Role of the RAGE Axis during the Immune Response after Severe Trauma: A Prospective Pilot Study.

abstract：OBJECTIVE:To evaluate the effects of psychological stress on periodontitis healing in rats and the contribution of basic fibroblast growth factor (bFGF) expression to the healing process. METHODS:Ninety-six rats were randomly distributed into control group, periodontitis group, and periodontitis plus stress group. The...

journal_title：Mediators of inflammation

authors： Zhao YJ,Li Q,Cheng BX,Zhang M,Chen YJ

更新日期：2012-01-01 00:00:00

abstract：:TLRs recognize a broad spectrum of microorganism molecules, triggering a variety of cellular responses. Among them, phagocytosis is a critical process for host defense. Leukotrienes (LTs), lipid mediators produced from 5-lipoxygenase (5-LO) enzyme, increase FcγR-mediated phagocytosis. Here, we evaluated the participat...

journal_title：Mediators of inflammation

authors： Pinheiro CDS,Monteiro APT,Dutra FF,Bozza MT,Peters-Golden M,Benjamim CF,Canetti C

更新日期：2017-01-01 00:00:00

abstract：:The pivotal role of epithelial cells is to secrete and absorb ions and water in order to allow the formation of a luminal fluid compartment that is fundamental for the epithelial function as a barrier against environmental factors. Importantly, epithelial cells also take part in the innate immune system. As a first li...

journal_title：Mediators of inflammation

authors： Schnúr A,Hegyi P,Rousseau S,Lukacs GL,Veit G

更新日期：2016-01-01 00:00:00

abstract：Objective:For patients with severe acute pancreatitis (SAP), a high body mass index (BMI) increases the possibility of infection derived from the intestine. In this study, we evaluate whether TAK242 can alleviate severe acute pancreatitis-associated injury of intestinal barrier in high-fat diet-fed rats. Methods:A SAP...

journal_title：Mediators of inflammation

authors： Su YR,Hong YP,Mei FC,Wang CY,Li M,Zhou Y,Zhao KL,Yu J,Wang WX

更新日期：2019-12-17 00:00:00

abstract：:Pregnancy is a unique immunological state in which a balance of immune tolerance and suppression is needed to protect the fetus without compromising the mother. It has long been established that a bias from the T helper 1 cytokine profile towards the T helper 2 profile contributes towards successful pregnancy maintena...

journal_title：Mediators of inflammation

authors： Sykes L,MacIntyre DA,Yap XJ,Teoh TG,Bennett PR

更新日期：2012-01-01 00:00:00

abstract：:Monocyte chemotactic protein (MCP-1) is a specific monocyte chemoattractant and activating factor produced by both immune cells (mononuclear phagocytes and lymphocytes) and non-immune cells (parenchymal and stromal cells). In order to define the conditions under which human monocytes express MCP-1, monocytes were expo...

journal_title：Mediators of inflammation

authors： Liebler JM,Kunkel SL,Allen RM,Burdick MD,Strieter RM

更新日期：1994-01-01 00:00:00

abstract：:With the development of culture-independent techniques, numerous studies have demonstrated that the lower airway is not sterile in health and harbors diverse microbial communities. Furthermore, new evidence suggests that there is a distinct lower airway microbiome in those with chronic respiratory disease. To understa...

journal_title：Mediators of inflammation

authors： Lu J,Xiong L,Zhang X,Liu Z,Wang S,Zhang C,Zheng J,Wang G,Zheng R,Simpson JL,Wang F

更新日期：2017-01-01 00:00:00

abstract：:Keishibukuryogan (KBG) is one of the traditional herbal formulations widely administered to patients with blood stagnation for improving blood circulation; currently, it is the most frequently prescribed medicine in Japan. KBG has been reported to improve conjunctional microcirculation. The aim of this study was to ev...

journal_title：Mediators of inflammation

authors： Yoshihisa Y,Furuichi M,Ur Rehman M,Ueda C,Makino T,Shimizu T

更新日期：2010-01-01 00:00:00

abstract：:Recently, we revealed the importance of follicular helper T cells (T(FH)) in the pathogenesis of primary Sjögren's syndrome (pSS). In the present study, we focused on the site of the inflammation and determined the composition of lymphocyte infiltration in labial salivary gland (LSG) biopsies with special emphasis on ...

journal_title：Mediators of inflammation

authors： Szabo K,Papp G,Dezso B,Zeher M

更新日期：2014-01-01 00:00:00

abstract：:L-Arginine is converted to the highly reactive and unstable nitric oxide (NO) and L-citrulline by an enzyme named nitric oxide synthase (NOS). NO decomposes into other nitrogen oxides such as nitrite (NO(2) (-)) and nitrate (NO(2) (-)), and in the presence of superoxide anion to the potent oxidizing agent peroxynitrit...

journal_title：Mediators of inflammation

authors： Jorens PG,Matthys KE,Bult H

更新日期：1995-01-01 00:00:00

abstract：:Serine proteinases have been recognized as playing an important role in inflammation via proteinase activated receptors (PARs). However, little is known about the influence of serine proteinases and PARs on TNF secretion from highly purified T cells. We challenged T cells from human peripheral blood with serine protei...

journal_title：Mediators of inflammation

authors： Yang H,Li T,Wei J,Zhang H,He S

更新日期：2013-01-01 00:00:00

abstract：:The apoptosis-associated speck-like protein containing a caspase recruit domain (ASC) is involved in apoptosis and innate immunity and is a major adaptor molecule responsible for procaspase-1 activation. ASC mRNA is encoded by three exons: exons 1 and 3 encode a pyrin domain (PYD) and caspase recruit domain (CARD), re...

journal_title：Mediators of inflammation

authors： Matsushita K,Takeoka M,Sagara J,Itano N,Kurose Y,Nakamura A,Taniguchi S

更新日期：2009-01-01 00:00:00

abstract：:Matrix metalloproteinase 9 is a proteolytic enzyme which is recently one of the more often studied biomarkers. Its possible use as a biomarker of neuronal damage in stroke, heart diseases, tumors, multiple sclerosis, and epilepsy is being widely indicated. In epilepsy, MMP-9 is suggested to play a role in epileptic fo...

journal_title：Mediators of inflammation

authors： Bronisz E,Kurkowska-Jastrzębska I

更新日期：2016-01-01 00:00:00

abstract：Background:Endothelial dysfunction and apoptosis resulting from oxidative stress can lead to the development of atherosclerosis. Our group has previously showed that CD137 signaling contributes to the progression of atherosclerosis and the vulnerability of plaques. The aim of this study is to investigate the effects of...

journal_title：Mediators of inflammation

authors： Geng T,Yan Y,Zhang Y,Xu L,Zang G,Yan JC

更新日期：2020-06-06 00:00:00

abstract：:Acute kidney injury (AKI), a clinical syndrome, is a sudden onset of kidney failure that severely affects the kidney tubules. One potential treatment is dexmedetomidine (DEX), a highly selective α2-adrenoreceptor agonist that is used as an anesthetic adjuvant. It also has anti-inflammatory, neuroprotective, and sympat...

journal_title：Mediators of inflammation

authors： Bao N,Dai D

更新日期：2020-04-03 00:00:00

abstract：Objective:To analyze the potential role of colchicine monotherapy in patients with tumor necrosis factor receptor associated periodic syndrome (TRAPS) in terms of control of clinical and laboratory manifestations. Methods:Patients with TRAPS treated with colchicine monotherapy were retrospectively enrolled; demographi...

journal_title：Mediators of inflammation

authors： Vitale A,Sota J,Obici L,Ricco N,Maggio MC,Cattalini M,Ruscitti P,Caso F,Manna R,Viapiana O,Caggiano V,Emmi G,Insalaco A,Montin D,Licciardi F,Soriano A,Dagna L,Salvarani C,Lamacchia V,Hernández-Rodríguez J,Giacomel

更新日期：2020-05-27 00:00:00

abstract：:CXCL8 displays several tumor-promoting effects. Targeting and/or lowering CXCL8 concentrations within the tumor microenvironment would produce a therapeutic benefit. Aim of this study was to test the effect of IFNγ on the basal and TNFα-stimulated secretion of CXCL8 in TCP-1 and BCPAP thyroid cancer cell lines (harbor...

journal_title：Mediators of inflammation

authors： Rotondi M,Coperchini F,Awwad O,Pignatti P,Di Buduo CA,Abbonante V,Magri F,Balduini A,Chiovato L

更新日期：2016-01-01 00:00:00

abstract：:The objective of this study was to evaluate the effects of peptides derived from synbiotics on improving inflammatory bowel disease (IBD). Five-week-old male C57BL/6 mice were administered with dextran sulfate sodium (DSS) via drinking water for seven days to induce IBD (IBD group). The mice in the IBD group were oral...

journal_title：Mediators of inflammation

authors： Ha J,Oh H,Oh NS,Seo Y,Kang J,Park MH,Kim KS,Kang SH,Yoon Y

更新日期：2020-07-04 00:00:00

abstract：BACKGROUND:We have previously reported a continuous activation of caspase-1 and increased interleukin (IL)-1β levels in early rheumatoid arthritis (RA). These observations raised the hypothesis that drugs targeting the IL-1β pathway, in addition to tumour necrosis factor (TNF), may be particularly effective for early R...

journal_title：Mediators of inflammation

authors： Cascão R,Vidal B,Raquel H,Neves-Costa A,Figueiredo N,Gupta V,Fonseca JE,Moita LF

更新日期：2014-01-01 00:00:00

abstract：:Interleukin- (IL-) 35 and IL-37 are newly discovered immune-suppressing cytokines. They have been described in inflammatory diseases such as collagen-induced arthritis and asthma. However, their expressions in inflammatory bowel disease (IBD) patients have not been yet explored. Our aim was to evaluate serum and infla...

journal_title：Mediators of inflammation

authors： Li Y,Wang Y,Liu Y,Wang Y,Zuo X,Li Y,Lu X

更新日期：2014-01-01 00:00:00

abstract：:The number of persons who relocate to regions of high altitude for work, pleasure, sport, or residence increases every year. It is known that the reduced supply of oxygen (O2) induced by acute or chronic increases in altitude stimulates the body to adapt to new metabolic challenges imposed by hypoxia. Sleep can suffer...

journal_title：Mediators of inflammation

authors： Lemos Vde A,dos Santos RV,Lira FS,Rodrigues B,Tufik S,de Mello MT

更新日期：2013-01-01 00:00:00

abstract：:[This corrects the article DOI: 10.1155/2020/6947482.]. ...

journal_title：Mediators of inflammation

authors： Zhao Y,Wang J,Zhang M,Li P,Qi S,Lin W

更新日期：2020-11-21 00:00:00

abstract：OBJECTIVE:To investigate the Th17/Treg immune balance in the ulcerative colitis (UC) patients in a Chinese Han population. METHODS:Ninety UC patients and 30 healthy subjects were enrolled. The serum IL-17 and TGF-β1 levels of these participants were measured with ELISA; the percentage of Th17 and Treg cells in periphe...

journal_title：Mediators of inflammation

authors： Gong Y,Lin Y,Zhao N,He X,Lu A,Wei W,Jiang M

更新日期：2016-01-01 00:00:00

abstract：:It is hypothesized that central nervous system inflammation induced by systematic inflammation due to surgical trauma plays a critical role in postoperative cognitive dysfunction. The potential inhibitory effect of nerve blockage with local anesthetics on peripheral inflammatory response has been reported. We hypothes...

journal_title：Mediators of inflammation

authors： He Y,Li Z,Zuo YX

更新日期：2015-01-01 00:00:00

abstract：:The most frequent pathogen that causes bacterial meningitis is the Gram-positive bacterium Streptococcus pneumoniae. By entering the brain, host cells will be activated and proinflammatory cytokines like interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) are released. The goal of the current study was to examine...

journal_title：Mediators of inflammation

authors： Albrecht LJ,Tauber SC,Merres J,Kress E,Stope MB,Jansen S,Pufe T,Brandenburg LO

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:Growth arrest specific gene 6 (Gas6) protein enhances survival of oligodendrocytes and neurons, and it is involved in autoimmunity. Therefore, we aimed to verify whether cerebrospinal-fluid (CSF) Gas6 concentration may represent a biomarker of disease activity in multiple sclerosis. METHODS:Sixty-five patie...

journal_title：Mediators of inflammation

authors： Sainaghi PP,Collimedaglia L,Alciato F,Molinari R,Sola D,Ranza E,Naldi P,Monaco F,Leone M,Pirisi M,Avanzi GC

更新日期：2013-01-01 00:00:00

abstract：:[This corrects the article DOI: 10.1155/2018/3809092.]. ...

journal_title：Mediators of inflammation

authors： Curtiss E,Jiang Y,Liu L,Hawthorne C,Zhang J,Steinle JJ

更新日期：2019-06-18 00:00:00

abstract：:Patients with inflammatory bowel disease (IBD) are at an increased risk of developing colorectal cancer (CRC). The risk factors of CRC in IBD patients include long disease duration, extensive colitis, severe histological inflammation, and coexistence with primary sclerosing cholangitis (PSC). Several molecular pathway...

journal_title：Mediators of inflammation

authors： Luo C,Zhang H

更新日期：2017-01-01 00:00:00

abstract：:Leptin participates in the inflammatory responses in multiple cell types and animal models. Chronic cerebral hypoperfusion (CCH) induces inflammation in the central nervous system (CNS), which acts as one of the main reasons for CCH-induced white matter lesions (WMLs). But whether leptin participates in the pathogenes...

journal_title：Mediators of inflammation

authors： Du Y,Song Y,Zhang X,Luo Y,Zou W,Zhang J,Fu J

更新日期：2020-12-18 00:00:00

abstract：:Microparticles (MPs) are induced during apoptosis, cell activation, and even "spontaneous" release. Initially MPs were considered to be inert cellular products with no biological function. However, an extensive research and functional characterization have shown that the molecular composition and the effects of MPs de...

journal_title：Mediators of inflammation

authors： Burbano C,Rojas M,Vásquez G,Castaño D

更新日期：2015-01-01 00:00:00