Overexpression of CXCL14 Alleviates Ventilator-Induced Lung Injury through the Downregulation of PKM2-Mediated Cytokine Production.

abstract：:Peripheral artery disease (PAD) is a common disease affecting 20-25% of population over 60 years old. Early diagnosis is difficult because symptoms only become evident in advanced stages of the disease. Inflammation, impaired metabolism, and mitochondrial dysfunction predispose to PAD, which is normally associated wit...

journal_title：Mediators of inflammation

authors： Hernández-Aguilera A,Fernández-Arroyo S,Cabre N,Luciano-Mateo F,Baiges-Gaya G,Fibla M,Martín-Paredero V,Menendez JA,Camps J,Joven J

更新日期：2018-09-20 00:00:00

abstract：Objective:To analyze the potential role of colchicine monotherapy in patients with tumor necrosis factor receptor associated periodic syndrome (TRAPS) in terms of control of clinical and laboratory manifestations. Methods:Patients with TRAPS treated with colchicine monotherapy were retrospectively enrolled; demographi...

journal_title：Mediators of inflammation

authors： Vitale A,Sota J,Obici L,Ricco N,Maggio MC,Cattalini M,Ruscitti P,Caso F,Manna R,Viapiana O,Caggiano V,Emmi G,Insalaco A,Montin D,Licciardi F,Soriano A,Dagna L,Salvarani C,Lamacchia V,Hernández-Rodríguez J,Giacomel

更新日期：2020-05-27 00:00:00

abstract：OBJECTIVE:To investigate the Th17/Treg immune balance in the ulcerative colitis (UC) patients in a Chinese Han population. METHODS:Ninety UC patients and 30 healthy subjects were enrolled. The serum IL-17 and TGF-β1 levels of these participants were measured with ELISA; the percentage of Th17 and Treg cells in periphe...

journal_title：Mediators of inflammation

authors： Gong Y,Lin Y,Zhao N,He X,Lu A,Wei W,Jiang M

更新日期：2016-01-01 00:00:00

abstract：:Chronic kidney disease (CKD) patients, characterized by traditional and nontraditional risk factors, are prone to develop atheromatosis and thus cardiovascular events and mortality. The angiogenesis of the adventitial vasa vasorum (aVV) surrounding the carotid has been described as the atheromatosis initiator. Therefo...

journal_title：Mediators of inflammation

authors： Arcidiacono MV,Martinez-Alonso M,Belart M,Vilar A,Martín M,Craver L,Betriu À,Mauricio D,Valdivielso JM,Fernández E,Borràs M

更新日期：2017-01-01 00:00:00

abstract：:This study was designated to evaluate the influence of behavioral depression on the airway leukocyte recruitment in allergic animals. To achieve this, total and differential cell counts in bronchoalveolar (BAL) fluid of ovalbumin (OVA)-sensitized and depressed rats was evaluated. Inescapable electric footshock, applie...

journal_title：Mediators of inflammation

authors： Varriano MA,Varriano AA,Datti F,Datti M,Antunes E,Teixeira NA

更新日期：2001-08-01 00:00:00

abstract：:Activation of macrophages is one of the key processes in generating the immune response against pathogens or misfolded/aggregated otherwise unharmful host's proteins. Antigens and their immune complexes (IC) may shape macrophage phenotype in various directions. Data on the impact of protein structure during inflammati...

journal_title：Mediators of inflammation

authors： Dalgėdienė I,Lučiūnaitė A,Žvirblienė A

更新日期：2018-11-18 00:00:00

abstract：:Modification of endogenous eicosanoid synthesis by dietary n-3 fatty acid supplementation reduces febrile responses, but the mechanisms underlying these effects in vivo have not been determined. In the present study, local inflammation was induced by intramuscular injection ofturpentine in rats fed control or n-3 supp...

journal_title：Mediators of inflammation

authors： Cooper AL,Turnbull AV,Hopkins SJ,Rothwell NJ

更新日期：1994-01-01 00:00:00

abstract：:Sepsis is a common complication of solid organ transplant procedures and, in particular, can affect the prognosis of orthotopic liver transplantation (OLT). This retrospective study determined the pre-, peri-, and postoperative risk factors for sepsis after OLT, using as reference the 2016 Third International Consensu...

journal_title：Mediators of inflammation

authors： Wang Y,Gu Y,Huang F,Liu D,Zhang Z,Zhou N,Liang J,Lu C,Yuan D,Hei Z

更新日期：2018-06-20 00:00:00

abstract：:This study tested the hypothesis that shock wave therapy (SW) enhances mitochondrial uptake into the lung epithelial and parenchymal cells to attenuate lung injury from acute respiratory distress syndrome (ARDS). ARDS was induced in rats through continuous inhalation of 100% oxygen for 48 h, while SW entailed applicat...

journal_title：Mediators of inflammation

authors： Lin KC,Wallace CG,Yin TC,Sung PH,Chen KH,Lu HI,Chai HT,Chen CH,Chen YL,Li YC,Shao PL,Lee MS,Sheu JJ,Yip HK

更新日期：2018-10-21 00:00:00

abstract：:Background. Inflammation mediators related to radiation proctitis are partially elucidated, and neovascularization is thought to play a key role. Objectives. To investigate the expression of vascular endothelial growth factor (VEGF) and CD31 as angiogenetic markers in postradiation rectal tissue. Methods. Rectal mucos...

journal_title：Mediators of inflammation

authors： Karamanolis G,Delladetsima I,Kouloulias V,Papaxoinis K,Panayiotides I,Haldeopoulos D,Triantafyllou K,Kelekis N,Ladas SD

更新日期：2013-01-01 00:00:00

abstract：:Although it is now accepted that killer-cell inhibitory receptors (KIRs), which were molecularly cloned in 1995, deliver negative signals to natural killer (NK) cells regarding the recognition of target cells, it is still unclear how the expression of these receptors on lymphocytes is regulated. Therefore, we investig...

journal_title：Mediators of inflammation

authors： Kogure T,Fujinaga H,Niizawa A,Hai LX,Shimada Y,Ochiai H,Terasawa K

更新日期：1999-01-01 00:00:00

abstract：:The purpose of this study is to assess the role of nitric oxide (NO) in the intestinal lesions of passive anaphylaxis, since this experimental model resembles necrotizing enterocolitis. Sprague-Dawley rats were sensitized with IgE anti-dinitrophenol monoclonal antibody. Extravasation of protein-rich plasma and haemorr...

journal_title：Mediators of inflammation

authors： Tavares JC,Moreno A,Crespo MS

更新日期：1997-01-01 00:00:00

abstract：:H. pylori induces a complicated local and systematic immune response and contributes to the carcinogenesis of gastric cancer. A primary type 1 immune response is evoked by H. pylori since its occurrence. However, it is not unusual that an inhibitory immunity is dominant in H. pylori-associated diseases, which are prom...

journal_title：Mediators of inflammation

authors： Li R,Jiang XX,Zhang LF,Liu XM,Hu TZ,Xia XJ,Li M,Xu CX

更新日期：2017-01-01 00:00:00

abstract：:Neuropathic pain is a serious clinical problem to be solved. This study is aimed at investigating protein kinase A (PKA) expression in neuropathic pain and its possible mechanisms of involvement. A neuropathic pain-related gene expression dataset was downloaded from Gene Expression Omnibus, and differentially expresse...

journal_title：Mediators of inflammation

authors： Deng Y,Yang L,Xie Q,Yang F,Li G,Zhang G,Li S,Wu Z,Wang J,Kang X

更新日期：2020-03-23 00:00:00

abstract：:In this study the question was addressed whether cAMP mediated drugs induce a differential reduction of branches of the arachidonic acid metabolism rather than a global reduction of eicosanoid synthesis. The isolated lungs of actively sensitized rats were employed to study prostaglandin and leukotriene release in the ...

journal_title：Mediators of inflammation

authors： Post MJ,Biesebeek JD,Wemer J,Rooij HH,Zijlstra FJ,Porsius AJ

更新日期：1992-01-01 00:00:00

abstract：:The aim of the present study was to compare serum levels of soluble forms of interleukin-2 receptor, CD4 and CD8, released by lymphocytes during activation of the immune system, in patients with allergic bronchial asthma, with those in healthy subjects. Significantly higher levels of soluble IL-2R and soluble CD4 were...

journal_title：Mediators of inflammation

authors： Lorenzo GD,Mansueto P,Melluso M,Morici G,Norrito F,Cigna D,Candore G,Caruso C

更新日期：1995-01-01 00:00:00

abstract：:Heparanase activity is correlated with the metastatic potential of several cancer cells and is a key enzyme in the breakdown of tissue barriers. It is also involved in the regulation of growth factor and cytokine activity. However, little is known about the factors that induce heparanase in cancer cells. We investigat...

journal_title：Mediators of inflammation

authors： Sasaki M,Ito T,Kashima M,Fukui S,Izumiyama N,Watanabe A,Sano M,Fujiwara Y,Miura M

更新日期：2001-10-01 00:00:00

abstract：:In sarcoidosis, increased Th17 cell fractions have been reported in bronchoalveolar lavage fluid, and elevated numbers of Th17 cells producing IFN- γ have been observed in peripheral blood. The balance between Th1, Th17, and FoxP3(+) CD4(+) T cell subsets in sarcoidosis remains unclear. Bronchoalveolar lavage fluid ce...

journal_title：Mediators of inflammation

authors： Tøndell A,Moen T,Børset M,Salvesen Ø,Rø AD,Sue-Chu M

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:The role of prolactin (PRL) on tissue injury and repair mechanisms in multiple sclerosis (MS) remains unclear. The aim of this work was to investigate the relationship between PRL plasma levels and brain damage as measured by magnetic resonance imaging (MRI). METHODS:We employed a chemiluminescence immunoas...

journal_title：Mediators of inflammation

authors： De Giglio L,Marinelli F,Prosperini L,Contessa GM,Gurreri F,Piattella MC,De Angelis F,Barletta VT,Tomassini V,Pantano P,Pozzilli C

更新日期：2015-01-01 00:00:00

abstract：:Cytokine-induced endothelial dysfunction leads to inflammation and vascular adhesion molecule production in retinal pigment epithelium (RPE) cells. Inflammation is a critical mediator in retinal degeneration (RD) diseases, including age-related macular degeneration (AMD), and RD progression may be prevented through an...

journal_title：Mediators of inflammation

authors： Huang WC,Liou CJ,Shen SC,Hu S,Hsiao CY,Wu SJ

更新日期：2020-10-16 00:00:00

abstract：:Chronic inflammation has an important role in the development and progression of most fibrotic diseases, for which no effective treatments exist. Tubulointerstitial fibrosis (TF) is characterized by irreversible deposition of fibrous tissue in chronic kidney diseases. Prolonged injurious stimuli and chronic inflammati...

journal_title：Mediators of inflammation

authors： Ramani K,Tan RJ,Zhou D,Coleman BM,Jawale CV,Liu Y,Biswas PS

更新日期：2018-10-14 00:00:00

abstract：:Leukocytosis and thrombocytopenia occur during cardiopulmonary bypass (CPB) with extracorporeal circulation (ECC). Elevated circulating concentrations of macrophage colony-stimulating factor (M-CSF) are reported during thrombocytopenia and leukopenia of different origins. We have assessed M-CSF concentrations in 40 pa...

journal_title：Mediators of inflammation

authors： Denizot Y,Fixe P,Cornu E,Nathan N

更新日期：1996-01-01 00:00:00

abstract：:Despite early recanalization of an occluded infarct artery, tissue reperfusion remains impaired in more than one-third of the acute myocardial infarction (AMI) patients owing to a process of reperfusion injury. The role of systemic inflammation in triggering this phenomenon is unknown. Proinflammatory factors (hs-CRP,...

journal_title：Mediators of inflammation

authors： Blancke F,Claeys MJ,Jorens P,Vermeiren G,Bosmans J,Wuyts FL,Vrints CJ

更新日期：2005-12-14 00:00:00

abstract：:Crohn's disease (CD) is a multifactorial chronic inflammatory bowel disease of unknown cause. The aim of the present study was to explore if mRNA over-expression of SSTR5 and CCR7 found in CD patients could be correlated to respective protein expression. When compared to healthy donors, SSTR5 was over-expressed 417 +/...

journal_title：Mediators of inflammation

authors： Taquet N,Dumont S,Vonesch JL,Hentsch D,Reimund JM,Muller CD

更新日期：2009-01-01 00:00:00

abstract：:This study examined the role of lymphotoxin (LT)-alpha in host defense against airborne infection with Francisella tularensis, a gram-negative facultative intracellular bacterium and the causative agent of tularemia. Following a low-dose aerosol infection with the highly virulent type A strain of F. tularensis, mice d...

journal_title：Mediators of inflammation

authors： Zhang D,Kuolee R,Harris G,Zhang Q,Conlan JW,Chen W

更新日期：2008-01-01 00:00:00

abstract：:The clinical outcome of autologous adipose stem cell (ASC) treatment of patients with multiple sclerosis (MS) was investigated following one year of observation. Methods. The clinical and MRI outcomes of 16 ASC-treated patients with RRMS and SPMS are reported after a one-year follow-up period. Results. At 18 months of...

journal_title：Mediators of inflammation

authors： Stepien A,Dabrowska NL,Maciagowska M,Macoch RP,Zolocinska A,Mazur S,Siennicka K,Frankowska E,Kidzinski R,Chalimoniuk M,Pojda Z

更新日期：2016-01-01 00:00:00

abstract：:Maresin1 (MaR1), a new anti-inflammatory and proresolving lipid mediator, has been proven to exert organ-protective effects in septic animal models. However, the potential mechanisms are still not fully elucidated. In this study, we sought to explore the impact of MaR1 on metabolic dysfunction in cecal ligation and pu...

journal_title：Mediators of inflammation

authors： Hao Y,Zheng H,Wang RH,Li H,Yang LL,Bhandari S,Liu YJ,Han J,Smith FG,Gao HC,Jin SW

更新日期：2019-01-16 00:00:00

abstract：:The number of persons who relocate to regions of high altitude for work, pleasure, sport, or residence increases every year. It is known that the reduced supply of oxygen (O2) induced by acute or chronic increases in altitude stimulates the body to adapt to new metabolic challenges imposed by hypoxia. Sleep can suffer...

journal_title：Mediators of inflammation

authors： Lemos Vde A,dos Santos RV,Lira FS,Rodrigues B,Tufik S,de Mello MT

更新日期：2013-01-01 00:00:00

abstract：:Podocyte injury critically contributes to the pathogenesis of obesity-related glomerulopathy (ORG). Recently, lipid accumulation and inflammatory responses have been found to be involved in podocyte injury. This study is to explore their role and relationship in podocyte injury of ORG. In animal experiments, the ORG m...

journal_title：Mediators of inflammation

authors： Zhao J,Rui HL,Yang M,Sun LJ,Dong HR,Cheng H

更新日期：2019-04-11 00:00:00

abstract：:The present study was carried out to investigate the effects and mechanisms of polydatin (PD) in septic mice. The model of cecal ligation and puncture (CLP-)induced sepsis was employed. Pretreatment of mice with PD (15, 45, and 100 mg/kg) dose-dependently reduced sepsis-induced mortality and lung injury, as indicated ...

journal_title：Mediators of inflammation

authors： Li XH,Gong X,Zhang L,Jiang R,Li HZ,Wu MJ,Wan JY

更新日期：2013-01-01 00:00:00