Abstract:
:Inflammatory bowel disease (IBD) describes different illnesses characterized by chronic inflammation of the gastrointestinal tract. Although the pathogenic mechanisms leading to IBD are poorly understood, immune system disturbances likely underlie its development. Sphingolipids (SLs) have been identified as important players and promising therapeutic targets to control inflammation in IBD. Interestingly, it seems that microorganisms of the normal gut microbiota and probiotics are involved in sphingolipid function. However, there is a great need to investigate the role of SLs as intermediates in the crosstalk between intestinal immunity and microorganisms. This review focuses on recent investigations that describe some mechanisms involved in the regulation of cytokine profiles by SLs. We also describe the importance of gut microbiota in providing signaling molecules that favor the communication between resident bacteria and intestinal cells. This, in turn, modulates the immune response in the bowel and likely in other peripheral organs. The potential of SLs and gut microbiota as targets or therapeutic agents for IBD is also discussed.
journal_name
Mediators Inflammjournal_title
Mediators of inflammationauthors
Bryan PF,Karla C,Edgar Alejandro MT,Sara Elva EP,Gemma F,Luz Cdoi
10.1155/2016/9890141subject
Has Abstractpub_date
2016-01-01 00:00:00pages
9890141eissn
0962-9351issn
1466-1861journal_volume
2016pub_type
杂志文章,评审abstract::The purpose of this paper is to evaluate the chronic effect of sitagliptin on metabolic profile, inflammation, and redox status in the Zucker Diabetic Fatty (ZDF) rat, an animal model of obese type 2 diabetes. Diabetic and obese ZDF (fa/fa) rats and their controls (ZDF +/+) were treated during 6 weeks with vehicle (co...
journal_title:Mediators of inflammation
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doi:10.1155/2010/592760
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journal_title:Mediators of inflammation
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journal_title:Mediators of inflammation
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journal_title:Mediators of inflammation
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journal_title:Mediators of inflammation
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doi:10.1155/2016/6769032
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journal_title:Mediators of inflammation
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journal_title:Mediators of inflammation
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journal_title:Mediators of inflammation
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doi:10.1155/2014/754965
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journal_title:Mediators of inflammation
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doi:10.1155/2018/9289417
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journal_title:Mediators of inflammation
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journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2013/979748
更新日期:2013-01-01 00:00:00
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journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2020/3572809
更新日期:2020-07-04 00:00:00
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journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
doi:10.1155/2018/6039171
更新日期:2018-03-08 00:00:00
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journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2020/7974537
更新日期:2020-12-18 00:00:00
abstract::Maternal intake of trans-fatty acids (TFAs) in the perinatal period triggers a proinflammatory state in offspring. Anthocyanins contained in fruit are promising modulators of inflammation. This study investigated the effect of Jussara supplementation in the maternal diet on the proinflammatory state of the colon in of...
journal_title:Mediators of inflammation
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doi:10.1155/2014/987927
更新日期:2014-01-01 00:00:00
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journal_title:Mediators of inflammation
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doi:10.1155/2016/3271579
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journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/S0962935196000518
更新日期:1996-01-01 00:00:00
abstract:Objective:Renal ischemia/reperfusion injury (RI/RI) is the main cause of acute kidney injury. Total glucosides of paeony (TGP) are a traditional Chinese medicine. This study was aimed at exploring the role of TGP in RI/RI and its underlying mechanism of action. Methods:Rat RI/RI models were constructed by surgical ope...
journal_title:Mediators of inflammation
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doi:10.1155/2020/8869511
更新日期:2020-11-24 00:00:00
abstract::Chagas disease, caused by the protozoan Trypanosoma cruzi, is endemic in Latin America and affects ca. 10 million people worldwide. About 30% of Chagas disease patients develop chronic Chagas disease cardiomyopathy (CCC), a particularly lethal inflammatory cardiomyopathy that occurs decades after the initial infection...
journal_title:Mediators of inflammation
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journal_title:Mediators of inflammation
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doi:10.1155/2012/984643
更新日期:2012-01-01 00:00:00
abstract::Inflammatory mediators, including cytokines, histamine, bradykinin, prostaglandins, and leukotrienes, impact the immune system, usually as proinflammatory factors. Other mediators act as regulatory components to establish homeostasis after injury or prevent the inflammatory process. Histamine, a biogenic vasoactive am...
journal_title:Mediators of inflammation
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doi:10.1155/2018/9524075
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journal_title:Mediators of inflammation
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doi:10.1155/2013/279365
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journal_title:Mediators of inflammation
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doi:10.1155/S0962935192000590
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abstract::The variable array of pattern receptor expression in different cells of the innate immune system explains the induction of distinct patterns of arachidonic acid (AA) metabolism. Peptidoglycan and mannan were strong stimuli in neutrophils, whereas the fungal extract zymosan was the most potent stimulus in monocyte-deri...
journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
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abstract::The aim of the present study was to compare serum levels of soluble forms of interleukin-2 receptor, CD4 and CD8, released by lymphocytes during activation ofthe immune system, in patients with histologically verified chronic active hepatitis associated to hepatitis C virus infection, with those in healthy subjects. S...
journal_title:Mediators of inflammation
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doi:10.1155/S0962935194000256
更新日期:1994-01-01 00:00:00
abstract::Tuberculosis is characterized by the presence of activated mononuclear cells both in the peripheral circulation and in pleural fluid. Expression and up-regulation of adhesion molecules is the basis of cell-cell adhesion in granuloma formation and in leukocyte migration to the inflammatory site. Soluble isoforms of adh...
journal_title:Mediators of inflammation
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doi:10.1155/S0962935196000403
更新日期:1996-01-01 00:00:00
abstract::Acute respiratory distress syndrome (ARDS) remains a high morbidity and mortality disease entity in critically ill patients, despite decades of numerous investigations into its pathogenesis. To obtain global protein expression changes in acute lung injury (ALI) lung tissues, we employed a high-throughput proteomics me...
journal_title:Mediators of inflammation
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abstract::Scorpion venoms consist of a complex of several toxins that exhibit a wide range of biological properties and actions, as well as chemical compositions, toxicity, and pharmacokinetic and pharmacodynamic characteristics. These venoms are associated with high morbility and mortality, especially among children. Victims o...
journal_title:Mediators of inflammation
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journal_title:Mediators of inflammation
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abstract::We investigated the influence of 2-chlorodeoxyadenosine (2-CdA) in combination with tumour necrosis factor-alpha (TNFalpha) or its mutein VI, which differs from the native molecule by N-terminal amino acid composition, on the survival time of mice inoculated with leukaemia L1210 or P388. Groups of mice with leukaemia ...
journal_title:Mediators of inflammation
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更新日期:1995-01-01 00:00:00