Abstract:
:Inflammatory mediators play a critical role in ulcerative colitis immune and inflammatory processes. The aim of the study was to investigate the effects of Ginkgo biloba extract on inflammatory mediators (SOD, MDA, TNF-alpha, NF-kappaBp65, IL-6) in TNBS-induced colitis in rats. Colitis in rats was induced by colonic administration with 2,4,6-trinitrobenzene sulfonic acid (TNBS, 150 mg/kg). EGB in doses of (50, 100, 200 mg/kg) was administered for 4 weeks to protect colitis. The results showed that EGB could significantly ameliorate macroscopic and histological damage, evidently elevate the activities of SOD and reduce the contents of MDA, inhibit the protein and mRNA expressions of TNF-alpha, NF-kappaBp65, and IL-6 in the colon tissues of experimental colitis in a dose-dependent manner compared with the model group. We concluded that the probable mechanisms of EGB ameliorated inflammatory injury in TNBS-induced colitis in rats by its modulation of inflammatory mediators and antioxidation.
journal_name
Mediators Inflammjournal_title
Mediators of inflammationauthors
Zhou YH,Yu JP,Liu YF,Teng XJ,Ming M,Lv P,An P,Liu SQ,Yu HGdoi
10.1155/MI/2006/92642subject
Has Abstractpub_date
2006-01-01 00:00:00pages
92642issue
5eissn
0962-9351issn
1466-1861pii
S0962935106926428journal_volume
2006pub_type
杂志文章abstract::The generation of ROS and lipid peroxidation has been considered to play an important role in the pathogenesis of chronic fluoride toxicity. In the present study, we observed that fluoride activated BV-2 microglia cell line by observing OX-42 expression in immunocytochemistry. Intracellular superoxide dismutase (SOD),...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2012/102954
更新日期:2012-01-01 00:00:00
abstract:Objective:To profile maternal plasma metabolome in spontaneous preterm birth. Method:In this retrospective case-control study, we have examined plasma of patient with preterm birth (between 22 and 36 weeks of pregnancy (n = 57)), with threatened preterm labor (between 23 and 36 weeks of pregnancy (n = 49)), and with t...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2018/9362820
更新日期:2018-02-15 00:00:00
abstract:AIM:The aim of this study was to evaluate the presence of the cytokines tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) in human periapical lesions. SUBJECTS AND METHODS:Samples were obtained from three groups of teeth: symptomatic teeth, asymptomatic lesions, and uninflamed periradicular tissues as a...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2007/38210
更新日期:2007-01-01 00:00:00
abstract::Microcystins (MCs) produced by toxic cyanobacteria cause serious water pollution and public health hazard to humans and animals. However, direct molecular mechanisms of MC-LR in vascular endothelial cells (ECs) have not been understood yet. In this study, we investigated whether MC-LR induces vascular inflammatory pro...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2015/942159
更新日期:2015-01-01 00:00:00
abstract:Background:Gut microbiota is implied in obesity, because of its ability to harvest energy from diet, and in the regulation of behavior. Given the link between gut microbiota, body composition, obesity, and anxiety, the aim of this study was to evaluate the effects of a new psychobiotic formulation. Methods:Eligible pa...
journal_title:Mediators of inflammation
pub_type: 杂志文章,随机对照试验
doi:10.1155/2017/5650627
更新日期:2017-01-01 00:00:00
abstract::Heparanase activity is correlated with the metastatic potential of several cancer cells and is a key enzyme in the breakdown of tissue barriers. It is also involved in the regulation of growth factor and cytokine activity. However, little is known about the factors that induce heparanase in cancer cells. We investigat...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1080/09629350120093731
更新日期:2001-10-01 00:00:00
abstract::Current studies have identified the multifaceted protective functions of dexmedetomidine on multiple organs. For the first time, we clarify effects of dexmedetomidine on monocyte-endothelial adherence and whether its underlying mechanism is relative to connexin43 (Cx43), a key factor regulating monocyte-endothelial ad...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2020/7039854
更新日期:2020-02-10 00:00:00
abstract::In recent years, many researchers are focusing their attention on the link between inflammation and cancer. The inflammation is involved in the tumor development and suppression, by stimulating the immune response. In particular, the transition from chronic inflammation to cancer produces angiogenic and growth factors...
journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
doi:10.1155/2016/3064643
更新日期:2016-01-01 00:00:00
abstract::Nephrolithiasis is characterized by calcification of stones in the kidneys from an unknown cause. Animal models demonstrated the functional roles of the transient receptor potential vanilloid member 5 (TRPV5) gene in calcium renal reabsorption and hypercalciuria. Therefore, TRPV5 was suggested to be involved in calciu...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2015/375427
更新日期:2015-01-01 00:00:00
abstract::The present study investigated the frequencies of rs1800450 (MBL ⁎B, G>A), rs1800451 (MBL ⁎C, G>A), and rs5030737 (MBL ⁎D, C>T) polymorphisms in exon 1 of the MBL2 gene among patients with chronic viral hepatitis. Blood samples from patients infected with hepatitis B virus (HBV; n = 65), hepatitis C virus (HCV; n = 92...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2017/3718451
更新日期:2017-01-01 00:00:00
abstract::Daily food intake is crucial to maintain health and determine endogenous fuel to practice endurance exercise. We investigated the association between quantity of macronutrient and micronutrient daily intake and inflammation induced by long-distance exercise. Methods. Forty-four Brazilian male amateurs' marathon finish...
journal_title:Mediators of inflammation
pub_type: 临床试验,杂志文章
doi:10.1155/2019/1537274
更新日期:2019-10-07 00:00:00
abstract:PURPOSE:To assess FGF-β, TGF-β, and COX2 expression and immunocompetent cells in the orbital tissue of patients with severe and mild Graves' orbitopathy. PATIENTS AND METHODS:Orbital tissue was taken from 27 patients with GO: (1) severe GO (n = 18), the mean clinical activity score (CAS) being 8.5 (SD 2.5); and (2) mi...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2014/412158
更新日期:2014-01-01 00:00:00
abstract::Periodontitis is a kind of chronic inflammatory disease that affects the tooth-supporting tissues. ET-1 is related to periodontitis and involved in the regulation of cytokines, but the mechanisms remain unclear. The aim of this study is to investigate how ET-1 affects proinflammatory cytokine expression and differenti...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2016/8467849
更新日期:2016-01-01 00:00:00
abstract::Human gingival fibroblast barrier dysfunction caused by inflammation contributes to gingivitis and can lead to inflammatory periodontal disease. The disease features include upregulated epithelial permeability, increased inflammatory mediators, and downregulated junctional complex molecules. Carbon monoxide- (CO-) rel...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2020/6302391
更新日期:2020-04-28 00:00:00
abstract::CXCL8 displays several tumor-promoting effects. Targeting and/or lowering CXCL8 concentrations within the tumor microenvironment would produce a therapeutic benefit. Aim of this study was to test the effect of IFNγ on the basal and TNFα-stimulated secretion of CXCL8 in TCP-1 and BCPAP thyroid cancer cell lines (harbor...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2016/8512417
更新日期:2016-01-01 00:00:00
abstract::Platelet-released growth factors (PRGF) and its related clinically used formulations (e.g., Vivostat Platelet-Rich Fibrin (PRF®)) contain a variety of chemokines, cytokines, and growth factors and are therefore used to support healing of chronic, hard-to-heal, or infected wounds. Human beta-defensin-3 (hBD-3) is an an...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2017/6157491
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND:The proinflammatory chemokine CXCL10, in addition to its chemotactic properties, is also involved in the stimulation of natural killer and T-cell migration in Mycobacterium tuberculosis infection. In this study, our experiments were designed to determine the role of interferon (IFN)-alphabeta in the producti...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1080/09629350400014099
更新日期:2004-12-01 00:00:00
abstract:OBJECTIVE:To investigate the effects and mechanisms of hydroxytyrosol (HT) during the pathogenesis of myocardial ischemia reperfusion (I/R) in rat hearts. METHODS:The rats were randomized into five groups: sham group, I/R group, HT+I/R group, HT+LY294002+I/R group, and LY+I/R group. Myocardial infarct size, markers of...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2016/1232103
更新日期:2016-01-01 00:00:00
abstract::This study examined the role of lymphotoxin (LT)-alpha in host defense against airborne infection with Francisella tularensis, a gram-negative facultative intracellular bacterium and the causative agent of tularemia. Following a low-dose aerosol infection with the highly virulent type A strain of F. tularensis, mice d...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2008/239740
更新日期:2008-01-01 00:00:00
abstract:BACKGROUND:Asthma is characterized by airway remodeling. Follistatin-like protein 1 (FSTL1) is an extracellular glycoprotein. Recent studies suggest that FSTL1 may participate in the pathogenesis of asthma. OBJECTIVES:To analyze the association between FSTL1 and some parameters and inspect the role of FSTL1 in asthma....
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2017/7918472
更新日期:2017-01-01 00:00:00
abstract::Matrix metalloproteinase-14 (MMP-14) promotes vulnerable plaque morphology in mice, whereas tissue inhibitor of metalloproteinases-3 (TIMP-3) overexpression is protective. MMP-14(hi) TIMP-3(lo) rabbit foam cells are more invasive and more prone to apoptosis than MMP-14(lo) TIMP-3(hi) cells. We investigated the implica...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2014/276457
更新日期:2014-01-01 00:00:00
abstract::Since iron can contribute to detrimental radical generating processes through the Fenton and Haber-Weiss reactions, it seems to be a reasonable approach to modulate iron-related pathways in inflammation. In the human organism a counterregulatory reduction in iron availability is observed during inflammatory diseases. ...
journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
doi:10.1155/2015/516740
更新日期:2015-01-01 00:00:00
abstract::Ghrelin, a peptide hormone produced mainly in the stomach, has emerged as an important modulator of the inflammatory responses that are of significance to the maintenance of gastric mucosal integrity. Here, we report on the role of ghrelin in controlling the apoptotic processes induced in gastric mucosal cells by H. p...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2010/280464
更新日期:2010-01-01 00:00:00
abstract::Tuberculosis is characterized by the presence of activated mononuclear cells both in the peripheral circulation and in pleural fluid. Expression and up-regulation of adhesion molecules is the basis of cell-cell adhesion in granuloma formation and in leukocyte migration to the inflammatory site. Soluble isoforms of adh...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/S0962935196000403
更新日期:1996-01-01 00:00:00
abstract::Vascular adhesion protein-1 (VAP-1) is an ectoenzyme that functions as a copper-containing amine oxidase and is involved in leukocyte adhesion at sites of inflammation. Inhibition of VAP-1 oxidative deamination has become an attractive target for anti-inflammatory therapy with demonstrated efficacy in rodent models of...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2020/3270513
更新日期:2020-01-20 00:00:00
abstract::Obesity-induced skeletal muscle inflammation is characterized by increased macrophage infiltration and inflammatory cytokine production. In this study, we investigated whether 4-1BB, a member of the TNF receptor superfamily (TNFRSF9) that provides inflammatory signals, participates in obesity-induced skeletal muscle i...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2013/865159
更新日期:2013-01-01 00:00:00
abstract::Cytokines play an important role in the regulation of the immune system (adaptive and innate). Given their importance in proinflammatory processes, cytokines have been used for understanding the pathogenesis and as biomarkers in many diseases. IL-31 and IL-33 are still considered novel cytokines. IL-31 controls signal...
journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
doi:10.1155/2018/3858032
更新日期:2018-03-11 00:00:00
abstract::The increased morbidity, mortality, and ineffective treatment associated with the pathogenesis of chronic inflammatory diseases such as asthma and chronic obstructive pulmonary disease (COPD) have generated much research interest. The key role is played by phospholipases from the A2 superfamily: enzymes which are invo...
journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
doi:10.1155/2013/793505
更新日期:2013-01-01 00:00:00
abstract::The number of persons who relocate to regions of high altitude for work, pleasure, sport, or residence increases every year. It is known that the reduced supply of oxygen (O2) induced by acute or chronic increases in altitude stimulates the body to adapt to new metabolic challenges imposed by hypoxia. Sleep can suffer...
journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
doi:10.1155/2013/279365
更新日期:2013-01-01 00:00:00
abstract:BACKGROUND:Growth arrest specific gene 6 (Gas6) protein enhances survival of oligodendrocytes and neurons, and it is involved in autoimmunity. Therefore, we aimed to verify whether cerebrospinal-fluid (CSF) Gas6 concentration may represent a biomarker of disease activity in multiple sclerosis. METHODS:Sixty-five patie...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2013/406483
更新日期:2013-01-01 00:00:00