Abstract:
:It was recently demonstrated that TLR4 activation via dietary lipids triggers inflammatory pathway and alters insulin responsiveness in the fat tissue during obesity. Here, we question whether other TLR family members could participate in the TLR-mediated inflammatory processes occurring in the obese adipose tissue. We thus studied the expression of TLR1, TLR2, TLR4, and TLR6 in adipose tissue. These receptors are expressed in omental and subcutaneous human fat tissue, the expression being higher in the omental tissue, independently of the metabolic status of the subject. We demonstrated a correlation of TLRs expression within and between each depot suggesting a coregulation. Murine 3T3-L1 preadipocyte cells stimulated with Pam3CSK4 induced the expression of some proinflammatory markers. Therefore, beside TLR4, other toll-like receptors are differentially expressed in human fat tissue, and functional in an adipocyte cell line, suggesting that they might participate omental adipose tissue-related inflammation that occurs in obesity.
journal_name
Mediators Inflammjournal_title
Mediators of inflammationauthors
Poulain-Godefroy O,Le Bacquer O,Plancq P,Lecoeur C,Pattou F,Frühbeck G,Froguel Pdoi
10.1155/2010/823486subject
Has Abstractpub_date
2010-01-01 00:00:00pages
823486eissn
0962-9351issn
1466-1861journal_volume
2010pub_type
杂志文章abstract:BACKGROUND:Icariin (ICA) is an active compound extracted from Epimedium brevicornum Maxim. Previous reports have shown that icariin has a clinically significant therapeutic effect on rheumatoid arthritis. However, little is known about the mechanism by which icariin inhibits cartilage and bone degradation. METHODS:New...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2016/9529630
更新日期:2016-01-01 00:00:00
abstract::The number of persons who relocate to regions of high altitude for work, pleasure, sport, or residence increases every year. It is known that the reduced supply of oxygen (O2) induced by acute or chronic increases in altitude stimulates the body to adapt to new metabolic challenges imposed by hypoxia. Sleep can suffer...
journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
doi:10.1155/2013/279365
更新日期:2013-01-01 00:00:00
abstract::Atherosclerosis is characterized by interaction between immune and vascular endothelial cells which is mediated by adhesion molecules occurring on the surface of the vascular endothelium leading to massive release of proinflammatory mediators. Ginkgo biloba L. (Ginkgoaceae) standardized extracts showing beneficial eff...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2019/6173893
更新日期:2019-06-25 00:00:00
abstract::As one of the ligands of aryl hydrocarbon receptor (AhR), baicalein, isolated from Scutellaria baicalensis Georgi, has been proved to exert potential therapeutic effects on ulcerative colitis (UC), but its therapeutic mechanism remains obscure. Authentically, ulcerative colitis can be alleviated by regulating the diff...
journal_title:Mediators of inflammation
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doi:10.1155/2020/5918587
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abstract::Platelet-released growth factors (PRGF) and its related clinically used formulations (e.g., Vivostat Platelet-Rich Fibrin (PRF®)) contain a variety of chemokines, cytokines, and growth factors and are therefore used to support healing of chronic, hard-to-heal, or infected wounds. Human beta-defensin-3 (hBD-3) is an an...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2017/6157491
更新日期:2017-01-01 00:00:00
abstract::Little work is done to develop Aloe vera (AV) using probiotics. To explore the potential benefits, the antioxidant effects and the antibacterial effects on foodborne pathogens of Aloe fermentation supernatant were evaluated in vitro. Our results indicated that the Aloe fermentation supernatant fermented by Lactobacill...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2016/2945650
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abstract::Inflammatory processes are known to be involved at least in the early phase of complex regional pain syndrome type 1 (CRPS1). Blister fluid obtained from the involved extremities displayed increased amounts of proinflammatory cytokines IL-6 and TNFalpha compared with the noninvolved extremities. The aim of this paper ...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/MI/2006/28398
更新日期:2006-01-01 00:00:00
abstract::The study monitored in vitro early response of connective tissue cells and immunocompetent cells to enosseal implant materials coated by different blood components (serum, activated plasma, and plasma/platelets) to evaluate human osteoblast proliferation and synthetic activity and inflammatory response presented as a ...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2016/8769347
更新日期:2016-01-01 00:00:00
abstract::We have previously shown that immunodominant MBP peptides encapsulated in mannosylated liposomes (Xemys) effectively suppressed experimental allergic encephalomyelitis (EAE). Within the frames of the successfully completed phase I clinical trial, we investigated changes in the serum cytokine profile after Xemys admini...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2016/2847232
更新日期:2016-01-01 00:00:00
abstract::Concentrations of acute phase proteins (CRP: C-reactive protein, albumin) change during surgery. We investigated the acute phase response to circumcision and the effects of anaesthesia on this response. The children were divided into four groups; group 1 (intratracheal general anaesthesia, n=40), group 2 (general anae...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/MI.2005.312
更新日期:2005-10-24 00:00:00
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journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2017/2086840
更新日期:2017-01-01 00:00:00
abstract::Matrix metalloproteinase 9 is a proteolytic enzyme which is recently one of the more often studied biomarkers. Its possible use as a biomarker of neuronal damage in stroke, heart diseases, tumors, multiple sclerosis, and epilepsy is being widely indicated. In epilepsy, MMP-9 is suggested to play a role in epileptic fo...
journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
doi:10.1155/2016/7369020
更新日期:2016-01-01 00:00:00
abstract::Microcystins (MCs) produced by toxic cyanobacteria cause serious water pollution and public health hazard to humans and animals. However, direct molecular mechanisms of MC-LR in vascular endothelial cells (ECs) have not been understood yet. In this study, we investigated whether MC-LR induces vascular inflammatory pro...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2015/942159
更新日期:2015-01-01 00:00:00
abstract::Increased insulin resistance and inflammatory action are observed in pregnancy-induced hypertension (PIH), but similar insulin resistance is observed also in successful pregnancy. To estimate insulin resistance and inflammatory activity in normal pregnancy and PIH, serum concentrations of free fatty acids (FFA; correc...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2012/432575
更新日期:2012-01-01 00:00:00
abstract::miRNA-10a is rhythmically expressed and regulates genes involved in lipid and glucose metabolism. However, the effects of miRNA-10a on obesity and glucose intolerance, as well as on the diurnal pattern of expression of circadian clock genes, remain unknown. We explored the effects of miRNA-10a-5p on insulin resistance...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2020/8192187
更新日期:2020-08-17 00:00:00
abstract::Inflammation is considered to be one of the most critical factors involved in the development of complex metabolic diseases such as type 2 diabetes, cancer, and cardiovascular disease. A few decades ago, the discovery of mitochondria-associated endoplasmic reticulum (ER) membrane (MAM) was followed by the identificati...
journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
doi:10.1155/2016/1851420
更新日期:2016-01-01 00:00:00
abstract::Among numerous inflammatory mediators a nitric oxide molecule is supposed to be important in the modulation of neutrophil survival in vivo and in vitro. The effect of exogenous supply of NO donors such as SNP, SIN-1, and GEA-3162 on the course of human neutrophil apoptosis and the role of extracellular antioxidants in...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/MI.2005.81
更新日期:2005-06-09 00:00:00
abstract::The present study investigated the association between the rs12979860 polymorphism in the IL-28B gene and HTLV-1 infection as well as the development of HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). HTLV-1-infected patients (26 HAM/TSP symptomatic and 53 asymptomatic) and 300 seronegative health...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2015/804167
更新日期:2015-01-01 00:00:00
abstract:Background:Sepsis-induced myocardial dysfunction is a severe clinical problem. Recent studies have indicated that autophagy and myocardial energy depletion play a major role in myocardial dysfunction during sepsis, a mechanistic target of rapamycin (mTOR) as a master sensor of energy status and autophagy mediator; howe...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2018/4798209
更新日期:2018-06-28 00:00:00
abstract::Schistosomiasis is a chronic inflammatory disease whose macrophages are involved in immunopathology modulation. Although P2X7 receptor signaling plays an important role in inflammatory responses mediated by macrophages, no reports have examined the role of P2X7 receptors in macrophage function during schistosomiasis. ...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2014/134974
更新日期:2014-01-01 00:00:00
abstract::The success of peritoneal dialysis (PD) is dependent on the structural and functional integrity of the peritoneal membrane. The mesothelium lines the peritoneal membrane and is the first line of defense against chemical and/or bacterial insult. Peritonitis remains a major complication of PD and is a predominant cause ...
journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
doi:10.1155/2012/484167
更新日期:2012-01-01 00:00:00
abstract::The recently discovered IL-33 as an IL-1 cytokine family member has been proved to be specifically released from osteonecrotic bones. We aimed to investigate the potential role of IL-33 in the development of osteonecrosis of femoral head (ONFH). Forty patients diagnosed with ONFH and forty age-, sex-, and body mass in...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2017/1732638
更新日期:2017-01-01 00:00:00
abstract::The purpose of this study is to assess the role of nitric oxide (NO) in the intestinal lesions of passive anaphylaxis, since this experimental model resembles necrotizing enterocolitis. Sprague-Dawley rats were sensitized with IgE anti-dinitrophenol monoclonal antibody. Extravasation of protein-rich plasma and haemorr...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1080/09629359791893
更新日期:1997-01-01 00:00:00
abstract::Infiltration and local proliferation are known factors that contribute to tubulointerstitial macrophage accumulation. This study explored the time course of these two contributors' roles as tubulointerstitial inflammation and fibrosis progressing, and evaluated the mechanisms of the protective effect of atorvastatin. ...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/MI/2006/12919
更新日期:2006-01-01 00:00:00
abstract::Increasing evidence has demonstrated that reactive oxygen species (ROS) induces oxidative stress and plays a crucial role in the pathogenesis of acute pancreatitis (AP). Hydrogen-rich saline (HRS), a well-known ROS scavenger, has been shown to possess therapeutic benefit on AP in many animal experiments. Recent findin...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2014/930894
更新日期:2014-01-01 00:00:00
abstract::Thiopurines are extensively used immunosuppressants for the treatment of inflammatory bowel disease (IBD). The polymorphism of thiopurine S-methyltransferase (TPMT) influences thiopurine metabolism and therapy outcome. We used a TPMT knockdown (kd) model of human Jurkat T-lymphocytes cells to study the effects of trea...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2015/434825
更新日期:2015-01-01 00:00:00
abstract::Fluid of artificial blisters from erythromelalgic skin areas in primary thrombocythaemia contained a high amount of prostaglandin-E-like activity. Dazoxiben did not alleviate the erythromelalgia in patients with primary thrombocythaemia despite complete inhibition of platelet malondialdehyde and thromboxane B(2) synth...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/S0962935193000547
更新日期:1993-01-01 00:00:00
abstract::Platelet size has been demonstrated to reflect platelet activity and seems to be a useful predictive and prognostic biomarker of cardiovascular events. It is associated with a variety of prothrombotic and proinflammatory diseases. The aim is a review of literature reports concerning changes in the mean platelet volume...
journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
doi:10.1155/2019/9213074
更新日期:2019-04-17 00:00:00
abstract:BACKGROUND:Production of antibodies that are specific for allergens is an important pathological process in inflammatory allergic diseases. These contain the antibodies against antigens of Candida albicans, one of the normal microbial flora in an intestinal tract. We studied the effects of the prednisolone administrati...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1080/09511920410001713510
更新日期:2004-06-01 00:00:00
abstract::It has been suggested that the supernatant of LPSstimulated macrophages (macrophage nociceptive factor, MNF) promotes nociception in mice. Intraperitoneal administration of MNF induced dose-related writhing, which reached a plateau between 18 and 26 min after injection and decreased within 60 min. The release of MNF w...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1080/09629359791686
更新日期:1997-01-01 00:00:00