Serum Levels of Soluble IL-2R, CD4 and CD8 in Chronic Active HCV Positive Hepatitis.

abstract：:Multiple sclerosis is an autoimmune disease with classical traits of demyelination, axonal damage, and neurodegeneration. The migration of autoimmune T cells and macrophages from blood to central nervous system as well as the destruction of blood brain barrier are thought to be the major processes in the development o...

journal_title：Mediators of inflammation

authors： Cheng W,Chen G

更新日期：2014-01-01 00:00:00

abstract：:Hydroxysafflor yellow A (HSYA) is an effective therapeutic agent for inflammatory diseases and autoimmune disorders; however, its regulatory effect on NLRP3 inflammasome activation in macrophages has not been investigated. In this study, we predicted the potential interaction between HSYA and xanthine oxidase (XO) via...

journal_title：Mediators of inflammation

authors： Xu X,Guo Y,Zhao J,Wang N,Ding J,Liu Q

更新日期：2016-01-01 00:00:00

abstract：:Background. Inflammation mediators related to radiation proctitis are partially elucidated, and neovascularization is thought to play a key role. Objectives. To investigate the expression of vascular endothelial growth factor (VEGF) and CD31 as angiogenetic markers in postradiation rectal tissue. Methods. Rectal mucos...

journal_title：Mediators of inflammation

authors： Karamanolis G,Delladetsima I,Kouloulias V,Papaxoinis K,Panayiotides I,Haldeopoulos D,Triantafyllou K,Kelekis N,Ladas SD

更新日期：2013-01-01 00:00:00

abstract：:Exosomes are nanosized vesicles released from every cell in the body including those in the respiratory tract and lungs. They are found in most body fluids and contain a number of different biomolecules including proteins, lipids, and both mRNA and noncoding RNAs. Since they can release their contents, particularly mi...

journal_title：Mediators of inflammation

authors： Alipoor SD,Mortaz E,Garssen J,Movassaghi M,Mirsaeidi M,Adcock IM

更新日期：2016-01-01 00:00:00

abstract：:Myeloproliferative neoplasms (MPNs) are a heterogeneous group of clonal diseases characterized by the excessive and chronic production of mature cells from one or several of the myeloid lineages. Recent advances in the biology of MPNs have greatly facilitated their molecular diagnosis since most patients present with ...

journal_title：Mediators of inflammation

authors： Hermouet S,Bigot-Corbel E,Gardie B

更新日期：2015-01-01 00:00:00

abstract：:Periodontitis is an inflammatory disease characterized by destruction of the tooth-supporting tissues. Obese individuals have an increased risk of periodontitis, and elevated circulating levels of nicotinamide phosphoribosyltransferase (NAMPT) may be a pathomechanistic link between both diseases. Recently, increased l...

journal_title：Mediators of inflammation

authors： Nokhbehsaim M,Keser S,Jäger A,Jepsen S,Deschner J

更新日期：2013-01-01 00:00:00

abstract：:The purpose of this study is to characterize synovial fluid- (SF-) derived exosomes of patients with gonarthrosis comparing two methods of isolation and to investigate their immune regulatory properties. Extracellular vesicles (EVs) have been isolated from inflamed SF by polymer precipitation method and quantified by ...

journal_title：Mediators of inflammation

authors： Domenis R,Zanutel R,Caponnetto F,Toffoletto B,Cifù A,Pistis C,Di Benedetto P,Causero A,Pozzi M,Bassini F,Fabris M,Niazi KR,Soon-Shiong P,Curcio F

更新日期：2017-01-01 00:00:00

abstract：:Infection by Leishmania takes place in the context of inflammation and tissue repair. Besides tissue resident macrophages, inflammatory macrophages and neutrophils are recruited to the infection site and serve both as host cells and as effectors against infection. Recent studies suggest additional important roles for ...

journal_title：Mediators of inflammation

authors： Lopes MF,Costa-da-Silva AC,DosReis GA

更新日期：2014-01-01 00:00:00

abstract：:Procalcitonin (PCT) is one of the best diagnostic and prognostic markers in clinical practice, widely used to evaluate the evolution of bacterial infections. Although it is mainly produced by thyroid, during sepsis almost all the peripheral tissues are involved in PCT production. Parenchymal cells have been suggested ...

journal_title：Mediators of inflammation

authors： Rami D,La Bianca M,Agostinis C,Zauli G,Radillo O,Bulla R

更新日期：2014-01-01 00:00:00

abstract：:Endoglin is a coreceptor of the TGF-β superfamily predominantly expressed on the vascular endothelium and selective subsets of immune cells. We previously demonstrated that Endoglin heterozygous (Eng (+/-)) mice subjected to dextran sulfate sodium (DSS) developed persistent gut inflammation and pathological angiogenes...

journal_title：Mediators of inflammation

authors： Peter MR,Jerkic M,Sotov V,Douda DN,Ardelean DS,Ghamami N,Lakschevitz F,Khan MA,Robertson SJ,Glogauer M,Philpott DJ,Palaniyar N,Letarte M

更新日期：2014-01-01 00:00:00

abstract：:Fibroblasts are important to host defence and immunity, can also as initiators of inflammation as well. As the endogenous "braking signal", Lipoxins can regulate anti-inflammation and the resolution of inflammation. We investigated the effect of lipoxinA(4) on the expression of cyclooxygenase-2 in lipopolysaccharide-s...

journal_title：Mediators of inflammation

authors： Zheng S,Wang Q,He Q,Song X,Ye D,Gao F,Jin S,Lian Q

更新日期：2011-01-01 00:00:00

abstract：:Inflammatory bowel disease (IBD) is a group of inflammatory conditions of the gastrointestinal tract of unclear aetiology of which two major forms are Crohn's disease (CD) and ulcerative colitis (UC). CD and UC are immunologically distinct, although they both result from hyperactivation of proinflammatory pathways in ...

journal_title：Mediators of inflammation

authors： Ślebioda TJ,Kmieć Z

更新日期：2014-01-01 00:00:00

abstract：:Pregnancy is a unique immunological state in which a balance of immune tolerance and suppression is needed to protect the fetus without compromising the mother. It has long been established that a bias from the T helper 1 cytokine profile towards the T helper 2 profile contributes towards successful pregnancy maintena...

journal_title：Mediators of inflammation

authors： Sykes L,MacIntyre DA,Yap XJ,Teoh TG,Bennett PR

更新日期：2012-01-01 00:00:00

abstract：:The stalks of Polygonum hydropiper L. (PHL) have been traditionally used in clinical practice for thousands of years in China to treat various inflammatory diseases. However, little research has been conducted to investigate the anti-inflammatory effects of PHL on TNBS-induced intestinal inflammation in rats. The aim ...

journal_title：Mediators of inflammation

authors： Zhang W,Pan Y,Qu S,Wang D,Cheng S,Liu X

更新日期：2018-05-07 00:00:00

abstract：:The expression of cytochrome P4501A1 (CYP1A1) enzyme is changed in various organs during the host response to inflammation or infection, leading to alterations in the metabolism of endogenous and exogenous compounds. Results of this study showed that CYP1A1 expression was significantly downregulated in the mammary tis...

journal_title：Mediators of inflammation

authors： Zhang WY,Wang H,Qi S,Wang X,Li X,Zhou K,Zhang Y,Gao MQ

更新日期：2018-02-28 00:00:00

abstract：Objective:To profile maternal plasma metabolome in spontaneous preterm birth. Method:In this retrospective case-control study, we have examined plasma of patient with preterm birth (between 22 and 36 weeks of pregnancy (n = 57)), with threatened preterm labor (between 23 and 36 weeks of pregnancy (n = 49)), and with t...

journal_title：Mediators of inflammation

authors： Lizewska B,Teul J,Kuc P,Lemancewicz A,Charkiewicz K,Goscik J,Kacerovsky M,Menon R,Miltyk W,Laudanski P

更新日期：2018-02-15 00:00:00

abstract：:Vascular complications of diabetes mellitus represent a major public health problem. Although many steps forward have been made to define the causes and to find the best possible therapies, the problem remains crucial. In recent years, more and more evidences have defined a link between microbiota and the initiation, ...

journal_title：Mediators of inflammation

authors： Biscetti F,Nardella E,Cecchini AL,Landolfi R,Flex A

更新日期：2019-05-08 00:00:00

abstract：:In the central nervous system (CNS), mastocytes and glial cells (microglia, astrocytes and oligodendrocytes) function as sensors of neuroinflammatory conditions, responding to stress triggers or becoming sensitized to subsequent proinflammatory challenges. The corticotropin-releasing hormone and glucocorticoids are cr...

journal_title：Mediators of inflammation

authors： Aguirre A,Maturana CJ,Harcha PA,Sáez JC

更新日期：2013-01-01 00:00:00

abstract：:Periodontitis (PD) and rheumatoid arthritis (RA) are immunoinflammatory diseases where leukocyte infiltration and inflammatory mediators induce alveolar bone loss, synovitis, and joint destruction, respectively. Thus, we reviewed the relationship between both diseases considering epidemiological aspects, mechanical pe...

journal_title：Mediators of inflammation

authors： Araújo VM,Melo IM,Lima V

更新日期：2015-01-01 00:00:00

abstract：:Cathepsin S is a cysteine protease and regulator of autophagy with possible involvement in periodontitis. The objective of this study was to investigate whether cathepsin S is involved in the pathogenesis of periodontal diseases. Human periodontal fibroblasts were cultured under inflammatory and infectious conditions ...

journal_title：Mediators of inflammation

authors： Memmert S,Damanaki A,Nogueira AVB,Eick S,Nokhbehsaim M,Papadopoulou AK,Till A,Rath B,Jepsen S,Götz W,Piperi C,Basdra EK,Cirelli JA,Jäger A,Deschner J

更新日期：2017-01-01 00:00:00

abstract：:Metabolic hormones have been associated with reproductive function modulation. Thus, the aim of this study was: (i) to characterize the immunolocalization, mRNA and protein levels of leptin (LEP), Ghrelin (GHR) and respective receptors LEPR and Ghr-R1A, throughout luteal phase; and (ii) to evaluate the role of LEP and...

journal_title：Mediators of inflammation

authors： Galvão A,Tramontano A,Rebordão MR,Amaral A,Bravo PP,Szóstek A,Skarzynski D,Mollo A,Ferreira-Dias G

更新日期：2014-01-01 00:00:00

abstract：:A TP II analogue, [1-Nal3] TP II, was synthesized by a conventional solution method, followed by deprotection with 1M TFMSA-thioanisole (molar ratio 1:1) in TFA in the presence of Me2Se and m-cresol as scavengers. The synthetic [1-Nal3] TP II, TP II and [Phe (4 F)3] TP II were tested for comparative effect on the impa...

journal_title：Mediators of inflammation

authors： Abiko T,Nakatsubo S

更新日期：2000-01-01 00:00:00

abstract：:Our understanding of inflammation's role in the pathogenesis of myeloproliferative neoplasm (MPN) is evolving. The impact of chronic inflammation, a characteristic feature of MPN, likely goes far beyond its role as a driver of constitutional symptoms. An inflammatory response to the neoplastic clone may be responsible...

journal_title：Mediators of inflammation

authors： Fleischman AG

更新日期：2015-01-01 00:00:00

abstract：:Acute kidney injury (AKI), a clinical syndrome, is a sudden onset of kidney failure that severely affects the kidney tubules. One potential treatment is dexmedetomidine (DEX), a highly selective α2-adrenoreceptor agonist that is used as an anesthetic adjuvant. It also has anti-inflammatory, neuroprotective, and sympat...

journal_title：Mediators of inflammation

authors： Bao N,Dai D

更新日期：2020-04-03 00:00:00

abstract：:There is some anecdotal evidence that oxygen-ozone therapy may be beneficial in some human diseases. However so far only a few biochemical and pharmacodynamic mechanisms have been elucidated. On the basis of preliminary data we postulated that controlled ozone administration would promote an oxidative preconditioning ...

journal_title：Mediators of inflammation

authors： León OS,Menéndez S,Merino N,Castillo R,Sam S,Pérez L,Cruz E,Bocci V

更新日期：1998-01-01 00:00:00

abstract：:Human periodontal ligament (hPDL) fibroblasts play a major role during periodontitis and orthodontic tooth movement, mediating periodontal inflammation, osteoclastogenesis, and collagen synthesis. The highly COX-2-selective NSAID etoricoxib has a favorable systemic side effect profile and high analgesic efficacy, part...

journal_title：Mediators of inflammation

authors： Kirschneck C,Küchler EC,Wolf M,Spanier G,Proff P,Schröder A

更新日期：2019-03-10 00:00:00

abstract：:Macrophages contribute to a continuous increase in blood pressure and kidney damage in hypertension, but their polarization status and the underlying mechanisms have not been clarified. This study revealed an important role for M2 macrophages and the YM1/Chi3l3 protein in hypertensive nephropathy in a mouse model of h...

journal_title：Mediators of inflammation

authors： Cavalcante PAM,Alenina N,Budu A,Freitas-Lima LC,Alves-Silva T,Agudelo JSH,Qadri F,Camara NOS,Bader M,Araújo RC

更新日期：2019-07-10 00:00:00

abstract：:Fasting insulin, adiponectin, high-sensitivity C-reactive protein (hs-CRP), and interleukin-1 receptor antagonist (IL-1Ra) were determined in 278 men and 273 women with blood pressure > or = 130 and/or > or = 85 mmHg and/or with antihypertensive medication. Metabolic syndrome (MetS) with the National Cholesterol Educa...

journal_title：Mediators of inflammation

authors： Ahonen T,Saltevo J,Laakso M,Kautiainen H,Kumpusalo E,Vanhala M

更新日期：2009-01-01 00:00:00

abstract：Objective:Neuropeptide Y (NPY), an orexigenic peptide known to cause hyperphagia, has been involved in the occurrence and development of obesity. However, differences in the distribution of serum NPY levels in obese phenotypes (including metabolically unhealthy obesity (MUO) phenotype and metabolically healthy obesity ...

journal_title：Mediators of inflammation

authors： Tang HN,Xiao F,Chen YR,Zhuang SQ,Guo Y,Wu HX,Zhou HD

更新日期：2020-08-04 00:00:00

abstract：:Surgery induces release of neuroendocrine hormones (cortisol), cytokines (interleukin-6: IL-6, tumour necrosis factor-alpha: TNF-alpha), acute phase proteins (C-reactive protein: CRP, leptin). We studied the effects of general and spinal anaesthesia on stress response to haemorrhoidectomy. Patients were assigned to ge...

journal_title：Mediators of inflammation

authors： Buyukkocak U,Caglayan O,Daphan C,Aydinuraz K,Saygun O,Agalar F

更新日期：2006-01-01 00:00:00