miRNA-10a-5p Alleviates Insulin Resistance and Maintains Diurnal Patterns of Triglycerides and Gut Microbiota in High-Fat Diet-Fed Mice.

abstract：:Invertebrates do not display the level of sophistication in immune reactivity characteristic of mammals and other 'higher' vertebrates. Their great number and diversity of forms, however, reflect their evolutionary success and hence they must have effective mechanisms of defence to deal with parasites and pathogens an...

journal_title：Mediators of inflammation

authors： Rowley AF

更新日期：1996-01-01 00:00:00

abstract：:The mechanisms underlying the recurrence of atrial fibrillation (AF) after radiofrequency catheter ablation (RFCA) are not well concerned. The study sought to explore the association between growth differentiation factor-15 (GDF-15) and the incidence of recurrent events among AF patients after the ablation procedure. ...

journal_title：Mediators of inflammation

authors： Wei Y,Liu S,Yu H,Zhang Y,Gao W,Cui M,Li L

更新日期：2020-08-21 00:00:00

abstract：:The carrageenan pleurisy model, which is characterized by cellular influx and oedema, has been used to examine the effects of anti-inflammatory compounds such as naproxen. Interleukin-1alpha and beta (IL-1) are known to be pro-inflammatory mediators, and their roles in this model are unknown. Intrapleural injection of...

journal_title：Mediators of inflammation

authors： Goodman R,Mantegna LR,McAilister CL,Bruin E,Dowling RL,George H,Feeser W,Freimark B,Lischwe M,Pick S,Harris RR,Kerr JS

更新日期：1993-01-01 00:00:00

abstract：:The purpose of this paper is to evaluate the chronic effect of sitagliptin on metabolic profile, inflammation, and redox status in the Zucker Diabetic Fatty (ZDF) rat, an animal model of obese type 2 diabetes. Diabetic and obese ZDF (fa/fa) rats and their controls (ZDF +/+) were treated during 6 weeks with vehicle (co...

journal_title：Mediators of inflammation

authors： Ferreira L,Teixeira-de-Lemos E,Pinto F,Parada B,Mega C,Vala H,Pinto R,Garrido P,Sereno J,Fernandes R,Santos P,Velada I,Melo A,Nunes S,Teixeira F,Reis F

更新日期：2010-01-01 00:00:00

abstract：:Human gingival fibroblast barrier dysfunction caused by inflammation contributes to gingivitis and can lead to inflammatory periodontal disease. The disease features include upregulated epithelial permeability, increased inflammatory mediators, and downregulated junctional complex molecules. Carbon monoxide- (CO-) rel...

journal_title：Mediators of inflammation

authors： Lv J,Liu Y,Jia S,Zhang Y,Tian H,Li J,Song H

更新日期：2020-04-28 00:00:00

abstract：:The production of nitric oxide (NO) was measured in cultures of spleen cells stimulated by lipopolysaccharide (LPS), IL-2 or LPS + IL-2. We observed that NO synthesis is increased by IFN-gamma but inhibited by IFN-alpha/beta. This is not the case when IL-2 is present in the cultures, since interferons play a minor rol...

journal_title：Mediators of inflammation

authors： Vaillier D,Daculsi R,Gualdel N

更新日期：1996-01-01 00:00:00

abstract：:It has been suggested that the supernatant of LPSstimulated macrophages (macrophage nociceptive factor, MNF) promotes nociception in mice. Intraperitoneal administration of MNF induced dose-related writhing, which reached a plateau between 18 and 26 min after injection and decreased within 60 min. The release of MNF w...

journal_title：Mediators of inflammation

authors： Thomazzi SM,Ribeiro RA,Campos DI,Cunha FQ,Ferreira SH

更新日期：1997-01-01 00:00:00

abstract：:Lysophosphatidic acid (LPA) is a bioactive phospholipid playing an important role in various inflammatory diseases by inducing expression and secretion of many inflammatory cytokines/chemokines. Here we report in a murine air pouch model of inflammation that LPA induced CXCL13 secretion in a time-dependent manner and ...

journal_title：Mediators of inflammation

authors： Hui W,Zhao C,Bourgoin SG

更新日期：2015-01-01 00:00:00

abstract：:Apolipoprotein E (apoE) is a multifunctional glycosylated protein characterized by its wide tissue distribution. Despite its importance in lipid transport and atherosclerosis pathogenesis, apoE is associated with neurodegenerative disorders such as Alzheimer's disease (AD) and Parkinson disease, and autoimmune disorde...

journal_title：Mediators of inflammation

authors： Zhang H,Wu LM,Wu J

更新日期：2011-01-01 00:00:00

abstract：:Mitotic catastrophe, as defined in 2012 by the International Nomenclature Committee on Cell Death, is a bona fide intrinsic oncosuppressive mechanism that senses mitotic failure and responds by driving a cell to an irreversible antiproliferative fate of death or senescence. Thus, failed mitotic catastrophe can promote...

journal_title：Mediators of inflammation

authors： Mc Gee MM

更新日期：2015-01-01 00:00:00

abstract：OBJECTIVES:Obesity and related diseases are dramatically increasing problems, particularly in children and adolescents. We determined circulating levels of different interleukin (IL)-1 family members in normal weight and overweight adolescents. METHODS:Seventy male, Caucasian adolescents (13-17 years) were recruited. ...

journal_title：Mediators of inflammation

authors： Jung C,Gerdes N,Fritzenwanger M,Figulla HR

更新日期：2010-01-01 00:00:00

abstract：:Background. Neutrophilic bronchial inflammation is a main feature of bronchiectasis, but not much is known about its relationship with other disease features. Aim. To compare airway inflammatory markers with clinical and functional findings in subjects with stable noncystic fibrosis bronchiectasis (NCFB). Methods. 152...

journal_title：Mediators of inflammation

authors： Dente FL,Bilotta M,Bartoli ML,Bacci E,Cianchetti S,Latorre M,Malagrinò L,Nieri D,Roggi MA,Vagaggini B,Paggiaro P

更新日期：2015-01-01 00:00:00

abstract：:This study was carried out to investigate whether ADM can modulate LPS-induced inflammation and apoptosis in rat Leydig cells. Leydig cells were treated with ADM before LPS-induced cytotoxicity. We determined the concentrations of ROS, MDA, GSH, LDH, and testosterone and the MMP. The mRNA levels of IL-1, IL-6, iNOS, a...

journal_title：Mediators of inflammation

authors： Zhou PH,Hu W,Zhang XB,Wang W,Zhang LJ

更新日期：2016-01-01 00:00:00

abstract：:Cathepsin S is a cysteine protease and regulator of autophagy with possible involvement in periodontitis. The objective of this study was to investigate whether cathepsin S is involved in the pathogenesis of periodontal diseases. Human periodontal fibroblasts were cultured under inflammatory and infectious conditions ...

journal_title：Mediators of inflammation

authors： Memmert S,Damanaki A,Nogueira AVB,Eick S,Nokhbehsaim M,Papadopoulou AK,Till A,Rath B,Jepsen S,Götz W,Piperi C,Basdra EK,Cirelli JA,Jäger A,Deschner J

更新日期：2017-01-01 00:00:00

abstract：Objectives:In this study, we assessed the effects of dietary magnesium on leukocyte telomere length (LTL). Designs:The current cross-sectional analysis was based on data collected within a type 2 diabetes project. Settings. Dietary magnesium intake is associated with peripheral blood leukocyte telomere length (LTL). H...

journal_title：Mediators of inflammation

authors： Yu J,Liu H,He S,Li P,Ma C,Ma M,Liu Y,Lv L,Ping F,Zhang H,Li W,Sun Q,Xu L,Li Y

更新日期：2020-05-22 00:00:00

abstract：BACKGROUND:We have previously reported a continuous activation of caspase-1 and increased interleukin (IL)-1β levels in early rheumatoid arthritis (RA). These observations raised the hypothesis that drugs targeting the IL-1β pathway, in addition to tumour necrosis factor (TNF), may be particularly effective for early R...

journal_title：Mediators of inflammation

authors： Cascão R,Vidal B,Raquel H,Neves-Costa A,Figueiredo N,Gupta V,Fonseca JE,Moita LF

更新日期：2014-01-01 00:00:00

abstract：:Since iron can contribute to detrimental radical generating processes through the Fenton and Haber-Weiss reactions, it seems to be a reasonable approach to modulate iron-related pathways in inflammation. In the human organism a counterregulatory reduction in iron availability is observed during inflammatory diseases. ...

journal_title：Mediators of inflammation

authors： Lehmann C,Islam S,Jarosch S,Zhou J,Hoskin D,Greenshields A,Al-Banna N,Sharawy N,Sczcesniak A,Kelly M,Wafa K,Cheliak W,Holbein B

更新日期：2015-01-01 00:00:00

abstract：:In sarcoidosis, increased Th17 cell fractions have been reported in bronchoalveolar lavage fluid, and elevated numbers of Th17 cells producing IFN- γ have been observed in peripheral blood. The balance between Th1, Th17, and FoxP3(+) CD4(+) T cell subsets in sarcoidosis remains unclear. Bronchoalveolar lavage fluid ce...

journal_title：Mediators of inflammation

authors： Tøndell A,Moen T,Børset M,Salvesen Ø,Rø AD,Sue-Chu M

更新日期：2014-01-01 00:00:00

abstract：:In addition to its well-established effect on T cells, cyclosporin A (CsA) also inhibits inflammatory cytokine production by macrophages. However, little is known about the mechanism of action of CsA on macrophage cytokine production. We measured the effect of CsA on basal and phorbol-myristate-acetate (PMA)-stimulate...

journal_title：Mediators of inflammation

authors： García JE,López AM,de Cabo MR,Rodríguez FM,Losada JP,Sarmiento RG,López AJ,Arellano JL

更新日期：1999-01-01 00:00:00

abstract：:Collagen triple helix repeat containing-1 (CTHRC1) has been identified as cancer-related protein. CTHRC1 expresses mainly in adventitial fibroblasts and neointimal smooth muscle cells of balloon-injured vessels and promotes cell migration and tissue repair in response to injury. CTHRC1 plays a pivotal role in some pat...

journal_title：Mediators of inflammation

authors： Mei D,Zhu Y,Zhang L,Wei W

更新日期：2020-08-12 00:00:00

abstract：:Podocyte injury critically contributes to the pathogenesis of obesity-related glomerulopathy (ORG). Recently, lipid accumulation and inflammatory responses have been found to be involved in podocyte injury. This study is to explore their role and relationship in podocyte injury of ORG. In animal experiments, the ORG m...

journal_title：Mediators of inflammation

authors： Zhao J,Rui HL,Yang M,Sun LJ,Dong HR,Cheng H

更新日期：2019-04-11 00:00:00

abstract：:Cysteinyl leukotrienes (CysLTs) are potent lipid inflammatory mediators synthesized from arachidonic acid, through the 5-lipoxygenase (5-LO) pathway. Owing to their properties, CysLTs play a crucial role in the pathogenesis of inflammation; therefore, CysLT modifiers as synthesis inhibitors or receptor antagonists, ce...

journal_title：Mediators of inflammation

authors： Colazzo F,Gelosa P,Tremoli E,Sironi L,Castiglioni L

更新日期：2017-01-01 00:00:00

abstract：:Systemic sclerosis (SSc) is an autoimmune connective tissue disorder of unknown etiology. This disease is characterized by a large variety of clinical patterns, which include the fibrosis of skin and visceral organs causing a variety of clinical manifestations. Genetic and environmental factors participate in the etio...

journal_title：Mediators of inflammation

authors： Grygiel-Górniak B,Puszczewicz M

更新日期：2014-01-01 00:00:00

abstract：Objectives:To investigate the protective effect of ginsenoside Rg1 on relieving sepsis-induced lung inflammation and injury in vivo and in vitro. Methods:Cultured human pulmonary epithelial cell line A549 was challenged with LPS to induce cell injury, and CLP mouse model was generated to mimic clinical condition of sy...

journal_title：Mediators of inflammation

authors： Wang QL,Yang L,Peng Y,Gao M,Yang MS,Xing W,Xiao XZ

更新日期：2019-02-24 00:00:00

abstract：:The role of eosinophils in inflammation and their mode of activation is not well understood. Eosinophil accumulation and subsequent expression of cytokines at the site of inflammation may play a role in exacerbation of inflammatory responses. In the present study, we have examined the role of TNF-alpha in eosinophil a...

journal_title：Mediators of inflammation

authors： Goldstein LA,Strieter RM,Evanoff HL,Kunkel SL,Lukacs NW

更新日期：1996-01-01 00:00:00

abstract：BACKGROUND:Severe traumatization induces a complex pathophysiology, driven by the patient's own immune system. The initial activation is a result of damage-associated molecular patterns, which are released from disrupted and dying cells and recognized by immune receptors, for example, RAGE. In this study we aimed to ev...

journal_title：Mediators of inflammation

authors： Uhle F,Lichtenstern C,Brenner T,Fleming T,Koch C,Hecker A,Heiss C,Nawroth PP,Hofer S,Weigand MA,Weismüller K

更新日期：2015-01-01 00:00:00

abstract：:Scorpion venoms consist of a complex of several toxins that exhibit a wide range of biological properties and actions, as well as chemical compositions, toxicity, and pharmacokinetic and pharmacodynamic characteristics. These venoms are associated with high morbility and mortality, especially among children. Victims o...

journal_title：Mediators of inflammation

authors： Petricevich VL

更新日期：2010-01-01 00:00:00

abstract：:Tissue engineering cell-based therapy using induced pluripotent stem cells and adipose-derived stem cells (ASCs) may be promising tools for therapeutic applications in tissue engineering because of their abundance, relatively easy harvesting, and high proliferation potential. The purpose of this study was to investiga...

journal_title：Mediators of inflammation

authors： Oh SJ,Park HY,Choi KU,Choi SW,Kim SD,Kong SK,Cho KS

更新日期：2018-03-18 00:00:00

abstract：OBJECTIVE:In this work we studied the correlation between platelet count, platelet activation, and systemic inflammation in overweight, obese, and morbidly obese individuals. METHODS AND SUBJECTS:A total of 6319 individuals participated in the study. Complete blood counts, high sensitivity C-reactive protein (hs-CRP) ...

journal_title：Mediators of inflammation

authors： Samocha-Bonet D,Justo D,Rogowski O,Saar N,Abu-Abeid S,Shenkerman G,Shapira I,Berliner S,Tomer A

更新日期：2008-01-01 00:00:00

abstract：:The effect of lipoprotein apheresis (Direct Adsorption of Lipids, DALI) (LA) on plasma levels of pentraxin 3 (PTX3), an inflammatory marker that reflects coronary plaque vulnerability, and expression of PTX3 mRNA was evaluated in patients with hyperLp(a)lipoproteinemia and angiographically defined atherosclerosis/coro...

journal_title：Mediators of inflammation

authors： Stefanutti C,Mazza F,Steiner M,Watts GF,De Nève J,Pasqualetti D,Paal J

更新日期：2016-01-01 00:00:00