Abstract:
:Development of solid cancer depends on escape from host immunosurveillance. Various types of immune cells contribute to tumor-induced immune suppression, including tumor associated macrophages, regulatory T cells, type 2 NKT cells, and myeloid-derived suppressor cells (MDSCs). Growing body of evidences shows that MDSCs play pivotal roles among these immunosuppressive cells in multiple steps of cancer progression. MDSCs are immature myeloid cells that arise from myeloid progenitor cells and comprise a heterogeneous immune cell population. MDSCs are characterized by the ability to suppress both adaptive and innate immunities mainly through direct inhibition of the cytotoxic functions of T cells and NK cells. In clinical settings, the number of circulating MDSCs is associated with clinical stages and response to treatment in several cancers. Moreover, MDSCs are reported to contribute to chemoresistant phenotype. Collectively, targeting MDSCs could potentially provide a rationale for novel treatment strategies in cancer. This review summarizes recent understandings of MDSCs in cancer and discusses promissing clinical approaches in cancer patients.
journal_name
Mediators Inflammjournal_title
Mediators of inflammationauthors
Katoh H,Watanabe Mdoi
10.1155/2015/159269subject
Has Abstractpub_date
2015-01-01 00:00:00pages
159269eissn
0962-9351issn
1466-1861journal_volume
2015pub_type
杂志文章,评审abstract::Chronic inflammation is a hallmark of HIV infection. Eicosanoids reflect inflammation, oxidant stress, and vascular health and vary by sex and metabolic parameters. Raltegravir (RAL) is an HIV-1 integrase inhibitor that may have limited metabolic effects. We assessed urinary F2-isoprostanes (F2-IsoPs), prostaglandin E...
journal_title:Mediators of inflammation
pub_type: 杂志文章,随机对照试验
doi:10.1155/2014/803095
更新日期:2014-01-01 00:00:00
abstract::Matrix metalloproteinase 9 is a proteolytic enzyme which is recently one of the more often studied biomarkers. Its possible use as a biomarker of neuronal damage in stroke, heart diseases, tumors, multiple sclerosis, and epilepsy is being widely indicated. In epilepsy, MMP-9 is suggested to play a role in epileptic fo...
journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
doi:10.1155/2016/7369020
更新日期:2016-01-01 00:00:00
abstract:Background:Acute lung injury (ALI) and subsequent pulmonary infection are the most severe and usually fatal complications for elderly hip fracture patients. It is necessary to find some biomarkers for early diagnosis and prognosis of it. Objective:This study is aimed at examining the differential expression of miR-146...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2018/8101359
更新日期:2018-10-28 00:00:00
abstract:Background:Systemic inflammation impairs cognitive performance, yet the brain networks mediating this process remain to be elucidated. The purpose of the current study was to use resting-state functional magnetic resonance imaging (fMRI) to explore changes in the functional connectivity in a lipopolysaccharide- (LPS-) ...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2019/6212934
更新日期:2019-05-09 00:00:00
abstract::Human gingival fibroblast barrier dysfunction caused by inflammation contributes to gingivitis and can lead to inflammatory periodontal disease. The disease features include upregulated epithelial permeability, increased inflammatory mediators, and downregulated junctional complex molecules. Carbon monoxide- (CO-) rel...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2020/6302391
更新日期:2020-04-28 00:00:00
abstract::Prevalence of thyroid dysfunction and its impact on cognition in older people has been demonstrated, but many points remain unclarified. In order to study the effect of aging on the thyroid gland, we compared the thyroid gland of very old mice with that of younger ones. We have first investigated the changes of thyroi...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2017/8102170
更新日期:2017-01-01 00:00:00
abstract::S. epidermidis is responsible for biofilm-related nonunions. This study compares the response to S. epidermidis-infected fractures in rats systemically or locally injected with vancomycin or bone marrow mesenchymal stem cells (BMSCs) in preventing the nonunion establishment. The 50% of rats receiving BMSCs intravenous...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2016/9595706
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND:Severe traumatization induces a complex pathophysiology, driven by the patient's own immune system. The initial activation is a result of damage-associated molecular patterns, which are released from disrupted and dying cells and recognized by immune receptors, for example, RAGE. In this study we aimed to ev...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2015/691491
更新日期:2015-01-01 00:00:00
abstract::The pivotal role of epithelial cells is to secrete and absorb ions and water in order to allow the formation of a luminal fluid compartment that is fundamental for the epithelial function as a barrier against environmental factors. Importantly, epithelial cells also take part in the innate immune system. As a first li...
journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
doi:10.1155/2016/7596531
更新日期:2016-01-01 00:00:00
abstract::Cardiovascular (CV) disease is the most common cause of premature mortality in patients with rheumatoid arthritis (RA). It is the result of an accelerated atherosclerotic process. Both RA and atherosclerosis are complex polygenic diseases. Besides traditional CV risk factors and chronic inflammation, a number of studi...
journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
doi:10.1155/2012/574817
更新日期:2012-01-01 00:00:00
abstract::Autism is a neurodevelopmental disorder characterized by problems in communication, social skills, and repetitive behavior. Recent studies suggest that apoptotic and inflammatory mechanisms may contribute to the pathogenesis of this disorder. Nuclear factor-κB (NF-κB) is an important gene transcriptional factor involv...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2011/785265
更新日期:2011-01-01 00:00:00
abstract::Alveolar macrophages have recently been postulated as being involved in the aetiology of adult respiratory distress syndrome (ARDS). To evaluate their role, basal cyclic AMP levels and responsiveness of adenylyl cyclase alveolar macrophages were determined at four intermediate stages of developing respiratory distress...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/S0962935193000341
更新日期:1993-01-01 00:00:00
abstract::TLRs recognize a broad spectrum of microorganism molecules, triggering a variety of cellular responses. Among them, phagocytosis is a critical process for host defense. Leukotrienes (LTs), lipid mediators produced from 5-lipoxygenase (5-LO) enzyme, increase FcγR-mediated phagocytosis. Here, we evaluated the participat...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2017/2086840
更新日期:2017-01-01 00:00:00
abstract::Exosomes are nanosized vesicles released from every cell in the body including those in the respiratory tract and lungs. They are found in most body fluids and contain a number of different biomolecules including proteins, lipids, and both mRNA and noncoding RNAs. Since they can release their contents, particularly mi...
journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
doi:10.1155/2016/5628404
更新日期:2016-01-01 00:00:00
abstract::We have previously shown that immunodominant MBP peptides encapsulated in mannosylated liposomes (Xemys) effectively suppressed experimental allergic encephalomyelitis (EAE). Within the frames of the successfully completed phase I clinical trial, we investigated changes in the serum cytokine profile after Xemys admini...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2016/2847232
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND:Airway smooth muscle (ASM) is considered to be a target for mediators released during airway inflammation. AIMS:To investigate the expression of c-fos, a constituent of the transcription factor activator protein-1, in human ASM cells. In addition, to measure the release of interleukin (IL)-6 into the condit...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1080/09629350124155
更新日期:2001-06-01 00:00:00
abstract:Objectives:To investigate the protective effect of ginsenoside Rg1 on relieving sepsis-induced lung inflammation and injury in vivo and in vitro. Methods:Cultured human pulmonary epithelial cell line A549 was challenged with LPS to induce cell injury, and CLP mouse model was generated to mimic clinical condition of sy...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2019/6453296
更新日期:2019-02-24 00:00:00
abstract::Pregnancy is a unique immunological state in which a balance of immune tolerance and suppression is needed to protect the fetus without compromising the mother. It has long been established that a bias from the T helper 1 cytokine profile towards the T helper 2 profile contributes towards successful pregnancy maintena...
journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
doi:10.1155/2012/967629
更新日期:2012-01-01 00:00:00
abstract::The inflammatory process has direct effects on normal and abnormal wound healing. Hypertrophic scar formation is an aberrant form of wound healing and is an indication of an exaggerated function of fibroblasts and excess accumulation of extracellular matrix during wound healing. Two cytokines--transforming growth fact...
journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
doi:10.1155/2010/413238
更新日期:2010-01-01 00:00:00
abstract::A prominent feature of inflammatory diseases is endothelial dysfunction. Factors associated with endothelial dysfunction include proinflammatory cytokines, adhesion molecules, and matrix degrading enzymes. At the transcriptional level, they are regulated by the histone deacetylase sirtuin (SIRT) 1 via its actions on t...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2012/597514
更新日期:2012-01-01 00:00:00
abstract::An underlying endothelial dysfunction plays a fundamental role in the pathogenesis of cardiovascular events and is the central feature of atherosclerosis. The protein-based communication between leukocytes and inflamed endothelial cells leading to diapedesis has been largely investigated and several key players such a...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2015/737310
更新日期:2015-01-01 00:00:00
abstract::Extracellular bacterial ribonucleases such as binase from Bacillus pumilus possess cytotoxic activity against tumor cells with a potential for clinical application. Moreover, they may induce activation of tumor-derived macrophages either into the M1-phenotype with well-documented functions in the regulation of the ant...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2017/4029641
更新日期:2017-01-01 00:00:00
abstract::Acute kidney injury (AKI), a clinical syndrome, is a sudden onset of kidney failure that severely affects the kidney tubules. One potential treatment is dexmedetomidine (DEX), a highly selective α2-adrenoreceptor agonist that is used as an anesthetic adjuvant. It also has anti-inflammatory, neuroprotective, and sympat...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2020/2120971
更新日期:2020-04-03 00:00:00
abstract::There is some anecdotal evidence that oxygen-ozone therapy may be beneficial in some human diseases. However so far only a few biochemical and pharmacodynamic mechanisms have been elucidated. On the basis of preliminary data we postulated that controlled ozone administration would promote an oxidative preconditioning ...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1080/09629359890983
更新日期:1998-01-01 00:00:00
abstract::The effect of exogenous RNA on many cellular functions has been studied in a variety of eukaryotic cells but there are few reports on macrophages. In the present study, it is demonstrated that cytoplasmatic RNA extracted from rat macrophages stimulated with Escherichia coli lipopolysaccharide (LPS), referred to as L-R...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/S0962935193000626
更新日期:1993-01-01 00:00:00
abstract::Background. Neutrophilic bronchial inflammation is a main feature of bronchiectasis, but not much is known about its relationship with other disease features. Aim. To compare airway inflammatory markers with clinical and functional findings in subjects with stable noncystic fibrosis bronchiectasis (NCFB). Methods. 152...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2015/642503
更新日期:2015-01-01 00:00:00
abstract::The secretory leukocyte protease inhibitor (SLPI) is a low-molecular-weight inhibitor of proteases, such as elastase and cathepsin G which are released from leukocytes during phagocytosis. The purpose of this study was to determine whether or not SLPI is able to inhibit IgE-mediated histamine release. Nasal mucosa fro...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1080/09629359891162
更新日期:1998-01-01 00:00:00
abstract::Respiratory syncytial virus (RSV) is the most common respiratory virus and is associated with pediatric pneumonia, causing bronchiolitis and significant mortality in infants and young children. MicroRNAs (miRNAs) are endogenous noncoding small RNAs that function in gene regulation and are associated with host immune r...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2020/8919534
更新日期:2020-05-01 00:00:00
abstract::Postoperative-fluid retention is a severe complication frequently reported in patients undergoing major surgical procedures. The complex network of molecules involved in such a severe surgery-induced condition remains poorly understood. Inflammation has been proposed among the various causes of fluid retention. Since ...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2013/159349
更新日期:2013-01-01 00:00:00
abstract::Stimulation of phosphoinositide hydrolysis in myocardium from autoimmune myocarditis mice by ThEA and histamine was assayed. Myocardium from autoimmune heart, but not the normal forms, specifically increased phosphoinositide turnover in the presence of histaminergic agonists. This increment was blocked by a specific H...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/S0962935193000444
更新日期:1993-01-01 00:00:00