Abstract:
:Long-term exposure to crystalline silica leads to silicosis, which is characterized by persistent lung inflammation and lung fibrosis. Multiple immune cells have been demonstrated to participate in crystalline silica-induced immune responses. Our previous study indicated that B10 could control lung inflammation through modulating the Th balance in experimental silicosis in mice. However, the regulatory mechanism of B10 on CD4+ T cells is still unclear. MACS-sorted CD19+ B cells from the three different groups were cultured with CD4+ T cells either with or without transwell insert plates to evaluate the effects of B10 on CD4+ T cells, including Teff and Treg. B10 was eliminated by anti-CD22 application in vivo. Flow cytometry was used to test the frequencies of CD4+ T cells, and the expressions of the related cytokines were detected by real-time PCR and CBA. Insufficient B10 elevated the levels of proinflammatory cytokines and promoted Th responses in a way independent upon cell-cell contact in the Teff and B cell coculture system. B10 could both increase Treg activity and enhance conversion of Teff into Treg. Our findings demonstrated that B10 could affect Th responses by the release of IL-10, enhancing Treg functions and converting Teff into Treg.
journal_name
Mediators Inflammjournal_title
Mediators of inflammationauthors
Lu Y,Liu F,Li C,Chen Y,Weng D,Chen Jdoi
10.1155/2017/8415094subject
Has Abstractpub_date
2017-01-01 00:00:00pages
8415094eissn
0962-9351issn
1466-1861journal_volume
2017pub_type
杂志文章abstract::Human respiratory syncytial virus (RSV) sometimes causes acute and severe lower respiratory tract illness in infants and young children. RSV strongly upregulates proinflammatory cytokines and the platelet-activating factor (PAF) receptor, which is a receptor for Streptococcus pneumoniae, in the pulmonary epithelial ce...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2012/528568
更新日期:2012-01-01 00:00:00
abstract:Objective:To analyze the potential role of colchicine monotherapy in patients with tumor necrosis factor receptor associated periodic syndrome (TRAPS) in terms of control of clinical and laboratory manifestations. Methods:Patients with TRAPS treated with colchicine monotherapy were retrospectively enrolled; demographi...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2020/1936960
更新日期:2020-05-27 00:00:00
abstract::Obesity-induced skeletal muscle inflammation is characterized by increased macrophage infiltration and inflammatory cytokine production. In this study, we investigated whether 4-1BB, a member of the TNF receptor superfamily (TNFRSF9) that provides inflammatory signals, participates in obesity-induced skeletal muscle i...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2013/865159
更新日期:2013-01-01 00:00:00
abstract::Parasites of the genus Leishmania are capable of inhibiting effector functions of macrophages. These parasites have developed the adaptive ability to escape host defenses; for example, they inactivate the NF-κB complex and suppress iNOS expression in infected macrophages, which are responsible for the production of th...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2016/2631625
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND:Noncystic fibrosis bronchiectasis (NCFB) is characterized by airway expansion and recurrent acute exacerbations. Macrolide has been shown to exhibit anti-inflammatory effects in some chronic airway diseases. OBJECTIVE:To assess the efficacy of roxithromycin on airway inflammation and remodeling in patients ...
journal_title:Mediators of inflammation
pub_type: 杂志文章,随机对照试验
doi:10.1155/2014/708608
更新日期:2014-01-01 00:00:00
abstract::The mixed leukocyte population obtained from the peritoneum of the August rat is a potentially important experimental model of inherent eosinophilia that has not been well characterized. In the present study, isolated cell preparations generated a concentration-dependent release of leukotriene (LT) C(4) when exposed t...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/S0962935196000610
更新日期:1996-01-01 00:00:00
abstract::Methyltransferase-like 3 (METTL3), an RNA N6-methyladenosine (m6A) methyltransferase, is essential for the m6A mRNA modification. As a key enzyme of m6A methylation modification, METTL3 has been implicated in immune and inflammation regulation. However, little is known of the role and underlying mechanism of METTL3 in...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2019/3120391
更新日期:2019-10-24 00:00:00
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journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2015/274025
更新日期:2015-01-01 00:00:00
abstract::We report here that the leptomeningeal cells transduce inflammatory signals from peripheral macrophages to brain-resident microglia in response to Porphyromonas gingivalis (P.g.) LPS. The expression of Toll-like receptor 2 (TLR2), TLR4, TNF-α, and inducible NO synthase was mainly detected in the gingival macrophages o...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2013/407562
更新日期:2013-01-01 00:00:00
abstract:AIM:This study was undertaken in order to determine whether anti-inflammatory cytokine interleukin-10 is responsible for a previously described protection against Klebsiella infection mediated by antilipopolysaccharide antibodies. METHODS:BALB/c mice were infected intraperitoneally with a lethal challenge of Klebsiell...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/MI/2006/69431
更新日期:2006-01-01 00:00:00
abstract::The aim of the study was to evaluate the role of Smad3, Smad7, and TGF-β1 in intrauterine adhesion (IUA) patients and experimental rabbit models. 60 IUA patients, 30 control participants, and 18 female rabbits were enrolled in this study. We found that the plasma concentrations and protein expressions of TGF-β1 were s...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2016/4158287
更新日期:2016-01-01 00:00:00
abstract::The mechanism of pain reduction involves bidirectional processes of pain blocking (nociception) and reductions in the levels of proinflammatory cytokines in the blood. Does transcutaneous electrical nerve stimulation (TENS) reduce blood levels of proinflammatory cytokines? For this systematic review, we searched in si...
journal_title:Mediators of inflammation
pub_type: 杂志文章,meta分析,评审
doi:10.1155/2018/1094352
更新日期:2018-04-02 00:00:00
abstract:BACKGROUND:Human and rodent leukocytes express high levels of the glucocorticoid-inducible protein annexin 1 (ANXA1) (previously referred to as lipocortin 1). Neutrophils and monocytes have abundant ANXA1 levels. AIM:We have investigated, for the first time, ANXA1 ultrastructural expression in rat eosinophils and comp...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1080/09629350210000015683
更新日期:2002-10-01 00:00:00
abstract::The clinical outcome of autologous adipose stem cell (ASC) treatment of patients with multiple sclerosis (MS) was investigated following one year of observation. Methods. The clinical and MRI outcomes of 16 ASC-treated patients with RRMS and SPMS are reported after a one-year follow-up period. Results. At 18 months of...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2016/5302120
更新日期:2016-01-01 00:00:00
abstract:Purpose:To explore the potential of monocyte-to-lymphocyte ratio (MLR) at hospital admission for predicting acute traumatic intraparenchymal hematoma (tICH) expansion in patients with cerebral contusion. Patients and Methods. This multicenter, observational study included patients with available at-hospital admission (...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2020/5483981
更新日期:2020-12-28 00:00:00
abstract::Tumor necrosis factor alpha (TNF-α) is a potent proinflammatory cytokine that plays a significant role in the pathogenesis of asthma by inducing hyperresponsiveness and airway remodeling. TNF-α diminishes the L-type voltage dependent Ca(2+) channel (L-VDCC) current in cardiac myocytes, an observation that seems parado...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2016/5972302
更新日期:2016-01-01 00:00:00
abstract::A prominent feature of inflammatory diseases is endothelial dysfunction. Factors associated with endothelial dysfunction include proinflammatory cytokines, adhesion molecules, and matrix degrading enzymes. At the transcriptional level, they are regulated by the histone deacetylase sirtuin (SIRT) 1 via its actions on t...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2012/597514
更新日期:2012-01-01 00:00:00
abstract::Maternal immune activation (MIA) is a potential risk factor for autism spectrum disorder (ASD) and schizophrenia (SZ). In rodents, MIA results in changes in cytokine profiles and abnormal behaviors in the offspring that model these neuropsychiatric conditions. Given the central role that mitochondria have in immunity ...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2013/609602
更新日期:2013-01-01 00:00:00
abstract:BACKGROUND:Growth arrest specific gene 6 (Gas6) protein enhances survival of oligodendrocytes and neurons, and it is involved in autoimmunity. Therefore, we aimed to verify whether cerebrospinal-fluid (CSF) Gas6 concentration may represent a biomarker of disease activity in multiple sclerosis. METHODS:Sixty-five patie...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2013/406483
更新日期:2013-01-01 00:00:00
abstract::The close relationship between increased TLR-2 expression in blood monocytes and insulin resistance in RA patients is shown in this study. Traditional risk factors for metabolic disorders, including the waist circumstance, body mass index (BMI), triglyceride (TG), and ratio of TG to high density lipoprotein (HDL) chol...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2012/690525
更新日期:2012-01-01 00:00:00
abstract:INTRODUCTION:Proliferative vitreoretinopathy (PVR) is a severe inflammatory complication of retinal detachment. Pathological epiretinal membranes grow on the retina surface leading to contraction, and surgery fails in 5% to 10% of the cases. We evaluated the expression of VEGF-A, Otx1, Otx2, Otx3, and p53 family member...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2013/857380
更新日期:2013-01-01 00:00:00
abstract::The present study was carried out to investigate the effects and mechanisms of polydatin (PD) in septic mice. The model of cecal ligation and puncture (CLP-)induced sepsis was employed. Pretreatment of mice with PD (15, 45, and 100 mg/kg) dose-dependently reduced sepsis-induced mortality and lung injury, as indicated ...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2013/354087
更新日期:2013-01-01 00:00:00
abstract::Adipokines are cytokines produced mainly by adipose tissue, besides many other tissues such as placenta, ovaries, peripheral-blood mononuclear cells, liver, muscle, kidney, heart, and bone marrow. Adipokines play a significant role in the metabolic syndrome and in cardiovascular diseases, have implications in regulati...
journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
doi:10.1155/2016/4981916
更新日期:2016-01-01 00:00:00
abstract::Increasing evidence has demonstrated that reactive oxygen species (ROS) induces oxidative stress and plays a crucial role in the pathogenesis of acute pancreatitis (AP). Hydrogen-rich saline (HRS), a well-known ROS scavenger, has been shown to possess therapeutic benefit on AP in many animal experiments. Recent findin...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2014/930894
更新日期:2014-01-01 00:00:00
abstract::Acute kidney injury (AKI), a clinical syndrome, is a sudden onset of kidney failure that severely affects the kidney tubules. One potential treatment is dexmedetomidine (DEX), a highly selective α2-adrenoreceptor agonist that is used as an anesthetic adjuvant. It also has anti-inflammatory, neuroprotective, and sympat...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2020/2120971
更新日期:2020-04-03 00:00:00
abstract::Edelweiss (Leontopodium alpinum Cass.) is traditionally employed in folk medicine as an anti-inflammatory remedy. In nature, the plant is sparsely available and protected; therefore production of callus cultures was established. A concentrated ethanolic extract of culture homogenate, with leontopodic acid representing...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2012/498373
更新日期:2012-01-01 00:00:00
abstract::Exposure to hog barn organic dust contributes to occupational lung diseases, which are mediated by inflammatory and oxidative stress pathways. Isoprostanes-a family of eicosanoids produced by oxidation of phospholipids by oxygen radicals-are biomarkers of pulmonary oxidative stress. Importantly, 8-isoprostane has been...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2019/7420468
更新日期:2019-08-01 00:00:00
abstract::The production of nitric oxide (NO) was measured in cultures of spleen cells stimulated by lipopolysaccharide (LPS), IL-2 or LPS + IL-2. We observed that NO synthesis is increased by IFN-gamma but inhibited by IFN-alpha/beta. This is not the case when IL-2 is present in the cultures, since interferons play a minor rol...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/S0962935196000117
更新日期:1996-01-01 00:00:00
abstract::A TP II analogue, [1-Nal3] TP II, was synthesized by a conventional solution method, followed by deprotection with 1M TFMSA-thioanisole (molar ratio 1:1) in TFA in the presence of Me2Se and m-cresol as scavengers. The synthetic [1-Nal3] TP II, TP II and [Phe (4 F)3] TP II were tested for comparative effect on the impa...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1080/09629350020002930
更新日期:2000-01-01 00:00:00
abstract::To evaluate the impact of low levels of high density lipoprotein cholesterol (HDL-c) on patients with LDL-c average levels, focusing on oxidative, lipidic, and inflammatory profiles. Patients with cardiovascular risk factors (n = 169) and control subjects (n = 73) were divided into 2 subgroups, one of normal HDL-c and...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2013/612038
更新日期:2013-01-01 00:00:00