Dietary n-3 Fatty Acids Inhibit Fever Induced by Inflammation in the Rat.

Abstract:

:Modification of endogenous eicosanoid synthesis by dietary n-3 fatty acid supplementation reduces febrile responses, but the mechanisms underlying these effects in vivo have not been determined. In the present study, local inflammation was induced by intramuscular injection ofturpentine in rats fed control or n-3 supplemented diets for 8-9 weeks. In animals fed the control diet, turpentine induced fever, hypermetabolism, marked local inflammation (oedema), increased plasma IL-6 concentrations and raised cerebrospinal fluid (CSF) concentrations of PGE2. N-3 fatty acid supplementation significantly inhibited the rise in CSF PGE2, fever and hypermetaboHsm induced by turpentine. Local inflammation and increased plasma IL-6 concentrations were not affected by n-3 supplementation. These findings suggest that modification of dietary fat intake inhibits fever via reduced release of prostaglandins, probably within the brain, but does not affect the local or afferent signals involved in fever generation.

journal_name

Mediators Inflamm

authors

Cooper AL,Turnbull AV,Hopkins SJ,Rothwell NJ

doi

10.1155/S0962935194000499

subject

Has Abstract

pub_date

1994-01-01 00:00:00

pages

353-7

issue

5

eissn

0962-9351

issn

1466-1861

journal_volume

3

pub_type

杂志文章
  • Evidence that behavioral depression does not influence airway cell influx in allergic rats.

    abstract::This study was designated to evaluate the influence of behavioral depression on the airway leukocyte recruitment in allergic animals. To achieve this, total and differential cell counts in bronchoalveolar (BAL) fluid of ovalbumin (OVA)-sensitized and depressed rats was evaluated. Inescapable electric footshock, applie...

    journal_title:Mediators of inflammation

    pub_type: 杂志文章

    doi:10.1080/09629350124118

    authors: Varriano MA,Varriano AA,Datti F,Datti M,Antunes E,Teixeira NA

    更新日期:2001-08-01 00:00:00

  • Enhanced levels of chemokines and their receptors in the colon of microscopic colitis patients indicate mixed immune cell recruitment.

    abstract::Microscopic colitis (MC), comprising collagenous colitis (CC) and lymphocytic colitis (LC), is a common cause of chronic diarrhea. Various immune cell infiltrations in the epithelium and lamina propria are seen in MC immunopathology. We compared gene and protein expressions of different immune cell attracting chemokin...

    journal_title:Mediators of inflammation

    pub_type: 杂志文章

    doi:10.1155/2015/132458

    authors: Günaltay S,Kumawat AK,Nyhlin N,Bohr J,Tysk C,Hultgren O,Hultgren Hörnquist E

    更新日期:2015-01-01 00:00:00

  • Exosomes and Exosomal miRNA in Respiratory Diseases.

    abstract::Exosomes are nanosized vesicles released from every cell in the body including those in the respiratory tract and lungs. They are found in most body fluids and contain a number of different biomolecules including proteins, lipids, and both mRNA and noncoding RNAs. Since they can release their contents, particularly mi...

    journal_title:Mediators of inflammation

    pub_type: 杂志文章,评审

    doi:10.1155/2016/5628404

    authors: Alipoor SD,Mortaz E,Garssen J,Movassaghi M,Mirsaeidi M,Adcock IM

    更新日期:2016-01-01 00:00:00

  • Progranulin Is Associated with Disease Activity in Patients with Rheumatoid Arthritis.

    abstract:OBJECTIVE:Progranulin (PGRN) is implicated in the pathogenesis of rheumatoid arthritis (RA). The aim of this study was to assess the relationship between PGRN and disease activity in RA. METHODS:PGRN levels were evaluated in patients with RA (n = 47) and OA (n = 42) and healthy controls (n = 41). Immunohistochemical a...

    journal_title:Mediators of inflammation

    pub_type: 杂志文章

    doi:10.1155/2015/740357

    authors: Cerezo LA,Kuklová M,Hulejová H,Vernerová Z,Kaspříková N,Veigl D,Pavelka K,Vencovský J,Šenolt L

    更新日期:2015-01-01 00:00:00

  • Interleukin 35 Polymorphisms Are Associated with Decreased Risk of Premature Coronary Artery Disease, Metabolic Parameters, and IL-35 Levels: The Genetics of Atherosclerotic Disease (GEA) Study.

    abstract::Interleukin 35 (IL-35) is a heterodimeric cytokine involved in the development of atherosclerosis. The aim of the present study was to establish if the polymorphisms of IL-12A and EBI3 genes that encode the IL-35 subunits are associated with the development of premature coronary artery disease (CAD) in Mexican individ...

    journal_title:Mediators of inflammation

    pub_type: 杂志文章

    doi:10.1155/2017/6012795

    authors: Posadas-Sánchez R,Pérez-Hernández N,Angeles-Martínez J,López-Bautista F,Villarreal-Molina T,Rodríguez-Pérez JM,Fragoso JM,Posadas-Romero C,Vargas-Alarcón G

    更新日期:2017-01-01 00:00:00

  • Urinary eicosanoid metabolites in HIV-infected women with central obesity switching to raltegravir: an analysis from the women, integrase, and fat accumulation trial.

    abstract::Chronic inflammation is a hallmark of HIV infection. Eicosanoids reflect inflammation, oxidant stress, and vascular health and vary by sex and metabolic parameters. Raltegravir (RAL) is an HIV-1 integrase inhibitor that may have limited metabolic effects. We assessed urinary F2-isoprostanes (F2-IsoPs), prostaglandin E...

    journal_title:Mediators of inflammation

    pub_type: 杂志文章,随机对照试验

    doi:10.1155/2014/803095

    authors: Hulgan T,Boger MS,Liao DH,McComsey GA,Wanke CA,Mangili A,Walmsley SL,McCreath H,Milne GL,Sanchez SC,Currier JS,Lake JE

    更新日期:2014-01-01 00:00:00

  • Peripheral mononuclear cell resistin mRNA expression is increased in type 2 diabetic women.

    abstract::Resistin has been shown to cause insulin resistance and to impair glucose tolerance in rodents, but in humans its physiological role still remains elusive. The aim of this study was to examine whether resistin mRNA expression in human peripheral mononuclear cells (PBMCs) and its corresponding plasma levels are altered...

    journal_title:Mediators of inflammation

    pub_type: 杂志文章

    doi:10.1155/2008/892864

    authors: Tsiotra PC,Tsigos C,Anastasiou E,Yfanti E,Boutati E,Souvatzoglou E,Kyrou I,Raptis SA

    更新日期:2008-01-01 00:00:00

  • Opposing roles of leptin and ghrelin in the equine corpus luteum regulation: an in vitro study.

    abstract::Metabolic hormones have been associated with reproductive function modulation. Thus, the aim of this study was: (i) to characterize the immunolocalization, mRNA and protein levels of leptin (LEP), Ghrelin (GHR) and respective receptors LEPR and Ghr-R1A, throughout luteal phase; and (ii) to evaluate the role of LEP and...

    journal_title:Mediators of inflammation

    pub_type: 杂志文章

    doi:10.1155/2014/682193

    authors: Galvão A,Tramontano A,Rebordão MR,Amaral A,Bravo PP,Szóstek A,Skarzynski D,Mollo A,Ferreira-Dias G

    更新日期:2014-01-01 00:00:00

  • Increased responsiveness of human coronary artery endothelial cells in inflammation and coagulation.

    abstract::The effects of anti-inflammatory plant extracts, such as black tea extract (BTE) and resveratrol (RSV) could modulate cell activation leading to atherosclerosis, however there is little comparative information about how different endothelial cell types are affected by these compounds. In order to compare human endothe...

    journal_title:Mediators of inflammation

    pub_type: 杂志文章

    doi:10.1155/2009/146872

    authors: Lakota K,Mrak-Poljsak K,Rozman B,Sodin-Semrl S

    更新日期:2009-01-01 00:00:00

  • Hemorrhagic Shock Sensitized the Diaphragm to Ventilator-Induced Dysfunction through the Activation of IL-6/JAK/STAT Signaling-Mediated Autophagy in Rats.

    abstract::Mechanical ventilation (MV) is a major life support technique for the management of trauma-associated hemorrhagic shock (HS). Ventilator-induced diaphragm dysfunction (VIDD), one of the most common complications of MV, has been well demonstrated in animal and human studies. However, few data are available concerning t...

    journal_title:Mediators of inflammation

    pub_type: 杂志文章

    doi:10.1155/2019/3738409

    authors: Zhang LJ,Ni SZ,Zhou XL,Zhao Y

    更新日期:2019-11-14 00:00:00

  • Elevated adiponectin serum levels in women with systemic autoimmune diseases.

    abstract::Adipose tissue produces a wide range of proteins that may influence the immune system. In this study, we assessed the serum levels of leptin, adiponectin, and ghrelin, in association with the measurements of body composition, in 15 female patients with various autoimmune diseases (systemic lupus erythematosus, primary...

    journal_title:Mediators of inflammation

    pub_type: 杂志文章

    doi:10.1155/2010/938408

    authors: Toussirot E,Gaugler B,Bouhaddi M,Nguyen NU,Saas P,Dumoulin G

    更新日期:2010-01-01 00:00:00

  • Cynanchum wilfordii Polysaccharides Suppress Dextran Sulfate Sodium-Induced Acute Colitis in Mice and the Production of Inflammatory Mediators from Macrophages.

    abstract::We recently reported the immune-enhancing effects of a high-molecular-weight fraction (HMF) of CW in macrophages and immunosuppressed mice, and this effect was attributed to a crude polysaccharide. As polysaccharides may also have anti-inflammatory functions, we investigated the anti-inflammatory effects and related m...

    journal_title:Mediators of inflammation

    pub_type: 杂志文章

    doi:10.1155/2017/3859856

    authors: Cho CW,Ahn S,Lim TG,Hong HD,Rhee YK,Yang DC,Jang M

    更新日期:2017-01-01 00:00:00

  • LPS-induced serum TNF production and lethality in mice: effect of L-carnitine and some acyl-derivatives.

    abstract::The effect of L-carnitine and some of its acyl derivatives on serum TNF production and lethality in a murine experimental endotoxin shock model was investigated. In some instances, serum IL-6 production was also evaluated. In this experimental model, C57BL/6 mice received 30 mg/kg LPS (E. cell 055:B5) injected intrape...

    journal_title:Mediators of inflammation

    pub_type: 杂志文章

    doi:10.1155/S0962935193000754

    authors: Ruggiero V,D'Urso CM,Albertoni C,Campo S,Foresta P,Martelli EA

    更新日期:1993-01-01 00:00:00

  • Differential modulation of annexin I binding sites on monocytes and neutrophils.

    abstract::Specific binding sites for the anti-inflammatory protein annexin I have been detected on the surface of human monocytes and polymorphonuclear leukocytes (PMN). These binding sites are proteinaceous in nature and are sensitive to cleavage by the proteolytic enzymes trypsin, collagenase, elastase and cathepsin G. When m...

    journal_title:Mediators of inflammation

    pub_type: 杂志文章

    doi:10.1080/09629359990720

    authors: Euzger HS,Flower RJ,Goulding NJ,Perretti M

    更新日期:1999-01-01 00:00:00

  • The evolution of inflammatory mediators.

    abstract::Invertebrates do not display the level of sophistication in immune reactivity characteristic of mammals and other 'higher' vertebrates. Their great number and diversity of forms, however, reflect their evolutionary success and hence they must have effective mechanisms of defence to deal with parasites and pathogens an...

    journal_title:Mediators of inflammation

    pub_type: 杂志文章

    doi:10.1155/S0962935196000014

    authors: Rowley AF

    更新日期:1996-01-01 00:00:00

  • Macrophage trafficking as key mediator of adenine-induced kidney injury.

    abstract::Macrophages play a special role in the onset of several diseases, including acute and chronic kidney injuries. In this sense, tubule interstitial nephritis (TIN) represents an underestimated insult, which can be triggered by different stimuli and, in the absence of a proper regulation, can lead to fibrosis deposition....

    journal_title:Mediators of inflammation

    pub_type: 杂志文章

    doi:10.1155/2014/291024

    authors: Correa-Costa M,Braga TT,Felizardo RJ,Andrade-Oliveira V,Perez KR,Cuccovia IM,Hiyane MI,da Silva JS,Câmara NO

    更新日期:2014-01-01 00:00:00

  • Mechanisms of chronic state of inflammation as mediators that link obese adipose tissue and metabolic syndrome.

    abstract::The metabolic syndrome is a cluster of cardiometabolic alterations that include the presence of arterial hypertension, insulin resistance, dyslipidemia, and abdominal obesity. Obesity is associated with a chronic inflammatory response, characterized by abnormal adipokine production, and the activation of proinflammato...

    journal_title:Mediators of inflammation

    pub_type: 杂志文章,评审

    doi:10.1155/2013/136584

    authors: Fuentes E,Fuentes F,Vilahur G,Badimon L,Palomo I

    更新日期:2013-01-01 00:00:00

  • Multiplex bead array assay for detection of 25 soluble cytokines in blister fluid of patients with complex regional pain syndrome type 1.

    abstract::Inflammatory processes are known to be involved at least in the early phase of complex regional pain syndrome type 1 (CRPS1). Blister fluid obtained from the involved extremities displayed increased amounts of proinflammatory cytokines IL-6 and TNFalpha compared with the noninvolved extremities. The aim of this paper ...

    journal_title:Mediators of inflammation

    pub_type: 杂志文章

    doi:10.1155/MI/2006/28398

    authors: Heijmans-Antonissen C,Wesseldijk F,Munnikes RJ,Huygen FJ,van der Meijden P,Hop WC,Hooijkaas H,Zijlstra FJ

    更新日期:2006-01-01 00:00:00

  • Scorpion venom and the inflammatory response.

    abstract::Scorpion venoms consist of a complex of several toxins that exhibit a wide range of biological properties and actions, as well as chemical compositions, toxicity, and pharmacokinetic and pharmacodynamic characteristics. These venoms are associated with high morbility and mortality, especially among children. Victims o...

    journal_title:Mediators of inflammation

    pub_type: 杂志文章,评审

    doi:10.1155/2010/903295

    authors: Petricevich VL

    更新日期:2010-01-01 00:00:00

  • Platelet counts and platelet activation markers in obese subjects.

    abstract:OBJECTIVE:In this work we studied the correlation between platelet count, platelet activation, and systemic inflammation in overweight, obese, and morbidly obese individuals. METHODS AND SUBJECTS:A total of 6319 individuals participated in the study. Complete blood counts, high sensitivity C-reactive protein (hs-CRP) ...

    journal_title:Mediators of inflammation

    pub_type: 杂志文章

    doi:10.1155/2008/834153

    authors: Samocha-Bonet D,Justo D,Rogowski O,Saar N,Abu-Abeid S,Shenkerman G,Shapira I,Berliner S,Tomer A

    更新日期:2008-01-01 00:00:00

  • Hydrogen-rich saline inhibits NLRP3 inflammasome activation and attenuates experimental acute pancreatitis in mice.

    abstract::Increasing evidence has demonstrated that reactive oxygen species (ROS) induces oxidative stress and plays a crucial role in the pathogenesis of acute pancreatitis (AP). Hydrogen-rich saline (HRS), a well-known ROS scavenger, has been shown to possess therapeutic benefit on AP in many animal experiments. Recent findin...

    journal_title:Mediators of inflammation

    pub_type: 杂志文章

    doi:10.1155/2014/930894

    authors: Ren JD,Ma J,Hou J,Xiao WJ,Jin WH,Wu J,Fan KH

    更新日期:2014-01-01 00:00:00

  • Implication of low HDL-c levels in patients with average LDL-c levels: a focus on oxidized LDL, large HDL subpopulation, and adiponectin.

    abstract::To evaluate the impact of low levels of high density lipoprotein cholesterol (HDL-c) on patients with LDL-c average levels, focusing on oxidative, lipidic, and inflammatory profiles. Patients with cardiovascular risk factors (n = 169) and control subjects (n = 73) were divided into 2 subgroups, one of normal HDL-c and...

    journal_title:Mediators of inflammation

    pub_type: 杂志文章

    doi:10.1155/2013/612038

    authors: Mascarenhas-Melo F,Sereno J,Teixeira-Lemos E,Marado D,Palavra F,Pinto R,Rocha-Pereira P,Teixeira F,Reis F

    更新日期:2013-01-01 00:00:00

  • Effects of Er,Cr:YSGG and Diode Lasers on Clinical Parameters and Gingival Crevicular Fluid IL-1β and IL-37 Levels in Generalized Aggressive Periodontitis.

    abstract:Aim:The objective of the current study is to analyze the correlation between cytokine levels and periodontal parameters in aggressive periodontitis patients before and after periodontal treatment that was performed by using two different laser therapies. Materials and Methods:Twenty-six generalized aggressive periodon...

    journal_title:Mediators of inflammation

    pub_type: 杂志文章

    doi:10.1155/2019/2780794

    authors: Talmac AC,Calisir M,Eroglu EG,Ertugrul AS

    更新日期:2019-06-12 00:00:00

  • Jussara (Euterpe edulis Mart.) supplementation during pregnancy and lactation modulates the gene and protein expression of inflammation biomarkers induced by trans-fatty acids in the colon of offspring.

    abstract::Maternal intake of trans-fatty acids (TFAs) in the perinatal period triggers a proinflammatory state in offspring. Anthocyanins contained in fruit are promising modulators of inflammation. This study investigated the effect of Jussara supplementation in the maternal diet on the proinflammatory state of the colon in of...

    journal_title:Mediators of inflammation

    pub_type: 杂志文章

    doi:10.1155/2014/987927

    authors: Almeida Morais C,Oyama LM,de Oliveira JL,Carvalho Garcia M,de Rosso VV,Sousa Mendes Amigo L,do Nascimento CM,Pisani LP

    更新日期:2014-01-01 00:00:00

  • Phosphoinositide hydrolysis mediated by H1 receptors in autoimmune myocarditis mice.

    abstract::Stimulation of phosphoinositide hydrolysis in myocardium from autoimmune myocarditis mice by ThEA and histamine was assayed. Myocardium from autoimmune heart, but not the normal forms, specifically increased phosphoinositide turnover in the presence of histaminergic agonists. This increment was blocked by a specific H...

    journal_title:Mediators of inflammation

    pub_type: 杂志文章

    doi:10.1155/S0962935193000444

    authors: Goren N,Leiros CP,Sterin-Borda L,Borda ES

    更新日期:1993-01-01 00:00:00

  • Chemokines and chemokine receptors in multiple sclerosis.

    abstract::Multiple sclerosis is an autoimmune disease with classical traits of demyelination, axonal damage, and neurodegeneration. The migration of autoimmune T cells and macrophages from blood to central nervous system as well as the destruction of blood brain barrier are thought to be the major processes in the development o...

    journal_title:Mediators of inflammation

    pub_type: 杂志文章,评审

    doi:10.1155/2014/659206

    authors: Cheng W,Chen G

    更新日期:2014-01-01 00:00:00

  • Caffeic Acid Prevented LPS-Induced Injury of Primary Bovine Mammary Epithelial Cells through Inhibiting NF-κB and MAPK Activation.

    abstract::In our previous study, lipopolysaccharide (LPS) significantly reduced the cell viability of primary bovine mammary epithelial cells (bMEC) leading to cell apoptosis, which were prevented by caffeic acid (CA) through inhibiting NF-κB activation and reducing proinflammatory cytokine expression. While the underlying mech...

    journal_title:Mediators of inflammation

    pub_type: 杂志文章

    doi:10.1155/2019/1897820

    authors: Liu M,Fang G,Yin S,Zhao X,Zhang C,Li J,Liu Z

    更新日期:2019-04-30 00:00:00

  • Comparison of Two Ginkgo biloba L. Extracts on Oxidative Stress and Inflammation Markers in Human Endothelial Cells.

    abstract::Atherosclerosis is characterized by interaction between immune and vascular endothelial cells which is mediated by adhesion molecules occurring on the surface of the vascular endothelium leading to massive release of proinflammatory mediators. Ginkgo biloba L. (Ginkgoaceae) standardized extracts showing beneficial eff...

    journal_title:Mediators of inflammation

    pub_type: 杂志文章

    doi:10.1155/2019/6173893

    authors: Piazza S,Pacchetti B,Fumagalli M,Bonacina F,Dell'Agli M,Sangiovanni E

    更新日期:2019-06-25 00:00:00

  • The Role of Immunosenescence in Neurodegenerative Diseases.

    abstract::Aging is characterized by the progressive decline of physiological function and tissue homeostasis leading to increased vulnerability, degeneration, and death. Aging-related changes of the innate and adaptive immune system include decline in the preservation and enhancement of many immune functions, such as changes in...

    journal_title:Mediators of inflammation

    pub_type: 杂志文章,评审

    doi:10.1155/2018/6039171

    authors: Costantini E,D'Angelo C,Reale M

    更新日期:2018-03-08 00:00:00

  • Mean Platelet Volume (MPV): New Perspectives for an Old Marker in the Course and Prognosis of Inflammatory Conditions.

    abstract::Platelet size has been demonstrated to reflect platelet activity and seems to be a useful predictive and prognostic biomarker of cardiovascular events. It is associated with a variety of prothrombotic and proinflammatory diseases. The aim is a review of literature reports concerning changes in the mean platelet volume...

    journal_title:Mediators of inflammation

    pub_type: 杂志文章,评审

    doi:10.1155/2019/9213074

    authors: Korniluk A,Koper-Lenkiewicz OM,Kamińska J,Kemona H,Dymicka-Piekarska V

    更新日期:2019-04-17 00:00:00