Involvement of steroids in anti-inflammatory effects of PK11195 in a murine model of pleurisy.

abstract：BACKGROUND:Airway smooth muscle (ASM) is considered to be a target for mediators released during airway inflammation. AIMS:To investigate the expression of c-fos, a constituent of the transcription factor activator protein-1, in human ASM cells. In addition, to measure the release of interleukin (IL)-6 into the condit...

journal_title：Mediators of inflammation

authors： McKay S,Bromhaar MM,de Jongste JC,Hoogsteden HC,Saxena PR,Sharma HS

更新日期：2001-06-01 00:00:00

abstract：:Periodontitis is a kind of chronic inflammatory disease that affects the tooth-supporting tissues. ET-1 is related to periodontitis and involved in the regulation of cytokines, but the mechanisms remain unclear. The aim of this study is to investigate how ET-1 affects proinflammatory cytokine expression and differenti...

journal_title：Mediators of inflammation

authors： Liang L,Zhou W,Yang N,Yu J,Liu H

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:Empirical observations have shown that ozonated autohemotherapy markedly improves the symptoms of chronic limb ischemia (muscular pain at rest, intermittent claudication, etc) in atherosclerotic patients, but mechanisms of action remain unclear. AIMS:Human endothelial cells (HUVECs) are known to release nit...

journal_title：Mediators of inflammation

authors： Valacchi G,Bocci V

更新日期：2000-01-01 00:00:00

abstract：:Sepsis is a common complication of solid organ transplant procedures and, in particular, can affect the prognosis of orthotopic liver transplantation (OLT). This retrospective study determined the pre-, peri-, and postoperative risk factors for sepsis after OLT, using as reference the 2016 Third International Consensu...

journal_title：Mediators of inflammation

authors： Wang Y,Gu Y,Huang F,Liu D,Zhang Z,Zhou N,Liang J,Lu C,Yuan D,Hei Z

更新日期：2018-06-20 00:00:00

abstract：:The purinergic P2X7 receptor (P2X7R) plays an important role during the immune response, participating in several events such as cytokine release, apoptosis, and necrosis. The bacterial endotoxin lipopolysaccharide (LPS) is one of the strongest stimuli of the immune response, and it has been shown that P2X7R activatio...

journal_title：Mediators of inflammation

authors： Leiva-Salcedo E,Coddou C,Rodríguez FE,Penna A,Lopez X,Neira T,Fernández R,Imarai M,Rios M,Escobar J,Montoya M,Huidobro-Toro JP,Escobar A,Acuña-Castillo C

更新日期：2011-01-01 00:00:00

abstract：OBJECTIVES:Obesity and related diseases are dramatically increasing problems, particularly in children and adolescents. We determined circulating levels of different interleukin (IL)-1 family members in normal weight and overweight adolescents. METHODS:Seventy male, Caucasian adolescents (13-17 years) were recruited. ...

journal_title：Mediators of inflammation

authors： Jung C,Gerdes N,Fritzenwanger M,Figulla HR

更新日期：2010-01-01 00:00:00

abstract：:Recent investigations have indicated that reactive metabolites and AGE-RAGE-mediated inflammation might play an important role in the pathogenesis of ischemia-reperfusion injury in liver transplantation. In this observational clinical study, 150 patients were enrolled following liver transplantation from deceased dono...

journal_title：Mediators of inflammation

authors： Brenner T,Fleming TH,Spranz D,Schemmer P,Bruckner T,Uhle F,Martin EO,Weigand MA,Hofer S

更新日期：2013-01-01 00:00:00

abstract：OBJECTIVE:To investigate the Th17/Treg immune balance in the ulcerative colitis (UC) patients in a Chinese Han population. METHODS:Ninety UC patients and 30 healthy subjects were enrolled. The serum IL-17 and TGF-β1 levels of these participants were measured with ELISA; the percentage of Th17 and Treg cells in periphe...

journal_title：Mediators of inflammation

authors： Gong Y,Lin Y,Zhao N,He X,Lu A,Wei W,Jiang M

更新日期：2016-01-01 00:00:00

abstract：STUDY OBJECTIVES:To assess serum amyloid alpha (SAA) pleural fluid levels in parapneumonic effusion (PPE) and to investigate SAA diagnostic performance in PPE diagnosis and outcome. METHODS:We studied prospectively 57 consecutive patients with PPE (empyema (EMP), complicated (CPE), and uncomplicated parapneumonic effu...

journal_title：Mediators of inflammation

authors： Boultadakis V,Skouras V,Makris D,Damianaki A,Nikoulis DJ,Kiropoulos T,Oikonomidi S,Tsilioni I,Gourgoulianis K

更新日期：2011-01-01 00:00:00

abstract：:Monocyte and macrophage diversity is evidenced by the modulation of cell surface markers and differential production of soluble mediators. These immune cells play key roles in controlling tissue homeostasis, infections, and excessive inflammation. Macrophages remove dead cells in a process named efferocytosis, contrib...

journal_title：Mediators of inflammation

authors： Stunault MI,Bories G,Guinamard RR,Ivanov S

更新日期：2018-12-10 00:00:00

abstract：INTRODUCTION:Impaired maternal immune tolerance resulting in systemic inflammation plays a pivotal role in the pathogenesis of preeclampsia. Phenotypical changes of monocytes and neutrophil granulocytes have already been studied in preeclampsia, and some studies also included T lymphocyte activation markers; however, t...

journal_title：Mediators of inflammation

authors： Bajnok A,Ivanova M,Rigó J Jr,Toldi G

更新日期：2017-01-01 00:00:00

abstract：:Parasites of the genus Leishmania are capable of inhibiting effector functions of macrophages. These parasites have developed the adaptive ability to escape host defenses; for example, they inactivate the NF-κB complex and suppress iNOS expression in infected macrophages, which are responsible for the production of th...

journal_title：Mediators of inflammation

authors： Marcusso Orsini T,Kawakami NY,Panis C,Fortes Dos Santos Thomazelli AP,Tomiotto-Pellissier F,Cataneo AH,Kian D,Megumi Yamauchi L,Gouveia Júnior FS,de França Lopes LG,Cecchini R,Nazareth Costa I,Jerley Nogueira da Silva J,Conchon

更新日期：2016-01-01 00:00:00

abstract：:The stalks of Polygonum hydropiper L. (PHL) have been traditionally used in clinical practice for thousands of years in China to treat various inflammatory diseases. However, little research has been conducted to investigate the anti-inflammatory effects of PHL on TNBS-induced intestinal inflammation in rats. The aim ...

journal_title：Mediators of inflammation

authors： Zhang W,Pan Y,Qu S,Wang D,Cheng S,Liu X

更新日期：2018-05-07 00:00:00

abstract：:Galectin-1 (Gal-1), an evolutionarily conserved β-galactoside-binding lectin, controls immune cell homeostasis and tempers acute and chronic inflammation by blunting proinflammatory cytokine synthesis, engaging T-cell apoptotic programs, promoting expansion of T regulatory (Treg) cells, and deactivating antigen-presen...

journal_title：Mediators of inflammation

authors： Seropian IM,González GE,Maller SM,Berrocal DH,Abbate A,Rabinovich GA

更新日期：2018-11-05 00:00:00

abstract：OBJECTIVE:Individuals with inflammation have a myriad of pregnancy aberrations including increasing their preterm birth risk. Toll-like receptors (TLRs) and receptor for advanced glycation end products (RAGE) and their ligands were all found to play a key role in inflammation. In the present study, we reviewed TLR and ...

journal_title：Mediators of inflammation

authors： Noguchi T,Sado T,Naruse K,Shigetomi H,Onogi A,Haruta S,Kawaguchi R,Nagai A,Tanase Y,Yoshida S,Kitanaka T,Oi H,Kobayashi H

更新日期：2010-01-01 00:00:00

abstract：:The aim of the present study was to compare serum levels of soluble forms of interleukin-2 receptor, CD4 and CD8, released by lymphocytes during activation of the immune system, in patients with allergic bronchial asthma, with those in healthy subjects. Significantly higher levels of soluble IL-2R and soluble CD4 were...

journal_title：Mediators of inflammation

authors： Lorenzo GD,Mansueto P,Melluso M,Morici G,Norrito F,Cigna D,Candore G,Caruso C

更新日期：1995-01-01 00:00:00

abstract：:Platelet size has been demonstrated to reflect platelet activity and seems to be a useful predictive and prognostic biomarker of cardiovascular events. It is associated with a variety of prothrombotic and proinflammatory diseases. The aim is a review of literature reports concerning changes in the mean platelet volume...

journal_title：Mediators of inflammation

authors： Korniluk A,Koper-Lenkiewicz OM,Kamińska J,Kemona H,Dymicka-Piekarska V

更新日期：2019-04-17 00:00:00

abstract：:Plasma GDF15 concentrations were measured in 612 Taiwanese individuals without overt systemic disease. Clinical parameters, GDF15 genetic variants, and 22 biomarker levels were analyzed. We further enrolled 86 patients with PAD and 481 patients with CAD, who received endovascular intervention and coronary angiography,...

journal_title：Mediators of inflammation

authors： Hsu LA,Wu S,Juang JJ,Chiang FT,Teng MS,Lin JF,Huang HL,Ko YL

更新日期：2017-01-01 00:00:00

abstract：:Alveolar macrophages have recently been postulated as being involved in the aetiology of adult respiratory distress syndrome (ARDS). To evaluate their role, basal cyclic AMP levels and responsiveness of adenylyl cyclase alveolar macrophages were determined at four intermediate stages of developing respiratory distress...

journal_title：Mediators of inflammation

authors： Amsterdam JG,Heijde RM,Grotjohan HP,Beusenberg FD

更新日期：1993-01-01 00:00:00

abstract：:The effects of intravenous injection of Porphyromonas gingivalis (Pg) on rabbit inflammatory immune response and atherosclerosis were evaluated by establishing a microamount Pg bacteremia model combined with high-fat diet. Twenty-four New Zealand rabbits were randomly divided into Groups A-D (n = 6). After 14 weeks, l...

journal_title：Mediators of inflammation

authors： Lin G,Chen S,Lei L,You X,Huang M,Luo L,Li Y,Zhao X,Yan F

更新日期：2015-01-01 00:00:00

abstract：:Tryptophan (trp) metabolism is an important regulatory component of gut mucosal homeostasis and the microbiome. Metabolic pathways targeting the trp can lead to a myriad of metabolites, of both host and microbial origins, some of which act as endogenous low-affinity ligands for the aryl hydrocarbon receptor (AhR), a c...

journal_title：Mediators of inflammation

authors： Puccetti M,Paolicelli G,Oikonomou V,De Luca A,Renga G,Borghi M,Pariano M,Stincardini C,Scaringi L,Giovagnoli S,Ricci M,Romani L,Zelante T

更新日期：2018-02-18 00:00:00

abstract：:Chronic inflammation is a hallmark of HIV infection. Eicosanoids reflect inflammation, oxidant stress, and vascular health and vary by sex and metabolic parameters. Raltegravir (RAL) is an HIV-1 integrase inhibitor that may have limited metabolic effects. We assessed urinary F2-isoprostanes (F2-IsoPs), prostaglandin E...

journal_title：Mediators of inflammation

authors： Hulgan T,Boger MS,Liao DH,McComsey GA,Wanke CA,Mangili A,Walmsley SL,McCreath H,Milne GL,Sanchez SC,Currier JS,Lake JE

更新日期：2014-01-01 00:00:00

abstract：:Extracellular superoxide dismutase (SOD3), an enzyme mediating dismutation of superoxide into hydrogen peroxide, has been shown to reduce inflammation by inhibiting macrophage migration into injured tissues. In inflamed tissues, superoxide is produced by the phagocytic NOX2 complex, which consists of the catalytic sub...

journal_title：Mediators of inflammation

authors： Kelkka T,Laurila JP,Sareila O,Olofsson P,Laukkanen MO,Holmdahl R

更新日期：2012-01-01 00:00:00

abstract：:Methyltransferase-like 3 (METTL3), an RNA N6-methyladenosine (m6A) methyltransferase, is essential for the m6A mRNA modification. As a key enzyme of m6A methylation modification, METTL3 has been implicated in immune and inflammation regulation. However, little is known of the role and underlying mechanism of METTL3 in...

journal_title：Mediators of inflammation

authors： Wang J,Yan S,Lu H,Wang S,Xu D

更新日期：2019-10-24 00:00:00

abstract：:Obesity-induced skeletal muscle inflammation is characterized by increased macrophage infiltration and inflammatory cytokine production. In this study, we investigated whether 4-1BB, a member of the TNF receptor superfamily (TNFRSF9) that provides inflammatory signals, participates in obesity-induced skeletal muscle i...

journal_title：Mediators of inflammation

authors： Le NH,Kim CS,Tu TH,Choi HS,Kim BS,Kawada T,Goto T,Park T,Park JH,Yu R

更新日期：2013-01-01 00:00:00

abstract：:The CCN family member 2 (CCN2, also known as connective tissue growth factor) may behave as a risk biomarker and a potential therapeutic target for renal disease. CCN2 participates in the regulation of inflammation and fibrosis. TGF-β is considered the main fibrogenic cytokine; however, in some pathological settings T...

journal_title：Mediators of inflammation

authors： Rodrigues-Díez R,Rayego-Mateos S,Orejudo M,Aroeira LS,Selgas R,Ortiz A,Egido J,Ruiz-Ortega M

更新日期：2015-01-01 00:00:00

abstract：:Behçet's disease (BD) is a multisystemic disorder of unknown etiology characterized by the "triple symptom complex" consisting of recurrent oral aphthosis, genital ulcers, and chronic relapsing bilateral uveitis. Recurrent mucocutaneous lesions are generally considered the hallmark of the disease, being the most commo...

journal_title：Mediators of inflammation

authors： Rotondo C,Lopalco G,Iannone F,Vitale A,Talarico R,Galeazzi M,Lapadula G,Cantarini L

更新日期：2015-01-01 00:00:00

abstract：:Interleukin- (IL-) 35 and IL-37 are newly discovered immune-suppressing cytokines. They have been described in inflammatory diseases such as collagen-induced arthritis and asthma. However, their expressions in inflammatory bowel disease (IBD) patients have not been yet explored. Our aim was to evaluate serum and infla...

journal_title：Mediators of inflammation

authors： Li Y,Wang Y,Liu Y,Wang Y,Zuo X,Li Y,Lu X

更新日期：2014-01-01 00:00:00

abstract：:Enterovirus 71 (EV71) is one of the most common intestinal virus that causes hand, foot, and mouth disease (HFMD) in infants and young children (mostly ≤5 years of age). Generally, children with EV71-infected HFMD have mild symptoms that resolve spontaneously within 7-14 days without complications. However, some EV71-...

journal_title：Mediators of inflammation

authors： Zhang W,Huang Z,Huang M,Zeng J

更新日期：2020-01-31 00:00:00

abstract：:Sanguisorbae Radix (SR) is well known as herbal medicine named "Zi-Yu" in Korea, which is the dried roots of Sanguisorba officinalis L. (Rosacease). We investigated the underlying mechanism on the inhibition of atopic dermatitis (AD) of an ethanol extract of SR (ESR) using 2,4-dinitrochlorobenzene- (DNCB-) induced AD ...

journal_title：Mediators of inflammation

authors： Yang JH,Yoo JM,Cho WK,Ma JY

更新日期：2016-01-01 00:00:00