Resolvin D1 reduces the immunoinflammatory response of the rat eye following uveitis.

abstract：:The alteration of resting tension (RT) from 0.5 g to 2.5 g increased significantly airway smooth muscle contractions induced by acetylcholine (ACh) in rabbit trachea. The decrease in extracellular calcium concentration [Ca2+]o from 2 mM to 0.2 mM reduced ACh-induced contractions only at 2.5 g RT with no effect at 0.5 ...

journal_title：Mediators of inflammation

authors： Kitsiopoulou E,Hatziefthimiou AA,Gourgoulianis KI,Molyvdas PA

更新日期：2007-01-01 00:00:00

abstract：:Matrix metalloproteinase 9 is a proteolytic enzyme which is recently one of the more often studied biomarkers. Its possible use as a biomarker of neuronal damage in stroke, heart diseases, tumors, multiple sclerosis, and epilepsy is being widely indicated. In epilepsy, MMP-9 is suggested to play a role in epileptic fo...

journal_title：Mediators of inflammation

authors： Bronisz E,Kurkowska-Jastrzębska I

更新日期：2016-01-01 00:00:00

abstract：:The therapeutic strategies used in the treatment of hepatitis C are essentially based on the combination of direct-acting antiviral agents (DAAs). This therapy has been shown to be very effective in relation to patient adherence to treatment and has shown high rates of sustained virological response (SVR). However, th...

journal_title：Mediators of inflammation

authors： Pereira GL,Tarragô AM,Neves WLL,da Silva Neto PV,de Souza PS,Dos Santos Affonso J,de Sousa KS,da Silva JA,Costa AG,da Silva Victoria F,Victoria MB,Malheiro A

更新日期：2019-11-04 00:00:00

abstract：:Cytokines play an important role in the regulation of the immune system (adaptive and innate). Given their importance in proinflammatory processes, cytokines have been used for understanding the pathogenesis and as biomarkers in many diseases. IL-31 and IL-33 are still considered novel cytokines. IL-31 controls signal...

journal_title：Mediators of inflammation

authors： Di Salvo E,Ventura-Spagnolo E,Casciaro M,Navarra M,Gangemi S

更新日期：2018-03-11 00:00:00

abstract：:Mitotic catastrophe, as defined in 2012 by the International Nomenclature Committee on Cell Death, is a bona fide intrinsic oncosuppressive mechanism that senses mitotic failure and responds by driving a cell to an irreversible antiproliferative fate of death or senescence. Thus, failed mitotic catastrophe can promote...

journal_title：Mediators of inflammation

authors： Mc Gee MM

更新日期：2015-01-01 00:00:00

abstract：:Early sensing of pathogenic bacteria by the host immune system is important to develop effective mechanisms to kill the invader. Microbial recognition, activation of signaling pathways, and effector mechanisms are sequential events that must be highly controlled to successfully eliminate the pathogen. Host recognizes ...

journal_title：Mediators of inflammation

authors： Oviedo-Boyso J,Bravo-Patiño A,Baizabal-Aguirre VM

更新日期：2014-01-01 00:00:00

abstract：:Little work is done to develop Aloe vera (AV) using probiotics. To explore the potential benefits, the antioxidant effects and the antibacterial effects on foodborne pathogens of Aloe fermentation supernatant were evaluated in vitro. Our results indicated that the Aloe fermentation supernatant fermented by Lactobacill...

journal_title：Mediators of inflammation

authors： Jiang M,Deng K,Jiang C,Fu M,Guo C,Wang X,Wang X,Meng F,Yang S,Deng K,Chen T,Xin H

更新日期：2016-01-01 00:00:00

abstract：UNLABELLED:The aim of this study was to investigate the relationship between urinary eosinophil protein X (uEPX) and asthma symptoms, lung function, and other markers of eosinophilic airway inflammation in asthmatic school children. METHODS:A cross-sectional study was performed in 180 steroid dependent atopic children...

journal_title：Mediators of inflammation

authors： Nuijsink M,Hop WC,Sterk PJ,Duiverman EJ,Hiemstra PS,de Jongste JC,CATO Study Group.

更新日期：2007-01-01 00:00:00

abstract：:The close relationship between increased TLR-2 expression in blood monocytes and insulin resistance in RA patients is shown in this study. Traditional risk factors for metabolic disorders, including the waist circumstance, body mass index (BMI), triglyceride (TG), and ratio of TG to high density lipoprotein (HDL) chol...

journal_title：Mediators of inflammation

authors： Wang SW,Lin TM,Wang CH,Liu HH,Houng JY

更新日期：2012-01-01 00:00:00

abstract：:S. epidermidis is responsible for biofilm-related nonunions. This study compares the response to S. epidermidis-infected fractures in rats systemically or locally injected with vancomycin or bone marrow mesenchymal stem cells (BMSCs) in preventing the nonunion establishment. The 50% of rats receiving BMSCs intravenous...

journal_title：Mediators of inflammation

authors： Lovati AB,Drago L,Bottagisio M,Bongio M,Ferrario M,Perego S,Sansoni V,De Vecchi E,Romanò CL

更新日期：2016-01-01 00:00:00

abstract：:Cathepsin S is a cysteine protease and regulator of autophagy with possible involvement in periodontitis. The objective of this study was to investigate whether cathepsin S is involved in the pathogenesis of periodontal diseases. Human periodontal fibroblasts were cultured under inflammatory and infectious conditions ...

journal_title：Mediators of inflammation

authors： Memmert S,Damanaki A,Nogueira AVB,Eick S,Nokhbehsaim M,Papadopoulou AK,Till A,Rath B,Jepsen S,Götz W,Piperi C,Basdra EK,Cirelli JA,Jäger A,Deschner J

更新日期：2017-01-01 00:00:00

abstract：:Osteoarthritis (OA) belongs to a group of degenerative diseases. Synovial inflammation, cartilage abrasion, and subchondral sclerosis are characteristics of OA. Researchers do not fully understand the exact etiology of OA. However, matrix metalloproteinases (MMPs), which are responsible for cartilage matrix degradatio...

journal_title：Mediators of inflammation

authors： Chen YT,Hou CH,Hou SM,Liu JF

更新日期：2014-01-01 00:00:00

abstract：:Galectin-1 (Gal-1), an evolutionarily conserved β-galactoside-binding lectin, controls immune cell homeostasis and tempers acute and chronic inflammation by blunting proinflammatory cytokine synthesis, engaging T-cell apoptotic programs, promoting expansion of T regulatory (Treg) cells, and deactivating antigen-presen...

journal_title：Mediators of inflammation

authors： Seropian IM,González GE,Maller SM,Berrocal DH,Abbate A,Rabinovich GA

更新日期：2018-11-05 00:00:00

abstract：Objectives:In this study, we assessed the effects of dietary magnesium on leukocyte telomere length (LTL). Designs:The current cross-sectional analysis was based on data collected within a type 2 diabetes project. Settings. Dietary magnesium intake is associated with peripheral blood leukocyte telomere length (LTL). H...

journal_title：Mediators of inflammation

authors： Yu J,Liu H,He S,Li P,Ma C,Ma M,Liu Y,Lv L,Ping F,Zhang H,Li W,Sun Q,Xu L,Li Y

更新日期：2020-05-22 00:00:00

abstract：:Epidermal growth factor (EGF) is a 53-amino acid peptide that plays an important role in regulating cell growth, survival, migration, apoptosis, proliferation, and differentiation. In addition, EGF has been established to be an effective intestinal regulator helping to protect intestinal barrier integrity, which was e...

journal_title：Mediators of inflammation

authors： Tang X,Liu H,Yang S,Li Z,Zhong J,Fang R

更新日期：2016-01-01 00:00:00

abstract：:To test the statistical association of the CRP and SAA1 locus variants with their corresponding circulating levels and metabolic and inflammatory biomarker levels by using mediation analysis, a sample population of 599 Taiwanese subjects was enrolled and five CRP and four SAA1 variants were genotyped. Correlation anal...

journal_title：Mediators of inflammation

authors： Ko YL,Hsu LA,Wu S,Teng MS,Chou HH

更新日期：2016-01-01 00:00:00

abstract：:Nitric oxide has enigmatic qualities in inflammation. In order to appreciate the precise contributions of nitric oxide to a pathophysiological process, one must account for enzyme source, coproduction of oxidants and antioxidant defences, time, rate of nitric oxide production, cellular source, peroxynitrite formation ...

journal_title：Mediators of inflammation

authors： Miller MJ,Grisham MB

更新日期：1995-01-01 00:00:00

abstract：:A family of eleven proteins comprises the Janus kinases (JAK) and signal transducers and activators of transcription (STAT) signaling pathway, which enables transduction of signal from cytokine receptor to the nucleus and activation of transcription of target genes. Irregular functioning of the cascade may contribute ...

journal_title：Mediators of inflammation

authors： Juczynska K,Wozniacka A,Waszczykowska E,Danilewicz M,Wagrowska-Danilewicz M,Wieczfinska J,Pawliczak R,Zebrowska A

更新日期：2017-01-01 00:00:00

abstract：:Diabetic retinopathy is considered a neurovascular disorder, hyperglycemia being considered the main risk factor for this pathology. Diabetic retinopathy also presents features of a low-grade chronic inflammatory disease, including increased levels of cytokines in the retina, such as interleukin-1 beta (IL-1β). Howeve...

journal_title：Mediators of inflammation

authors： Baptista FI,Aveleira CA,Castilho ÁF,Ambrósio AF

更新日期：2017-01-01 00:00:00

abstract：:Serine proteinases have been recognized as playing an important role in inflammation via proteinase activated receptors (PARs). However, little is known about the influence of serine proteinases and PARs on TNF secretion from highly purified T cells. We challenged T cells from human peripheral blood with serine protei...

journal_title：Mediators of inflammation

authors： Yang H,Li T,Wei J,Zhang H,He S

更新日期：2013-01-01 00:00:00

abstract：:Human periodontal ligament (hPDL) fibroblasts play a major role during periodontitis and orthodontic tooth movement, mediating periodontal inflammation, osteoclastogenesis, and collagen synthesis. The highly COX-2-selective NSAID etoricoxib has a favorable systemic side effect profile and high analgesic efficacy, part...

journal_title：Mediators of inflammation

authors： Kirschneck C,Küchler EC,Wolf M,Spanier G,Proff P,Schröder A

更新日期：2019-03-10 00:00:00

abstract：:Innate lymphoid cells (ILCs) are a group of hematopoietic cells devoid of antigen receptors that have important functions in lymphoid organogenesis, in the defense against extracellular pathogens, and in the maintenance of the epithelial barrier. Three distinct groups of ILCs have been identified on the basis of pheno...

journal_title：Mediators of inflammation

authors： Sedda S,Marafini I,Figliuzzi MM,Pallone F,Monteleone G

更新日期：2014-01-01 00:00:00

abstract：:Background. Neutrophilic bronchial inflammation is a main feature of bronchiectasis, but not much is known about its relationship with other disease features. Aim. To compare airway inflammatory markers with clinical and functional findings in subjects with stable noncystic fibrosis bronchiectasis (NCFB). Methods. 152...

journal_title：Mediators of inflammation

authors： Dente FL,Bilotta M,Bartoli ML,Bacci E,Cianchetti S,Latorre M,Malagrinò L,Nieri D,Roggi MA,Vagaggini B,Paggiaro P

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:We have previously reported a continuous activation of caspase-1 and increased interleukin (IL)-1β levels in early rheumatoid arthritis (RA). These observations raised the hypothesis that drugs targeting the IL-1β pathway, in addition to tumour necrosis factor (TNF), may be particularly effective for early R...

journal_title：Mediators of inflammation

authors： Cascão R,Vidal B,Raquel H,Neves-Costa A,Figueiredo N,Gupta V,Fonseca JE,Moita LF

更新日期：2014-01-01 00:00:00

abstract：:Autism is a neurodevelopmental disorder characterized by problems in communication, social skills, and repetitive behavior. Recent studies suggest that apoptotic and inflammatory mechanisms may contribute to the pathogenesis of this disorder. Nuclear factor-κB (NF-κB) is an important gene transcriptional factor involv...

journal_title：Mediators of inflammation

authors： Malik M,Tauqeer Z,Sheikh AM,Wen G,Nagori A,Yang K,Brown WT,Li X

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:Severe traumatization induces a complex pathophysiology, driven by the patient's own immune system. The initial activation is a result of damage-associated molecular patterns, which are released from disrupted and dying cells and recognized by immune receptors, for example, RAGE. In this study we aimed to ev...

journal_title：Mediators of inflammation

authors： Uhle F,Lichtenstern C,Brenner T,Fleming T,Koch C,Hecker A,Heiss C,Nawroth PP,Hofer S,Weigand MA,Weismüller K

更新日期：2015-01-01 00:00:00

abstract：:The pathogenesis of brain inflammation and damage by human immunodeficiency virus (HIV) infection is unclear. Because blood-brain barrier damage and impaired cerebral perfusion are common features of HIV-1 infection, we evaluated the role of tumour necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) in ...

journal_title：Mediators of inflammation

authors： Sharief MK,Ciardi M,Thompson EJ,Sorice F,Rossi F,Vullo V,Cirelli A

更新日期：1992-01-01 00:00:00

abstract：:The probiotic Enterococcus faecium HDRsEf1 (Ef1) has been shown to have positive effects on piglet diarrhoea, but the mechanism has not yet been elucidated. In this study, using the IPEC-J2 cell line to mimic intestinal epithelial cells and enterotoxigenic Escherichia coli (ETEC) K88ac as a representative intestinal p...

journal_title：Mediators of inflammation

authors： Tian Z,Liu X,Dai R,Xiao Y,Wang X,Bi D,Shi D

更新日期：2016-01-01 00:00:00

abstract：:High-fructose diet induced changes in gut microbiota structure and function, which have been linked to inflammatory response. However, the effect of small or appropriate doses of fructose on gut microbiota and inflammatory cytokines is not fully understood. Hence, the abundance changes of gut microbiota in fructose-tr...

journal_title：Mediators of inflammation

authors： Wang Y,Qi W,Song G,Pang S,Peng Z,Li Y,Wang P

更新日期：2020-11-30 00:00:00

abstract：:There is great need for a therapeutic that would limit tuberculosis related pathology and thus curtail spread of disease between individuals by establishing a "firebreak" to slow transmission. A promising avenue to increase current therapeutic efficacy may be through incorporation of adjunct components that slow or st...

journal_title：Mediators of inflammation

authors： Actor JK

更新日期：2015-01-01 00:00:00