当前位置： SCI文献检索 > MEDIATORS OF INFLAMMATION期刊下所有文献 > Induction of tumor necrosis factor (TNF) release from subtypes of T cells by agonists of proteinase activated receptors.

Induction of tumor necrosis factor (TNF) release from subtypes of T cells by agonists of proteinase activated receptors.

Abstract：

:Serine proteinases have been recognized as playing an important role in inflammation via proteinase activated receptors (PARs). However, little is known about the influence of serine proteinases and PARs on TNF secretion from highly purified T cells. We challenged T cells from human peripheral blood with serine proteinases and agonist peptides of PARs and measured the levels of TNF in culture supernatants by ELISA. The results showed that thrombin and trypsin, but not tryptase, stimulated approximately up to 2.5-fold increase in TNF release from T cells following 16 h incubation. Proteinase inhibitors and PAR-1 antagonist SCH 79797 almost completely abolished thrombin- and trypsin-induced TNF release from T cells. Agonist peptides of PAR-1, but not PAR-2 induced TNF release from T cells. Moreover, trypsin- and thrombin-induced upregulated expression of TNF was observed in CD4+, IL-4+, or CD25+ T cells, but not in IFN+ or IL-17+ T cells. The signaling pathways MAPK/ERK and PI3K/Akt are involved in the thrombin- and trypsin-induced TNF release from T cells. In conclusion, thrombin and trypsin can induce TNF release from IL-4+ and CD25+ T cells through activation of PAR-1 and therefore contribute to regulation of immune response and inflammation of the body.

journal_name

Mediators Inflamm

journal_title

Mediators of inflammation

authors

Yang H,Li T,Wei J,Zhang H,He S

doi

10.1155/2013/165453

subject

Has Abstract

pub_date

2013-01-01 00:00:00

pages

165453

eissn

0962-9351

issn

1466-1861

journal_volume

2013

pub_type

杂志文章

相关文献

MEDIATORS OF INFLAMMATION文献大全
  • Potential Biomarkers of Fat Loss as a Feature of Cancer Cachexia.

    abstract：:Fat loss is associated with shorter survival and reduced quality of life in cancer patients. Effective intervention for fat loss in cachexia requires identification of the condition using prognostic biomarkers for early detection and prevention of further depletion. No biomarkers of fat mass alterations have been defi...

    journal_title：Mediators of inflammation

    pub_type： 杂志文章,评审

    doi：10.1155/2015/820934

    authors： Ebadi M,Mazurak VC

    更新日期：2015-01-01 00:00:00

  • RNA from LPS-stirnulated macrophages induces the release of tumour necrosis factor-alpha and interleukin-1 by resident macrophages.

    abstract：:The effect of exogenous RNA on many cellular functions has been studied in a variety of eukaryotic cells but there are few reports on macrophages. In the present study, it is demonstrated that cytoplasmatic RNA extracted from rat macrophages stimulated with Escherichia coli lipopolysaccharide (LPS), referred to as L-R...

    journal_title：Mediators of inflammation

    pub_type： 杂志文章

    doi：10.1155/S0962935193000626

    authors： Ribeiro RA,Lucca FL,Flores CA,Cunha FQ,Ferreira SH

    更新日期：1993-01-01 00:00:00

  • Increased Risk of Cancer in relation to Gout: A Review of Three Prospective Cohort Studies with 50,358 Subjects.

    abstract：:Gout is a common inflammatory disease characterized by acute arthritis and hyperuricemia. A number of epidemiological studies have suggested the critical role of gout in carcinogenesis. The aim of this study was to estimate the association between gout and cancer risk by meta-analysis of all relevant studies published...

    journal_title：Mediators of inflammation

    pub_type： 杂志文章,meta分析,评审

    doi：10.1155/2015/680853

    authors： Wang W,Xu D,Wang B,Yan S,Wang X,Yin Y,Wang X,Sun B,Sun X

    更新日期：2015-01-01 00:00:00

  • Caffeic Acid Prevented LPS-Induced Injury of Primary Bovine Mammary Epithelial Cells through Inhibiting NF-κB and MAPK Activation.

    abstract：:In our previous study, lipopolysaccharide (LPS) significantly reduced the cell viability of primary bovine mammary epithelial cells (bMEC) leading to cell apoptosis, which were prevented by caffeic acid (CA) through inhibiting NF-κB activation and reducing proinflammatory cytokine expression. While the underlying mech...

    journal_title：Mediators of inflammation

    pub_type： 杂志文章

    doi：10.1155/2019/1897820

    authors： Liu M,Fang G,Yin S,Zhao X,Zhang C,Li J,Liu Z

    更新日期：2019-04-30 00:00:00

  • Lymphotoxin-alpha plays only a minor role in host resistance to respiratory infection with virulent type A Francisella tularensis in mice.

    abstract：:This study examined the role of lymphotoxin (LT)-alpha in host defense against airborne infection with Francisella tularensis, a gram-negative facultative intracellular bacterium and the causative agent of tularemia. Following a low-dose aerosol infection with the highly virulent type A strain of F. tularensis, mice d...

    journal_title：Mediators of inflammation

    pub_type： 杂志文章

    doi：10.1155/2008/239740

    authors： Zhang D,Kuolee R,Harris G,Zhang Q,Conlan JW,Chen W

    更新日期：2008-01-01 00:00:00

  • Histamine N-methyltransferase Modulates Human Bronchial Smooth Muscle Contraction.

    abstract：:To elucidate the modulatory role of histamine-degrading enzymes in airway constrictor responses, human bronchial strips were studied under isometric conditions in vitro. Pretreatment of tissues with the histamine N-methyltransferase (HMT) inhibitor SKF 91488 specifically potentiated the contractile responses to histam...

    journal_title：Mediators of inflammation

    pub_type： 杂志文章

    doi：10.1155/S0962935194000153

    authors： Tamaoki J,Chiyotani A,Tagaya E,Isono K,Konno K

    更新日期：1994-01-01 00:00:00

  • Gestation Related Gene Expression of the Endocannabinoid Pathway in Rat Placenta.

    abstract：:Mammalian placentation is a vital facet of the development of a healthy and viable offspring. Throughout gestation the placenta changes to accommodate, provide for, and meet the demands of a growing fetus. Gestational gene expression is a crucial part of placenta development. The endocannabinoid pathway is activated i...

    journal_title：Mediators of inflammation

    pub_type： 杂志文章

    doi：10.1155/2015/850471

    authors： Vaswani K,Chan HW,Peiris HN,Nitert MD,Bradley RJ,Armitage JA,Rice GE,Mitchell MD

    更新日期：2015-01-01 00:00:00

  • Inflammatory mediators release in urine from mice injected with Crotalus durissus terrificus venom.

    abstract：:In this study, we investigated in groups of female BALB/c mice injected with Crotalus durissus terrificus venom (Cdt) the renal function based on creatinine clearance, percentage of fractional excretion cytokines and histological examination of renal tissue. Cdt caused renal alterations that induced proteinuria during...

    journal_title：Mediators of inflammation

    pub_type： 杂志文章

    doi：10.1155/2011/103193

    authors： Hernández Cruz A,Barbosa Navarro L,Mendonça RZ,Petricevich VL

    更新日期：2011-01-01 00:00:00

  • CD137 Signaling Promotes Endothelial Apoptosis by Inhibiting Nrf2 Pathway, and Upregulating NF-κB Pathway.

    abstract：Background:Endothelial dysfunction and apoptosis resulting from oxidative stress can lead to the development of atherosclerosis. Our group has previously showed that CD137 signaling contributes to the progression of atherosclerosis and the vulnerability of plaques. The aim of this study is to investigate the effects of...

    journal_title：Mediators of inflammation

    pub_type： 杂志文章

    doi：10.1155/2020/4321912

    authors： Geng T,Yan Y,Zhang Y,Xu L,Zang G,Yan JC

    更新日期：2020-06-06 00:00:00

  • High Levels of Hemoglobin Promote Carotid Adventitial Vasa Vasorum Neoangiogenesis in Chronic Kidney Disease.

    abstract：:Chronic kidney disease (CKD) patients, characterized by traditional and nontraditional risk factors, are prone to develop atheromatosis and thus cardiovascular events and mortality. The angiogenesis of the adventitial vasa vasorum (aVV) surrounding the carotid has been described as the atheromatosis initiator. Therefo...

    journal_title：Mediators of inflammation

    pub_type： 杂志文章

    doi：10.1155/2017/3795142

    authors： Arcidiacono MV,Martinez-Alonso M,Belart M,Vilar A,Martín M,Craver L,Betriu À,Mauricio D,Valdivielso JM,Fernández E,Borràs M

    更新日期：2017-01-01 00:00:00

  • Evidences of a New Psychobiotic Formulation on Body Composition and Anxiety.

    abstract：Background:Gut microbiota is implied in obesity, because of its ability to harvest energy from diet, and in the regulation of behavior. Given the link between gut microbiota, body composition, obesity, and anxiety, the aim of this study was to evaluate the effects of a new psychobiotic formulation. Methods:Eligible pa...

    journal_title：Mediators of inflammation

    pub_type： 杂志文章,随机对照试验

    doi：10.1155/2017/5650627

    authors： Colica C,Avolio E,Bollero P,Costa de Miranda R,Ferraro S,Sinibaldi Salimei P,De Lorenzo A,Di Renzo L

    更新日期：2017-01-01 00:00:00

  • The Anti-Inflammatory Effects of Shinbaro3 Is Mediated by Downregulation of the TLR4 Signalling Pathway in LPS-Stimulated RAW 264.7 Macrophages.

    abstract：:Shinbaro3, a formulation derived from the hydrolysed roots of Harpagophytum procumbens var. sublobatum (Engl.) Stapf, has been clinically used in the pharamacopuncture treatment of arthritis in Korea. In the present study, Shinbaro3 inhibited NO generation in LPS-induced RAW 264.7 cells in a dose-dependent manner. Shi...

    journal_title：Mediators of inflammation

    pub_type： 杂志文章,收录出版

    doi：10.1155/2018/4514329

    authors： Chung HJ,Koh W,Kim WK,Shin JS,Lee J,Lee SK,Ha IH

    更新日期：2018-04-05 00:00:00

  • M1 and M2 Functional Imprinting of Primary Microglia: Role of P2X7 Activation and miR-125b.

    abstract：:Amyotrophic lateral sclerosis (ALS) is a most frequently occurring and severe form of motor neuron disease, causing death within 3-5 years from diagnosis and with a worldwide incidence of about 2 per 100,000 person-years. Mutations in over twenty genes associated with familial forms of ALS have provided insights into ...

    journal_title：Mediators of inflammation

    pub_type： 杂志文章,评审

    doi：10.1155/2016/2989548

    authors： Parisi C,Napoli G,Pelegrin P,Volonté C

    更新日期：2016-01-01 00:00:00

  • Active smoking increases microsomal PGE2-synthase-1/PGE-receptor-4 axis in human abdominal aortic aneurysms.

    abstract：BACKGROUND:The cyclooxygenase- (COX-) 2/microsomal PGE-synthase- (mPGES-) 1/PGE-receptor- (EP-) 4 axis could play a key role in the physiopathology of abdominal aortic aneurysm (AAA) in humans. In this study, we investigated the influence of cardiovascular risk factors on the expression of the PGE2 pathway in human AAA...

    journal_title：Mediators of inflammation

    pub_type： 杂志文章

    doi：10.1155/2014/316150

    authors： Dilmé JF,Solà-Villà D,Bellmunt S,Romero JM,Escudero JR,Camacho M,Vila L

    更新日期：2014-01-01 00:00:00

  • Circulating sCD138 and some angiogenesis-involved cytokines help to anticipate the disease progression of early-stage B-cell chronic lymphocytic leukemia.

    abstract：:Syndecan-1 (CD138) is a transmembrane heparin sulfate proteoglycan expressed on distinct stages of differentiation of B-lymphoid cells. Its prognostic value in B-cell chronic lymphocytic leukemia (B-CLL) has not been evaluated so far. The serum concentration of sCD138 and some angiogenesis-involved cytokines: vascular...

    journal_title：Mediators of inflammation

    pub_type： 杂志文章

    doi：10.1155/MI/2006/42394

    authors： Wołowiec D,Dybko J,Wróbel T,Urbaniak-Kujda D,Jaźwiec B,Tomaszewska-Toporska B,Kapelko-Słowik K,Potoczek S,Kuliczkowski K

    更新日期：2006-01-01 00:00:00

  • The differential diagnostic values of cytokine levels in pleural effusions.

    abstract：:The aim is to examine whether the changes in pleural fluid interleukin (IL)-1beta, IL-2, IL-6, and IL-8 levels were significant in differential diagnosis of childhood pleural effusions. IL-1beta, IL-2, IL-6, and IL-8 levels in pleural fluids of all 36 patients were measured. The levels of IL-1beta, IL-2, IL-6, and IL-...

    journal_title：Mediators of inflammation

    pub_type： 杂志文章

    doi：10.1155/MI.2005.2

    authors： Akarsu S,Kurt AN,Dogan Y,Yilmaz E,Godekmerdan A,Aygun AD

    更新日期：2005-02-24 00:00:00

  • NK Cell-Dependent Growth Inhibition of Lewis Lung Cancer by Yu-Ping-Feng, an Ancient Chinese Herbal Formula.

    abstract：:Little is known about Yu-Ping-Feng (YPF), a typical Chinese herbal decoction, for its antitumor efficacy in non-small-cell lung cancer (NSCLC). Here, we found that YPF significantly inhibited the growth of Lewis lung cancer, prolonged the survival of tumor-bearing mice, promoted NK cell tumor infiltration, increased t...

    journal_title：Mediators of inflammation

    pub_type： 杂志文章

    doi：10.1155/2016/3541283

    authors： Luo Y,Wu J,Zhu X,Gong C,Yao C,Ni Z,Wang L,Ni L,Li Y,Zhu S

    更新日期：2016-01-01 00:00:00

  • Growth Arrest-Specific 6 Enhances the Suppressive Function of CD4+CD25+ Regulatory T Cells Mainly through Axl Receptor.

    abstract：:Background. Growth arrest-specific (Gas) 6 is one of the endogenous ligands of TAM receptors (Tyro3, Axl, and Mertk), and its role as an immune modulator has been recently emphasized. Naturally occurring CD4+CD25+ regulatory T cells (Tregs) are essential for the active suppression of autoimmunity. The present study wa...

    journal_title：Mediators of inflammation

    pub_type： 杂志文章

    doi：10.1155/2017/6848430

    authors： Zhao GJ,Zheng JY,Bian JL,Chen LW,Dong N,Yu Y,Hong GL,Chandoo A,Yao YM,Lu ZQ

    更新日期：2017-01-01 00:00:00

  • 15-Lipoxygenase-1 Is Involved in the Effects of Atorvastatin on Endothelial Dysfunction.

    abstract：:Statins exert pleiotropic effects on endothelial cells in addition to lowering cholesterol. 15-Lipoxygenase-1 (ALOX15) has been implicated in vascular inflammation and disease. The relationship between atorvastatin and ALOX15 was investigated using a rat carotid artery balloon-injury model. Hematoxylin and eosin (HE) ...

    journal_title：Mediators of inflammation

    pub_type： 杂志文章

    doi：10.1155/2016/6769032

    authors： Zhang P,Xing X,Hu C,Yu H,Dong Q,Chang G,Qin S,Liu J,Zhang D

    更新日期：2016-01-01 00:00:00

  • Decreased Plasma Maresin 1 Concentration Is Associated with Diabetic Foot Ulcer.

    abstract：Aims:To assess the maresin 1 (MaR1) contents in type 2 diabetic patients with or without diabetic foot ulcer and to analyze the association of MaR1 concentrations with several metabolism-related parameters. Methods:Plasma MaR1 concentrations were analyzed in 96 subjects with normal glucose tolerant (NC, n = 43), type ...

    journal_title：Mediators of inflammation

    pub_type： 杂志文章

    doi：10.1155/2020/4539035

    authors： Miao T,Huang B,He N,Sun L,Du G,Gong X,Xu Y,Zheng Y,Zheng H,Qu H

    更新日期：2020-04-16 00:00:00

  • Hydroxysafflor Yellow A Inhibits LPS-Induced NLRP3 Inflammasome Activation via Binding to Xanthine Oxidase in Mouse RAW264.7 Macrophages.

    abstract：:Hydroxysafflor yellow A (HSYA) is an effective therapeutic agent for inflammatory diseases and autoimmune disorders; however, its regulatory effect on NLRP3 inflammasome activation in macrophages has not been investigated. In this study, we predicted the potential interaction between HSYA and xanthine oxidase (XO) via...

    journal_title：Mediators of inflammation

    pub_type： 杂志文章

    doi：10.1155/2016/8172706

    authors： Xu X,Guo Y,Zhao J,Wang N,Ding J,Liu Q

    更新日期：2016-01-01 00:00:00

  • In Situ Cytokine Expression and Morphometric Evaluation of Total Collagen and Collagens Type I and Type III in Keloid Scars.

    abstract：:Keloids are characterized by excessive collagen deposition and growth beyond the edges of the initial injury, and cytokines may be related to their formation. The objective of this study was to evaluate the collagen fibers, analyze in situ expression of cytokines in keloid lesions, and compare to the control group. Re...

    journal_title：Mediators of inflammation

    pub_type： 杂志文章

    doi：10.1155/2017/6573802

    authors： da Silva IR,Tiveron LCRDC,da Silva MV,Peixoto AB,Carneiro CAX,Dos Reis MA,Furtado PC,Rodrigues BR,Rodrigues V Jr,Rodrigues DBR

    更新日期：2017-01-01 00:00:00

  • LPA Promotes T Cell Recruitment through Synthesis of CXCL13.

    abstract：:Lysophosphatidic acid (LPA) is a bioactive phospholipid playing an important role in various inflammatory diseases by inducing expression and secretion of many inflammatory cytokines/chemokines. Here we report in a murine air pouch model of inflammation that LPA induced CXCL13 secretion in a time-dependent manner and ...

    journal_title：Mediators of inflammation

    pub_type： 杂志文章

    doi：10.1155/2015/248492

    authors： Hui W,Zhao C,Bourgoin SG

    更新日期：2015-01-01 00:00:00

  • Inflammation and the peritoneal membrane: causes and impact on structure and function during peritoneal dialysis.

    abstract：:Peritoneal dialysis therapy has increased in popularity since the end of the 1970s. This method provides a patient survival rate equivalent to hemodialysis and better preservation of residual renal function. However, technique failure by peritonitis, and ultrafiltration failure, which is a multifactorial complication ...

    journal_title：Mediators of inflammation

    pub_type： 杂志文章,评审

    doi：10.1155/2012/912595

    authors： Baroni G,Schuinski A,de Moraes TP,Meyer F,Pecoits-Filho R

    更新日期：2012-01-01 00:00:00

  • The Therapeutic Potential of MicroRNAs in Atrial Fibrillation.

    abstract：:One of the most globally prevalent supraventricular arrhythmias is atrial fibrillation (AF). Knowledge of the structures and functions of messenger RNA (mRNA) has recently increased. It is no longer viewed as solely an intermediate molecule between DNA and proteins but has come to be seen as a dynamic and modifiable g...

    journal_title：Mediators of inflammation

    pub_type： 杂志文章,评审

    doi：10.1155/2020/3053520

    authors： Xu X,Zhao Z,Li G

    更新日期：2020-03-12 00:00:00

  • Markers of inflammation and fibrosis in the orbital fat/connective tissue of patients with Graves' orbitopathy: clinical implications.

    abstract：PURPOSE:To assess FGF-β, TGF-β, and COX2 expression and immunocompetent cells in the orbital tissue of patients with severe and mild Graves' orbitopathy. PATIENTS AND METHODS:Orbital tissue was taken from 27 patients with GO: (1) severe GO (n = 18), the mean clinical activity score (CAS) being 8.5 (SD 2.5); and (2) mi...

    journal_title：Mediators of inflammation

    pub_type： 杂志文章

    doi：10.1155/2014/412158

    authors： Pawlowski P,Reszec J,Eckstein A,Johnson K,Grzybowski A,Chyczewski L,Mysliwiec J

    更新日期：2014-01-01 00:00:00

  • Effects of fluticasone propionate inhalation on levels of arachidonic acid metabolites in patients with chronic obstructive pulmonary disease.

    abstract：BACKGROUND:In smoking COPD patients the bronchoalveolar lavage (BAL) fluid contains high numbers of inflammatory cells. These cells might produce arachidonic acid (AA) metabolites, which contribute to inflammation and an increased bronchomotor tone. AIMS:To investigate levels of AA metabolites in BAL fluid, before and...

    journal_title：Mediators of inflammation

    pub_type： 临床试验,杂志文章

    doi：10.1080/09629350123056

    authors： Verhoeven GT,Garrelds IM,Hoogsteden HC,Zijlstra FJ

    更新日期：2001-02-01 00:00:00

  • Protection from endotoxic uveitis by intravitreal Resolvin D1: involvement of lymphocytes, miRNAs, ubiquitin-proteasome, and M1/M2 macrophages.

    abstract：:This study investigated the protective effects of intravitreal Resolvin D1 (RvD1) against LPS-induced rat endotoxic uveitis (EIU). RvD1 was administered into the right eye at a single injection of 5 μL volume containing 10-100-1000 ng/kg RvD1 1 h post-LPS injection (200 μg, Salmonella minnesota) into thefootpad of Spr...

    journal_title：Mediators of inflammation

    pub_type： 杂志文章

    doi：10.1155/2015/149381

    authors： Rossi S,Di Filippo C,Gesualdo C,Potenza N,Russo A,Trotta MC,Zippo MV,Maisto R,Ferraraccio F,Simonelli F,D'Amico M

    更新日期：2015-01-01 00:00:00

  • The traditional Japanese formula keishibukuryogan inhibits the production of inflammatory cytokines by dermal endothelial cells.

    abstract：:Keishibukuryogan (KBG) is one of the traditional herbal formulations widely administered to patients with blood stagnation for improving blood circulation; currently, it is the most frequently prescribed medicine in Japan. KBG has been reported to improve conjunctional microcirculation. The aim of this study was to ev...

    journal_title：Mediators of inflammation

    pub_type： 杂志文章

    doi：10.1155/2010/804298

    authors： Yoshihisa Y,Furuichi M,Ur Rehman M,Ueda C,Makino T,Shimizu T

    更新日期：2010-01-01 00:00:00

  • MMP8 Is Increased in Lesions and Blood of Acne Inversa Patients: A Potential Link to Skin Destruction and Metabolic Alterations.

    abstract：:Acne inversa (AI; also designated as hidradenitis suppurativa) is a chronic inflammatory disease with still unknown pathogenesis that affects the intertriginous skin of perianal, inguinal, and axillary sites. It leads to painful nodules, abscesses, and fistulas with malodorous secretion and is frequently associated wi...

    journal_title：Mediators of inflammation

    pub_type： 杂志文章

    doi：10.1155/2016/4097574

    authors： Tsaousi A,Witte E,Witte K,Röwert-Huber HJ,Volk HD,Sterry W,Wolk K,Schneider-Burrus S,Sabat R

    更新日期：2016-01-01 00:00:00