Abstract:
:Inflammatory mediators, including cytokines, histamine, bradykinin, prostaglandins, and leukotrienes, impact the immune system, usually as proinflammatory factors. Other mediators act as regulatory components to establish homeostasis after injury or prevent the inflammatory process. Histamine, a biogenic vasoactive amine, causes symptoms such as allergies and has a pleiotropic effect that is dependent on its interaction with its four histamine receptors. In this review, we discuss the dualistic effects of histamine: how histamine affects inflammation of the immune system through the activation of intracellular pathways that induce the production of inflammatory mediators and cytokines in different immune cells and how histamine exerts regulatory functions in innate and adaptive immune responses. We also evaluate the interactions between these effects.
journal_name
Mediators Inflammjournal_title
Mediators of inflammationauthors
Branco ACCC,Yoshikawa FSY,Pietrobon AJ,Sato MNdoi
10.1155/2018/9524075subject
Has Abstractpub_date
2018-08-27 00:00:00pages
9524075eissn
0962-9351issn
1466-1861journal_volume
2018pub_type
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