Abstract:
:Chronic kidney disease (CKD) patients, characterized by traditional and nontraditional risk factors, are prone to develop atheromatosis and thus cardiovascular events and mortality. The angiogenesis of the adventitial vasa vasorum (aVV) surrounding the carotid has been described as the atheromatosis initiator. Therefore, the aim of the study was to (1) evaluate if the carotid aVV in CKD patients increases in comparison to its physiological value of healthy patients; (2) explore which traditional or nontraditional risk factor including inflammation, bone and mineral metabolism, and anemia could be related to the aVV angiogenesis. CKD patients without previous cardiovascular events (44, stages 3-4; 37, stage 5D) and 65 healthy subjects were compared. The carotid aVV and the intima-media thickness (cIMT) were evaluated by ultrasound. CKD patients at stages 3-4 showed higher aVV of the right carotid artery even after adjusting for age. Importantly, a multiple linear regression model showed hemoglobin levels > 12.5 g/dL as the factor for an estimated higher aVV of the right carotid artery. In conclusion, the association of hemoglobin with higher aVV could suggest the role of high hemoglobin in the higher incidence of adverse cardiovascular outcomes in CKD patients.
journal_name
Mediators Inflammjournal_title
Mediators of inflammationauthors
Arcidiacono MV,Martinez-Alonso M,Belart M,Vilar A,Martín M,Craver L,Betriu À,Mauricio D,Valdivielso JM,Fernández E,Borràs Mdoi
10.1155/2017/3795142subject
Has Abstractpub_date
2017-01-01 00:00:00pages
3795142eissn
0962-9351issn
1466-1861journal_volume
2017pub_type
杂志文章abstract::Ventilator-induced lung injury (VILI) is one of the most common complications of mechanical ventilation (MV), which strongly impacts the outcome of ventilated patients. Current evidences indicated that inflammation is a major contributor to the pathogenesis of VILI. Our results showed that MV induced excessive proinfl...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2020/7650978
更新日期:2020-07-23 00:00:00
abstract::Human Vγ9Vδ2 T cells recognise pyrophosphate-based antigens (phosphoantigens) and have multiple functions in innate and adaptive immunity, including a unique ability to activate other cells of the immune system. We used flow cytometry and ELISA to define the early cytokine profiles of Vγ9Vδ2 T cells stimulated in vitr...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2010/704941
更新日期:2010-01-01 00:00:00
abstract::Inflammatory bowel disease (IBD) describes different illnesses characterized by chronic inflammation of the gastrointestinal tract. Although the pathogenic mechanisms leading to IBD are poorly understood, immune system disturbances likely underlie its development. Sphingolipids (SLs) have been identified as important ...
journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
doi:10.1155/2016/9890141
更新日期:2016-01-01 00:00:00
abstract::There is great need for a therapeutic that would limit tuberculosis related pathology and thus curtail spread of disease between individuals by establishing a "firebreak" to slow transmission. A promising avenue to increase current therapeutic efficacy may be through incorporation of adjunct components that slow or st...
journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
doi:10.1155/2015/409596
更新日期:2015-01-01 00:00:00
abstract::Background and Objectives. Malaria infection, caused by Plasmodium falciparum, is the most lethal and frequently culminates in severe clinical complications. Interleukin-22 (IL-22) has been implicated in several diseases including malaria. The objective of this study was to investigate the role of IL-22 gene polymorph...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2020/5193723
更新日期:2020-02-19 00:00:00
abstract:BACKGROUND:The cyclooxygenase- (COX-) 2/microsomal PGE-synthase- (mPGES-) 1/PGE-receptor- (EP-) 4 axis could play a key role in the physiopathology of abdominal aortic aneurysm (AAA) in humans. In this study, we investigated the influence of cardiovascular risk factors on the expression of the PGE2 pathway in human AAA...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2014/316150
更新日期:2014-01-01 00:00:00
abstract::Inflammatory mediators, including cytokines, histamine, bradykinin, prostaglandins, and leukotrienes, impact the immune system, usually as proinflammatory factors. Other mediators act as regulatory components to establish homeostasis after injury or prevent the inflammatory process. Histamine, a biogenic vasoactive am...
journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
doi:10.1155/2018/9524075
更新日期:2018-08-27 00:00:00
abstract::The effect of lipoprotein apheresis (Direct Adsorption of Lipids, DALI) (LA) on plasma levels of pentraxin 3 (PTX3), an inflammatory marker that reflects coronary plaque vulnerability, and expression of PTX3 mRNA was evaluated in patients with hyperLp(a)lipoproteinemia and angiographically defined atherosclerosis/coro...
journal_title:Mediators of inflammation
pub_type: 临床试验,杂志文章
doi:10.1155/2016/4739512
更新日期:2016-01-01 00:00:00
abstract::The aim of our work was to find if MCP-1 -2518 (A/G) single nucleotide polymorphism (SNP) influences somehow the serum concentrations of high-sensitive CRP (hsCRP) both in patients suffering from ischemic heart disease (IHD), myocardial infarction (MI), angina pectoris (AP), and hypertension (HT) and in control group ...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2009/390951
更新日期:2009-01-01 00:00:00
abstract::We report here that the leptomeningeal cells transduce inflammatory signals from peripheral macrophages to brain-resident microglia in response to Porphyromonas gingivalis (P.g.) LPS. The expression of Toll-like receptor 2 (TLR2), TLR4, TNF-α, and inducible NO synthase was mainly detected in the gingival macrophages o...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2013/407562
更新日期:2013-01-01 00:00:00
abstract::Th17 cells provide protective immunity to infections by fungi and extracellular bacteria as well as cancer but are also involved in chronic inflammation. The cells were first identified by their ability to produce interleukin 17A (IL-17A) and, subsequently, associated with chronic inflammation and autoimmunity. Th17 c...
journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
doi:10.1155/2015/205156
更新日期:2015-01-01 00:00:00
abstract::Mitotic catastrophe, as defined in 2012 by the International Nomenclature Committee on Cell Death, is a bona fide intrinsic oncosuppressive mechanism that senses mitotic failure and responds by driving a cell to an irreversible antiproliferative fate of death or senescence. Thus, failed mitotic catastrophe can promote...
journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
doi:10.1155/2015/146282
更新日期:2015-01-01 00:00:00
abstract::Alcohol-related disorders are one of the challenging current health problems with medical, social, and economic consequences. Endotoxemia, oxidative stress, and release of a variety of inflammatory molecules are established mediators in alcoholic liver injury (ALD). Probiotics like L. plantarum though were reported to...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2014/715130
更新日期:2014-01-01 00:00:00
abstract::Syndecan-1 (CD138) is a transmembrane heparin sulfate proteoglycan expressed on distinct stages of differentiation of B-lymphoid cells. Its prognostic value in B-cell chronic lymphocytic leukemia (B-CLL) has not been evaluated so far. The serum concentration of sCD138 and some angiogenesis-involved cytokines: vascular...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/MI/2006/42394
更新日期:2006-01-01 00:00:00
abstract::Periodontitis is an inflammatory disease characterized by destruction of the tooth-supporting tissues. Obese individuals have an increased risk of periodontitis, and elevated circulating levels of nicotinamide phosphoribosyltransferase (NAMPT) may be a pathomechanistic link between both diseases. Recently, increased l...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2013/202530
更新日期:2013-01-01 00:00:00
abstract::Fasting insulin, adiponectin, high-sensitivity C-reactive protein (hs-CRP), and interleukin-1 receptor antagonist (IL-1Ra) were determined in 278 men and 273 women with blood pressure > or = 130 and/or > or = 85 mmHg and/or with antihypertensive medication. Metabolic syndrome (MetS) with the National Cholesterol Educa...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2009/959281
更新日期:2009-01-01 00:00:00
abstract::The stalks of Polygonum hydropiper L. (PHL) have been traditionally used in clinical practice for thousands of years in China to treat various inflammatory diseases. However, little research has been conducted to investigate the anti-inflammatory effects of PHL on TNBS-induced intestinal inflammation in rats. The aim ...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2018/6029135
更新日期:2018-05-07 00:00:00
abstract::Plasma GDF15 concentrations were measured in 612 Taiwanese individuals without overt systemic disease. Clinical parameters, GDF15 genetic variants, and 22 biomarker levels were analyzed. We further enrolled 86 patients with PAD and 481 patients with CAD, who received endovascular intervention and coronary angiography,...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2017/9398401
更新日期:2017-01-01 00:00:00
abstract::The destruction of joints caused by rheumatoid arthritis and osteoarthritis is characterized by an imbalance of enzyme catalysed cartilage breakdown and regeneration. A complex cytokine network perpetuates joint conditions by direct regulation of metalloproteases, by indirect recruitment of cells that secrete degradat...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/S0962935194000359
更新日期:1994-01-01 00:00:00
abstract::The mechanisms underlying the recurrence of atrial fibrillation (AF) after radiofrequency catheter ablation (RFCA) are not well concerned. The study sought to explore the association between growth differentiation factor-15 (GDF-15) and the incidence of recurrent events among AF patients after the ablation procedure. ...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2020/8360936
更新日期:2020-08-21 00:00:00
abstract:Aim:The objective of the current study is to analyze the correlation between cytokine levels and periodontal parameters in aggressive periodontitis patients before and after periodontal treatment that was performed by using two different laser therapies. Materials and Methods:Twenty-six generalized aggressive periodon...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2019/2780794
更新日期:2019-06-12 00:00:00
abstract::Inflammatory response in Chagas disease is related to parasite and host factors. However, immune system regulation has not been fully elucidated. Thus, this study is aimed at evaluating IL-4 influence on acute phase of Trypanosoma cruzi experimental infection through dosage of cytokine levels in cardiac homogenate of ...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2018/3421897
更新日期:2018-11-28 00:00:00
abstract::Endothelial dysfunction is regarded as an important factor in the pathogenesis of vascular disease in obesity-related type 2 diabetes. The imbalance in repair and injury (hyperglycemia, hypertension, dyslipidemia) results in microvascular changes, including apoptosis of microvascular cells, ultimately leading to diabe...
journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
doi:10.1155/2010/792393
更新日期:2010-01-01 00:00:00
abstract::Platelet size has been demonstrated to reflect platelet activity and seems to be a useful predictive and prognostic biomarker of cardiovascular events. It is associated with a variety of prothrombotic and proinflammatory diseases. The aim is a review of literature reports concerning changes in the mean platelet volume...
journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
doi:10.1155/2019/9213074
更新日期:2019-04-17 00:00:00
abstract::Maternal intake of trans-fatty acids (TFAs) in the perinatal period triggers a proinflammatory state in offspring. Anthocyanins contained in fruit are promising modulators of inflammation. This study investigated the effect of Jussara supplementation in the maternal diet on the proinflammatory state of the colon in of...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2014/987927
更新日期:2014-01-01 00:00:00
abstract::Surgery induces release of neuroendocrine hormones (cortisol), cytokines (interleukin-6: IL-6, tumour necrosis factor-alpha: TNF-alpha), acute phase proteins (C-reactive protein: CRP, leptin). We studied the effects of general and spinal anaesthesia on stress response to haemorrhoidectomy. Patients were assigned to ge...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/MI/2006/97257
更新日期:2006-01-01 00:00:00
abstract::Inflammatory mediators play a critical role in ulcerative colitis immune and inflammatory processes. The aim of the study was to investigate the effects of Ginkgo biloba extract on inflammatory mediators (SOD, MDA, TNF-alpha, NF-kappaBp65, IL-6) in TNBS-induced colitis in rats. Colitis in rats was induced by colonic a...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/MI/2006/92642
更新日期:2006-01-01 00:00:00
abstract::To investigate the role of AEG-1 in glycolysis and tumorigenesis, we construct myc-AEG-1 expression vector and demonstrate a novel mechanism that AEG-1 may increase the activity of AMPK by Thr172 phosphorylation. The higher expression levels of AEG-1 in colorectal carcinoma cells were found but showed significant diff...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2014/287381
更新日期:2014-01-01 00:00:00
abstract::Background. Neutrophilic bronchial inflammation is a main feature of bronchiectasis, but not much is known about its relationship with other disease features. Aim. To compare airway inflammatory markers with clinical and functional findings in subjects with stable noncystic fibrosis bronchiectasis (NCFB). Methods. 152...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2015/642503
更新日期:2015-01-01 00:00:00
abstract::B-1a cells are distinguishable from conventional B cells, which are designated B-2 cells, on the basis of their developmental origin, surface marker expression, and functions. In addition to the unique expression of the CD5 antigen, B-1a cells are characterized by the expression level of CD23. Although B-1a cells are ...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2018/9289417
更新日期:2018-12-23 00:00:00