Abstract:
:Chemokines (CKs) and chemokine receptors (CKR) promote leukocyte recruitment into cardiac tissue infected by the Trypanosoma cruzi. This study investigated the long-term treatment with subantimicrobial doses of doxycycline (Dox) in association, or not, with benznidazole (Bz) on the expression of CK and CKR in cardiac tissue. Thirty mongrel dogs were infected, or not, with the Berenice-78 strain of T. cruzi and grouped according their treatments: (i) two months after infection, Dox (50 mg/kg) 2x/day for 12 months; (ii) nine months after infection, Bz (3,5 mg/kg) 2x/day for 60 days; (iii) Dox + Bz; and (iv) vehicle. After 14 months of infection, hearts were excised and processed for qPCR analysis of Th1 (CCL2, CCL3, CCL4, CCL5, CXCL9, and CXCL11), Th2 (CCL1, CCL17, CCL24, and CCL26), Th17 (CCL20) CKs, Th1 (CCR5, CCR6, and CXCR3), and Th2/Th17 (CCR3, CCR4, and CCR8) CKR, as well as IL-17. T. cruzi infection increases CCL1, CCL2, CCL4, CCL5, CCL17, CXCL10, and CCR5 expression in the heart. Dox, Bz, or Dox + Bz treatments cause a reversal of CK and CKR and reduce the expression of CCL20, IL-17, CCR6, and CXCR3. Our data reveal an immune modulatory effect of Dox with Bz, during the chronic phase of infection suggesting a promising therapy for cardiac protection.
journal_name
Mediators Inflammjournal_title
Mediators of inflammationauthors
de Paula Costa G,Lopes LR,da Silva MC,Horta AL,Pontes WM,Milanezi CM,Guedes PM,de Lima WG,Schulz R,da Silva JS,Talvani Adoi
10.1155/2016/3694714subject
Has Abstractpub_date
2016-01-01 00:00:00pages
3694714eissn
0962-9351issn
1466-1861journal_volume
2016pub_type
杂志文章abstract:PURPOSE:To assess FGF-β, TGF-β, and COX2 expression and immunocompetent cells in the orbital tissue of patients with severe and mild Graves' orbitopathy. PATIENTS AND METHODS:Orbital tissue was taken from 27 patients with GO: (1) severe GO (n = 18), the mean clinical activity score (CAS) being 8.5 (SD 2.5); and (2) mi...
journal_title:Mediators of inflammation
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journal_title:Mediators of inflammation
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journal_title:Mediators of inflammation
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journal_title:Mediators of inflammation
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journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
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journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2020/3276148
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journal_title:Mediators of inflammation
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journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2020/4321912
更新日期:2020-06-06 00:00:00
abstract::Scorpion venoms consist of a complex of several toxins that exhibit a wide range of biological properties and actions, as well as chemical compositions, toxicity, and pharmacokinetic and pharmacodynamic characteristics. These venoms are associated with high morbility and mortality, especially among children. Victims o...
journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
doi:10.1155/2010/903295
更新日期:2010-01-01 00:00:00
abstract::The expression of cytochrome P4501A1 (CYP1A1) enzyme is changed in various organs during the host response to inflammation or infection, leading to alterations in the metabolism of endogenous and exogenous compounds. Results of this study showed that CYP1A1 expression was significantly downregulated in the mammary tis...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2018/4093285
更新日期:2018-02-28 00:00:00
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journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
doi:10.1155/2013/928315
更新日期:2013-01-01 00:00:00
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journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2013/202530
更新日期:2013-01-01 00:00:00
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journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2015/460125
更新日期:2015-01-01 00:00:00
abstract::Inflammatory mediators, including cytokines, histamine, bradykinin, prostaglandins, and leukotrienes, impact the immune system, usually as proinflammatory factors. Other mediators act as regulatory components to establish homeostasis after injury or prevent the inflammatory process. Histamine, a biogenic vasoactive am...
journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
doi:10.1155/2018/9524075
更新日期:2018-08-27 00:00:00
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journal_title:Mediators of inflammation
pub_type: 杂志文章,收录出版
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更新日期:2018-04-05 00:00:00
abstract:OBJECTIVE:Our aim was to evaluate the significance of homocysteine (Hcy) in Behcet's disease (BD) and the association of elevated Hcy levels associated with the indices of inflammation in BD. METHODS:Untreated 70 patients with BD and 33 healthy individuals were included into the study. Hcy, tumor necrosis alpha (TNF-a...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2008/407972
更新日期:2008-01-01 00:00:00
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journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2013/407562
更新日期:2013-01-01 00:00:00
abstract::As one of the ligands of aryl hydrocarbon receptor (AhR), baicalein, isolated from Scutellaria baicalensis Georgi, has been proved to exert potential therapeutic effects on ulcerative colitis (UC), but its therapeutic mechanism remains obscure. Authentically, ulcerative colitis can be alleviated by regulating the diff...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2020/5918587
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journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
doi:10.1155/2014/659206
更新日期:2014-01-01 00:00:00
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journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2010/149678
更新日期:2010-01-01 00:00:00
abstract::The role of eosinophils in inflammation and their mode of activation is not well understood. Eosinophil accumulation and subsequent expression of cytokines at the site of inflammation may play a role in exacerbation of inflammatory responses. In the present study, we have examined the role of TNF-alpha in eosinophil a...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/S0962935196000312
更新日期:1996-01-01 00:00:00
abstract::Tryptophan (trp) metabolism is an important regulatory component of gut mucosal homeostasis and the microbiome. Metabolic pathways targeting the trp can lead to a myriad of metabolites, of both host and microbial origins, some of which act as endogenous low-affinity ligands for the aryl hydrocarbon receptor (AhR), a c...
journal_title:Mediators of inflammation
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doi:10.1155/2018/1601486
更新日期:2018-02-18 00:00:00
abstract::Many therapies are now available for patients with rheumatoid arthritis (RA) who have an inadequate response to methotrexate including tumor necrosis factor inhibitors, abatacept, tocilizumab, and rituximab. Clinical response to drugs varies widely between individuals. A part of this variability is due to the characte...
journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
doi:10.1155/2014/386148
更新日期:2014-01-01 00:00:00
abstract::Endothelial dysfunction is regarded as an important factor in the pathogenesis of vascular disease in obesity-related type 2 diabetes. The imbalance in repair and injury (hyperglycemia, hypertension, dyslipidemia) results in microvascular changes, including apoptosis of microvascular cells, ultimately leading to diabe...
journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
doi:10.1155/2010/792393
更新日期:2010-01-01 00:00:00
abstract::Previous studies showed little CD137 expressed in normal vascular smooth muscle cells (VSMCs) and it is important to find a valid way to elevate it before studying its function. The level of CD137 was detected by RT-PCR, western blot, and flow cytometry, respectively. CD137 signaling activation was activated by agonis...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2017/1382805
更新日期:2017-01-01 00:00:00
abstract::Trypanosoma cruzi infection was studied in mouse lines selected for maximal (AIRmax) or minimal (AIRmin) acute inflammatory reaction and for high (HIII) or low (LIII) antibody (Ab) responses to complex antigens. Resistance was associated with gender (females) and strain-the high responder lines AIRmax and HIII were re...
journal_title:Mediators of inflammation
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doi:10.1155/2014/952857
更新日期:2014-01-01 00:00:00
abstract::Patients with inflammatory bowel disease (IBD) are at an increased risk of developing colorectal cancer (CRC). The risk factors of CRC in IBD patients include long disease duration, extensive colitis, severe histological inflammation, and coexistence with primary sclerosing cholangitis (PSC). Several molecular pathway...
journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
doi:10.1155/2017/5126048
更新日期:2017-01-01 00:00:00