Abstract:
:Surgery induces release of neuroendocrine hormones (cortisol), cytokines (interleukin-6: IL-6, tumour necrosis factor-alpha: TNF-alpha), acute phase proteins (C-reactive protein: CRP, leptin). We studied the effects of general and spinal anaesthesia on stress response to haemorrhoidectomy. Patients were assigned to general and spinal anaesthesia groups (n = 7). Blood samples were drawn before induction and 24 hours after surgery. Perioperative levels of IL-6, TNF-alpha, CRP, cortisol, and leptin were comparable among the groups. Twenty four hours after surgery, TNF-alpha and cortisol did not change; IL-6 and CRP increased significantly in all patients. Significant increase in leptin levels was found in patients undergoing spinal anaesthesia. Except for the increase in leptin levels, there was no significant difference related to the effects of general and spinal anaesthesia.
journal_name
Mediators Inflammjournal_title
Mediators of inflammationauthors
Buyukkocak U,Caglayan O,Daphan C,Aydinuraz K,Saygun O,Agalar Fdoi
10.1155/MI/2006/97257subject
Has Abstractpub_date
2006-01-01 00:00:00pages
97257issue
1eissn
0962-9351issn
1466-1861pii
S0962935106972573journal_volume
2006pub_type
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