M1 and M2 Functional Imprinting of Primary Microglia: Role of P2X7 Activation and miR-125b.

abstract：:Long-term exposure to crystalline silica leads to silicosis, which is characterized by persistent lung inflammation and lung fibrosis. Multiple immune cells have been demonstrated to participate in crystalline silica-induced immune responses. Our previous study indicated that B10 could control lung inflammation throug...

journal_title：Mediators of inflammation

authors： Lu Y,Liu F,Li C,Chen Y,Weng D,Chen J

更新日期：2017-01-01 00:00:00

abstract：:H. pylori induces a complicated local and systematic immune response and contributes to the carcinogenesis of gastric cancer. A primary type 1 immune response is evoked by H. pylori since its occurrence. However, it is not unusual that an inhibitory immunity is dominant in H. pylori-associated diseases, which are prom...

journal_title：Mediators of inflammation

authors： Li R,Jiang XX,Zhang LF,Liu XM,Hu TZ,Xia XJ,Li M,Xu CX

更新日期：2017-01-01 00:00:00

abstract：:This study investigated whether the administration of resolvin D1 to rats with endotoxininduced uveitis (EIU) ameliorates the immuno-inflammatory profile of the eye. 24 h after the administration of 200 μg LPS into the footpad of Sprague-Dawley rats, severe changes of the structure of the eye occurred concomitantly wi...

journal_title：Mediators of inflammation

authors： Settimio R,Clara DF,Franca F,Francesca S,Michele D

更新日期：2012-01-01 00:00:00

abstract：:Microparticles (MPs) are induced during apoptosis, cell activation, and even "spontaneous" release. Initially MPs were considered to be inert cellular products with no biological function. However, an extensive research and functional characterization have shown that the molecular composition and the effects of MPs de...

journal_title：Mediators of inflammation

authors： Burbano C,Rojas M,Vásquez G,Castaño D

更新日期：2015-01-01 00:00:00

abstract：:In our previous study, lipopolysaccharide (LPS) significantly reduced the cell viability of primary bovine mammary epithelial cells (bMEC) leading to cell apoptosis, which were prevented by caffeic acid (CA) through inhibiting NF-κB activation and reducing proinflammatory cytokine expression. While the underlying mech...

journal_title：Mediators of inflammation

authors： Liu M,Fang G,Yin S,Zhao X,Zhang C,Li J,Liu Z

更新日期：2019-04-30 00:00:00

abstract：BACKGROUND:We have previously reported a continuous activation of caspase-1 and increased interleukin (IL)-1β levels in early rheumatoid arthritis (RA). These observations raised the hypothesis that drugs targeting the IL-1β pathway, in addition to tumour necrosis factor (TNF), may be particularly effective for early R...

journal_title：Mediators of inflammation

authors： Cascão R,Vidal B,Raquel H,Neves-Costa A,Figueiredo N,Gupta V,Fonseca JE,Moita LF

更新日期：2014-01-01 00:00:00

abstract：:Atherosclerosis is characterized by interaction between immune and vascular endothelial cells which is mediated by adhesion molecules occurring on the surface of the vascular endothelium leading to massive release of proinflammatory mediators. Ginkgo biloba L. (Ginkgoaceae) standardized extracts showing beneficial eff...

journal_title：Mediators of inflammation

authors： Piazza S,Pacchetti B,Fumagalli M,Bonacina F,Dell'Agli M,Sangiovanni E

更新日期：2019-06-25 00:00:00

abstract：:Little is known about Yu-Ping-Feng (YPF), a typical Chinese herbal decoction, for its antitumor efficacy in non-small-cell lung cancer (NSCLC). Here, we found that YPF significantly inhibited the growth of Lewis lung cancer, prolonged the survival of tumor-bearing mice, promoted NK cell tumor infiltration, increased t...

journal_title：Mediators of inflammation

authors： Luo Y,Wu J,Zhu X,Gong C,Yao C,Ni Z,Wang L,Ni L,Li Y,Zhu S

更新日期：2016-01-01 00:00:00

abstract：:B-1a cells are distinguishable from conventional B cells, which are designated B-2 cells, on the basis of their developmental origin, surface marker expression, and functions. In addition to the unique expression of the CD5 antigen, B-1a cells are characterized by the expression level of CD23. Although B-1a cells are ...

journal_title：Mediators of inflammation

authors： Yamamoto W,Toyoda H,Xu DQ,Hanaki R,Morimoto M,Nakato D,Ito T,Iwamoto S,Bonno M,Tanaka S,Hirayama M

更新日期：2018-12-23 00:00:00

abstract：:The aim of our work was to find if MCP-1 -2518 (A/G) single nucleotide polymorphism (SNP) influences somehow the serum concentrations of high-sensitive CRP (hsCRP) both in patients suffering from ischemic heart disease (IHD), myocardial infarction (MI), angina pectoris (AP), and hypertension (HT) and in control group ...

journal_title：Mediators of inflammation

authors： Bucova M,Lietava J,Penz P,Mrazek F,Petrkova J,Bernadic M,Petrek M

更新日期：2009-01-01 00:00:00

abstract：:The variable array of pattern receptor expression in different cells of the innate immune system explains the induction of distinct patterns of arachidonic acid (AA) metabolism. Peptidoglycan and mannan were strong stimuli in neutrophils, whereas the fungal extract zymosan was the most potent stimulus in monocyte-deri...

journal_title：Mediators of inflammation

authors： Alvarez Y,Valera I,Municio C,Hugo E,Padrón F,Blanco L,Rodríguez M,Fernández N,Crespo MS

更新日期：2010-01-01 00:00:00

abstract：:The aim of the present study was to compare serum levels of soluble forms of interleukin-2 receptor, CD4 and CD8, released by lymphocytes during activation ofthe immune system, in patients with histologically verified chronic active hepatitis associated to hepatitis C virus infection, with those in healthy subjects. S...

journal_title：Mediators of inflammation

authors： Caruso C,Candore G,Cigna D,Tripi S,Di Gaetano G,Migneco G,Montalto G,Ruggieri I,Notarbartolo A

更新日期：1994-01-01 00:00:00

abstract：:Non-cystic fibrosis-related bronchiectasis is a chronic inflammatory lung disease, which is regarded as an "orphan" lung disease, with little research devoted to the study of this condition. Bronchiectasis results in impaired quality of life and mortality if left untreated. The tools available in the armamentarium for...

journal_title：Mediators of inflammation

authors： Masekela R,Green RJ

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:Airway smooth muscle (ASM) is considered to be a target for mediators released during airway inflammation. AIMS:To investigate the expression of c-fos, a constituent of the transcription factor activator protein-1, in human ASM cells. In addition, to measure the release of interleukin (IL)-6 into the condit...

journal_title：Mediators of inflammation

authors： McKay S,Bromhaar MM,de Jongste JC,Hoogsteden HC,Saxena PR,Sharma HS

更新日期：2001-06-01 00:00:00

abstract：BACKGROUND:Hepatic ischemia-reperfusion (I/R) injury is a pivotal clinical problem occurring in many clinical conditions such as transplantation, trauma, and hepatic failure after hemorrhagic shock. Apoptosis and autophagy have been shown to contribute to cell death in hepatic I/R injury. Ethyl pyruvate, a stable and s...

journal_title：Mediators of inflammation

authors： Shen M,Lu J,Dai W,Wang F,Xu L,Chen K,He L,Cheng P,Zhang Y,Wang C,Wu D,Yang J,Zhu R,Zhang H,Zhou Y,Guo C

更新日期：2013-01-01 00:00:00

abstract：:Nitrooleic acid (OA-NO2) is an endogenous lipid product which has novel signaling properties, particularly the activation of peroxisome proliferator-activated receptors. The current study aimed to evaluate the protective effects of OA-NO2 against cisplatin-induced kidney injury in mice. Mice were pretreated with OA-NO...

journal_title：Mediators of inflammation

authors： Wang H,Jia Z,Sun J,Xu L,Zhao B,Yu K,Yang M,Yang T,Wang R

更新日期：2015-01-01 00:00:00

abstract：:Apolipoprotein E (apoE) is a multifunctional glycosylated protein characterized by its wide tissue distribution. Despite its importance in lipid transport and atherosclerosis pathogenesis, apoE is associated with neurodegenerative disorders such as Alzheimer's disease (AD) and Parkinson disease, and autoimmune disorde...

journal_title：Mediators of inflammation

authors： Zhang H,Wu LM,Wu J

更新日期：2011-01-01 00:00:00

abstract：:Neuropathic pain is a serious clinical problem to be solved. This study is aimed at investigating protein kinase A (PKA) expression in neuropathic pain and its possible mechanisms of involvement. A neuropathic pain-related gene expression dataset was downloaded from Gene Expression Omnibus, and differentially expresse...

journal_title：Mediators of inflammation

authors： Deng Y,Yang L,Xie Q,Yang F,Li G,Zhang G,Li S,Wu Z,Wang J,Kang X

更新日期：2020-03-23 00:00:00

abstract：:The secretory leukocyte protease inhibitor (SLPI) is a low-molecular-weight inhibitor of proteases, such as elastase and cathepsin G which are released from leukocytes during phagocytosis. The purpose of this study was to determine whether or not SLPI is able to inhibit IgE-mediated histamine release. Nasal mucosa fro...

journal_title：Mediators of inflammation

authors： Westin U,Lundberg E,Ohlsson K

更新日期：1998-01-01 00:00:00

abstract：:Periodontitis is an inflammatory disease characterized by destruction of the tooth-supporting tissues. Obese individuals have an increased risk of periodontitis, and elevated circulating levels of nicotinamide phosphoribosyltransferase (NAMPT) may be a pathomechanistic link between both diseases. Recently, increased l...

journal_title：Mediators of inflammation

authors： Nokhbehsaim M,Keser S,Jäger A,Jepsen S,Deschner J

更新日期：2013-01-01 00:00:00

abstract：:Recent investigations have indicated that reactive metabolites and AGE-RAGE-mediated inflammation might play an important role in the pathogenesis of ischemia-reperfusion injury in liver transplantation. In this observational clinical study, 150 patients were enrolled following liver transplantation from deceased dono...

journal_title：Mediators of inflammation

authors： Brenner T,Fleming TH,Spranz D,Schemmer P,Bruckner T,Uhle F,Martin EO,Weigand MA,Hofer S

更新日期：2013-01-01 00:00:00

abstract：:The aim of this study was to evaluate the relationship between serum transforming growth factor β 1 (TGF- β 1) concentrations and the duration of type 1 diabetes mellitus (T1DM) in children and adolescents. One hundred and sixteen patients with T1DM and 19 healthy controls were examined. Serum TGF- β 1 concentrations ...

journal_title：Mediators of inflammation

authors： Zorena K,Raczyńska D,Wiśniewski P,Malinowska E,Myśliwiec M,Raczyńska K,Rachoń D

更新日期：2013-01-01 00:00:00

abstract：:In this study the question was addressed whether cAMP mediated drugs induce a differential reduction of branches of the arachidonic acid metabolism rather than a global reduction of eicosanoid synthesis. The isolated lungs of actively sensitized rats were employed to study prostaglandin and leukotriene release in the ...

journal_title：Mediators of inflammation

authors： Post MJ,Biesebeek JD,Wemer J,Rooij HH,Zijlstra FJ,Porsius AJ

更新日期：1992-01-01 00:00:00

abstract：:The effects of anti-inflammatory plant extracts, such as black tea extract (BTE) and resveratrol (RSV) could modulate cell activation leading to atherosclerosis, however there is little comparative information about how different endothelial cell types are affected by these compounds. In order to compare human endothe...

journal_title：Mediators of inflammation

authors： Lakota K,Mrak-Poljsak K,Rozman B,Sodin-Semrl S

更新日期：2009-01-01 00:00:00

abstract：:This study investigated the protective effects of intravitreal Resolvin D1 (RvD1) against LPS-induced rat endotoxic uveitis (EIU). RvD1 was administered into the right eye at a single injection of 5 μL volume containing 10-100-1000 ng/kg RvD1 1 h post-LPS injection (200 μg, Salmonella minnesota) into thefootpad of Spr...

journal_title：Mediators of inflammation

authors： Rossi S,Di Filippo C,Gesualdo C,Potenza N,Russo A,Trotta MC,Zippo MV,Maisto R,Ferraraccio F,Simonelli F,D'Amico M

更新日期：2015-01-01 00:00:00

abstract：:Ghrelin, a peptide hormone produced mainly in the stomach, has emerged as an important modulator of the inflammatory responses that are of significance to the maintenance of gastric mucosal integrity. Here, we report on the role of ghrelin in controlling the apoptotic processes induced in gastric mucosal cells by H. p...

journal_title：Mediators of inflammation

authors： Slomiany BL,Slomiany A

更新日期：2010-01-01 00:00:00

abstract：:The present paradigm of atherogenesis proposes that low density lipoproteins (LDLs) are trapped in subendothelial space of the vascular wall where they are oxidized. Previously, we showed that oxidation is not restricted to the subendothelial location. Myeloperoxidase (MPO), an enzyme secreted by neutrophils and macro...

journal_title：Mediators of inflammation

authors： Boudjeltia KZ,Delporte C,Van Antwerpen P,Franck T,Serteyn D,Moguilevsky N,Raes M,Vanhamme L,Vanhaeverbeek M,Van Meerhaeghe A,Roumeguère T

更新日期：2013-01-01 00:00:00

abstract：:Cytokines and chemokines are proteins that coordinate the immune response throughout the body. The dysregulation of cytokines and chemokines is a central feature in the development of neuroinflammation, neurodegeneration, and demyelination both in the central and peripheral nervous systems and in conditions of neuropa...

journal_title：Mediators of inflammation

authors： Ramesh G,MacLean AG,Philipp MT

更新日期：2013-01-01 00:00:00

abstract：:We have observed uncontrollable cardiogenic shock as a cardiovascular manifestation of systemic inflammatory response syndrome (SIRS) leading to death in a 62-year-old woman. The diagnosis of SIRS was based on the demonstration of endotoxinaemia, and highly elevated plasma levels of tumour necrosis factor (TNF)-alpha,...

journal_title：Mediators of inflammation

authors： Sipka S,Seres T,Dinya Z,Szekanecz Z,Szentmiklósi J,Bodolay E,Szegedi G

更新日期：1995-01-01 00:00:00

abstract：:Extracellular bacterial ribonucleases such as binase from Bacillus pumilus possess cytotoxic activity against tumor cells with a potential for clinical application. Moreover, they may induce activation of tumor-derived macrophages either into the M1-phenotype with well-documented functions in the regulation of the ant...

journal_title：Mediators of inflammation

authors： Makeeva A,Rodriguez-Montesinos J,Zelenikhin P,Nesmelov A,Preissner KT,Cabrera-Fuentes HA,Ilinskaya ON

更新日期：2017-01-01 00:00:00