Abstract:
:The pivotal role of epithelial cells is to secrete and absorb ions and water in order to allow the formation of a luminal fluid compartment that is fundamental for the epithelial function as a barrier against environmental factors. Importantly, epithelial cells also take part in the innate immune system. As a first line of defense they detect pathogens and react by secreting and responding to chemokines and cytokines, thus aggravating immune responses or resolving inflammatory states. Loss of epithelial anion transport is well documented in a variety of diseases including cystic fibrosis, chronic obstructive pulmonary disease, asthma, pancreatitis, and cholestatic liver disease. Here we review the effect of aberrant anion secretion with focus on the release of inflammatory mediators by epithelial cells and discuss putative mechanisms linking these transport defects to the augmented epithelial release of chemokines and cytokines. These mechanisms may contribute to the excessive and persistent inflammation in many respiratory and gastrointestinal diseases.
journal_name
Mediators Inflammjournal_title
Mediators of inflammationauthors
Schnúr A,Hegyi P,Rousseau S,Lukacs GL,Veit Gdoi
10.1155/2016/7596531subject
Has Abstractpub_date
2016-01-01 00:00:00pages
7596531eissn
0962-9351issn
1466-1861journal_volume
2016pub_type
杂志文章,评审abstract::Metabolic hormones have been associated with reproductive function modulation. Thus, the aim of this study was: (i) to characterize the immunolocalization, mRNA and protein levels of leptin (LEP), Ghrelin (GHR) and respective receptors LEPR and Ghr-R1A, throughout luteal phase; and (ii) to evaluate the role of LEP and...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2014/682193
更新日期:2014-01-01 00:00:00
abstract::Sepsis is a common complication of solid organ transplant procedures and, in particular, can affect the prognosis of orthotopic liver transplantation (OLT). This retrospective study determined the pre-, peri-, and postoperative risk factors for sepsis after OLT, using as reference the 2016 Third International Consensu...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2018/8703172
更新日期:2018-06-20 00:00:00
abstract::Recent investigations have indicated that reactive metabolites and AGE-RAGE-mediated inflammation might play an important role in the pathogenesis of ischemia-reperfusion injury in liver transplantation. In this observational clinical study, 150 patients were enrolled following liver transplantation from deceased dono...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2013/501430
更新日期:2013-01-01 00:00:00
abstract::The effects of chronic mild prenatal stress on leukocyte infiltration into the airways was investigated in rat offspring. The chronic prenatal stress consisted of transitory and variable changes in the rat's living conditions. Offspring at adult age were actively sensitized (day 0) and intratracheally challenged (day ...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1080/09629359990621
更新日期:1999-01-01 00:00:00
abstract::Surgery induces release of neuroendocrine hormones (cortisol), cytokines (interleukin-6: IL-6, tumour necrosis factor-alpha: TNF-alpha), acute phase proteins (C-reactive protein: CRP, leptin). We studied the effects of general and spinal anaesthesia on stress response to haemorrhoidectomy. Patients were assigned to ge...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/MI/2006/97257
更新日期:2006-01-01 00:00:00
abstract::Monocyte and macrophage diversity is evidenced by the modulation of cell surface markers and differential production of soluble mediators. These immune cells play key roles in controlling tissue homeostasis, infections, and excessive inflammation. Macrophages remove dead cells in a process named efferocytosis, contrib...
journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
doi:10.1155/2018/2426138
更新日期:2018-12-10 00:00:00
abstract::Shinbaro3, a formulation derived from the hydrolysed roots of Harpagophytum procumbens var. sublobatum (Engl.) Stapf, has been clinically used in the pharamacopuncture treatment of arthritis in Korea. In the present study, Shinbaro3 inhibited NO generation in LPS-induced RAW 264.7 cells in a dose-dependent manner. Shi...
journal_title:Mediators of inflammation
pub_type: 杂志文章,收录出版
doi:10.1155/2018/4514329
更新日期:2018-04-05 00:00:00
abstract::Interleukin-37 (IL-37) is unique in the IL-1 family since it broadly suppresses innate immunity and elevates in humans with inflammatory and autoimmune diseases. IL-37 shows definite groups and transcripts for human IL37 gene, but it is still not completely understood the effect and mechanisms of inflammatory response...
journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
doi:10.1155/2019/2650590
更新日期:2019-01-08 00:00:00
abstract:Background:Gut microbiota is implied in obesity, because of its ability to harvest energy from diet, and in the regulation of behavior. Given the link between gut microbiota, body composition, obesity, and anxiety, the aim of this study was to evaluate the effects of a new psychobiotic formulation. Methods:Eligible pa...
journal_title:Mediators of inflammation
pub_type: 杂志文章,随机对照试验
doi:10.1155/2017/5650627
更新日期:2017-01-01 00:00:00
abstract::Chemokines (CKs) and chemokine receptors (CKR) promote leukocyte recruitment into cardiac tissue infected by the Trypanosoma cruzi. This study investigated the long-term treatment with subantimicrobial doses of doxycycline (Dox) in association, or not, with benznidazole (Bz) on the expression of CK and CKR in cardiac ...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2016/3694714
更新日期:2016-01-01 00:00:00
abstract::The metabolic syndrome is a cluster of cardiometabolic alterations that include the presence of arterial hypertension, insulin resistance, dyslipidemia, and abdominal obesity. Obesity is associated with a chronic inflammatory response, characterized by abnormal adipokine production, and the activation of proinflammato...
journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
doi:10.1155/2013/136584
更新日期:2013-01-01 00:00:00
abstract:BACKGROUND:Studies on peripheral benzodiazepine receptor function have yielded a diverse list of activities of which the anti-inflammatory effects need to be further examined. AIMS:To evaluate the role of steroids, nitric oxide and adenosine-deaminase in the anti-inflammatory effect of PK11195. METHODS:Pleurisy was i...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1080/09629350410001688486
更新日期:2004-04-01 00:00:00
abstract::It was recently demonstrated that TLR4 activation via dietary lipids triggers inflammatory pathway and alters insulin responsiveness in the fat tissue during obesity. Here, we question whether other TLR family members could participate in the TLR-mediated inflammatory processes occurring in the obese adipose tissue. W...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2010/823486
更新日期:2010-01-01 00:00:00
abstract::Apolipoprotein E (apoE) is a multifunctional glycosylated protein characterized by its wide tissue distribution. Despite its importance in lipid transport and atherosclerosis pathogenesis, apoE is associated with neurodegenerative disorders such as Alzheimer's disease (AD) and Parkinson disease, and autoimmune disorde...
journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
doi:10.1155/2011/949072
更新日期:2011-01-01 00:00:00
abstract::Chronic inflammation has an important role in the development and progression of most fibrotic diseases, for which no effective treatments exist. Tubulointerstitial fibrosis (TF) is characterized by irreversible deposition of fibrous tissue in chronic kidney diseases. Prolonged injurious stimuli and chronic inflammati...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2018/5103672
更新日期:2018-10-14 00:00:00
abstract::The effects of intravenous injection of Porphyromonas gingivalis (Pg) on rabbit inflammatory immune response and atherosclerosis were evaluated by establishing a microamount Pg bacteremia model combined with high-fat diet. Twenty-four New Zealand rabbits were randomly divided into Groups A-D (n = 6). After 14 weeks, l...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2015/364391
更新日期:2015-01-01 00:00:00
abstract::The close relationship between increased TLR-2 expression in blood monocytes and insulin resistance in RA patients is shown in this study. Traditional risk factors for metabolic disorders, including the waist circumstance, body mass index (BMI), triglyceride (TG), and ratio of TG to high density lipoprotein (HDL) chol...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2012/690525
更新日期:2012-01-01 00:00:00
abstract::Infiltration and local proliferation are known factors that contribute to tubulointerstitial macrophage accumulation. This study explored the time course of these two contributors' roles as tubulointerstitial inflammation and fibrosis progressing, and evaluated the mechanisms of the protective effect of atorvastatin. ...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/MI/2006/12919
更新日期:2006-01-01 00:00:00
abstract::There is great need for a therapeutic that would limit tuberculosis related pathology and thus curtail spread of disease between individuals by establishing a "firebreak" to slow transmission. A promising avenue to increase current therapeutic efficacy may be through incorporation of adjunct components that slow or st...
journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
doi:10.1155/2015/409596
更新日期:2015-01-01 00:00:00
abstract::To determine the role of mutant SOD1 gene (SOD1(G93A)) on muscle cell differentiation, we derived C2C12 muscle cell lines carrying a stably transfected SOD1(G93A) gene under the control of a myosin light chain (MLC) promoter-enhancer cassette. Expression of MLC/SOD1(G93A) in C2C12 cells resulted in dramatic inhibition...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2015/537853
更新日期:2015-01-01 00:00:00
abstract:OBJECTIVE:Individuals with inflammation have a myriad of pregnancy aberrations including increasing their preterm birth risk. Toll-like receptors (TLRs) and receptor for advanced glycation end products (RAGE) and their ligands were all found to play a key role in inflammation. In the present study, we reviewed TLR and ...
journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
doi:10.1155/2010/490406
更新日期:2010-01-01 00:00:00
abstract::Obesity characterized by increased mass of adipose tissue leads to systemic inflammation. Calorie restriction (CR) improves parameters associated with immune response and antioxidant defense. We hypothesized that CR with a high fat diet (HFCR) regulates local and systemic inflammation and oxidative stress damage in a ...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2012/984643
更新日期:2012-01-01 00:00:00
abstract::Inflammation is a complex biological response to detrimental stimuli and can be a double-edged sword. Inflammation plays a protective role in removing pathogenic factors, but dysregulated inflammation is associated with several major fatal diseases such as asthma, cancer, and cardiovascular diseases. Asthma is a compl...
journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
doi:10.1155/2016/2180417
更新日期:2016-01-01 00:00:00
abstract::In this study we demonstrated that ΔCaecm33 double mutant showed reduced biofilm formation and causes less damage to gingival mucosa tissues. This was confirmed by the reduced level of necrotic cells and Bax/Bcl2 gene expression as apoptotic markers. In contrast, parental and Caecm33 mutant strains decreased basement ...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2012/398207
更新日期:2012-01-01 00:00:00
abstract:OBJECTIVE:To evaluate the effects of psychological stress on periodontitis healing in rats and the contribution of basic fibroblast growth factor (bFGF) expression to the healing process. METHODS:Ninety-six rats were randomly distributed into control group, periodontitis group, and periodontitis plus stress group. The...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2012/732902
更新日期:2012-01-01 00:00:00
abstract::The probiotic Enterococcus faecium HDRsEf1 (Ef1) has been shown to have positive effects on piglet diarrhoea, but the mechanism has not yet been elucidated. In this study, using the IPEC-J2 cell line to mimic intestinal epithelial cells and enterotoxigenic Escherichia coli (ETEC) K88ac as a representative intestinal p...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2016/7474306
更新日期:2016-01-01 00:00:00
abstract::H. pylori induces a complicated local and systematic immune response and contributes to the carcinogenesis of gastric cancer. A primary type 1 immune response is evoked by H. pylori since its occurrence. However, it is not unusual that an inhibitory immunity is dominant in H. pylori-associated diseases, which are prom...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2017/4927964
更新日期:2017-01-01 00:00:00
abstract::This study examined the role of lymphotoxin (LT)-alpha in host defense against airborne infection with Francisella tularensis, a gram-negative facultative intracellular bacterium and the causative agent of tularemia. Following a low-dose aerosol infection with the highly virulent type A strain of F. tularensis, mice d...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2008/239740
更新日期:2008-01-01 00:00:00
abstract::Platelet activating factor (PAF) is a potent inflammatory lipid. In this study we assessed the ability of PAF to impact lymphatic vessel function by altering prenodal lymphatic resistance. Intralymphatic PAF (7.47 x 10(-6), 7.47 x 10(-5) and 7.47 x 10(-4) M) increased lymphatic perfusion pressure at the two highest in...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/S0962935192000590
更新日期:1992-01-01 00:00:00
abstract::The inflammatory process has direct effects on normal and abnormal wound healing. Hypertrophic scar formation is an aberrant form of wound healing and is an indication of an exaggerated function of fibroblasts and excess accumulation of extracellular matrix during wound healing. Two cytokines--transforming growth fact...
journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
doi:10.1155/2010/413238
更新日期:2010-01-01 00:00:00