Abstract:
:Recent investigations have indicated that reactive metabolites and AGE-RAGE-mediated inflammation might play an important role in the pathogenesis of ischemia-reperfusion injury in liver transplantation. In this observational clinical study, 150 patients were enrolled following liver transplantation from deceased donors. The occurrence of short-term complications within 10 days of transplantation was documented. Blood samples were collected prior to transplantation, immediately after transplantation, and at consecutive time points, for a total of seven days after transplantation. Plasma levels of methylglyoxal were determined using HPLC, whereas plasma levels of L-arginine, asymmetric dimethylarginine, advanced glycation endproducts-carboxylmethyllysine, soluble receptor for advanced glycation endproducts, and total antioxidant capacity were measured by ELISA. Patients following liver transplantation were shown to suffer from increased RAGE-associated inflammation with an AGE load mainly dependent upon reactive carbonyl species-derived AGEs. In contrast, carboxylmethyllysine-derived AGEs were of a minor importance. As assessed by the ratio of L-arginine/asymmetric dimethylarginine, the bioavailability of nitric oxide was shown to be reduced in hepatic IRI, especially in those patients suffering from perfusion disorders following liver transplantation. For the early identification of patients at high risk of perfusion disorders, the implementation of asymmetric dimethylarginine measurements in routine diagnostics following liver transplantation from deceased donors should be taken into consideration.
journal_name
Mediators Inflammjournal_title
Mediators of inflammationauthors
Brenner T,Fleming TH,Spranz D,Schemmer P,Bruckner T,Uhle F,Martin EO,Weigand MA,Hofer Sdoi
10.1155/2013/501430subject
Has Abstractpub_date
2013-01-01 00:00:00pages
501430eissn
0962-9351issn
1466-1861journal_volume
2013pub_type
杂志文章abstract::Acne inversa (AI; also designated as hidradenitis suppurativa) is a chronic inflammatory disease with still unknown pathogenesis that affects the intertriginous skin of perianal, inguinal, and axillary sites. It leads to painful nodules, abscesses, and fistulas with malodorous secretion and is frequently associated wi...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2016/4097574
更新日期:2016-01-01 00:00:00
abstract::The role of eosinophils in inflammation and their mode of activation is not well understood. Eosinophil accumulation and subsequent expression of cytokines at the site of inflammation may play a role in exacerbation of inflammatory responses. In the present study, we have examined the role of TNF-alpha in eosinophil a...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/S0962935196000312
更新日期:1996-01-01 00:00:00
abstract:BACKGROUND:Rodent models suggest that follistatin-like 3 (fstl3) is associated with diabetes and obesity. In humans, plasma fstl3 is reduced with gestational diabetes. In vitro, TNF-α induces fstl3 secretion, which suggests a link to inflammation. OBJECTIVE:To elucidate the association between plasma fstl3 and obesity...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2014/364209
更新日期:2014-01-01 00:00:00
abstract::Interleukin-33 (IL-33) is associated with the development of Th2 responses. This study examined the potential role of IL-33 in the pathogenic process of chronic hepatitis C (CHC) in Chinese patients. The levels of serum IL-33 and sST2 in 154 patients with CHC, 24 with spontaneously resolved HCV (SR-HCV) infection and ...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2012/819636
更新日期:2012-01-01 00:00:00
abstract::The purpose of this study is to characterize synovial fluid- (SF-) derived exosomes of patients with gonarthrosis comparing two methods of isolation and to investigate their immune regulatory properties. Extracellular vesicles (EVs) have been isolated from inflamed SF by polymer precipitation method and quantified by ...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2017/4814987
更新日期:2017-01-01 00:00:00
abstract::The aim of the present study was to compare serum levels of soluble forms of interleukin-2 receptor, CD4 and CD8, released by lymphocytes during activation of the immune system, in patients with allergic bronchial asthma, with those in healthy subjects. Significantly higher levels of soluble IL-2R and soluble CD4 were...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/S0962935195000433
更新日期:1995-01-01 00:00:00
abstract::In sarcoidosis, increased Th17 cell fractions have been reported in bronchoalveolar lavage fluid, and elevated numbers of Th17 cells producing IFN- γ have been observed in peripheral blood. The balance between Th1, Th17, and FoxP3(+) CD4(+) T cell subsets in sarcoidosis remains unclear. Bronchoalveolar lavage fluid ce...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2014/438070
更新日期:2014-01-01 00:00:00
abstract::We have observed uncontrollable cardiogenic shock as a cardiovascular manifestation of systemic inflammatory response syndrome (SIRS) leading to death in a 62-year-old woman. The diagnosis of SIRS was based on the demonstration of endotoxinaemia, and highly elevated plasma levels of tumour necrosis factor (TNF)-alpha,...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/S0962935195000731
更新日期:1995-01-01 00:00:00
abstract::We investigated the serum concentrations of interleukin-6 (IL-6) and two IL-6 family of cytokines (leukaemia inhibitory factor (LIF) and ciliary neurotrophic factor (CNTF) as well as IL-6 soluble receptor (sIL-6R) using an enzyme-linked immunosorbent assay (ELISA) in 66 patients with rheumatoid arthritis (RA) and 24 h...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1080/09629359890875
更新日期:1998-01-01 00:00:00
abstract::Cardiovascular disease linked to atherosclerosis is the leading cause of death worldwide. Atherosclerosis is mainly linked to dysfunction in vascular endothelial cells and subendothelial accumulation of oxidized forms of LDL. In the present study, we investigated the role of myeloperoxidase oxidized LDL (Mox-LDL) in e...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2014/134635
更新日期:2014-01-01 00:00:00
abstract::Aim. Inflammation is important in heart failure (HF). The role of the immune receptor toll-like receptor 9 (TLR9) in HF is not understood and not investigated in diastolic HF. We investigated the role of TLR9 in a murine diastolic HF model caused by cardiomyocyte SERCA2a excision. Methods and Results. We crossed SERCA...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2017/9450439
更新日期:2017-01-01 00:00:00
abstract::Tuberculosis is characterized by the presence of activated mononuclear cells both in the peripheral circulation and in pleural fluid. Expression and up-regulation of adhesion molecules is the basis of cell-cell adhesion in granuloma formation and in leukocyte migration to the inflammatory site. Soluble isoforms of adh...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/S0962935196000403
更新日期:1996-01-01 00:00:00
abstract::[This corrects the article DOI: 10.1155/2016/3214105.]. ...
journal_title:Mediators of inflammation
pub_type: 已发布勘误
doi:10.1155/2017/2917134
更新日期:2017-01-01 00:00:00
abstract::Multiple sclerosis (MS) is a chronic demyelinating disease of the human central nervous system (CNS). The condition predominantly affects young adults and is characterised by immunological and inflammatory changes in the periphery and CNS that contribute to neurovascular disruption, haemopoietic cell invasion of targe...
journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
doi:10.1155/MI/2006/93684
更新日期:2006-01-01 00:00:00
abstract:BACKGROUND:Asthma is a disorder characterized by a predominance of Th2 cells and eosinophilic inflammation. Suppressors of cytokine signaling (SOCS) proteins act as negative regulators of cytokine signaling. In particular, SOCS1 and SOCS3 play an important role in immune response by controlling the balance between Th1 ...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2011/823279
更新日期:2011-01-01 00:00:00
abstract::Multiple sclerosis is an autoimmune disease with classical traits of demyelination, axonal damage, and neurodegeneration. The migration of autoimmune T cells and macrophages from blood to central nervous system as well as the destruction of blood brain barrier are thought to be the major processes in the development o...
journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
doi:10.1155/2014/659206
更新日期:2014-01-01 00:00:00
abstract::Mammalian placentation is a vital facet of the development of a healthy and viable offspring. Throughout gestation the placenta changes to accommodate, provide for, and meet the demands of a growing fetus. Gestational gene expression is a crucial part of placenta development. The endocannabinoid pathway is activated i...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2015/850471
更新日期:2015-01-01 00:00:00
abstract::The acute respiratory distress syndrome (ARDS), a clinical complication of severe acute lung injury (ALI) in humans, is a leading cause of morbidity and mortality in critically ill patients. Despite decades of research, few therapeutic strategies for clinical ARDS have emerged. Here we carefully evaluated the effect o...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2012/540794
更新日期:2012-01-01 00:00:00
abstract:Objective:Renal ischemia/reperfusion injury (RI/RI) is the main cause of acute kidney injury. Total glucosides of paeony (TGP) are a traditional Chinese medicine. This study was aimed at exploring the role of TGP in RI/RI and its underlying mechanism of action. Methods:Rat RI/RI models were constructed by surgical ope...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2020/8869511
更新日期:2020-11-24 00:00:00
abstract::Human Vγ9Vδ2 T cells recognise pyrophosphate-based antigens (phosphoantigens) and have multiple functions in innate and adaptive immunity, including a unique ability to activate other cells of the immune system. We used flow cytometry and ELISA to define the early cytokine profiles of Vγ9Vδ2 T cells stimulated in vitr...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2010/704941
更新日期:2010-01-01 00:00:00
abstract::Little is known about the cause and pathophysiology of middermal elastolysis (MDE). In this condition, variable inflammatory infiltrate may be present or not together with loss of elastic fibres in the middermis that spares both papillary and lower reticular dermis. MDE may be a consequence of abnormal extracellular m...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2017/9524594
更新日期:2017-01-01 00:00:00
abstract::Recent studies suggest that tumor-associated macrophage-produced IL-6 is an important mediator within the tumor microenvironment that promotes tumor growth. The activation of IL-6/STAT3 axis has been associated with chemoresistance and poor prognosis of a variety of cancers including colorectal carcinoma and thus serv...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2016/8026494
更新日期:2016-01-01 00:00:00
abstract::Thousands of people suffer from severe malaria every year. The innate immune response plays a determinant role in host's defence to malaria. Transient receptor potential vanilloid 1 (TRPV1) modulates macrophage-mediated responses in sepsis, but its role in other pathogenic diseases has never been addressed. We investi...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2014/506450
更新日期:2014-01-01 00:00:00
abstract::Methyltransferase-like 3 (METTL3), an RNA N6-methyladenosine (m6A) methyltransferase, is essential for the m6A mRNA modification. As a key enzyme of m6A methylation modification, METTL3 has been implicated in immune and inflammation regulation. However, little is known of the role and underlying mechanism of METTL3 in...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2019/3120391
更新日期:2019-10-24 00:00:00
abstract::Rheumatoid arthritis (RA) is characterized by an abnormal cellular and cytokine infiltration of inflamed joints. This study addresses a previously unrecognized interaction between neutrophilic-myeloperoxidase (MPO) and macrophages (Mphi) which could explain the perpetuation of inflammation associated with RA. A monoar...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1080/09629359890758
更新日期:1998-01-01 00:00:00
abstract::Acute necrotizing encephalopathy (ANE) is a rare but distinctive type of acute encephalopathy with global distribution. Occurrence of ANE is usually preceded by a virus-associated febrile illness and ensued by rapid deterioration. However, the causal relationship between viral infections and ANE and the exact pathogen...
journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
doi:10.1155/2015/792578
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND:Nonbacterial prostatitis has no established etiology. We hypothesized that proteinase-activated receptor-1 (PAR1) can play a role in prostatitis. We therefore investigated the effects of PAR1 stimulation in the context of a new model of murine nonbacterial prostatitis. METHODS:Using a hapten (ethanol-dinitr...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2013/748395
更新日期:2013-01-01 00:00:00
abstract::Enterovirus 71 (EV71) is one of the most common intestinal virus that causes hand, foot, and mouth disease (HFMD) in infants and young children (mostly ≤5 years of age). Generally, children with EV71-infected HFMD have mild symptoms that resolve spontaneously within 7-14 days without complications. However, some EV71-...
journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
doi:10.1155/2020/9273241
更新日期:2020-01-31 00:00:00
abstract:Background:Over the last 20 years, the prevalence of hepatitis B virus (HBV) infection in China has decreased gradually due to the application of a national HBV vaccination program. In contrast, the prevalence of alcoholic liver disease (ALD), nonalcoholic fatty liver disease, autoimmune liver disease, and drug-induced...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2017/5605981
更新日期:2017-01-01 00:00:00
abstract::H. pylori induces a complicated local and systematic immune response and contributes to the carcinogenesis of gastric cancer. A primary type 1 immune response is evoked by H. pylori since its occurrence. However, it is not unusual that an inhibitory immunity is dominant in H. pylori-associated diseases, which are prom...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2017/4927964
更新日期:2017-01-01 00:00:00