Gut inflammation and immunity: what is the role of the human gut virome?

abstract：:The purpose of this study is to assess the role of nitric oxide (NO) in the intestinal lesions of passive anaphylaxis, since this experimental model resembles necrotizing enterocolitis. Sprague-Dawley rats were sensitized with IgE anti-dinitrophenol monoclonal antibody. Extravasation of protein-rich plasma and haemorr...

journal_title：Mediators of inflammation

authors： Tavares JC,Moreno A,Crespo MS

更新日期：1997-01-01 00:00:00

abstract：:Infection by Leishmania takes place in the context of inflammation and tissue repair. Besides tissue resident macrophages, inflammatory macrophages and neutrophils are recruited to the infection site and serve both as host cells and as effectors against infection. Recent studies suggest additional important roles for ...

journal_title：Mediators of inflammation

authors： Lopes MF,Costa-da-Silva AC,DosReis GA

更新日期：2014-01-01 00:00:00

abstract：:The observed effects after ozone exposure strongly depend on ozone concentration and exposure time. We hypothesized that depending on the O3 exposure protocol, mainly either an oxidant damage or an inflammation will determine the O3 toxicity. We compared two different ozone exposure protocols: an acute exposure (3 ppm...

journal_title：Mediators of inflammation

authors： van Hoof HJ,Zijlstra FJ,Voss HP,Garrelds IM,Dormans JA,van Bree L,Bast A

更新日期：1997-01-01 00:00:00

abstract：:Endothelial dysfunction is regarded as an important factor in the pathogenesis of vascular disease in obesity-related type 2 diabetes. The imbalance in repair and injury (hyperglycemia, hypertension, dyslipidemia) results in microvascular changes, including apoptosis of microvascular cells, ultimately leading to diabe...

journal_title：Mediators of inflammation

authors： van den Oever IA,Raterman HG,Nurmohamed MT,Simsek S

更新日期：2010-01-01 00:00:00

abstract：:Methyltransferase-like 3 (METTL3), an RNA N6-methyladenosine (m6A) methyltransferase, is essential for the m6A mRNA modification. As a key enzyme of m6A methylation modification, METTL3 has been implicated in immune and inflammation regulation. However, little is known of the role and underlying mechanism of METTL3 in...

journal_title：Mediators of inflammation

authors： Wang J,Yan S,Lu H,Wang S,Xu D

更新日期：2019-10-24 00:00:00

abstract：:Recent studies suggest that tumor-associated macrophage-produced IL-6 is an important mediator within the tumor microenvironment that promotes tumor growth. The activation of IL-6/STAT3 axis has been associated with chemoresistance and poor prognosis of a variety of cancers including colorectal carcinoma and thus serv...

journal_title：Mediators of inflammation

authors： Wang ZY,Zhang JA,Wu XJ,Liang YF,Lu YB,Gao YC,Dai YC,Yu SY,Jia Y,Fu XX,Rao X,Xu JF,Zhong J

更新日期：2016-01-01 00:00:00

abstract：:TThe molecular mechanisms responsible for the development of hepatic fibrosis are not fully understood. The Nlrc4 inflammasome detects cytosolic presence of bacterial components, activating inflammatory cytokines to facilitate clearance of pathogens and infected cells. We hypothesized that low-grade constitutive activ...

journal_title：Mediators of inflammation

authors： DeSantis DA,Ko CW,Wang L,Lee P,Croniger CM

更新日期：2015-01-01 00:00:00

abstract：:Current studies have identified the multifaceted protective functions of dexmedetomidine on multiple organs. For the first time, we clarify effects of dexmedetomidine on monocyte-endothelial adherence and whether its underlying mechanism is relative to connexin43 (Cx43), a key factor regulating monocyte-endothelial ad...

journal_title：Mediators of inflammation

authors： Chai Y,Yu R,Liu Y,Wang S,Yuan D,Chen J

更新日期：2020-02-10 00:00:00

abstract：:Mechanical ventilation (MV) is a major life support technique for the management of trauma-associated hemorrhagic shock (HS). Ventilator-induced diaphragm dysfunction (VIDD), one of the most common complications of MV, has been well demonstrated in animal and human studies. However, few data are available concerning t...

journal_title：Mediators of inflammation

authors： Zhang LJ,Ni SZ,Zhou XL,Zhao Y

更新日期：2019-11-14 00:00:00

abstract：:Background. Inflammation mediators related to radiation proctitis are partially elucidated, and neovascularization is thought to play a key role. Objectives. To investigate the expression of vascular endothelial growth factor (VEGF) and CD31 as angiogenetic markers in postradiation rectal tissue. Methods. Rectal mucos...

journal_title：Mediators of inflammation

authors： Karamanolis G,Delladetsima I,Kouloulias V,Papaxoinis K,Panayiotides I,Haldeopoulos D,Triantafyllou K,Kelekis N,Ladas SD

更新日期：2013-01-01 00:00:00

abstract：:Procalcitonin (PCT) is one of the best diagnostic and prognostic markers in clinical practice, widely used to evaluate the evolution of bacterial infections. Although it is mainly produced by thyroid, during sepsis almost all the peripheral tissues are involved in PCT production. Parenchymal cells have been suggested ...

journal_title：Mediators of inflammation

authors： Rami D,La Bianca M,Agostinis C,Zauli G,Radillo O,Bulla R

更新日期：2014-01-01 00:00:00

abstract：:The mechanism of pain reduction involves bidirectional processes of pain blocking (nociception) and reductions in the levels of proinflammatory cytokines in the blood. Does transcutaneous electrical nerve stimulation (TENS) reduce blood levels of proinflammatory cytokines? For this systematic review, we searched in si...

journal_title：Mediators of inflammation

authors： do Carmo Almeida TC,Dos Santos Figueiredo FW,Barbosa Filho VC,de Abreu LC,Fonseca FLA,Adami F

更新日期：2018-04-02 00:00:00

abstract：:Observation of the microcirculation of the hamster cheek pouch by intravital microscopy revealed five steps of neutrophil migration from the venules after topical application of leukotriene B(4) to the microvasculature: rolling along the venular wall (Step 1), adhesion to it (Step 2), disappearance from the vascular l...

journal_title：Mediators of inflammation

authors： Oda T,Katori M,Hatanaka K,Nagai Y

更新日期：1995-01-01 00:00:00

abstract：:Dysfunction of the blood-brain barrier (BBB) is a primary characteristic of experimental autoimmune encephalomyelitis (EAE), an experimental model of multiple sclerosis (MS). Matrine (MAT), a quinolizidine alkaloid derived from the herb Radix Sophorae Flave, has been recently found to suppress clinical EAE and CNS inf...

journal_title：Mediators of inflammation

authors： Zhang S,Kan QC,Xu Y,Zhang GX,Zhu L

更新日期：2013-01-01 00:00:00

abstract：:Severe acute pancreatitis (SAP) characterized by atrocious progression and numerous complications often leads to a high mortality rate due to hypermetabolism, systemic inflammatory response syndrome (SIRS), and multiple organs dysfunction syndrome (MODS). Studies have revealed that both early enteral nutrition (EEN) a...

journal_title：Mediators of inflammation

authors： Wang G,Sun B,Gao Y,Meng QH,Jiang HC

更新日期：2007-01-01 00:00:00

abstract：:Cathepsin G is a serine protease secreted by activated neutrophils that play a role in the inflammatory response. Because neutrophils are known to be invading leukocytes in various tumors, their products may influence the characteristics of tumor cells such as the growth state, motility, and the adhesiveness between c...

journal_title：Mediators of inflammation

authors： Kudo T,Kigoshi H,Hagiwara T,Takino T,Yamazaki M,Yui S

更新日期：2009-01-01 00:00:00

abstract：:The mechanisms underlying the recurrence of atrial fibrillation (AF) after radiofrequency catheter ablation (RFCA) are not well concerned. The study sought to explore the association between growth differentiation factor-15 (GDF-15) and the incidence of recurrent events among AF patients after the ablation procedure. ...

journal_title：Mediators of inflammation

authors： Wei Y,Liu S,Yu H,Zhang Y,Gao W,Cui M,Li L

更新日期：2020-08-21 00:00:00

abstract：Background:Sepsis-induced myocardial dysfunction is a severe clinical problem. Recent studies have indicated that autophagy and myocardial energy depletion play a major role in myocardial dysfunction during sepsis, a mechanistic target of rapamycin (mTOR) as a master sensor of energy status and autophagy mediator; howe...

journal_title：Mediators of inflammation

authors： Han W,Wang H,Su L,Long Y,Cui N,Liu D

更新日期：2018-06-28 00:00:00

abstract：:Accumulated studies have implicated microRNAs (miRNAs) exert modifying effects on colorectal cancer (CRC). Protein tyrosine phosphatase, receptor type O (PTPRO) has been identified as a tumor suppressor in several kinds of cancer, including CRC. Previously, we have found that exosome-encapsulated miR-6803-5p is increa...

journal_title：Mediators of inflammation

authors： Yan S,Cheng M,Duan Q,Wang Z,Gao W,Ren B,Xu D

更新日期：2019-11-20 00:00:00

abstract：:Acne inversa (AI; also designated as hidradenitis suppurativa) is a chronic inflammatory disease with still unknown pathogenesis that affects the intertriginous skin of perianal, inguinal, and axillary sites. It leads to painful nodules, abscesses, and fistulas with malodorous secretion and is frequently associated wi...

journal_title：Mediators of inflammation

authors： Tsaousi A,Witte E,Witte K,Röwert-Huber HJ,Volk HD,Sterry W,Wolk K,Schneider-Burrus S,Sabat R

更新日期：2016-01-01 00:00:00

abstract：:Postoperative cognitive dysfunction (POCD) increases morbidity and mortality after surgery. But the underlying mechanism is not clear yet. While age is now accepted as the top one risk factor for POCD, results from studies investigating postoperative cognitive functions in adults have been controversial, and data abou...

journal_title：Mediators of inflammation

authors： Zhao Y,Huang L,Xu H,Wu G,Zhu M,Tian J,Wang H,Wang X,Yu W,Yang L,Su D

更新日期：2016-01-01 00:00:00

abstract：:Silica inhalation can induce chronic lung inflammation and fibrosis. Upon silica stimulation, activated macrophages trigger the T-lymphocyte which can differentiate into many different types of Th cells, including the recently discovered Th17 cells. IL-17A, the typical Th17 cytokine, is reported in some inflammatory d...

journal_title：Mediators of inflammation

authors： Tang W,Liu F,Chen Y,Song L,Dai W,Li C,Weng D,Chen J

更新日期：2014-01-01 00:00:00

abstract：PURPOSE:To assess FGF-β, TGF-β, and COX2 expression and immunocompetent cells in the orbital tissue of patients with severe and mild Graves' orbitopathy. PATIENTS AND METHODS:Orbital tissue was taken from 27 patients with GO: (1) severe GO (n = 18), the mean clinical activity score (CAS) being 8.5 (SD 2.5); and (2) mi...

journal_title：Mediators of inflammation

authors： Pawlowski P,Reszec J,Eckstein A,Johnson K,Grzybowski A,Chyczewski L,Mysliwiec J

更新日期：2014-01-01 00:00:00

abstract：:Macrophages contribute to a continuous increase in blood pressure and kidney damage in hypertension, but their polarization status and the underlying mechanisms have not been clarified. This study revealed an important role for M2 macrophages and the YM1/Chi3l3 protein in hypertensive nephropathy in a mouse model of h...

journal_title：Mediators of inflammation

authors： Cavalcante PAM,Alenina N,Budu A,Freitas-Lima LC,Alves-Silva T,Agudelo JSH,Qadri F,Camara NOS,Bader M,Araújo RC

更新日期：2019-07-10 00:00:00

abstract：OBJECTIVES:In the present study, the ability of magnolol, a hydroxylated biphenyl compound isolated from Magnolia officinalis, to stimulate osteoblast function and inhibit the release of bone-resorbing mediators was investigated in osteoblastic MC3T3-E1 cells. METHODS:Osteoblast function was measured by cell growth, a...

journal_title：Mediators of inflammation

authors： Kwak EJ,Lee YS,Choi EM

更新日期：2012-01-01 00:00:00

abstract：:Fluid of artificial blisters from erythromelalgic skin areas in primary thrombocythaemia contained a high amount of prostaglandin-E-like activity. Dazoxiben did not alleviate the erythromelalgia in patients with primary thrombocythaemia despite complete inhibition of platelet malondialdehyde and thromboxane B(2) synth...

journal_title：Mediators of inflammation

authors： Michiels JJ,Zijlstra FJ

更新日期：1993-01-01 00:00:00

abstract：:This study investigated whether the administration of resolvin D1 to rats with endotoxininduced uveitis (EIU) ameliorates the immuno-inflammatory profile of the eye. 24 h after the administration of 200 μg LPS into the footpad of Sprague-Dawley rats, severe changes of the structure of the eye occurred concomitantly wi...

journal_title：Mediators of inflammation

authors： Settimio R,Clara DF,Franca F,Francesca S,Michele D

更新日期：2012-01-01 00:00:00

abstract：:Paricalcitol, a selective vitamin D receptor (VDR) activator used for treatment of secondary hyperparathyroidism in chronic kidney disease (CKD), has been associated with survival advantages, suggesting that this drug, beyond its ability to suppress parathyroid hormone, may have additional beneficial actions. In this ...

journal_title：Mediators of inflammation

authors： Donate-Correa J,Domínguez-Pimentel V,Méndez-Pérez ML,Muros-de-Fuentes M,Mora-Fernández C,Martín-Núñez E,Cazaña-Pérez V,Navarro-González JF

更新日期：2014-01-01 00:00:00

abstract：:Plasma levels of endotoxin and various cytokines were assessed in 70 patients with gastrointestinal tract perforation. Sepsis developed in 29 of them, and eight of these (27.6%) had on admission endotoxin levels higher than 9.8 pg ml(-1). The clinical outcome correlated with the level of tumour necrosis factor alpha (...

journal_title：Mediators of inflammation

authors： Endo S,Inada K,Inoue Y,Otsu T,Kasai T,Kuwata Y,Hoshi S,Yoshida M

更新日期：1992-01-01 00:00:00

abstract：:A TP II analogue, [1-Nal3] TP II, was synthesized by a conventional solution method, followed by deprotection with 1M TFMSA-thioanisole (molar ratio 1:1) in TFA in the presence of Me2Se and m-cresol as scavengers. The synthetic [1-Nal3] TP II, TP II and [Phe (4 F)3] TP II were tested for comparative effect on the impa...

journal_title：Mediators of inflammation

authors： Abiko T,Nakatsubo S

更新日期：2000-01-01 00:00:00