Platelet counts and platelet activation markers in obese subjects.

abstract：Background:Gut microbiota is implied in obesity, because of its ability to harvest energy from diet, and in the regulation of behavior. Given the link between gut microbiota, body composition, obesity, and anxiety, the aim of this study was to evaluate the effects of a new psychobiotic formulation. Methods:Eligible pa...

journal_title：Mediators of inflammation

authors： Colica C,Avolio E,Bollero P,Costa de Miranda R,Ferraro S,Sinibaldi Salimei P,De Lorenzo A,Di Renzo L

更新日期：2017-01-01 00:00:00

abstract：:Atherosclerosis is characterized by interaction between immune and vascular endothelial cells which is mediated by adhesion molecules occurring on the surface of the vascular endothelium leading to massive release of proinflammatory mediators. Ginkgo biloba L. (Ginkgoaceae) standardized extracts showing beneficial eff...

journal_title：Mediators of inflammation

authors： Piazza S,Pacchetti B,Fumagalli M,Bonacina F,Dell'Agli M,Sangiovanni E

更新日期：2019-06-25 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is considered a multifactorial, multisystem disease in which inflammation and the immune system play important roles in development and progression. The pleiotropic cytokine TNFα is one of the major players governing the inflammation in the central nervous system and peripheral dist...

journal_title：Mediators of inflammation

authors： Tortarolo M,Lo Coco D,Veglianese P,Vallarola A,Giordana MT,Marcon G,Beghi E,Poloni M,Strong MJ,Iyer AM,Aronica E,Bendotti C

更新日期：2017-01-01 00:00:00

abstract：:In addition to the spectrum of biological action already known to be exhibited by acetylsalicylic acid (ASA) as an analgesic, anti-inflammatory and platelet aggregation inhibitor, there is growing evidence of a stimulatory effect on the immune system. ASA has been found to increase the production ofcytokines and to in...

journal_title：Mediators of inflammation

authors： Jäpel M,Lötzerich H,Rogalla K

更新日期：1994-01-01 00:00:00

abstract：Objectives:In this study, we assessed the effects of dietary magnesium on leukocyte telomere length (LTL). Designs:The current cross-sectional analysis was based on data collected within a type 2 diabetes project. Settings. Dietary magnesium intake is associated with peripheral blood leukocyte telomere length (LTL). H...

journal_title：Mediators of inflammation

authors： Yu J,Liu H,He S,Li P,Ma C,Ma M,Liu Y,Lv L,Ping F,Zhang H,Li W,Sun Q,Xu L,Li Y

更新日期：2020-05-22 00:00:00

abstract：:The increased morbidity, mortality, and ineffective treatment associated with the pathogenesis of chronic inflammatory diseases such as asthma and chronic obstructive pulmonary disease (COPD) have generated much research interest. The key role is played by phospholipases from the A2 superfamily: enzymes which are invo...

journal_title：Mediators of inflammation

authors： Pniewska E,Pawliczak R

更新日期：2013-01-01 00:00:00

abstract：:Antimicrobial peptides (AMPs) are usually small molecule peptides, which display broad-spectrum antimicrobial activity, high efficiency, and stability. For the multiple-antibiotic-resistant strains, AMPs play a significant role in the development of novel antibiotics because of their broad-spectrum antimicrobial activ...

journal_title：Mediators of inflammation

authors： Sun Y,Shang D

更新日期：2015-01-01 00:00:00

abstract：:Sestrin2 (sesn2) is an endogenous antioxidant protein that has recently gained attention for its potential to treat various inflammatory diseases. However, the relationship of sesn2 with cardiomyopathy is still unclear. In H9c2 cells, sesn2 knockdown reduced the level of 5' adenosine monophosphate-activated protein ki...

journal_title：Mediators of inflammation

authors： Hwang HJ,Kim JW,Chung HS,Seo JA,Kim SG,Kim NH,Choi KM,Baik SH,Yoo HJ

更新日期：2018-07-05 00:00:00

abstract：:In this study the question was addressed whether cAMP mediated drugs induce a differential reduction of branches of the arachidonic acid metabolism rather than a global reduction of eicosanoid synthesis. The isolated lungs of actively sensitized rats were employed to study prostaglandin and leukotriene release in the ...

journal_title：Mediators of inflammation

authors： Post MJ,Biesebeek JD,Wemer J,Rooij HH,Zijlstra FJ,Porsius AJ

更新日期：1992-01-01 00:00:00

abstract：:Behçet's disease (BD) is an autoinflammatory disease that can lead to life- and sight-threating complications. Dendritic cells (DCs) are the most potent antigen-presenting cells that can regulate multiple inflammatory pathways. The objective of this study was to investigate the association of the DC stimulatory molecu...

journal_title：Mediators of inflammation

authors： Islam SMS,Byun HO,Choi B,Sohn S

更新日期：2019-09-09 00:00:00

abstract：:To investigate the role of AEG-1 in glycolysis and tumorigenesis, we construct myc-AEG-1 expression vector and demonstrate a novel mechanism that AEG-1 may increase the activity of AMPK by Thr172 phosphorylation. The higher expression levels of AEG-1 in colorectal carcinoma cells were found but showed significant diff...

journal_title：Mediators of inflammation

authors： Song HT,Qin Y,Yao GD,Tian ZN,Fu SB,Geng JS

更新日期：2014-01-01 00:00:00

abstract：:Development of solid cancer depends on escape from host immunosurveillance. Various types of immune cells contribute to tumor-induced immune suppression, including tumor associated macrophages, regulatory T cells, type 2 NKT cells, and myeloid-derived suppressor cells (MDSCs). Growing body of evidences shows that MDSC...

journal_title：Mediators of inflammation

authors： Katoh H,Watanabe M

更新日期：2015-01-01 00:00:00

abstract：Objectives:To investigate the protective effect of ginsenoside Rg1 on relieving sepsis-induced lung inflammation and injury in vivo and in vitro. Methods:Cultured human pulmonary epithelial cell line A549 was challenged with LPS to induce cell injury, and CLP mouse model was generated to mimic clinical condition of sy...

journal_title：Mediators of inflammation

authors： Wang QL,Yang L,Peng Y,Gao M,Yang MS,Xing W,Xiao XZ

更新日期：2019-02-24 00:00:00

abstract：:The therapeutic strategies used in the treatment of hepatitis C are essentially based on the combination of direct-acting antiviral agents (DAAs). This therapy has been shown to be very effective in relation to patient adherence to treatment and has shown high rates of sustained virological response (SVR). However, th...

journal_title：Mediators of inflammation

authors： Pereira GL,Tarragô AM,Neves WLL,da Silva Neto PV,de Souza PS,Dos Santos Affonso J,de Sousa KS,da Silva JA,Costa AG,da Silva Victoria F,Victoria MB,Malheiro A

更新日期：2019-11-04 00:00:00

abstract：:Vascular adhesion protein-1 (VAP-1) is an ectoenzyme that functions as a copper-containing amine oxidase and is involved in leukocyte adhesion at sites of inflammation. Inhibition of VAP-1 oxidative deamination has become an attractive target for anti-inflammatory therapy with demonstrated efficacy in rodent models of...

journal_title：Mediators of inflammation

authors： Kubota R,Reid MJ,Lieu KL,Orme M,Diamond C,Tulberg N,Henry SH

更新日期：2020-01-20 00:00:00

abstract：:Dengue is an acute febrile illness with a wide spectrum of signs and symptoms ranging from mild to severe forms characterized by plasma leakage that can be fatal. NK cells are one of the main effectors in early infection and may play an important role in dengue pathogenesis. We investigated NK cell involvement during ...

journal_title：Mediators of inflammation

authors： Gandini M,Petitinga-Paiva F,Marinho CF,Correa G,De Oliveira-Pinto LM,de Souza LJ,Cunha RV,Kubelka CF,de Azeredo EL

更新日期：2017-01-01 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is a most frequently occurring and severe form of motor neuron disease, causing death within 3-5 years from diagnosis and with a worldwide incidence of about 2 per 100,000 person-years. Mutations in over twenty genes associated with familial forms of ALS have provided insights into ...

journal_title：Mediators of inflammation

authors： Parisi C,Napoli G,Pelegrin P,Volonté C

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:Influenza virus is a worldwide health problem with significant economic consequences. To study the gene expression pattern induced by influenza virus infection, it is useful to reveal the pathogenesis of influenza virus infection; but this has not been well examined, especially in vivo study. AIMS:To assess...

journal_title：Mediators of inflammation

authors： Sakai S,Mantani N,Kogure T,Ochiai H,Shimada Y,Terasawa K

更新日期：2002-12-01 00:00:00

abstract：:The effect of L-carnitine and some of its acyl derivatives on serum TNF production and lethality in a murine experimental endotoxin shock model was investigated. In some instances, serum IL-6 production was also evaluated. In this experimental model, C57BL/6 mice received 30 mg/kg LPS (E. cell 055:B5) injected intrape...

journal_title：Mediators of inflammation

authors： Ruggiero V,D'Urso CM,Albertoni C,Campo S,Foresta P,Martelli EA

更新日期：1993-01-01 00:00:00

abstract：:An underlying endothelial dysfunction plays a fundamental role in the pathogenesis of cardiovascular events and is the central feature of atherosclerosis. The protein-based communication between leukocytes and inflamed endothelial cells leading to diapedesis has been largely investigated and several key players such a...

journal_title：Mediators of inflammation

authors： Dorosz SA,Ginolhac A,Kähne T,Naumann M,Sauter T,Salsmann A,Bueb JL

更新日期：2015-01-01 00:00:00

abstract：:Parasites of the genus Leishmania are capable of inhibiting effector functions of macrophages. These parasites have developed the adaptive ability to escape host defenses; for example, they inactivate the NF-κB complex and suppress iNOS expression in infected macrophages, which are responsible for the production of th...

journal_title：Mediators of inflammation

authors： Marcusso Orsini T,Kawakami NY,Panis C,Fortes Dos Santos Thomazelli AP,Tomiotto-Pellissier F,Cataneo AH,Kian D,Megumi Yamauchi L,Gouveia Júnior FS,de França Lopes LG,Cecchini R,Nazareth Costa I,Jerley Nogueira da Silva J,Conchon

更新日期：2016-01-01 00:00:00

abstract：:Platelet-released growth factors (PRGF) and its related clinically used formulations (e.g., Vivostat Platelet-Rich Fibrin (PRF®)) contain a variety of chemokines, cytokines, and growth factors and are therefore used to support healing of chronic, hard-to-heal, or infected wounds. Human beta-defensin-3 (hBD-3) is an an...

journal_title：Mediators of inflammation

authors： Bayer A,Lammel J,Tohidnezhad M,Lippross S,Behrendt P,Klüter T,Pufe T,Cremer J,Jahr H,Rademacher F,Gläser R,Harder J

更新日期：2017-01-01 00:00:00

abstract：:A TP II analogue, [1-Nal3] TP II, was synthesized by a conventional solution method, followed by deprotection with 1M TFMSA-thioanisole (molar ratio 1:1) in TFA in the presence of Me2Se and m-cresol as scavengers. The synthetic [1-Nal3] TP II, TP II and [Phe (4 F)3] TP II were tested for comparative effect on the impa...

journal_title：Mediators of inflammation

authors： Abiko T,Nakatsubo S

更新日期：2000-01-01 00:00:00

abstract：:Inflammation is an important component of diabetic retinal damage. We previously reported that a novel β-adrenergic receptor agonist, Compound 49b, reduced Toll-like receptor 4 (TLR4) signaling in retinal endothelial cells (REC) grown in high glucose. Others reported that TLR4 activates high-mobility group box 1 (HMGB...

journal_title：Mediators of inflammation

authors： Jiang Y,Liu L,Curtiss E,Steinle JJ

更新日期：2017-01-01 00:00:00

abstract：OBJECTIVES:Obesity and related diseases are dramatically increasing problems, particularly in children and adolescents. We determined circulating levels of different interleukin (IL)-1 family members in normal weight and overweight adolescents. METHODS:Seventy male, Caucasian adolescents (13-17 years) were recruited. ...

journal_title：Mediators of inflammation

authors： Jung C,Gerdes N,Fritzenwanger M,Figulla HR

更新日期：2010-01-01 00:00:00

abstract：:The purpose of this study is to characterize synovial fluid- (SF-) derived exosomes of patients with gonarthrosis comparing two methods of isolation and to investigate their immune regulatory properties. Extracellular vesicles (EVs) have been isolated from inflamed SF by polymer precipitation method and quantified by ...

journal_title：Mediators of inflammation

authors： Domenis R,Zanutel R,Caponnetto F,Toffoletto B,Cifù A,Pistis C,Di Benedetto P,Causero A,Pozzi M,Bassini F,Fabris M,Niazi KR,Soon-Shiong P,Curcio F

更新日期：2017-01-01 00:00:00

abstract：:Nitric oxide has enigmatic qualities in inflammation. In order to appreciate the precise contributions of nitric oxide to a pathophysiological process, one must account for enzyme source, coproduction of oxidants and antioxidant defences, time, rate of nitric oxide production, cellular source, peroxynitrite formation ...

journal_title：Mediators of inflammation

authors： Miller MJ,Grisham MB

更新日期：1995-01-01 00:00:00

abstract：:To test the statistical association of the CRP and SAA1 locus variants with their corresponding circulating levels and metabolic and inflammatory biomarker levels by using mediation analysis, a sample population of 599 Taiwanese subjects was enrolled and five CRP and four SAA1 variants were genotyped. Correlation anal...

journal_title：Mediators of inflammation

authors： Ko YL,Hsu LA,Wu S,Teng MS,Chou HH

更新日期：2016-01-01 00:00:00

abstract：:Maternal immune activation (MIA) is a potential risk factor for autism spectrum disorder (ASD) and schizophrenia (SZ). In rodents, MIA results in changes in cytokine profiles and abnormal behaviors in the offspring that model these neuropsychiatric conditions. Given the central role that mitochondria have in immunity ...

journal_title：Mediators of inflammation

authors： Giulivi C,Napoli E,Schwartzer J,Careaga M,Ashwood P

更新日期：2013-01-01 00:00:00

abstract：:To elucidate the role of (1-->3)-beta-D-glucan in pulmonary aspergilloma, serum concentrations of (1-->3)-beta-D-glucan were measured repeatedly for as long as 10 months in eight patients. In four patients with inactive disease, concentrations of (1-->3)-beta-D-glucan were in the normal range.The concentrations of (1-...

journal_title：Mediators of inflammation

authors： Yuasa K,Goto H

更新日期：1997-01-01 00:00:00