Potent anti-inflammatory and antiproliferative effects of gambogic acid in a rat model of antigen-induced arthritis.

abstract：:Thymosin beta(4) is a polypeptide isolated from thymosin fraction 5. This peptide exhibits important activities in the regulation and differentiation of thymus-dependent lymphocytes. An analogue of thymosin beta(4), [Phe(4F)(12)] deacetyl- thymosin beta(4), was synthesized by a solution method, followed by deprotectio...

journal_title：Mediators of inflammation

authors： Abiko T,Sekino H

更新日期：1992-01-01 00:00:00

abstract：:The purinergic P2X7 receptor (P2X7R) plays an important role during the immune response, participating in several events such as cytokine release, apoptosis, and necrosis. The bacterial endotoxin lipopolysaccharide (LPS) is one of the strongest stimuli of the immune response, and it has been shown that P2X7R activatio...

journal_title：Mediators of inflammation

authors： Leiva-Salcedo E,Coddou C,Rodríguez FE,Penna A,Lopez X,Neira T,Fernández R,Imarai M,Rios M,Escobar J,Montoya M,Huidobro-Toro JP,Escobar A,Acuña-Castillo C

更新日期：2011-01-01 00:00:00

abstract：:Tantalum (Ta) is gaining attention as a biomaterial in bone tissue engineering. Although the clinical advantage of Ta-based implants for primary and revision total joint replacement (TJA) has been well documented, few studies investigated the effect of wear products of Ta implants on peri-implant cells, and their pote...

journal_title：Mediators of inflammation

authors： Zhang L,Haddouti EM,Beckert H,Biehl R,Pariyar S,Rüwald JM,Li X,Jaenisch M,Burger C,Wirtz DC,Kabir K,Schildberg FA

更新日期：2020-12-03 00:00:00

abstract：:BCG, the only registered vaccine against Mycobacterial Tuberculosis (TB) infection, has been questioned for its protective efficacy for decades. Although lots of efforts were made to improve the BCG antigenicity, few studies were devoted to understand the role of host factors in the variability of the BCG protection. ...

journal_title：Mediators of inflammation

authors： Xu H,Jia Y,Li Y,Wei C,Wang W,Guo R,Jia J,Wu Y,Li Z,Wei Z,Qi X,Li Y,Gao X

更新日期：2019-06-12 00:00:00

abstract：:The effect of exogenous RNA on many cellular functions has been studied in a variety of eukaryotic cells but there are few reports on macrophages. In the present study, it is demonstrated that cytoplasmatic RNA extracted from rat macrophages stimulated with Escherichia coli lipopolysaccharide (LPS), referred to as L-R...

journal_title：Mediators of inflammation

authors： Ribeiro RA,Lucca FL,Flores CA,Cunha FQ,Ferreira SH

更新日期：1993-01-01 00:00:00

abstract：:Particulate matter with an aerodynamic diameter equal or less than 2.5 micrometers (PM2.5) is associated with the development of chronic obstructive pulmonary disease (COPD). The mechanisms by which PM2.5 accelerates disease progression in COPD are poorly understood. In this study, we aimed to investigate the effect o...

journal_title：Mediators of inflammation

authors： Wang J,Li Y,Zhao P,Tian Y,Liu X,He H,Jia R,Oliver BG,Li J

更新日期：2020-05-08 00:00:00

abstract：:Mammalian placentation is a vital facet of the development of a healthy and viable offspring. Throughout gestation the placenta changes to accommodate, provide for, and meet the demands of a growing fetus. Gestational gene expression is a crucial part of placenta development. The endocannabinoid pathway is activated i...

journal_title：Mediators of inflammation

authors： Vaswani K,Chan HW,Peiris HN,Nitert MD,Bradley RJ,Armitage JA,Rice GE,Mitchell MD

更新日期：2015-01-01 00:00:00

abstract：:Despite early recanalization of an occluded infarct artery, tissue reperfusion remains impaired in more than one-third of the acute myocardial infarction (AMI) patients owing to a process of reperfusion injury. The role of systemic inflammation in triggering this phenomenon is unknown. Proinflammatory factors (hs-CRP,...

journal_title：Mediators of inflammation

authors： Blancke F,Claeys MJ,Jorens P,Vermeiren G,Bosmans J,Wuyts FL,Vrints CJ

更新日期：2005-12-14 00:00:00

abstract：:The close relationship between increased TLR-2 expression in blood monocytes and insulin resistance in RA patients is shown in this study. Traditional risk factors for metabolic disorders, including the waist circumstance, body mass index (BMI), triglyceride (TG), and ratio of TG to high density lipoprotein (HDL) chol...

journal_title：Mediators of inflammation

authors： Wang SW,Lin TM,Wang CH,Liu HH,Houng JY

更新日期：2012-01-01 00:00:00

abstract：:The effect of lipoprotein apheresis (Direct Adsorption of Lipids, DALI) (LA) on plasma levels of pentraxin 3 (PTX3), an inflammatory marker that reflects coronary plaque vulnerability, and expression of PTX3 mRNA was evaluated in patients with hyperLp(a)lipoproteinemia and angiographically defined atherosclerosis/coro...

journal_title：Mediators of inflammation

authors： Stefanutti C,Mazza F,Steiner M,Watts GF,De Nève J,Pasqualetti D,Paal J

更新日期：2016-01-01 00:00:00

abstract：:Specific binding sites for the anti-inflammatory protein annexin I have been detected on the surface of human monocytes and polymorphonuclear leukocytes (PMN). These binding sites are proteinaceous in nature and are sensitive to cleavage by the proteolytic enzymes trypsin, collagenase, elastase and cathepsin G. When m...

journal_title：Mediators of inflammation

authors： Euzger HS,Flower RJ,Goulding NJ,Perretti M

更新日期：1999-01-01 00:00:00

abstract：BACKGROUND:Rodent models suggest that follistatin-like 3 (fstl3) is associated with diabetes and obesity. In humans, plasma fstl3 is reduced with gestational diabetes. In vitro, TNF-α induces fstl3 secretion, which suggests a link to inflammation. OBJECTIVE:To elucidate the association between plasma fstl3 and obesity...

journal_title：Mediators of inflammation

authors： Brandt C,Pedersen M,Rinnov A,Andreasen AS,Møller K,Hojman P,Pedersen BK,Plomgaard P

更新日期：2014-01-01 00:00:00

abstract：:Paricalcitol, a selective vitamin D receptor (VDR) activator used for treatment of secondary hyperparathyroidism in chronic kidney disease (CKD), has been associated with survival advantages, suggesting that this drug, beyond its ability to suppress parathyroid hormone, may have additional beneficial actions. In this ...

journal_title：Mediators of inflammation

authors： Donate-Correa J,Domínguez-Pimentel V,Méndez-Pérez ML,Muros-de-Fuentes M,Mora-Fernández C,Martín-Núñez E,Cazaña-Pérez V,Navarro-González JF

更新日期：2014-01-01 00:00:00

abstract：:Gout is a common inflammatory disease characterized by acute arthritis and hyperuricemia. A number of epidemiological studies have suggested the critical role of gout in carcinogenesis. The aim of this study was to estimate the association between gout and cancer risk by meta-analysis of all relevant studies published...

journal_title：Mediators of inflammation

authors： Wang W,Xu D,Wang B,Yan S,Wang X,Yin Y,Wang X,Sun B,Sun X

更新日期：2015-01-01 00:00:00

abstract：:Severe acute pancreatitis (SAP) characterized by atrocious progression and numerous complications often leads to a high mortality rate due to hypermetabolism, systemic inflammatory response syndrome (SIRS), and multiple organs dysfunction syndrome (MODS). Studies have revealed that both early enteral nutrition (EEN) a...

journal_title：Mediators of inflammation

authors： Wang G,Sun B,Gao Y,Meng QH,Jiang HC

更新日期：2007-01-01 00:00:00

abstract：:This study was carried out to investigate whether ADM can modulate LPS-induced inflammation and apoptosis in rat Leydig cells. Leydig cells were treated with ADM before LPS-induced cytotoxicity. We determined the concentrations of ROS, MDA, GSH, LDH, and testosterone and the MMP. The mRNA levels of IL-1, IL-6, iNOS, a...

journal_title：Mediators of inflammation

authors： Zhou PH,Hu W,Zhang XB,Wang W,Zhang LJ

更新日期：2016-01-01 00:00:00

abstract：:The aim of the present study was to compare serum levels of soluble forms of interleukin-2 receptor, CD4 and CD8, released by lymphocytes during activation of the immune system, in patients with allergic bronchial asthma, with those in healthy subjects. Significantly higher levels of soluble IL-2R and soluble CD4 were...

journal_title：Mediators of inflammation

authors： Lorenzo GD,Mansueto P,Melluso M,Morici G,Norrito F,Cigna D,Candore G,Caruso C

更新日期：1995-01-01 00:00:00

abstract：OBJECTIVE:Acute ST-segment elevation myocardial infarction (ASTEMI) is accompanied by increased expression of inflammation and decreased expression of anti-inflammation. IL-37 was found to be involved in the atherosclerosis-related diseases and increased in acute coronary syndrome. However, the level of IL-37 in blood ...

journal_title：Mediators of inflammation

authors： Wang X,Cai X,Chen L,Xu D,Li J

更新日期：2015-01-01 00:00:00

abstract：:Lactobacillus species can exert health promoting effects in the gastrointestinal tract (GIT) through many mechanisms, which include pathogen inhibition, maintenance of microbial balance, immunomodulation, and enhancement of the epithelial barrier function. Different species of the genus Lactobacillus can evoke differe...

journal_title：Mediators of inflammation

authors： Sengupta R,Altermann E,Anderson RC,McNabb WC,Moughan PJ,Roy NC

更新日期：2013-01-01 00:00:00

abstract：:Podocyte injury critically contributes to the pathogenesis of obesity-related glomerulopathy (ORG). Recently, lipid accumulation and inflammatory responses have been found to be involved in podocyte injury. This study is to explore their role and relationship in podocyte injury of ORG. In animal experiments, the ORG m...

journal_title：Mediators of inflammation

authors： Zhao J,Rui HL,Yang M,Sun LJ,Dong HR,Cheng H

更新日期：2019-04-11 00:00:00

abstract：:[This corrects the article DOI: 10.1155/2018/3809092.]. ...

journal_title：Mediators of inflammation

authors： Curtiss E,Jiang Y,Liu L,Hawthorne C,Zhang J,Steinle JJ

更新日期：2019-06-18 00:00:00

abstract：:The pivotal role of epithelial cells is to secrete and absorb ions and water in order to allow the formation of a luminal fluid compartment that is fundamental for the epithelial function as a barrier against environmental factors. Importantly, epithelial cells also take part in the innate immune system. As a first li...

journal_title：Mediators of inflammation

authors： Schnúr A,Hegyi P,Rousseau S,Lukacs GL,Veit G

更新日期：2016-01-01 00:00:00

abstract：:Lysophosphatidic acid (LPA) is a bioactive phospholipid playing an important role in various inflammatory diseases by inducing expression and secretion of many inflammatory cytokines/chemokines. Here we report in a murine air pouch model of inflammation that LPA induced CXCL13 secretion in a time-dependent manner and ...

journal_title：Mediators of inflammation

authors： Hui W,Zhao C,Bourgoin SG

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Infection in the neonatal period is an extremely serious condition and diagnosis is difficult. C-reactive protein (CRP) is widely used as a marker of infection; however, its usefulness is limited in the early phase. The role of soluble intracellular adhesion molecule-1 (sICAM-1), an adhesion molecule, has be...

journal_title：Mediators of inflammation

authors： Apostolou M,Dimitriou H,Kaleyias J,Perdikogianni C,Stiakaki E,Costalos C,Kalmanti MC

更新日期：2002-04-01 00:00:00

abstract：STUDY OBJECTIVES:To assess serum amyloid alpha (SAA) pleural fluid levels in parapneumonic effusion (PPE) and to investigate SAA diagnostic performance in PPE diagnosis and outcome. METHODS:We studied prospectively 57 consecutive patients with PPE (empyema (EMP), complicated (CPE), and uncomplicated parapneumonic effu...

journal_title：Mediators of inflammation

authors： Boultadakis V,Skouras V,Makris D,Damianaki A,Nikoulis DJ,Kiropoulos T,Oikonomidi S,Tsilioni I,Gourgoulianis K

更新日期：2011-01-01 00:00:00

abstract：:The therapeutic strategies used in the treatment of hepatitis C are essentially based on the combination of direct-acting antiviral agents (DAAs). This therapy has been shown to be very effective in relation to patient adherence to treatment and has shown high rates of sustained virological response (SVR). However, th...

journal_title：Mediators of inflammation

authors： Pereira GL,Tarragô AM,Neves WLL,da Silva Neto PV,de Souza PS,Dos Santos Affonso J,de Sousa KS,da Silva JA,Costa AG,da Silva Victoria F,Victoria MB,Malheiro A

更新日期：2019-11-04 00:00:00

abstract：:To investigate the role of AEG-1 in glycolysis and tumorigenesis, we construct myc-AEG-1 expression vector and demonstrate a novel mechanism that AEG-1 may increase the activity of AMPK by Thr172 phosphorylation. The higher expression levels of AEG-1 in colorectal carcinoma cells were found but showed significant diff...

journal_title：Mediators of inflammation

authors： Song HT,Qin Y,Yao GD,Tian ZN,Fu SB,Geng JS

更新日期：2014-01-01 00:00:00

abstract：:Surgery induces release of neuroendocrine hormones (cortisol), cytokines (interleukin-6: IL-6, tumour necrosis factor-alpha: TNF-alpha), acute phase proteins (C-reactive protein: CRP, leptin). We studied the effects of general and spinal anaesthesia on stress response to haemorrhoidectomy. Patients were assigned to ge...

journal_title：Mediators of inflammation

authors： Buyukkocak U,Caglayan O,Daphan C,Aydinuraz K,Saygun O,Agalar F

更新日期：2006-01-01 00:00:00

abstract：:Periploca forrestii Schltr. has been used as a Chinese folk medicine due to its versatile pharmacological effects such as promoting wounds and rheumatoid arthritis. However, the antiarthritic activity of Periploca forrestii saponin (PFS) and its active compound Periplocin has still not been demonstrated. Here, we eval...

journal_title：Mediators of inflammation

authors： Liu Y,Li M,He Q,Yang X,Ruan F,Sun G

更新日期：2016-01-01 00:00:00

abstract：:We previously demonstrated that Bothrops jararaca venom (BjV) has an antitumor effect on Ehrlich ascites tumor (EAT) cells and induces an increase of polymorphonuclear leukocytes in early stages of tumor growth. It has been reported that this venom presents an important inflammatory effect when inoculated in animal mo...

journal_title：Mediators of inflammation

authors： da Silva RJ,da Silva MG,Vilela LC,Fecchio D

更新日期：2002-08-01 00:00:00