The Antimicrobial Peptide Human Beta-Defensin-3 Is Induced by Platelet-Released Growth Factors in Primary Keratinocytes.

abstract：BACKGROUND:Production of antibodies that are specific for allergens is an important pathological process in inflammatory allergic diseases. These contain the antibodies against antigens of Candida albicans, one of the normal microbial flora in an intestinal tract. We studied the effects of the prednisolone administrati...

journal_title：Mediators of inflammation

authors： Tansho S,Abe S,Ishibashi H,Mitsuya M,Wada K,Ikeda T,Suegara N,Koshio O,Ono Y,Yamaguchi H

更新日期：2004-06-01 00:00:00

abstract：:Sestrin2 (sesn2) is an endogenous antioxidant protein that has recently gained attention for its potential to treat various inflammatory diseases. However, the relationship of sesn2 with cardiomyopathy is still unclear. In H9c2 cells, sesn2 knockdown reduced the level of 5' adenosine monophosphate-activated protein ki...

journal_title：Mediators of inflammation

authors： Hwang HJ,Kim JW,Chung HS,Seo JA,Kim SG,Kim NH,Choi KM,Baik SH,Yoo HJ

更新日期：2018-07-05 00:00:00

abstract：:Gout is a common inflammatory disease characterized by acute arthritis and hyperuricemia. A number of epidemiological studies have suggested the critical role of gout in carcinogenesis. The aim of this study was to estimate the association between gout and cancer risk by meta-analysis of all relevant studies published...

journal_title：Mediators of inflammation

authors： Wang W,Xu D,Wang B,Yan S,Wang X,Yin Y,Wang X,Sun B,Sun X

更新日期：2015-01-01 00:00:00

abstract：:Galectin-1 (Gal-1), an evolutionarily conserved β-galactoside-binding lectin, controls immune cell homeostasis and tempers acute and chronic inflammation by blunting proinflammatory cytokine synthesis, engaging T-cell apoptotic programs, promoting expansion of T regulatory (Treg) cells, and deactivating antigen-presen...

journal_title：Mediators of inflammation

authors： Seropian IM,González GE,Maller SM,Berrocal DH,Abbate A,Rabinovich GA

更新日期：2018-11-05 00:00:00

abstract：:Inflammatory mediators play a critical role in ulcerative colitis immune and inflammatory processes. The aim of the study was to investigate the effects of Ginkgo biloba extract on inflammatory mediators (SOD, MDA, TNF-alpha, NF-kappaBp65, IL-6) in TNBS-induced colitis in rats. Colitis in rats was induced by colonic a...

journal_title：Mediators of inflammation

authors： Zhou YH,Yu JP,Liu YF,Teng XJ,Ming M,Lv P,An P,Liu SQ,Yu HG

更新日期：2006-01-01 00:00:00

abstract：:The mechanism of pain reduction involves bidirectional processes of pain blocking (nociception) and reductions in the levels of proinflammatory cytokines in the blood. Does transcutaneous electrical nerve stimulation (TENS) reduce blood levels of proinflammatory cytokines? For this systematic review, we searched in si...

journal_title：Mediators of inflammation

authors： do Carmo Almeida TC,Dos Santos Figueiredo FW,Barbosa Filho VC,de Abreu LC,Fonseca FLA,Adami F

更新日期：2018-04-02 00:00:00

abstract：:Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized by chronic inflammation of multiple joints. The central pathogenesis of RA is the proliferation of synovial fibroblasts in response to inflammatory cytokines. However, some of the targeted therapies for inflammation reactions do not display signi...

journal_title：Mediators of inflammation

authors： Yin G,Wang Y,Cen XM,Yang M,Liang Y,Xie QB

更新日期：2015-01-01 00:00:00

abstract：:Schistosomiasis is a chronic inflammatory disease whose macrophages are involved in immunopathology modulation. Although P2X7 receptor signaling plays an important role in inflammatory responses mediated by macrophages, no reports have examined the role of P2X7 receptors in macrophage function during schistosomiasis. ...

journal_title：Mediators of inflammation

authors： Oliveira SD,Nanini HF,Savio LE,Waghabi MC,Silva CL,Coutinho-Silva R

更新日期：2014-01-01 00:00:00

abstract：:Background. Patients with UC have shown an important defect in the secretion and maintenance of the mucosal barrier as part of inadequate expression of mucin genes. The aim of the present study was to determine the expression of MUC12, MUC16, and MUC20 in colonic tissue from patients with UC in regard to their clinica...

journal_title：Mediators of inflammation

authors： Yamamoto-Furusho JK,Ascaño-Gutiérrez I,Furuzawa-Carballeda J,Fonseca-Camarillo G

更新日期：2015-01-01 00:00:00

abstract：:One of the most globally prevalent supraventricular arrhythmias is atrial fibrillation (AF). Knowledge of the structures and functions of messenger RNA (mRNA) has recently increased. It is no longer viewed as solely an intermediate molecule between DNA and proteins but has come to be seen as a dynamic and modifiable g...

journal_title：Mediators of inflammation

authors： Xu X,Zhao Z,Li G

更新日期：2020-03-12 00:00:00

abstract：:Recently, we revealed the importance of follicular helper T cells (T(FH)) in the pathogenesis of primary Sjögren's syndrome (pSS). In the present study, we focused on the site of the inflammation and determined the composition of lymphocyte infiltration in labial salivary gland (LSG) biopsies with special emphasis on ...

journal_title：Mediators of inflammation

authors： Szabo K,Papp G,Dezso B,Zeher M

更新日期：2014-01-01 00:00:00

abstract：:Vascular adhesion protein-1 (VAP-1) is an ectoenzyme that functions as a copper-containing amine oxidase and is involved in leukocyte adhesion at sites of inflammation. Inhibition of VAP-1 oxidative deamination has become an attractive target for anti-inflammatory therapy with demonstrated efficacy in rodent models of...

journal_title：Mediators of inflammation

authors： Kubota R,Reid MJ,Lieu KL,Orme M,Diamond C,Tulberg N,Henry SH

更新日期：2020-01-20 00:00:00

abstract：:Resistin has been shown to cause insulin resistance and to impair glucose tolerance in rodents, but in humans its physiological role still remains elusive. The aim of this study was to examine whether resistin mRNA expression in human peripheral mononuclear cells (PBMCs) and its corresponding plasma levels are altered...

journal_title：Mediators of inflammation

authors： Tsiotra PC,Tsigos C,Anastasiou E,Yfanti E,Boutati E,Souvatzoglou E,Kyrou I,Raptis SA

更新日期：2008-01-01 00:00:00

abstract：Objectives:In this study, we assessed the effects of dietary magnesium on leukocyte telomere length (LTL). Designs:The current cross-sectional analysis was based on data collected within a type 2 diabetes project. Settings. Dietary magnesium intake is associated with peripheral blood leukocyte telomere length (LTL). H...

journal_title：Mediators of inflammation

authors： Yu J,Liu H,He S,Li P,Ma C,Ma M,Liu Y,Lv L,Ping F,Zhang H,Li W,Sun Q,Xu L,Li Y

更新日期：2020-05-22 00:00:00

abstract：:miRNA-10a is rhythmically expressed and regulates genes involved in lipid and glucose metabolism. However, the effects of miRNA-10a on obesity and glucose intolerance, as well as on the diurnal pattern of expression of circadian clock genes, remain unknown. We explored the effects of miRNA-10a-5p on insulin resistance...

journal_title：Mediators of inflammation

authors： Guo Y,Zhu X,Zeng S,He M,Xing X,Wang C

更新日期：2020-08-17 00:00:00

abstract：:The human virome comprises viruses that infect host cells, virus-derived elements in our chromosomes, and viruses that infect other organisms, including bacteriophages and plant viruses. The development of high-throughput sequencing techniques has shown that the human gut microbiome is a complex community in which the...

journal_title：Mediators of inflammation

authors： Focà A,Liberto MC,Quirino A,Marascio N,Zicca E,Pavia G

更新日期：2015-01-01 00:00:00

abstract：:Innate lymphoid cells (ILCs) are a group of hematopoietic cells devoid of antigen receptors that have important functions in lymphoid organogenesis, in the defense against extracellular pathogens, and in the maintenance of the epithelial barrier. Three distinct groups of ILCs have been identified on the basis of pheno...

journal_title：Mediators of inflammation

authors： Sedda S,Marafini I,Figliuzzi MM,Pallone F,Monteleone G

更新日期：2014-01-01 00:00:00

abstract：:The aim of the study was to evaluate the role of Smad3, Smad7, and TGF-β1 in intrauterine adhesion (IUA) patients and experimental rabbit models. 60 IUA patients, 30 control participants, and 18 female rabbits were enrolled in this study. We found that the plasma concentrations and protein expressions of TGF-β1 were s...

journal_title：Mediators of inflammation

authors： Salma U,Xue M,Ali Sheikh MS,Guan X,Xu B,Zhang A,Huang L,Xu D

更新日期：2016-01-01 00:00:00

abstract：:Plasma GDF15 concentrations were measured in 612 Taiwanese individuals without overt systemic disease. Clinical parameters, GDF15 genetic variants, and 22 biomarker levels were analyzed. We further enrolled 86 patients with PAD and 481 patients with CAD, who received endovascular intervention and coronary angiography,...

journal_title：Mediators of inflammation

authors： Hsu LA,Wu S,Juang JJ,Chiang FT,Teng MS,Lin JF,Huang HL,Ko YL

更新日期：2017-01-01 00:00:00

abstract：:Interleukin-10 (IL-10) is a cytokine derived from CD4+ T-helper type 2 (T(H2)) cells identified as a suppressor of cytokines from T-helper type 1(T(H1)) cells. Interleukin-12 (IL-12) is produced by B cells, macrophages and dendritic cells, and primarily regulates T(H1) cell differentiation, while suppressing the expan...

journal_title：Mediators of inflammation

authors： Chung F

更新日期：2001-04-01 00:00:00

abstract：:Recent studies suggest that tumor-associated macrophage-produced IL-6 is an important mediator within the tumor microenvironment that promotes tumor growth. The activation of IL-6/STAT3 axis has been associated with chemoresistance and poor prognosis of a variety of cancers including colorectal carcinoma and thus serv...

journal_title：Mediators of inflammation

authors： Wang ZY,Zhang JA,Wu XJ,Liang YF,Lu YB,Gao YC,Dai YC,Yu SY,Jia Y,Fu XX,Rao X,Xu JF,Zhong J

更新日期：2016-01-01 00:00:00

abstract：:Non-cystic fibrosis-related bronchiectasis is a chronic inflammatory lung disease, which is regarded as an "orphan" lung disease, with little research devoted to the study of this condition. Bronchiectasis results in impaired quality of life and mortality if left untreated. The tools available in the armamentarium for...

journal_title：Mediators of inflammation

authors： Masekela R,Green RJ

更新日期：2012-01-01 00:00:00

abstract：Background:Sphingosine-1-phosphate (S1P) is a biologically active lysophospholipid mediator involved in modulating inflammatory process. We investigated the effects of FTY720, a structural analogue of S1P after phosphorylation, on lung injury induced by hindlimb ischemia reperfusion (IR) in rats. Methods:Fifty Sprague...

journal_title：Mediators of inflammation

authors： Wang L,Chen F,Pan Y,Lin L,Xiong X

更新日期：2017-01-01 00:00:00

abstract：:The regulatory functions of glycosaminoglycan hyaluronan (HA) are suggested to be dependent on its molecular weight (MW). Proinflammatory and stimulatory effects are proposed mainly for the low MW HA. However, the complex response of blood phagocytes to HA of different MW is unclear. Herein, the effects of highly puri...

journal_title：Mediators of inflammation

authors： Safrankova B,Gajdova S,Kubala L

更新日期：2010-01-01 00:00:00

abstract：:The clinical outcome of autologous adipose stem cell (ASC) treatment of patients with multiple sclerosis (MS) was investigated following one year of observation. Methods. The clinical and MRI outcomes of 16 ASC-treated patients with RRMS and SPMS are reported after a one-year follow-up period. Results. At 18 months of...

journal_title：Mediators of inflammation

authors： Stepien A,Dabrowska NL,Maciagowska M,Macoch RP,Zolocinska A,Mazur S,Siennicka K,Frankowska E,Kidzinski R,Chalimoniuk M,Pojda Z

更新日期：2016-01-01 00:00:00

abstract：:Surgery induces release of neuroendocrine hormones (cortisol), cytokines (interleukin-6: IL-6, tumour necrosis factor-alpha: TNF-alpha), acute phase proteins (C-reactive protein: CRP, leptin). We studied the effects of general and spinal anaesthesia on stress response to haemorrhoidectomy. Patients were assigned to ge...

journal_title：Mediators of inflammation

authors： Buyukkocak U,Caglayan O,Daphan C,Aydinuraz K,Saygun O,Agalar F

更新日期：2006-01-01 00:00:00

abstract：:Chronic inflammation is a hallmark of HIV infection. Eicosanoids reflect inflammation, oxidant stress, and vascular health and vary by sex and metabolic parameters. Raltegravir (RAL) is an HIV-1 integrase inhibitor that may have limited metabolic effects. We assessed urinary F2-isoprostanes (F2-IsoPs), prostaglandin E...

journal_title：Mediators of inflammation

authors： Hulgan T,Boger MS,Liao DH,McComsey GA,Wanke CA,Mangili A,Walmsley SL,McCreath H,Milne GL,Sanchez SC,Currier JS,Lake JE

更新日期：2014-01-01 00:00:00

abstract：:Inflammation is a complex biological response to detrimental stimuli and can be a double-edged sword. Inflammation plays a protective role in removing pathogenic factors, but dysregulated inflammation is associated with several major fatal diseases such as asthma, cancer, and cardiovascular diseases. Asthma is a compl...

journal_title：Mediators of inflammation

authors： Dong Z,Xiong L,Zhang W,Gibson PG,Wang T,Lu Y,Wang G,Li H,Wang F

更新日期：2016-01-01 00:00:00

abstract：:Little work is done to develop Aloe vera (AV) using probiotics. To explore the potential benefits, the antioxidant effects and the antibacterial effects on foodborne pathogens of Aloe fermentation supernatant were evaluated in vitro. Our results indicated that the Aloe fermentation supernatant fermented by Lactobacill...

journal_title：Mediators of inflammation

authors： Jiang M,Deng K,Jiang C,Fu M,Guo C,Wang X,Wang X,Meng F,Yang S,Deng K,Chen T,Xin H

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:Asthma is a disorder characterized by a predominance of Th2 cells and eosinophilic inflammation. Suppressors of cytokine signaling (SOCS) proteins act as negative regulators of cytokine signaling. In particular, SOCS1 and SOCS3 play an important role in immune response by controlling the balance between Th1 ...

journal_title：Mediators of inflammation

authors： López E,Zafra MP,Sastre B,Gámez C,Lahoz C,del Pozo V

更新日期：2011-01-01 00:00:00