Total Glucosides of Paeony Alleviate Cell Apoptosis and Inflammation by Targeting the Long Noncoding RNA XIST/MicroRNA-124-3p/ITGB1 Axis in Renal Ischemia/Reperfusion Injury.

abstract：:Monocyte chemotactic protein (MCP-1) is a specific monocyte chemoattractant and activating factor produced by both immune cells (mononuclear phagocytes and lymphocytes) and non-immune cells (parenchymal and stromal cells). In order to define the conditions under which human monocytes express MCP-1, monocytes were expo...

journal_title：Mediators of inflammation

authors： Liebler JM,Kunkel SL,Allen RM,Burdick MD,Strieter RM

更新日期：1994-01-01 00:00:00

abstract：BACKGROUND:Exhaled nitric oxide (FeNO) has been reported to be elevated in the oxidative stress involved in asthmatic patients, and the reaction of nitric oxide (NO) with superoxide anions results in the formation of nitrotyrosine. The purpose of this study was to investigate the effect of inhaled steroid treatment on ...

journal_title：Mediators of inflammation

authors： Bodini A,Peroni DG,Zardini F,Corradi M,Alinovi R,Boner AL,Piacentini GL

更新日期：2006-01-01 00:00:00

abstract：:Tumor necrosis factor alpha (TNF-α) is a potent proinflammatory cytokine that plays a significant role in the pathogenesis of asthma by inducing hyperresponsiveness and airway remodeling. TNF-α diminishes the L-type voltage dependent Ca(2+) channel (L-VDCC) current in cardiac myocytes, an observation that seems parado...

journal_title：Mediators of inflammation

authors： Reyes-García J,Flores-Soto E,Solís-Chagoyán H,Sommer B,Díaz-Hernández V,García-Hernández LM,Montaño LM

更新日期：2016-01-01 00:00:00

abstract：:Little is known about the cause and pathophysiology of middermal elastolysis (MDE). In this condition, variable inflammatory infiltrate may be present or not together with loss of elastic fibres in the middermis that spares both papillary and lower reticular dermis. MDE may be a consequence of abnormal extracellular m...

journal_title：Mediators of inflammation

authors： De Cunto G,Lamberti A,de Santi MM,Miracco C,Fimiani M,Lungarella G,Cavarra E

更新日期：2017-01-01 00:00:00

abstract：:Although the initiating events of Crohn's disease are unknown, models of experimental colitis have provided new insights in the immunologically mediated pathways of mucosal inflammation. In Crohn's disease activated mucosal T lymphocytes produce proinflammatory cytokines within the mucosal compartment. With this under...

journal_title：Mediators of inflammation

authors： van Montfrans C,Camoglio L,van Deventer SJ

更新日期：1998-01-01 00:00:00

abstract：BACKGROUND:Asthma is characterized by airway remodeling. Follistatin-like protein 1 (FSTL1) is an extracellular glycoprotein. Recent studies suggest that FSTL1 may participate in the pathogenesis of asthma. OBJECTIVES:To analyze the association between FSTL1 and some parameters and inspect the role of FSTL1 in asthma....

journal_title：Mediators of inflammation

authors： Liu Y,Liu T,Wu J,Li T,Jiao X,Zhang H,Zhao J,Wang J,Liu L,Cao L,Li S,Xu J,Xu J,Ma X,Yang L,Dong L

更新日期：2017-01-01 00:00:00

abstract：Aim:The objective of the current study is to analyze the correlation between cytokine levels and periodontal parameters in aggressive periodontitis patients before and after periodontal treatment that was performed by using two different laser therapies. Materials and Methods:Twenty-six generalized aggressive periodon...

journal_title：Mediators of inflammation

authors： Talmac AC,Calisir M,Eroglu EG,Ertugrul AS

更新日期：2019-06-12 00:00:00

abstract：:Endothelial dysfunction is regarded as an important factor in the pathogenesis of vascular disease in obesity-related type 2 diabetes. The imbalance in repair and injury (hyperglycemia, hypertension, dyslipidemia) results in microvascular changes, including apoptosis of microvascular cells, ultimately leading to diabe...

journal_title：Mediators of inflammation

authors： van den Oever IA,Raterman HG,Nurmohamed MT,Simsek S

更新日期：2010-01-01 00:00:00

abstract：Background:Inflammation plays a pivotal role in the pathogenesis of chronic obstructive pulmonary disease (COPD). We evaluated the lncRNA and mRNA expression profile of peripheral blood mononuclear cells (PBMCs) from healthy nonsmokers, smokers without airflow limitation, and COPD patients. Methods:lncRNA and mRNA pro...

journal_title：Mediators of inflammation

authors： Qu X,Dang X,Wang W,Li Y,Xu D,Shang D,Chang Y

更新日期：2018-03-13 00:00:00

abstract：BACKGROUND:Empirical observations have shown that ozonated autohemotherapy markedly improves the symptoms of chronic limb ischemia (muscular pain at rest, intermittent claudication, etc) in atherosclerotic patients, but mechanisms of action remain unclear. AIMS:Human endothelial cells (HUVECs) are known to release nit...

journal_title：Mediators of inflammation

authors： Valacchi G,Bocci V

更新日期：2000-01-01 00:00:00

abstract：BACKGROUND:Production of antibodies that are specific for allergens is an important pathological process in inflammatory allergic diseases. These contain the antibodies against antigens of Candida albicans, one of the normal microbial flora in an intestinal tract. We studied the effects of the prednisolone administrati...

journal_title：Mediators of inflammation

authors： Tansho S,Abe S,Ishibashi H,Mitsuya M,Wada K,Ikeda T,Suegara N,Koshio O,Ono Y,Yamaguchi H

更新日期：2004-06-01 00:00:00

abstract：Background:Sepsis-induced myocardial dysfunction is a severe clinical problem. Recent studies have indicated that autophagy and myocardial energy depletion play a major role in myocardial dysfunction during sepsis, a mechanistic target of rapamycin (mTOR) as a master sensor of energy status and autophagy mediator; howe...

journal_title：Mediators of inflammation

authors： Han W,Wang H,Su L,Long Y,Cui N,Liu D

更新日期：2018-06-28 00:00:00

abstract：:The human virome comprises viruses that infect host cells, virus-derived elements in our chromosomes, and viruses that infect other organisms, including bacteriophages and plant viruses. The development of high-throughput sequencing techniques has shown that the human gut microbiome is a complex community in which the...

journal_title：Mediators of inflammation

authors： Focà A,Liberto MC,Quirino A,Marascio N,Zicca E,Pavia G

更新日期：2015-01-01 00:00:00

abstract：:The most frequent pathogen that causes bacterial meningitis is the Gram-positive bacterium Streptococcus pneumoniae. By entering the brain, host cells will be activated and proinflammatory cytokines like interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) are released. The goal of the current study was to examine...

journal_title：Mediators of inflammation

authors： Albrecht LJ,Tauber SC,Merres J,Kress E,Stope MB,Jansen S,Pufe T,Brandenburg LO

更新日期：2016-01-01 00:00:00

abstract：:Paraoxonase 1 (PON1) activity is markedly influenced by coding polymorphisms, Q/R at position 192 and M/L at position 55 of the PON1 gene. We investigated the frequencies of these polymorphisms and their effects on PON1 and antioxidant activities in 844 South African mixed ancestry individuals. Genotyping was done usi...

journal_title：Mediators of inflammation

authors： Macharia M,Kengne AP,Blackhurst DM,Erasmus RT,Matsha TE

更新日期：2014-01-01 00:00:00

abstract：:Mammalian placentation is a vital facet of the development of a healthy and viable offspring. Throughout gestation the placenta changes to accommodate, provide for, and meet the demands of a growing fetus. Gestational gene expression is a crucial part of placenta development. The endocannabinoid pathway is activated i...

journal_title：Mediators of inflammation

authors： Vaswani K,Chan HW,Peiris HN,Nitert MD,Bradley RJ,Armitage JA,Rice GE,Mitchell MD

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Growth arrest specific gene 6 (Gas6) protein enhances survival of oligodendrocytes and neurons, and it is involved in autoimmunity. Therefore, we aimed to verify whether cerebrospinal-fluid (CSF) Gas6 concentration may represent a biomarker of disease activity in multiple sclerosis. METHODS:Sixty-five patie...

journal_title：Mediators of inflammation

authors： Sainaghi PP,Collimedaglia L,Alciato F,Molinari R,Sola D,Ranza E,Naldi P,Monaco F,Leone M,Pirisi M,Avanzi GC

更新日期：2013-01-01 00:00:00

abstract：:[This corrects the article DOI: 10.1155/2019/2056085.]. ...

journal_title：Mediators of inflammation

authors： Pacheco-Fernández T,Juárez-Avelar I,Illescas O,Terrazas LI,Hernández-Pando R,Pérez-Plasencia C,Gutiérrez-Cirlos EB,Ávila-Moreno F,Chirino YI,Reyes JL,Maldonado V,Rodriguez-Sosa M

更新日期：2020-06-17 00:00:00

abstract：:One of the most globally prevalent supraventricular arrhythmias is atrial fibrillation (AF). Knowledge of the structures and functions of messenger RNA (mRNA) has recently increased. It is no longer viewed as solely an intermediate molecule between DNA and proteins but has come to be seen as a dynamic and modifiable g...

journal_title：Mediators of inflammation

authors： Xu X,Zhao Z,Li G

更新日期：2020-03-12 00:00:00

abstract：:Inflammation is considered to be one of the most critical factors involved in the development of complex metabolic diseases such as type 2 diabetes, cancer, and cardiovascular disease. A few decades ago, the discovery of mitochondria-associated endoplasmic reticulum (ER) membrane (MAM) was followed by the identificati...

journal_title：Mediators of inflammation

authors： Thoudam T,Jeon JH,Ha CM,Lee IK

更新日期：2016-01-01 00:00:00

abstract：:Neonates are extremely susceptible to bacterial infections, and evidences suggest that phagocytosis-induced cell death (PICD) is less frequently triggered in neonatal monocytes than in monocytes from adult donors. An insufficient termination of the inflammatory response, leading to a prolonged survival of neonatal mon...

journal_title：Mediators of inflammation

authors： Platen C,Dreschers S,Wappler J,Ludwig A,Düsterhöft S,Reiss LK,Orlikowsky TW

更新日期：2019-11-03 00:00:00

abstract：:The present study investigated the association between the rs12979860 polymorphism in the IL-28B gene and HTLV-1 infection as well as the development of HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). HTLV-1-infected patients (26 HAM/TSP symptomatic and 53 asymptomatic) and 300 seronegative health...

journal_title：Mediators of inflammation

authors： Vallinoto AC,Santana BB,Sá KS,Ferreira TC,Sousa RC,Azevedo VN,Feitosa RN,Machado LF,Ishak MO,Ishak R

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:In smoking COPD patients the bronchoalveolar lavage (BAL) fluid contains high numbers of inflammatory cells. These cells might produce arachidonic acid (AA) metabolites, which contribute to inflammation and an increased bronchomotor tone. AIMS:To investigate levels of AA metabolites in BAL fluid, before and...

journal_title：Mediators of inflammation

authors： Verhoeven GT,Garrelds IM,Hoogsteden HC,Zijlstra FJ

更新日期：2001-02-01 00:00:00

abstract：:The mixed leukocyte population obtained from the peritoneum of the August rat is a potentially important experimental model of inherent eosinophilia that has not been well characterized. In the present study, isolated cell preparations generated a concentration-dependent release of leukotriene (LT) C(4) when exposed t...

journal_title：Mediators of inflammation

authors： Huebner JM,Eversole RR,Jackson WF,Mackenzie CD,Stapleton SR,Beuving LJ

更新日期：1996-01-01 00:00:00

abstract：:To determine the role of mutant SOD1 gene (SOD1(G93A)) on muscle cell differentiation, we derived C2C12 muscle cell lines carrying a stably transfected SOD1(G93A) gene under the control of a myosin light chain (MLC) promoter-enhancer cassette. Expression of MLC/SOD1(G93A) in C2C12 cells resulted in dramatic inhibition...

journal_title：Mediators of inflammation

authors： Martini M,Dobrowolny G,Aucello M,Musarò A

更新日期：2015-01-01 00:00:00

abstract：:We report here that the leptomeningeal cells transduce inflammatory signals from peripheral macrophages to brain-resident microglia in response to Porphyromonas gingivalis (P.g.) LPS. The expression of Toll-like receptor 2 (TLR2), TLR4, TNF-α, and inducible NO synthase was mainly detected in the gingival macrophages o...

journal_title：Mediators of inflammation

authors： Liu Y,Wu Z,Zhang X,Ni J,Yu W,Zhou Y,Nakanishi H

更新日期：2013-01-01 00:00:00

abstract：:Parasites of the genus Leishmania are capable of inhibiting effector functions of macrophages. These parasites have developed the adaptive ability to escape host defenses; for example, they inactivate the NF-κB complex and suppress iNOS expression in infected macrophages, which are responsible for the production of th...

journal_title：Mediators of inflammation

authors： Marcusso Orsini T,Kawakami NY,Panis C,Fortes Dos Santos Thomazelli AP,Tomiotto-Pellissier F,Cataneo AH,Kian D,Megumi Yamauchi L,Gouveia Júnior FS,de França Lopes LG,Cecchini R,Nazareth Costa I,Jerley Nogueira da Silva J,Conchon

更新日期：2016-01-01 00:00:00

abstract：:Surgery induces release of neuroendocrine hormones (cortisol), cytokines (interleukin-6: IL-6, tumour necrosis factor-alpha: TNF-alpha), acute phase proteins (C-reactive protein: CRP, leptin). We studied the effects of general and spinal anaesthesia on stress response to haemorrhoidectomy. Patients were assigned to ge...

journal_title：Mediators of inflammation

authors： Buyukkocak U,Caglayan O,Daphan C,Aydinuraz K,Saygun O,Agalar F

更新日期：2006-01-01 00:00:00

abstract：:Cytokine-induced endothelial dysfunction leads to inflammation and vascular adhesion molecule production in retinal pigment epithelium (RPE) cells. Inflammation is a critical mediator in retinal degeneration (RD) diseases, including age-related macular degeneration (AMD), and RD progression may be prevented through an...

journal_title：Mediators of inflammation

authors： Huang WC,Liou CJ,Shen SC,Hu S,Hsiao CY,Wu SJ

更新日期：2020-10-16 00:00:00

abstract：:The apoptosis-associated speck-like protein containing a caspase recruit domain (ASC) is involved in apoptosis and innate immunity and is a major adaptor molecule responsible for procaspase-1 activation. ASC mRNA is encoded by three exons: exons 1 and 3 encode a pyrin domain (PYD) and caspase recruit domain (CARD), re...

journal_title：Mediators of inflammation

authors： Matsushita K,Takeoka M,Sagara J,Itano N,Kurose Y,Nakamura A,Taniguchi S

更新日期：2009-01-01 00:00:00