardioprotective Effects Partly through Autophagy in CLP Rats.

    abstract：Background:Sepsis-induced myocardial dysfunction is a severe clinical problem. Recent studies have indicated that autophagy and myocardial energy depletion play a major role in myocardial dysfunction during sepsis, a mechanistic target of rapamycin (mTOR) as a master sensor of energy status and autophagy mediator; howe...

    journal_title：Mediators of inflammation

    pub_type： 杂志文章

    doi：10.1155/2018/4798209

    authors： Han W,Wang H,Su L,Long Y,Cui N,Liu D

    更新日期：2018-06-28 00:00:00

  • The effect of emodin-assisted early enteral nutrition on severe acute pancreatitis and secondary hepatic injury.

    abstract：:Severe acute pancreatitis (SAP) characterized by atrocious progression and numerous complications often leads to a high mortality rate due to hypermetabolism, systemic inflammatory response syndrome (SIRS), and multiple organs dysfunction syndrome (MODS). Studies have revealed that both early enteral nutrition (EEN) a...

    journal_title：Mediators of inflammation

    pub_type： 杂志文章

    doi：10.1155/2007/29638

    authors： Wang G,Sun B,Gao Y,Meng QH,Jiang HC

    更新日期：2007-01-01 00:00:00

  • Elevated adiponectin serum levels in women with systemic autoimmune diseases.

    abstract：:Adipose tissue produces a wide range of proteins that may influence the immune system. In this study, we assessed the serum levels of leptin, adiponectin, and ghrelin, in association with the measurements of body composition, in 15 female patients with various autoimmune diseases (systemic lupus erythematosus, primary...

    journal_title：Mediators of inflammation

    pub_type： 杂志文章

    doi：10.1155/2010/938408

    authors： Toussirot E,Gaugler B,Bouhaddi M,Nguyen NU,Saas P,Dumoulin G

    更新日期：2010-01-01 00:00:00

  • Tumour necrosis factor superfamily members in the pathogenesis of inflammatory bowel disease.

    abstract：:Inflammatory bowel disease (IBD) is a group of inflammatory conditions of the gastrointestinal tract of unclear aetiology of which two major forms are Crohn's disease (CD) and ulcerative colitis (UC). CD and UC are immunologically distinct, although they both result from hyperactivation of proinflammatory pathways in ...

    journal_title：Mediators of inflammation

    pub_type： 杂志文章,评审

    doi：10.1155/2014/325129

    authors： Ślebioda TJ,Kmieć Z

    更新日期：2014-01-01 00:00:00

  • Preferential Th1 cytokine profile of phosphoantigen-stimulated human Vγ9Vδ2 T cells.

    abstract：:Human Vγ9Vδ2 T cells recognise pyrophosphate-based antigens (phosphoantigens) and have multiple functions in innate and adaptive immunity, including a unique ability to activate other cells of the immune system. We used flow cytometry and ELISA to define the early cytokine profiles of Vγ9Vδ2 T cells stimulated in vitr...

    journal_title：Mediators of inflammation

    pub_type： 杂志文章

    doi：10.1155/2010/704941

    authors： Dunne MR,Mangan BA,Madrigal-Estebas L,Doherty DG

    更新日期：2010-01-01 00:00:00

  • A polymorphism of ORAI1 rs7135617, is associated with susceptibility to rheumatoid arthritis.

    abstract：:Rheumatoid arthritis (RA), a chronic inflammatory disease usually occurring in synovial tissues and joints, is highly associated with genetic and environmental factors. ORAI1, a gene related to cellular immune system, has been shown to be involved in the pathogenesis of chronic inflammatory diseases and immune disease...

    journal_title：Mediators of inflammation

    pub_type： 杂志文章

    doi：10.1155/2014/834831

    authors： Yen JH,Chang CM,Hsu YW,Lee CH,Wu MS,Hwang DY,Chen BK,Liao HT,Wu MT,Chang WC

    更新日期：2014-01-01 00:00:00

  • Calorie restriction with a high-fat diet effectively attenuated inflammatory response and oxidative stress-related markers in obese tissues of the high diet fed rats.

    abstract：:Obesity characterized by increased mass of adipose tissue leads to systemic inflammation. Calorie restriction (CR) improves parameters associated with immune response and antioxidant defense. We hypothesized that CR with a high fat diet (HFCR) regulates local and systemic inflammation and oxidative stress damage in a ...

    journal_title：Mediators of inflammation

    pub_type： 杂志文章

    doi：10.1155/2012/984643

    authors： Park S,Park NY,Valacchi G,Lim Y

    更新日期：2012-01-01 00:00:00

  • Levels of soluble ICAM-1 in premature and full-term neonates with infection.

    abstract：BACKGROUND:Infection in the neonatal period is an extremely serious condition and diagnosis is difficult. C-reactive protein (CRP) is widely used as a marker of infection; however, its usefulness is limited in the early phase. The role of soluble intracellular adhesion molecule-1 (sICAM-1), an adhesion molecule, has be...

    journal_title：Mediators of inflammation

    pub_type： 杂志文章

    doi：10.1080/09629350220131944

    authors： Apostolou M,Dimitriou H,Kaleyias J,Perdikogianni C,Stiakaki E,Costalos C,Kalmanti MC

    更新日期：2002-04-01 00:00:00

  • Differential modulation of annexin I binding sites on monocytes and neutrophils.

    abstract：:Specific binding sites for the anti-inflammatory protein annexin I have been detected on the surface of human monocytes and polymorphonuclear leukocytes (PMN). These binding sites are proteinaceous in nature and are sensitive to cleavage by the proteolytic enzymes trypsin, collagenase, elastase and cathepsin G. When m...

    journal_title：Mediators of inflammation

    pub_type： 杂志文章

    doi：10.1080/09629359990720

    authors： Euzger HS,Flower RJ,Goulding NJ,Perretti M

    更新日期：1999-01-01 00:00:00

  • IL-10 Dampens the Th1 and Tc Activation through Modulating DC Functions in BCG Vaccination.

    abstract：:BCG, the only registered vaccine against Mycobacterial Tuberculosis (TB) infection, has been questioned for its protective efficacy for decades. Although lots of efforts were made to improve the BCG antigenicity, few studies were devoted to understand the role of host factors in the variability of the BCG protection. ...

    journal_title：Mediators of inflammation

    pub_type： 杂志文章

    doi：10.1155/2019/8616154

    authors： Xu H,Jia Y,Li Y,Wei C,Wang W,Guo R,Jia J,Wu Y,Li Z,Wei Z,Qi X,Li Y,Gao X

    更新日期：2019-06-12 00:00:00

  • Erythromycin and clarithromycin modulation of growth factor-induced expression of heparanase mRNA on human lung cancer cells in vitro.

    abstract：:Heparanase activity is correlated with the metastatic potential of several cancer cells and is a key enzyme in the breakdown of tissue barriers. It is also involved in the regulation of growth factor and cytokine activity. However, little is known about the factors that induce heparanase in cancer cells. We investigat...

    journal_title：Mediators of inflammation

    pub_type： 杂志文章

    doi：10.1080/09629350120093731

    authors： Sasaki M,Ito T,Kashima M,Fukui S,Izumiyama N,Watanabe A,Sano M,Fujiwara Y,Miura M

    更新日期：2001-10-01 00:00:00

  • sST2 as a New Biomarker of Chronic Kidney Disease-Induced Cardiac Remodeling: Impact on Risk Prediction.

    abstract：:Heart failure is the most frequent cardiac complication of chronic kidney disease (CKD). Biomarkers help identify high-risk patients. Natriuretic peptides (BNP and NT-proBNP) are largely used for monitoring patients with cardiac failure but are highly dependent on glomerular filtration rate (GFR). Soluble suppression ...

    journal_title：Mediators of inflammation

    pub_type： 杂志文章

    doi：10.1155/2018/3952526

    authors： Plawecki M,Morena M,Kuster N,Chenine L,Leray-Moragues H,Jover B,Fesler P,Lotierzo M,Dupuy AM,Klouche K,Cristol JP

    更新日期：2018-10-08 00:00:00

  • Effect of Blood Component Coatings of Enosseal Implants on Proliferation and Synthetic Activity of Human Osteoblasts and Cytokine Production of Peripheral Blood Mononuclear Cells.

    abstract：:The study monitored in vitro early response of connective tissue cells and immunocompetent cells to enosseal implant materials coated by different blood components (serum, activated plasma, and plasma/platelets) to evaluate human osteoblast proliferation and synthetic activity and inflammatory response presented as a ...

    journal_title：Mediators of inflammation

    pub_type： 杂志文章

    doi：10.1155/2016/8769347

    authors： Himmlova L,Kubies D,Hulejova H,Bartova J,Riedel T,Stikarova J,Suttnar J,Pesakova V

    更新日期：2016-01-01 00:00:00

  • Effect of Interferon-γ on the Basal and the TNFα-Stimulated Secretion of CXCL8 in Thyroid Cancer Cell Lines Bearing Either the RET/PTC Rearrangement Or the BRAF V600e Mutation.

    abstract：:CXCL8 displays several tumor-promoting effects. Targeting and/or lowering CXCL8 concentrations within the tumor microenvironment would produce a therapeutic benefit. Aim of this study was to test the effect of IFNγ on the basal and TNFα-stimulated secretion of CXCL8 in TCP-1 and BCPAP thyroid cancer cell lines (harbor...

    journal_title：Mediators of inflammation

    pub_type： 杂志文章

    doi：10.1155/2016/8512417

    authors： Rotondi M,Coperchini F,Awwad O,Pignatti P,Di Buduo CA,Abbonante V,Magri F,Balduini A,Chiovato L

    更新日期：2016-01-01 00:00:00

  • Obesity and low-grade inflammation increase plasma follistatin-like 3 in humans.

    abstract：BACKGROUND:Rodent models suggest that follistatin-like 3 (fstl3) is associated with diabetes and obesity. In humans, plasma fstl3 is reduced with gestational diabetes. In vitro, TNF-α induces fstl3 secretion, which suggests a link to inflammation. OBJECTIVE:To elucidate the association between plasma fstl3 and obesity...

    journal_title：Mediators of inflammation

    pub_type： 杂志文章

    doi：10.1155/2014/364209

    authors： Brandt C,Pedersen M,Rinnov A,Andreasen AS,Møller K,Hojman P,Pedersen BK,Plomgaard P

    更新日期：2014-01-01 00:00:00

  • The Correlation between FSTL1 Expression and Airway Remodeling in Asthmatics.

    abstract：BACKGROUND:Asthma is characterized by airway remodeling. Follistatin-like protein 1 (FSTL1) is an extracellular glycoprotein. Recent studies suggest that FSTL1 may participate in the pathogenesis of asthma. OBJECTIVES:To analyze the association between FSTL1 and some parameters and inspect the role of FSTL1 in asthma....

    journal_title：Mediators of inflammation

    pub_type： 杂志文章

    doi：10.1155/2017/7918472

    authors： Liu Y,Liu T,Wu J,Li T,Jiao X,Zhang H,Zhao J,Wang J,Liu L,Cao L,Li S,Xu J,Xu J,Ma X,Yang L,Dong L

    更新日期：2017-01-01 00:00:00

  • Urinary eicosanoid metabolites in HIV-infected women with central obesity switching to raltegravir: an analysis from the women, integrase, and fat accumulation trial.

    abstract：:Chronic inflammation is a hallmark of HIV infection. Eicosanoids reflect inflammation, oxidant stress, and vascular health and vary by sex and metabolic parameters. Raltegravir (RAL) is an HIV-1 integrase inhibitor that may have limited metabolic effects. We assessed urinary F2-isoprostanes (F2-IsoPs), prostaglandin E...

    journal_title：Mediators of inflammation

    pub_type： 杂志文章,随机对照试验

    doi：10.1155/2014/803095

    authors： Hulgan T,Boger MS,Liao DH,McComsey GA,Wanke CA,Mangili A,Walmsley SL,McCreath H,Milne GL,Sanchez SC,Currier JS,Lake JE

    更新日期：2014-01-01 00:00:00

  • Ghrelin protection against lipopolysaccharide-induced gastric mucosal cell apoptosis involves constitutive nitric oxide synthase-mediated caspase-3 S-nitrosylation.

    abstract：:Ghrelin, a peptide hormone produced mainly in the stomach, has emerged as an important modulator of the inflammatory responses that are of significance to the maintenance of gastric mucosal integrity. Here, we report on the role of ghrelin in controlling the apoptotic processes induced in gastric mucosal cells by H. p...

    journal_title：Mediators of inflammation

    pub_type： 杂志文章

    doi：10.1155/2010/280464

    authors： Slomiany BL,Slomiany A

    更新日期：2010-01-01 00:00:00

  • Selective vitamin D receptor activation as anti-inflammatory target in chronic kidney disease.

    abstract：:Paricalcitol, a selective vitamin D receptor (VDR) activator used for treatment of secondary hyperparathyroidism in chronic kidney disease (CKD), has been associated with survival advantages, suggesting that this drug, beyond its ability to suppress parathyroid hormone, may have additional beneficial actions. In this ...

    journal_title：Mediators of inflammation

    pub_type： 杂志文章

    doi：10.1155/2014/670475

    authors： Donate-Correa J,Domínguez-Pimentel V,Méndez-Pérez ML,Muros-de-Fuentes M,Mora-Fernández C,Martín-Núñez E,Cazaña-Pérez V,Navarro-González JF

    更新日期：2014-01-01 00:00:00

  • LincRNA Cox-2 Regulates Lipopolysaccharide-Induced Inflammatory Response of Human Peritoneal Mesothelial Cells via Modulating miR-21/NF-κB Axis.

    abstract：:Postoperative peritoneal adhesion (PPA) is a common postoperative complication caused by any peritoneal inflammatory process. This study aimed to identify the biological function of large intergenic non-coding RNAs (lincRNAs) Cox-2 in the inflammation reaction of adhesion formation. The Cox-2 expression in peritoneal ...

    journal_title：Mediators of inflammation

    pub_type： 杂志文章

    doi：10.1155/2019/8626703

    authors： Bian Y,Yang L,Zhang B,Li W,Wang S,Jiang S,Chen X,Li W,Zeng L

    更新日期：2019-12-03 00:00:00

  • Opposing roles of leptin and ghrelin in the equine corpus luteum regulation: an in vitro study.

    abstract：:Metabolic hormones have been associated with reproductive function modulation. Thus, the aim of this study was: (i) to characterize the immunolocalization, mRNA and protein levels of leptin (LEP), Ghrelin (GHR) and respective receptors LEPR and Ghr-R1A, throughout luteal phase; and (ii) to evaluate the role of LEP and...

    journal_title：Mediators of inflammation

    pub_type： 杂志文章

    doi：10.1155/2014/682193

    authors： Galvão A,Tramontano A,Rebordão MR,Amaral A,Bravo PP,Szóstek A,Skarzynski D,Mollo A,Ferreira-Dias G

    更新日期：2014-01-01 00:00:00

  • Recent Advances in Antiviral Therapy for Chronic Hepatitis C.

    abstract：:Hepatitis C virus (HCV) infection is a major worldwide health problem. Chronic infection induces continuous inflammation in the liver, progression of hepatic fibrosis, eventual cirrhosis, and possible hepatocellular carcinoma. Eradication of the virus is one of the most important treatment aims. A number of promising ...

    journal_title：Mediators of inflammation

    pub_type： 杂志文章,评审

    doi：10.1155/2016/6841628

    authors： Tamori A,Enomoto M,Kawada N

    更新日期：2016-01-01 00:00:00

  • The Antimicrobial Peptide Human Beta-Defensin-3 Is Induced by Platelet-Released Growth Factors in Primary Keratinocytes.

    abstract：:Platelet-released growth factors (PRGF) and its related clinically used formulations (e.g., Vivostat Platelet-Rich Fibrin (PRF®)) contain a variety of chemokines, cytokines, and growth factors and are therefore used to support healing of chronic, hard-to-heal, or infected wounds. Human beta-defensin-3 (hBD-3) is an an...

    journal_title：Mediators of inflammation

    pub_type： 杂志文章

    doi：10.1155/2017/6157491

    authors： Bayer A,Lammel J,Tohidnezhad M,Lippross S,Behrendt P,Klüter T,Pufe T,Cremer J,Jahr H,Rademacher F,Gläser R,Harder J

    更新日期：2017-01-01 00:00:00

  • Identification of miRNA-mRNA Crosstalk in Respiratory Syncytial Virus- (RSV-) Associated Pediatric Pneumonia through Integrated miRNAome and Transcriptome Analysis.

    abstract：:Respiratory syncytial virus (RSV) is the most common respiratory virus and is associated with pediatric pneumonia, causing bronchiolitis and significant mortality in infants and young children. MicroRNAs (miRNAs) are endogenous noncoding small RNAs that function in gene regulation and are associated with host immune r...

    journal_title：Mediators of inflammation

    pub_type： 杂志文章

    doi：10.1155/2020/8919534

    authors： Zhang X,Huang F,Yang D,Peng T,Lu G

    更新日期：2020-05-01 00:00:00

  • The Role of Immunosenescence in Neurodegenerative Diseases.

    abstract：:Aging is characterized by the progressive decline of physiological function and tissue homeostasis leading to increased vulnerability, degeneration, and death. Aging-related changes of the innate and adaptive immune system include decline in the preservation and enhancement of many immune functions, such as changes in...

    journal_title：Mediators of inflammation

    pub_type： 杂志文章,评审

    doi：10.1155/2018/6039171

    authors： Costantini E,D'Angelo C,Reale M

    更新日期：2018-03-08 00:00:00

  • Anti-inflammatory properties of sirtuin 6 in human umbilical vein endothelial cells.

    abstract：:A prominent feature of inflammatory diseases is endothelial dysfunction. Factors associated with endothelial dysfunction include proinflammatory cytokines, adhesion molecules, and matrix degrading enzymes. At the transcriptional level, they are regulated by the histone deacetylase sirtuin (SIRT) 1 via its actions on t...

    journal_title：Mediators of inflammation

    pub_type： 杂志文章

    doi：10.1155/2012/597514

    authors： Lappas M

    更新日期：2012-01-01 00:00:00