Recent Advances in Antiviral Therapy for Chronic Hepatitis C.

abstract：:Spinal cord injury (SCI) results in complex posttraumatic sequelae affecting the whole neuraxis. Due to its involvement in varied neuromodulatory processes, the chemokine-ligand/receptor-network is a key element of secondary lesion cascades induced by SCI. This review will provide a synopsis of chemokine-ligand/recept...

journal_title：Mediators of inflammation

authors： Knerlich-Lukoschus F,Held-Feindt J

更新日期：2015-01-01 00:00:00

abstract：:Particulate matter with an aerodynamic diameter equal or less than 2.5 micrometers (PM2.5) is associated with the development of chronic obstructive pulmonary disease (COPD). The mechanisms by which PM2.5 accelerates disease progression in COPD are poorly understood. In this study, we aimed to investigate the effect o...

journal_title：Mediators of inflammation

authors： Wang J,Li Y,Zhao P,Tian Y,Liu X,He H,Jia R,Oliver BG,Li J

更新日期：2020-05-08 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is considered a multifactorial, multisystem disease in which inflammation and the immune system play important roles in development and progression. The pleiotropic cytokine TNFα is one of the major players governing the inflammation in the central nervous system and peripheral dist...

journal_title：Mediators of inflammation

authors： Tortarolo M,Lo Coco D,Veglianese P,Vallarola A,Giordana MT,Marcon G,Beghi E,Poloni M,Strong MJ,Iyer AM,Aronica E,Bendotti C

更新日期：2017-01-01 00:00:00

abstract：Background:Gut microbiota is implied in obesity, because of its ability to harvest energy from diet, and in the regulation of behavior. Given the link between gut microbiota, body composition, obesity, and anxiety, the aim of this study was to evaluate the effects of a new psychobiotic formulation. Methods:Eligible pa...

journal_title：Mediators of inflammation

authors： Colica C,Avolio E,Bollero P,Costa de Miranda R,Ferraro S,Sinibaldi Salimei P,De Lorenzo A,Di Renzo L

更新日期：2017-01-01 00:00:00

abstract：:The aim of our work was to find if MCP-1 -2518 (A/G) single nucleotide polymorphism (SNP) influences somehow the serum concentrations of high-sensitive CRP (hsCRP) both in patients suffering from ischemic heart disease (IHD), myocardial infarction (MI), angina pectoris (AP), and hypertension (HT) and in control group ...

journal_title：Mediators of inflammation

authors： Bucova M,Lietava J,Penz P,Mrazek F,Petrkova J,Bernadic M,Petrek M

更新日期：2009-01-01 00:00:00

abstract：:The purpose of this study is to characterize synovial fluid- (SF-) derived exosomes of patients with gonarthrosis comparing two methods of isolation and to investigate their immune regulatory properties. Extracellular vesicles (EVs) have been isolated from inflamed SF by polymer precipitation method and quantified by ...

journal_title：Mediators of inflammation

authors： Domenis R,Zanutel R,Caponnetto F,Toffoletto B,Cifù A,Pistis C,Di Benedetto P,Causero A,Pozzi M,Bassini F,Fabris M,Niazi KR,Soon-Shiong P,Curcio F

更新日期：2017-01-01 00:00:00

abstract：:In addition to the spectrum of biological action already known to be exhibited by acetylsalicylic acid (ASA) as an analgesic, anti-inflammatory and platelet aggregation inhibitor, there is growing evidence of a stimulatory effect on the immune system. ASA has been found to increase the production ofcytokines and to in...

journal_title：Mediators of inflammation

authors： Jäpel M,Lötzerich H,Rogalla K

更新日期：1994-01-01 00:00:00

abstract：:Methyltransferase-like 3 (METTL3), an RNA N6-methyladenosine (m6A) methyltransferase, is essential for the m6A mRNA modification. As a key enzyme of m6A methylation modification, METTL3 has been implicated in immune and inflammation regulation. However, little is known of the role and underlying mechanism of METTL3 in...

journal_title：Mediators of inflammation

authors： Wang J,Yan S,Lu H,Wang S,Xu D

更新日期：2019-10-24 00:00:00

abstract：:Infection with dengue virus (DENV) causes an increase in proinflammatory responses, such as nitric oxide (NO) generation and TNF-α expression; however, the molecular mechanism underlying this inflammatory activation remains undefined, although the activation of the transcription factor NF-κB is generally involved. In ...

journal_title：Mediators of inflammation

authors： Cheng YL,Lin YS,Chen CL,Wan SW,Ou YD,Yu CY,Tsai TT,Tseng PC,Lin CF

更新日期：2015-01-01 00:00:00

abstract：:Leptin participates in the inflammatory responses in multiple cell types and animal models. Chronic cerebral hypoperfusion (CCH) induces inflammation in the central nervous system (CNS), which acts as one of the main reasons for CCH-induced white matter lesions (WMLs). But whether leptin participates in the pathogenes...

journal_title：Mediators of inflammation

authors： Du Y,Song Y,Zhang X,Luo Y,Zou W,Zhang J,Fu J

更新日期：2020-12-18 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is a most frequently occurring and severe form of motor neuron disease, causing death within 3-5 years from diagnosis and with a worldwide incidence of about 2 per 100,000 person-years. Mutations in over twenty genes associated with familial forms of ALS have provided insights into ...

journal_title：Mediators of inflammation

authors： Parisi C,Napoli G,Pelegrin P,Volonté C

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:Empirical observations have shown that ozonated autohemotherapy markedly improves the symptoms of chronic limb ischemia (muscular pain at rest, intermittent claudication, etc) in atherosclerotic patients, but mechanisms of action remain unclear. AIMS:Human endothelial cells (HUVECs) are known to release nit...

journal_title：Mediators of inflammation

authors： Valacchi G,Bocci V

更新日期：2000-01-01 00:00:00

abstract：:The present study investigated the association between the rs12979860 polymorphism in the IL-28B gene and HTLV-1 infection as well as the development of HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). HTLV-1-infected patients (26 HAM/TSP symptomatic and 53 asymptomatic) and 300 seronegative health...

journal_title：Mediators of inflammation

authors： Vallinoto AC,Santana BB,Sá KS,Ferreira TC,Sousa RC,Azevedo VN,Feitosa RN,Machado LF,Ishak MO,Ishak R

更新日期：2015-01-01 00:00:00

abstract：OBJECTIVE:To evaluate the effects of psychological stress on periodontitis healing in rats and the contribution of basic fibroblast growth factor (bFGF) expression to the healing process. METHODS:Ninety-six rats were randomly distributed into control group, periodontitis group, and periodontitis plus stress group. The...

journal_title：Mediators of inflammation

authors： Zhao YJ,Li Q,Cheng BX,Zhang M,Chen YJ

更新日期：2012-01-01 00:00:00

abstract：:Dysfunctions of the L-arginine (L-arg)/nitric-oxide (NO) pathway are suspected to be important for the pathogenesis of multiple organ dysfunction syndrome (MODS) in septic shock. Therefore plasma concentrations of L-arg and asymmetric dimethylarginine (ADMA) were measured in 60 patients with septic shock, 30 surgical ...

journal_title：Mediators of inflammation

authors： Brenner T,Fleming TH,Rosenhagen C,Krauser U,Mieth M,Bruckner T,Martin E,Nawroth PP,Weigand MA,Bierhaus A,Hofer S

更新日期：2012-01-01 00:00:00

abstract：:Scorpion venoms consist of a complex of several toxins that exhibit a wide range of biological properties and actions, as well as chemical compositions, toxicity, and pharmacokinetic and pharmacodynamic characteristics. These venoms are associated with high morbility and mortality, especially among children. Victims o...

journal_title：Mediators of inflammation

authors： Petricevich VL

更新日期：2010-01-01 00:00:00

abstract：OBJECTIVE:In this work we studied the correlation between platelet count, platelet activation, and systemic inflammation in overweight, obese, and morbidly obese individuals. METHODS AND SUBJECTS:A total of 6319 individuals participated in the study. Complete blood counts, high sensitivity C-reactive protein (hs-CRP) ...

journal_title：Mediators of inflammation

authors： Samocha-Bonet D,Justo D,Rogowski O,Saar N,Abu-Abeid S,Shenkerman G,Shapira I,Berliner S,Tomer A

更新日期：2008-01-01 00:00:00

abstract：:Current studies have identified the multifaceted protective functions of dexmedetomidine on multiple organs. For the first time, we clarify effects of dexmedetomidine on monocyte-endothelial adherence and whether its underlying mechanism is relative to connexin43 (Cx43), a key factor regulating monocyte-endothelial ad...

journal_title：Mediators of inflammation

authors： Chai Y,Yu R,Liu Y,Wang S,Yuan D,Chen J

更新日期：2020-02-10 00:00:00

abstract：:Podocyte injury critically contributes to the pathogenesis of obesity-related glomerulopathy (ORG). Recently, lipid accumulation and inflammatory responses have been found to be involved in podocyte injury. This study is to explore their role and relationship in podocyte injury of ORG. In animal experiments, the ORG m...

journal_title：Mediators of inflammation

authors： Zhao J,Rui HL,Yang M,Sun LJ,Dong HR,Cheng H

更新日期：2019-04-11 00:00:00

abstract：:Inflammatory mediators play a critical role in ulcerative colitis immune and inflammatory processes. The aim of the study was to investigate the effects of Ginkgo biloba extract on inflammatory mediators (SOD, MDA, TNF-alpha, NF-kappaBp65, IL-6) in TNBS-induced colitis in rats. Colitis in rats was induced by colonic a...

journal_title：Mediators of inflammation

authors： Zhou YH,Yu JP,Liu YF,Teng XJ,Ming M,Lv P,An P,Liu SQ,Yu HG

更新日期：2006-01-01 00:00:00

abstract：:A marked proliferation of synovial fibroblasts in joints leads to pannus formation in rheumatoid arthritis (RA). Various kinds of cytokines are produced in the pannus. The purpose of this study is to elucidate the effects of phosphodiesterase 4 (PDE4) inhibitors in a new animal model for the evaluation of pannus forma...

journal_title：Mediators of inflammation

authors： Kobayashi K,Suda T,Manabe H,Miki I

更新日期：2007-01-01 00:00:00

abstract：:In our previous study, lipopolysaccharide (LPS) significantly reduced the cell viability of primary bovine mammary epithelial cells (bMEC) leading to cell apoptosis, which were prevented by caffeic acid (CA) through inhibiting NF-κB activation and reducing proinflammatory cytokine expression. While the underlying mech...

journal_title：Mediators of inflammation

authors： Liu M,Fang G,Yin S,Zhao X,Zhang C,Li J,Liu Z

更新日期：2019-04-30 00:00:00

abstract：:Ghrelin, a peptide hormone produced mainly in the stomach, has emerged as an important modulator of the inflammatory responses that are of significance to the maintenance of gastric mucosal integrity. Here, we report on the role of ghrelin in controlling the apoptotic processes induced in gastric mucosal cells by H. p...

journal_title：Mediators of inflammation

authors： Slomiany BL,Slomiany A

更新日期：2010-01-01 00:00:00

abstract：Objective:For patients with severe acute pancreatitis (SAP), a high body mass index (BMI) increases the possibility of infection derived from the intestine. In this study, we evaluate whether TAK242 can alleviate severe acute pancreatitis-associated injury of intestinal barrier in high-fat diet-fed rats. Methods:A SAP...

journal_title：Mediators of inflammation

authors： Su YR,Hong YP,Mei FC,Wang CY,Li M,Zhou Y,Zhao KL,Yu J,Wang WX

更新日期：2019-12-17 00:00:00

abstract：:Acute respiratory distress syndrome (ARDS) remains a high morbidity and mortality disease entity in critically ill patients, despite decades of numerous investigations into its pathogenesis. To obtain global protein expression changes in acute lung injury (ALI) lung tissues, we employed a high-throughput proteomics me...

journal_title：Mediators of inflammation

authors： Liu D,Mao P,Huang Y,Liu Y,Liu X,Pang X,Li Y

更新日期：2014-01-01 00:00:00

abstract：:[This corrects the article DOI: 10.1155/2018/3809092.]. ...

journal_title：Mediators of inflammation

authors： Curtiss E,Jiang Y,Liu L,Hawthorne C,Zhang J,Steinle JJ

更新日期：2019-06-18 00:00:00

abstract：:[This corrects the article DOI: 10.1155/2020/6947482.]. ...

journal_title：Mediators of inflammation

authors： Zhao Y,Wang J,Zhang M,Li P,Qi S,Lin W

更新日期：2020-11-21 00:00:00

abstract：:Lysophosphatidic acid (LPA) is a bioactive phospholipid playing an important role in various inflammatory diseases by inducing expression and secretion of many inflammatory cytokines/chemokines. Here we report in a murine air pouch model of inflammation that LPA induced CXCL13 secretion in a time-dependent manner and ...

journal_title：Mediators of inflammation

authors： Hui W,Zhao C,Bourgoin SG

更新日期：2015-01-01 00:00:00

abstract：:Plasma GDF15 concentrations were measured in 612 Taiwanese individuals without overt systemic disease. Clinical parameters, GDF15 genetic variants, and 22 biomarker levels were analyzed. We further enrolled 86 patients with PAD and 481 patients with CAD, who received endovascular intervention and coronary angiography,...

journal_title：Mediators of inflammation

authors： Hsu LA,Wu S,Juang JJ,Chiang FT,Teng MS,Lin JF,Huang HL,Ko YL

更新日期：2017-01-01 00:00:00

abstract：:Mechanical ventilation (MV) is a major life support technique for the management of trauma-associated hemorrhagic shock (HS). Ventilator-induced diaphragm dysfunction (VIDD), one of the most common complications of MV, has been well demonstrated in animal and human studies. However, few data are available concerning t...

journal_title：Mediators of inflammation

authors： Zhang LJ,Ni SZ,Zhou XL,Zhao Y

更新日期：2019-11-14 00:00:00