Abstract:
:Fat loss is associated with shorter survival and reduced quality of life in cancer patients. Effective intervention for fat loss in cachexia requires identification of the condition using prognostic biomarkers for early detection and prevention of further depletion. No biomarkers of fat mass alterations have been defined for application to the neoplastic state. Several inflammatory cytokines have been implicated in mediating fat loss associated with cachexia; however, plasma levels may not relate to adipose atrophy. Zinc-α2-glycoprotein may be a local catabolic mediator within adipose tissue rather than serving as a plasma biomarker of fat loss. Plasma glycerol and leptin associate with adipose tissue atrophy and mass, respectively; however, no study has evaluated their potential as a prognostic biomarker of cachexia-associated fat loss. This review confirms the need for further studies to identify valid prognostic biomarkers to identify loss of fat based on changes in plasma levels of biomarkers.
journal_name
Mediators Inflammjournal_title
Mediators of inflammationauthors
Ebadi M,Mazurak VCdoi
10.1155/2015/820934subject
Has Abstractpub_date
2015-01-01 00:00:00pages
820934eissn
0962-9351issn
1466-1861journal_volume
2015pub_type
杂志文章,评审abstract::Delayed rectifier K(+)-channels (Kv1.3) are predominantly expressed in T lymphocytes. Based on patch-clamp studies, the channels play crucial roles in facilitating the calcium influx necessary to trigger lymphocyte activation and proliferation. Using selective channel inhibitors in experimental animal models, in vivo ...
journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
doi:10.1155/2015/436572
更新日期:2015-01-01 00:00:00
abstract:PURPOSE:To assess FGF-β, TGF-β, and COX2 expression and immunocompetent cells in the orbital tissue of patients with severe and mild Graves' orbitopathy. PATIENTS AND METHODS:Orbital tissue was taken from 27 patients with GO: (1) severe GO (n = 18), the mean clinical activity score (CAS) being 8.5 (SD 2.5); and (2) mi...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2014/412158
更新日期:2014-01-01 00:00:00
abstract::Matrix metalloproteinase 9 is a proteolytic enzyme which is recently one of the more often studied biomarkers. Its possible use as a biomarker of neuronal damage in stroke, heart diseases, tumors, multiple sclerosis, and epilepsy is being widely indicated. In epilepsy, MMP-9 is suggested to play a role in epileptic fo...
journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
doi:10.1155/2016/7369020
更新日期:2016-01-01 00:00:00
abstract::Amyotrophic lateral sclerosis (ALS) is considered a multifactorial, multisystem disease in which inflammation and the immune system play important roles in development and progression. The pleiotropic cytokine TNFα is one of the major players governing the inflammation in the central nervous system and peripheral dist...
journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
doi:10.1155/2017/2985051
更新日期:2017-01-01 00:00:00
abstract::Early sensing of pathogenic bacteria by the host immune system is important to develop effective mechanisms to kill the invader. Microbial recognition, activation of signaling pathways, and effector mechanisms are sequential events that must be highly controlled to successfully eliminate the pathogen. Host recognizes ...
journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
doi:10.1155/2014/432785
更新日期:2014-01-01 00:00:00
abstract::The aim of the study was to evaluate the role of Smad3, Smad7, and TGF-β1 in intrauterine adhesion (IUA) patients and experimental rabbit models. 60 IUA patients, 30 control participants, and 18 female rabbits were enrolled in this study. We found that the plasma concentrations and protein expressions of TGF-β1 were s...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2016/4158287
更新日期:2016-01-01 00:00:00
abstract:Objective:To analyze the potential role of colchicine monotherapy in patients with tumor necrosis factor receptor associated periodic syndrome (TRAPS) in terms of control of clinical and laboratory manifestations. Methods:Patients with TRAPS treated with colchicine monotherapy were retrospectively enrolled; demographi...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2020/1936960
更新日期:2020-05-27 00:00:00
abstract::Specific binding sites for the anti-inflammatory protein annexin I have been detected on the surface of human monocytes and polymorphonuclear leukocytes (PMN). These binding sites are proteinaceous in nature and are sensitive to cleavage by the proteolytic enzymes trypsin, collagenase, elastase and cathepsin G. When m...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1080/09629359990720
更新日期:1999-01-01 00:00:00
abstract:BACKGROUND:Coronary atherosclerotic heart disease (CHD) is one of the major concerns in type 2 diabetes (T2D). The systemic chronic inflammation has been postulated to bridge the increased risk of cardiovascular disease and T2D. We formulated that increased peripheral proinflammatory T helper subsets contributed to the...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2014/596967
更新日期:2014-01-01 00:00:00
abstract::Multiple sclerosis (MS) is a chronic demyelinating disease of the human central nervous system (CNS). The condition predominantly affects young adults and is characterised by immunological and inflammatory changes in the periphery and CNS that contribute to neurovascular disruption, haemopoietic cell invasion of targe...
journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
doi:10.1155/MI/2006/93684
更新日期:2006-01-01 00:00:00
abstract::Abnormal angiogenesis and vascular remodeling contribute to pathogenesis of a number of disorders such as tumor, arthritis, atherosclerosis, restenosis, hypertension, and neurodegeneration. During angiogenesis and vascular remodeling, behaviors of stem/progenitor cells, endothelial cells (ECs), and vascular smooth mus...
journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
doi:10.1155/2013/928315
更新日期:2013-01-01 00:00:00
abstract::Trypanosoma cruzi infection was studied in mouse lines selected for maximal (AIRmax) or minimal (AIRmin) acute inflammatory reaction and for high (HIII) or low (LIII) antibody (Ab) responses to complex antigens. Resistance was associated with gender (females) and strain-the high responder lines AIRmax and HIII were re...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2014/952857
更新日期:2014-01-01 00:00:00
abstract::To elucidate the modulatory role of histamine-degrading enzymes in airway constrictor responses, human bronchial strips were studied under isometric conditions in vitro. Pretreatment of tissues with the histamine N-methyltransferase (HMT) inhibitor SKF 91488 specifically potentiated the contractile responses to histam...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/S0962935194000153
更新日期:1994-01-01 00:00:00
abstract::In this study we demonstrated that ΔCaecm33 double mutant showed reduced biofilm formation and causes less damage to gingival mucosa tissues. This was confirmed by the reduced level of necrotic cells and Bax/Bcl2 gene expression as apoptotic markers. In contrast, parental and Caecm33 mutant strains decreased basement ...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2012/398207
更新日期:2012-01-01 00:00:00
abstract:Aim:To analyze changes in peripheral blood monocytes and their clinical significance in patients with early stage of idiopathic membranous nephropathy (IMN). Methods:A total of 27 patients with early stage of IMN and 16 age- and sex-matched healthy controls (HCs) were recruited for the study. The monocyte subset count...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2018/5270657
更新日期:2018-06-21 00:00:00
abstract:BACKGROUND:Severe traumatization induces a complex pathophysiology, driven by the patient's own immune system. The initial activation is a result of damage-associated molecular patterns, which are released from disrupted and dying cells and recognized by immune receptors, for example, RAGE. In this study we aimed to ev...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2015/691491
更新日期:2015-01-01 00:00:00
abstract::Plasma GDF15 concentrations were measured in 612 Taiwanese individuals without overt systemic disease. Clinical parameters, GDF15 genetic variants, and 22 biomarker levels were analyzed. We further enrolled 86 patients with PAD and 481 patients with CAD, who received endovascular intervention and coronary angiography,...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2017/9398401
更新日期:2017-01-01 00:00:00
abstract::The present study was carried out to investigate the effects and mechanisms of polydatin (PD) in septic mice. The model of cecal ligation and puncture (CLP-)induced sepsis was employed. Pretreatment of mice with PD (15, 45, and 100 mg/kg) dose-dependently reduced sepsis-induced mortality and lung injury, as indicated ...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2013/354087
更新日期:2013-01-01 00:00:00
abstract::Peptide 204-212 of lipocortin (LC) 5 inhibited porcine pancreatic phospholipase A(2) (PLA(2)) induced rat stomach strip contractions and ADP induced rabbit platelet aggregation in a concentration dependent manner (IC(30) of 10 muM and 400 muM, respectively). The first two amino acids are not necessary since the eptape...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/S0962935193000146
更新日期:1993-01-01 00:00:00
abstract:BACKGROUND:Growth arrest specific gene 6 (Gas6) protein enhances survival of oligodendrocytes and neurons, and it is involved in autoimmunity. Therefore, we aimed to verify whether cerebrospinal-fluid (CSF) Gas6 concentration may represent a biomarker of disease activity in multiple sclerosis. METHODS:Sixty-five patie...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2013/406483
更新日期:2013-01-01 00:00:00
abstract::[This retracts the article DOI: 10.1155/2018/4514329.]. ...
journal_title:Mediators of inflammation
pub_type: 撤回出版物
doi:10.1155/2020/7859157
更新日期:2020-09-29 00:00:00
abstract::[This corrects the article DOI: 10.1155/2016/3214105.]. ...
journal_title:Mediators of inflammation
pub_type: 已发布勘误
doi:10.1155/2017/2917134
更新日期:2017-01-01 00:00:00
abstract:Background:Systemic inflammation impairs cognitive performance, yet the brain networks mediating this process remain to be elucidated. The purpose of the current study was to use resting-state functional magnetic resonance imaging (fMRI) to explore changes in the functional connectivity in a lipopolysaccharide- (LPS-) ...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2019/6212934
更新日期:2019-05-09 00:00:00
abstract::Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized by chronic inflammation of multiple joints. The central pathogenesis of RA is the proliferation of synovial fibroblasts in response to inflammatory cytokines. However, some of the targeted therapies for inflammation reactions do not display signi...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2015/460310
更新日期:2015-01-01 00:00:00
abstract::Osteoporosis is a civilization disease which is still challenging for contemporary medicine in terms of treatment and prophylaxis. It results from excessive activation of the osteoclastic cell line and immune cells like macrophages and lymphocytes. Cell-to-cell inflammatory information transfer occurs via factors incl...
journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
doi:10.1155/2019/7570452
更新日期:2019-11-12 00:00:00
abstract::We investigated whether TNB alters colonic tissue levels of PAF at the expense of changes in colonic motility in the isolated perfused rabbit left colon. Colonic inflammation was induced by the intracolonic administration of 0.25 ml of 50% ethanol containing 30 mg of trinitrobenzene. Strain gauge transducers were sewn...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/S0962935195000032
更新日期:1995-01-01 00:00:00
abstract:OBJECTIVE:Our aim was to evaluate the significance of homocysteine (Hcy) in Behcet's disease (BD) and the association of elevated Hcy levels associated with the indices of inflammation in BD. METHODS:Untreated 70 patients with BD and 33 healthy individuals were included into the study. Hcy, tumor necrosis alpha (TNF-a...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2008/407972
更新日期:2008-01-01 00:00:00
abstract::Background. Patients with UC have shown an important defect in the secretion and maintenance of the mucosal barrier as part of inadequate expression of mucin genes. The aim of the present study was to determine the expression of MUC12, MUC16, and MUC20 in colonic tissue from patients with UC in regard to their clinica...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2015/659018
更新日期:2015-01-01 00:00:00
abstract::Endothelial dysfunction is regarded as an important factor in the pathogenesis of vascular disease in obesity-related type 2 diabetes. The imbalance in repair and injury (hyperglycemia, hypertension, dyslipidemia) results in microvascular changes, including apoptosis of microvascular cells, ultimately leading to diabe...
journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
doi:10.1155/2010/792393
更新日期:2010-01-01 00:00:00
abstract::Psoriasis is a common chronic inflammatory multisystemic disease with a complex pathogenesis consisting of genetic, immunological, and environmental components. It is associated with a number of comorbidities, including diabetes, metabolic syndrome, obesity, and myocardial infarction. In addition, the severity of psor...
journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
doi:10.1155/2019/7353420
更新日期:2019-05-28 00:00:00