Abstract:
:Lysophosphatidic acid (LPA) is a bioactive phospholipid playing an important role in various inflammatory diseases by inducing expression and secretion of many inflammatory cytokines/chemokines. Here we report in a murine air pouch model of inflammation that LPA induced CXCL13 secretion in a time-dependent manner and with exacerbation of the response when LPA was administered after a pretreatment with TNF-α, a key inflammatory cytokine. LPA mediates recruitment of leukocytes, including that of CD3(+) cells into unprimed and TNF-α-primed air pouches. CXCL13 neutralization using a blocking antibody injected into air pouches prior to administration of LPA into TNF-α-primed air pouches decreased CD3(+) cell influx. Our data highlight that LPA-mediated CXCL13 secretion plays a role in T cell recruitment and participates in regulation of the inflammatory response.
journal_name
Mediators Inflammjournal_title
Mediators of inflammationauthors
Hui W,Zhao C,Bourgoin SGdoi
10.1155/2015/248492subject
Has Abstractpub_date
2015-01-01 00:00:00pages
248492eissn
0962-9351issn
1466-1861journal_volume
2015pub_type
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