Cross-talk between apolipoprotein E and cytokines.

abstract：:Chagas disease, caused by the protozoan Trypanosoma cruzi, is endemic in Latin America and affects ca. 10 million people worldwide. About 30% of Chagas disease patients develop chronic Chagas disease cardiomyopathy (CCC), a particularly lethal inflammatory cardiomyopathy that occurs decades after the initial infection...

journal_title：Mediators of inflammation

authors： Cunha-Neto E,Chevillard C

更新日期：2014-01-01 00:00:00

abstract：:In this study, we investigated in groups of female BALB/c mice injected with Crotalus durissus terrificus venom (Cdt) the renal function based on creatinine clearance, percentage of fractional excretion cytokines and histological examination of renal tissue. Cdt caused renal alterations that induced proteinuria during...

journal_title：Mediators of inflammation

authors： Hernández Cruz A,Barbosa Navarro L,Mendonça RZ,Petricevich VL

更新日期：2011-01-01 00:00:00

abstract：:To determine the role of mutant SOD1 gene (SOD1(G93A)) on muscle cell differentiation, we derived C2C12 muscle cell lines carrying a stably transfected SOD1(G93A) gene under the control of a myosin light chain (MLC) promoter-enhancer cassette. Expression of MLC/SOD1(G93A) in C2C12 cells resulted in dramatic inhibition...

journal_title：Mediators of inflammation

authors： Martini M,Dobrowolny G,Aucello M,Musarò A

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Severe traumatization induces a complex pathophysiology, driven by the patient's own immune system. The initial activation is a result of damage-associated molecular patterns, which are released from disrupted and dying cells and recognized by immune receptors, for example, RAGE. In this study we aimed to ev...

journal_title：Mediators of inflammation

authors： Uhle F,Lichtenstern C,Brenner T,Fleming T,Koch C,Hecker A,Heiss C,Nawroth PP,Hofer S,Weigand MA,Weismüller K

更新日期：2015-01-01 00:00:00

abstract：:The mixed leukocyte population obtained from the peritoneum of the August rat is a potentially important experimental model of inherent eosinophilia that has not been well characterized. In the present study, isolated cell preparations generated a concentration-dependent release of leukotriene (LT) C(4) when exposed t...

journal_title：Mediators of inflammation

authors： Huebner JM,Eversole RR,Jackson WF,Mackenzie CD,Stapleton SR,Beuving LJ

更新日期：1996-01-01 00:00:00

abstract：:Exposure to hog barn organic dust contributes to occupational lung diseases, which are mediated by inflammatory and oxidative stress pathways. Isoprostanes-a family of eicosanoids produced by oxidation of phospholipids by oxygen radicals-are biomarkers of pulmonary oxidative stress. Importantly, 8-isoprostane has been...

journal_title：Mediators of inflammation

authors： Gerald CL,McClendon CJ,Ranabhat RS,Waterman JT,Kloc LL,Conklin DR,Barton KT,Khatiwada JR,Williams LL

更新日期：2019-08-01 00:00:00

abstract：:Ghrelin, a peptide hormone produced mainly in the stomach, has emerged as an important modulator of the inflammatory responses that are of significance to the maintenance of gastric mucosal integrity. Here, we report on the role of ghrelin in controlling the apoptotic processes induced in gastric mucosal cells by H. p...

journal_title：Mediators of inflammation

authors： Slomiany BL,Slomiany A

更新日期：2010-01-01 00:00:00

abstract：:Vascular adhesion protein-1 (VAP-1) is an ectoenzyme that functions as a copper-containing amine oxidase and is involved in leukocyte adhesion at sites of inflammation. Inhibition of VAP-1 oxidative deamination has become an attractive target for anti-inflammatory therapy with demonstrated efficacy in rodent models of...

journal_title：Mediators of inflammation

authors： Kubota R,Reid MJ,Lieu KL,Orme M,Diamond C,Tulberg N,Henry SH

更新日期：2020-01-20 00:00:00

abstract：:A complex web of dynamic relationships between innate and adaptive immunity is now evident for many autoinflammatory and autoimmune disorders, the first deriving from abnormal activation of innate immune system without any conventional danger triggers and the latter from self-/non-self-discrimination loss of tolerance...

journal_title：Mediators of inflammation

authors： Lopalco G,Cantarini L,Vitale A,Iannone F,Anelli MG,Andreozzi L,Lapadula G,Galeazzi M,Rigante D

更新日期：2015-01-01 00:00:00

abstract：:Keishibukuryogan (KBG) is one of the traditional herbal formulations widely administered to patients with blood stagnation for improving blood circulation; currently, it is the most frequently prescribed medicine in Japan. KBG has been reported to improve conjunctional microcirculation. The aim of this study was to ev...

journal_title：Mediators of inflammation

authors： Yoshihisa Y,Furuichi M,Ur Rehman M,Ueda C,Makino T,Shimizu T

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND:Icariin (ICA) is an active compound extracted from Epimedium brevicornum Maxim. Previous reports have shown that icariin has a clinically significant therapeutic effect on rheumatoid arthritis. However, little is known about the mechanism by which icariin inhibits cartilage and bone degradation. METHODS:New...

journal_title：Mediators of inflammation

authors： Wei CC,Ping DQ,You FT,Qiang CY,Tao C

更新日期：2016-01-01 00:00:00

abstract：:Exosomes are nanosized vesicles released from every cell in the body including those in the respiratory tract and lungs. They are found in most body fluids and contain a number of different biomolecules including proteins, lipids, and both mRNA and noncoding RNAs. Since they can release their contents, particularly mi...

journal_title：Mediators of inflammation

authors： Alipoor SD,Mortaz E,Garssen J,Movassaghi M,Mirsaeidi M,Adcock IM

更新日期：2016-01-01 00:00:00

abstract：Background:Sepsis-induced myocardial dysfunction is a severe clinical problem. Recent studies have indicated that autophagy and myocardial energy depletion play a major role in myocardial dysfunction during sepsis, a mechanistic target of rapamycin (mTOR) as a master sensor of energy status and autophagy mediator; howe...

journal_title：Mediators of inflammation

authors： Han W,Wang H,Su L,Long Y,Cui N,Liu D

更新日期：2018-06-28 00:00:00

abstract：:To elucidate the modulatory role of histamine-degrading enzymes in airway constrictor responses, human bronchial strips were studied under isometric conditions in vitro. Pretreatment of tissues with the histamine N-methyltransferase (HMT) inhibitor SKF 91488 specifically potentiated the contractile responses to histam...

journal_title：Mediators of inflammation

authors： Tamaoki J,Chiyotani A,Tagaya E,Isono K,Konno K

更新日期：1994-01-01 00:00:00

abstract：:Dysfunction of the blood-brain barrier (BBB) is a primary characteristic of experimental autoimmune encephalomyelitis (EAE), an experimental model of multiple sclerosis (MS). Matrine (MAT), a quinolizidine alkaloid derived from the herb Radix Sophorae Flave, has been recently found to suppress clinical EAE and CNS inf...

journal_title：Mediators of inflammation

authors： Zhang S,Kan QC,Xu Y,Zhang GX,Zhu L

更新日期：2013-01-01 00:00:00

abstract：:It was recently demonstrated that TLR4 activation via dietary lipids triggers inflammatory pathway and alters insulin responsiveness in the fat tissue during obesity. Here, we question whether other TLR family members could participate in the TLR-mediated inflammatory processes occurring in the obese adipose tissue. W...

journal_title：Mediators of inflammation

authors： Poulain-Godefroy O,Le Bacquer O,Plancq P,Lecoeur C,Pattou F,Frühbeck G,Froguel P

更新日期：2010-01-01 00:00:00

abstract：:Background. Neutrophilic bronchial inflammation is a main feature of bronchiectasis, but not much is known about its relationship with other disease features. Aim. To compare airway inflammatory markers with clinical and functional findings in subjects with stable noncystic fibrosis bronchiectasis (NCFB). Methods. 152...

journal_title：Mediators of inflammation

authors： Dente FL,Bilotta M,Bartoli ML,Bacci E,Cianchetti S,Latorre M,Malagrinò L,Nieri D,Roggi MA,Vagaggini B,Paggiaro P

更新日期：2015-01-01 00:00:00

abstract：:Cathepsin G is a serine protease secreted by activated neutrophils that play a role in the inflammatory response. Because neutrophils are known to be invading leukocytes in various tumors, their products may influence the characteristics of tumor cells such as the growth state, motility, and the adhesiveness between c...

journal_title：Mediators of inflammation

authors： Kudo T,Kigoshi H,Hagiwara T,Takino T,Yamazaki M,Yui S

更新日期：2009-01-01 00:00:00

abstract：:Macrophages play a special role in the onset of several diseases, including acute and chronic kidney injuries. In this sense, tubule interstitial nephritis (TIN) represents an underestimated insult, which can be triggered by different stimuli and, in the absence of a proper regulation, can lead to fibrosis deposition....

journal_title：Mediators of inflammation

authors： Correa-Costa M,Braga TT,Felizardo RJ,Andrade-Oliveira V,Perez KR,Cuccovia IM,Hiyane MI,da Silva JS,Câmara NO

更新日期：2014-01-01 00:00:00

abstract：:The CCN family member 2 (CCN2, also known as connective tissue growth factor) may behave as a risk biomarker and a potential therapeutic target for renal disease. CCN2 participates in the regulation of inflammation and fibrosis. TGF-β is considered the main fibrogenic cytokine; however, in some pathological settings T...

journal_title：Mediators of inflammation

authors： Rodrigues-Díez R,Rayego-Mateos S,Orejudo M,Aroeira LS,Selgas R,Ortiz A,Egido J,Ruiz-Ortega M

更新日期：2015-01-01 00:00:00

abstract：:Infection with dengue virus (DENV) causes an increase in proinflammatory responses, such as nitric oxide (NO) generation and TNF-α expression; however, the molecular mechanism underlying this inflammatory activation remains undefined, although the activation of the transcription factor NF-κB is generally involved. In ...

journal_title：Mediators of inflammation

authors： Cheng YL,Lin YS,Chen CL,Wan SW,Ou YD,Yu CY,Tsai TT,Tseng PC,Lin CF

更新日期：2015-01-01 00:00:00

abstract：:An underlying endothelial dysfunction plays a fundamental role in the pathogenesis of cardiovascular events and is the central feature of atherosclerosis. The protein-based communication between leukocytes and inflamed endothelial cells leading to diapedesis has been largely investigated and several key players such a...

journal_title：Mediators of inflammation

authors： Dorosz SA,Ginolhac A,Kähne T,Naumann M,Sauter T,Salsmann A,Bueb JL

更新日期：2015-01-01 00:00:00

abstract：:miRNA-10a is rhythmically expressed and regulates genes involved in lipid and glucose metabolism. However, the effects of miRNA-10a on obesity and glucose intolerance, as well as on the diurnal pattern of expression of circadian clock genes, remain unknown. We explored the effects of miRNA-10a-5p on insulin resistance...

journal_title：Mediators of inflammation

authors： Guo Y,Zhu X,Zeng S,He M,Xing X,Wang C

更新日期：2020-08-17 00:00:00

abstract：:There is great need for a therapeutic that would limit tuberculosis related pathology and thus curtail spread of disease between individuals by establishing a "firebreak" to slow transmission. A promising avenue to increase current therapeutic efficacy may be through incorporation of adjunct components that slow or st...

journal_title：Mediators of inflammation

authors： Actor JK

更新日期：2015-01-01 00:00:00

abstract：OBJECTIVE:Acute ST-segment elevation myocardial infarction (ASTEMI) is accompanied by increased expression of inflammation and decreased expression of anti-inflammation. IL-37 was found to be involved in the atherosclerosis-related diseases and increased in acute coronary syndrome. However, the level of IL-37 in blood ...

journal_title：Mediators of inflammation

authors： Wang X,Cai X,Chen L,Xu D,Li J

更新日期：2015-01-01 00:00:00

abstract：Objective:To analyze the potential role of colchicine monotherapy in patients with tumor necrosis factor receptor associated periodic syndrome (TRAPS) in terms of control of clinical and laboratory manifestations. Methods:Patients with TRAPS treated with colchicine monotherapy were retrospectively enrolled; demographi...

journal_title：Mediators of inflammation

authors： Vitale A,Sota J,Obici L,Ricco N,Maggio MC,Cattalini M,Ruscitti P,Caso F,Manna R,Viapiana O,Caggiano V,Emmi G,Insalaco A,Montin D,Licciardi F,Soriano A,Dagna L,Salvarani C,Lamacchia V,Hernández-Rodríguez J,Giacomel

更新日期：2020-05-27 00:00:00

abstract：Objectives:To investigate the protective effect of ginsenoside Rg1 on relieving sepsis-induced lung inflammation and injury in vivo and in vitro. Methods:Cultured human pulmonary epithelial cell line A549 was challenged with LPS to induce cell injury, and CLP mouse model was generated to mimic clinical condition of sy...

journal_title：Mediators of inflammation

authors： Wang QL,Yang L,Peng Y,Gao M,Yang MS,Xing W,Xiao XZ

更新日期：2019-02-24 00:00:00

abstract：INTRODUCTION:Impaired maternal immune tolerance resulting in systemic inflammation plays a pivotal role in the pathogenesis of preeclampsia. Phenotypical changes of monocytes and neutrophil granulocytes have already been studied in preeclampsia, and some studies also included T lymphocyte activation markers; however, t...

journal_title：Mediators of inflammation

authors： Bajnok A,Ivanova M,Rigó J Jr,Toldi G

更新日期：2017-01-01 00:00:00

abstract：:Interleukin-5 (IL-5) is a cytokine that preferentially effects the development and function of eosinophils, and is considered important in the pathophysiology of allergic inflammation. In this study, we evaluated the ability of recombinant human IL-5 (rHu IL-5) to promote tissue eosinophilia and the importance of this...

journal_title：Mediators of inflammation

authors： Minnicozzi M,Durán WN,Kim D,Gleich GJ,Wagner J,Egan RW

更新日期：1995-01-01 00:00:00

abstract：:In addition to its well-established effect on T cells, cyclosporin A (CsA) also inhibits inflammatory cytokine production by macrophages. However, little is known about the mechanism of action of CsA on macrophage cytokine production. We measured the effect of CsA on basal and phorbol-myristate-acetate (PMA)-stimulate...

journal_title：Mediators of inflammation

authors： García JE,López AM,de Cabo MR,Rodríguez FM,Losada JP,Sarmiento RG,López AJ,Arellano JL

更新日期：1999-01-01 00:00:00