Inhibitory effect of matrine on blood-brain barrier disruption for the treatment of experimental autoimmune encephalomyelitis.

abstract：OBJECTIVE:Our aim was to evaluate the significance of homocysteine (Hcy) in Behcet's disease (BD) and the association of elevated Hcy levels associated with the indices of inflammation in BD. METHODS:Untreated 70 patients with BD and 33 healthy individuals were included into the study. Hcy, tumor necrosis alpha (TNF-a...

journal_title：Mediators of inflammation

authors： Kartal Durmazlar SP,Akgul A,Eskioglu F

更新日期：2008-01-01 00:00:00

abstract：:In this study, we investigated in groups of female BALB/c mice injected with Crotalus durissus terrificus venom (Cdt) the renal function based on creatinine clearance, percentage of fractional excretion cytokines and histological examination of renal tissue. Cdt caused renal alterations that induced proteinuria during...

journal_title：Mediators of inflammation

authors： Hernández Cruz A,Barbosa Navarro L,Mendonça RZ,Petricevich VL

更新日期：2011-01-01 00:00:00

abstract：:Obesity characterized by increased mass of adipose tissue leads to systemic inflammation. Calorie restriction (CR) improves parameters associated with immune response and antioxidant defense. We hypothesized that CR with a high fat diet (HFCR) regulates local and systemic inflammation and oxidative stress damage in a ...

journal_title：Mediators of inflammation

authors： Park S,Park NY,Valacchi G,Lim Y

更新日期：2012-01-01 00:00:00

abstract：:L-Arginine is converted to the highly reactive and unstable nitric oxide (NO) and L-citrulline by an enzyme named nitric oxide synthase (NOS). NO decomposes into other nitrogen oxides such as nitrite (NO(2) (-)) and nitrate (NO(2) (-)), and in the presence of superoxide anion to the potent oxidizing agent peroxynitrit...

journal_title：Mediators of inflammation

authors： Jorens PG,Matthys KE,Bult H

更新日期：1995-01-01 00:00:00

abstract：:The causes of retinal hypoxia are many and varied. Under hypoxic conditions, a variety of soluble factors are secreted into the vitreous cavity including growth factors, cytokines, and chemokines. Cytokines, which usually serve as signals between neighboring cells, are involved in essentially every important biologica...

journal_title：Mediators of inflammation

authors： dell'Omo R,Semeraro F,Bamonte G,Cifariello F,Romano MR,Costagliola C

更新日期：2013-01-01 00:00:00

abstract：:Chronic pain has to be considered in all respects a debilitating disease and 10-20% of the world's adult population is affected by this disease. In the most general terms, pain is symptomatic of some form of dysfunction and (often) the resulting inflammatory processes in the body. In the study of pain, great attention...

journal_title：Mediators of inflammation

authors： Vodo S,Bechi N,Petroni A,Muscoli C,Aloisi AM

更新日期：2013-01-01 00:00:00

abstract：:Cathepsin G is a serine protease secreted by activated neutrophils that play a role in the inflammatory response. Because neutrophils are known to be invading leukocytes in various tumors, their products may influence the characteristics of tumor cells such as the growth state, motility, and the adhesiveness between c...

journal_title：Mediators of inflammation

authors： Kudo T,Kigoshi H,Hagiwara T,Takino T,Yamazaki M,Yui S

更新日期：2009-01-01 00:00:00

abstract：:Inflammatory response in Chagas disease is related to parasite and host factors. However, immune system regulation has not been fully elucidated. Thus, this study is aimed at evaluating IL-4 influence on acute phase of Trypanosoma cruzi experimental infection through dosage of cytokine levels in cardiac homogenate of ...

journal_title：Mediators of inflammation

authors： da Silva MV,de Almeida VL,de Oliveira WD,Matos Cascudo NC,de Oliveira PG,da Silva CA,da Silva ACS,Dos Reis Monteiro MLG,Correa RRM,Oliveira MAP,Lino-Júnior RS,Celes MRN,Machado JR

更新日期：2018-11-28 00:00:00

abstract：AIM:This study was undertaken in order to determine whether anti-inflammatory cytokine interleukin-10 is responsible for a previously described protection against Klebsiella infection mediated by antilipopolysaccharide antibodies. METHODS:BALB/c mice were infected intraperitoneally with a lethal challenge of Klebsiell...

journal_title：Mediators of inflammation

authors： Rukavina T,Ticac B,Vasiljev V

更新日期：2006-01-01 00:00:00

abstract：:Systemic and intraplaque biomarkers have been widely investigated in clinical cohorts as promising surrogate parameters of cardiovascular vulnerability. In this pilot study, we investigated if systemic and intraplaque levels of calcification biomarkers were affected by treatment with a statin in a cohort of patients w...

journal_title：Mediators of inflammation

authors： Lenglet S,Quercioli A,Fabre M,Galan K,Pelli G,Nencioni A,Bauer I,Pende A,Python M,Bertolotto M,Spinella G,Pane B,Palombo D,Dallegri F,Mach F,Vuilleumier N,Montecucco F

更新日期：2014-01-01 00:00:00

abstract：:The mechanism of pain reduction involves bidirectional processes of pain blocking (nociception) and reductions in the levels of proinflammatory cytokines in the blood. Does transcutaneous electrical nerve stimulation (TENS) reduce blood levels of proinflammatory cytokines? For this systematic review, we searched in si...

journal_title：Mediators of inflammation

authors： do Carmo Almeida TC,Dos Santos Figueiredo FW,Barbosa Filho VC,de Abreu LC,Fonseca FLA,Adami F

更新日期：2018-04-02 00:00:00

abstract：BACKGROUND:Exhaled nitric oxide (FeNO) has been reported to be elevated in the oxidative stress involved in asthmatic patients, and the reaction of nitric oxide (NO) with superoxide anions results in the formation of nitrotyrosine. The purpose of this study was to investigate the effect of inhaled steroid treatment on ...

journal_title：Mediators of inflammation

authors： Bodini A,Peroni DG,Zardini F,Corradi M,Alinovi R,Boner AL,Piacentini GL

更新日期：2006-01-01 00:00:00

abstract：:Our understanding of inflammation's role in the pathogenesis of myeloproliferative neoplasm (MPN) is evolving. The impact of chronic inflammation, a characteristic feature of MPN, likely goes far beyond its role as a driver of constitutional symptoms. An inflammatory response to the neoplastic clone may be responsible...

journal_title：Mediators of inflammation

authors： Fleischman AG

更新日期：2015-01-01 00:00:00

abstract：:Interleukin-5 (IL-5) is a cytokine that preferentially effects the development and function of eosinophils, and is considered important in the pathophysiology of allergic inflammation. In this study, we evaluated the ability of recombinant human IL-5 (rHu IL-5) to promote tissue eosinophilia and the importance of this...

journal_title：Mediators of inflammation

authors： Minnicozzi M,Durán WN,Kim D,Gleich GJ,Wagner J,Egan RW

更新日期：1995-01-01 00:00:00

abstract：Aim:The objective of the current study is to analyze the correlation between cytokine levels and periodontal parameters in aggressive periodontitis patients before and after periodontal treatment that was performed by using two different laser therapies. Materials and Methods:Twenty-six generalized aggressive periodon...

journal_title：Mediators of inflammation

authors： Talmac AC,Calisir M,Eroglu EG,Ertugrul AS

更新日期：2019-06-12 00:00:00

abstract：:The influence of an anti-allergic agent, suplatast tosilate (IPD-1151T; (+/-)-[2-[4-(3-ethoxy-2-hydroxypropoxy)phenyl-carbamoyl]-ethyl] dimethylsulfonium p-toluenesulfonate) on allergic bronchoconstriction induced by allergen and methacholine (MCh) were examined in mice. BALB/c mice were sensitized by intraperitoneal ...

journal_title：Mediators of inflammation

authors： Asano K,Mizutani T,Shimane T,Hisano M,Hisamitsu T,Suzaki H

更新日期：2000-01-01 00:00:00

abstract：:Postoperative cognitive dysfunction (POCD) increases morbidity and mortality after surgery. But the underlying mechanism is not clear yet. While age is now accepted as the top one risk factor for POCD, results from studies investigating postoperative cognitive functions in adults have been controversial, and data abou...

journal_title：Mediators of inflammation

authors： Zhao Y,Huang L,Xu H,Wu G,Zhu M,Tian J,Wang H,Wang X,Yu W,Yang L,Su D

更新日期：2016-01-01 00:00:00

abstract：:Early sensing of pathogenic bacteria by the host immune system is important to develop effective mechanisms to kill the invader. Microbial recognition, activation of signaling pathways, and effector mechanisms are sequential events that must be highly controlled to successfully eliminate the pathogen. Host recognizes ...

journal_title：Mediators of inflammation

authors： Oviedo-Boyso J,Bravo-Patiño A,Baizabal-Aguirre VM

更新日期：2014-01-01 00:00:00

abstract：:The study monitored in vitro early response of connective tissue cells and immunocompetent cells to enosseal implant materials coated by different blood components (serum, activated plasma, and plasma/platelets) to evaluate human osteoblast proliferation and synthetic activity and inflammatory response presented as a ...

journal_title：Mediators of inflammation

authors： Himmlova L,Kubies D,Hulejova H,Bartova J,Riedel T,Stikarova J,Suttnar J,Pesakova V

更新日期：2016-01-01 00:00:00

abstract：:The pivotal role of epithelial cells is to secrete and absorb ions and water in order to allow the formation of a luminal fluid compartment that is fundamental for the epithelial function as a barrier against environmental factors. Importantly, epithelial cells also take part in the innate immune system. As a first li...

journal_title：Mediators of inflammation

authors： Schnúr A,Hegyi P,Rousseau S,Lukacs GL,Veit G

更新日期：2016-01-01 00:00:00

abstract：:This study examined the role of lymphotoxin (LT)-alpha in host defense against airborne infection with Francisella tularensis, a gram-negative facultative intracellular bacterium and the causative agent of tularemia. Following a low-dose aerosol infection with the highly virulent type A strain of F. tularensis, mice d...

journal_title：Mediators of inflammation

authors： Zhang D,Kuolee R,Harris G,Zhang Q,Conlan JW,Chen W

更新日期：2008-01-01 00:00:00

abstract：:Background and Objectives. Malaria infection, caused by Plasmodium falciparum, is the most lethal and frequently culminates in severe clinical complications. Interleukin-22 (IL-22) has been implicated in several diseases including malaria. The objective of this study was to investigate the role of IL-22 gene polymorph...

journal_title：Mediators of inflammation

authors： Aljarba NH,Al-Anazi MR,Shafeai MI,Rudiny FH,Bin Dajem SM,Alothaid H,Darraj M,Alkahtani S,Alghamdi J,Al-Ahdal MN,Al-Qahtani AA

更新日期：2020-02-19 00:00:00

abstract：:The effect of lipoprotein apheresis (Direct Adsorption of Lipids, DALI) (LA) on plasma levels of pentraxin 3 (PTX3), an inflammatory marker that reflects coronary plaque vulnerability, and expression of PTX3 mRNA was evaluated in patients with hyperLp(a)lipoproteinemia and angiographically defined atherosclerosis/coro...

journal_title：Mediators of inflammation

authors： Stefanutti C,Mazza F,Steiner M,Watts GF,De Nève J,Pasqualetti D,Paal J

更新日期：2016-01-01 00:00:00

abstract：:Peritoneal dialysis therapy has increased in popularity since the end of the 1970s. This method provides a patient survival rate equivalent to hemodialysis and better preservation of residual renal function. However, technique failure by peritonitis, and ultrafiltration failure, which is a multifactorial complication ...

journal_title：Mediators of inflammation

authors： Baroni G,Schuinski A,de Moraes TP,Meyer F,Pecoits-Filho R

更新日期：2012-01-01 00:00:00

abstract：:Periodontitis is a kind of chronic inflammatory disease that affects the tooth-supporting tissues. ET-1 is related to periodontitis and involved in the regulation of cytokines, but the mechanisms remain unclear. The aim of this study is to investigate how ET-1 affects proinflammatory cytokine expression and differenti...

journal_title：Mediators of inflammation

authors： Liang L,Zhou W,Yang N,Yu J,Liu H

更新日期：2016-01-01 00:00:00

abstract：:The therapeutic strategies used in the treatment of hepatitis C are essentially based on the combination of direct-acting antiviral agents (DAAs). This therapy has been shown to be very effective in relation to patient adherence to treatment and has shown high rates of sustained virological response (SVR). However, th...

journal_title：Mediators of inflammation

authors： Pereira GL,Tarragô AM,Neves WLL,da Silva Neto PV,de Souza PS,Dos Santos Affonso J,de Sousa KS,da Silva JA,Costa AG,da Silva Victoria F,Victoria MB,Malheiro A

更新日期：2019-11-04 00:00:00

abstract：:Osteoporosis is a civilization disease which is still challenging for contemporary medicine in terms of treatment and prophylaxis. It results from excessive activation of the osteoclastic cell line and immune cells like macrophages and lymphocytes. Cell-to-cell inflammatory information transfer occurs via factors incl...

journal_title：Mediators of inflammation

authors： Wojdasiewicz P,Turczyn P,Dobies-Krzesniak B,Frasunska J,Tarnacka B

更新日期：2019-11-12 00:00:00

abstract：Objective:Neuropeptide Y (NPY), an orexigenic peptide known to cause hyperphagia, has been involved in the occurrence and development of obesity. However, differences in the distribution of serum NPY levels in obese phenotypes (including metabolically unhealthy obesity (MUO) phenotype and metabolically healthy obesity ...

journal_title：Mediators of inflammation

authors： Tang HN,Xiao F,Chen YR,Zhuang SQ,Guo Y,Wu HX,Zhou HD

更新日期：2020-08-04 00:00:00

abstract：:The stalks of Polygonum hydropiper L. (PHL) have been traditionally used in clinical practice for thousands of years in China to treat various inflammatory diseases. However, little research has been conducted to investigate the anti-inflammatory effects of PHL on TNBS-induced intestinal inflammation in rats. The aim ...

journal_title：Mediators of inflammation

authors： Zhang W,Pan Y,Qu S,Wang D,Cheng S,Liu X

更新日期：2018-05-07 00:00:00

abstract：:The effect of exogenous RNA on many cellular functions has been studied in a variety of eukaryotic cells but there are few reports on macrophages. In the present study, it is demonstrated that cytoplasmatic RNA extracted from rat macrophages stimulated with Escherichia coli lipopolysaccharide (LPS), referred to as L-R...

journal_title：Mediators of inflammation

authors： Ribeiro RA,Lucca FL,Flores CA,Cunha FQ,Ferreira SH

更新日期：1993-01-01 00:00:00