Abstract:
AIM:The aim of this study was to evaluate the presence of the cytokines tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) in human periapical lesions. SUBJECTS AND METHODS:Samples were obtained from three groups of teeth: symptomatic teeth, asymptomatic lesions, and uninflamed periradicular tissues as a control. RESULTS:TNF-alpha levels were significantly increased in symptomatic lesions compared to control. Group with asymptomatic lesions had significantly higher concentrations compared to control. There were no significant differences in TNF-alpha levels between symptomatic and asymptomatic lesions. In group with symptomatic lesions, IL-6 levels were significantly higher than in group with asymptomatic lesions. The IL-6 levels in symptomatic group also showed significantly higher concentration in comparison with control group. In asymptomatic group, the IL-6 level had significantly higher concentrations compared to control. CONCLUSION:These results indicate that symptomatic lesions represent an immunologically active stage of disease, and asymptomatic lesions are the point from which the process advances toward healing.
journal_name
Mediators Inflammjournal_title
Mediators of inflammationauthors
Prso IB,Kocjan W,Simić H,Brumini G,Pezelj-Ribarić S,Borcić J,Ferreri S,Karlović IMdoi
10.1155/2007/38210subject
Has Abstractpub_date
2007-01-01 00:00:00pages
38210eissn
0962-9351issn
1466-1861journal_volume
2007pub_type
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