Anti-inflammatory cytokines in asthma and allergy: interleukin-10, interleukin-12, interferon-gamma.

abstract：:Increasing evidence has demonstrated that reactive oxygen species (ROS) induces oxidative stress and plays a crucial role in the pathogenesis of acute pancreatitis (AP). Hydrogen-rich saline (HRS), a well-known ROS scavenger, has been shown to possess therapeutic benefit on AP in many animal experiments. Recent findin...

journal_title：Mediators of inflammation

authors： Ren JD,Ma J,Hou J,Xiao WJ,Jin WH,Wu J,Fan KH

更新日期：2014-01-01 00:00:00

abstract：:The effect of lipoprotein apheresis (Direct Adsorption of Lipids, DALI) (LA) on plasma levels of pentraxin 3 (PTX3), an inflammatory marker that reflects coronary plaque vulnerability, and expression of PTX3 mRNA was evaluated in patients with hyperLp(a)lipoproteinemia and angiographically defined atherosclerosis/coro...

journal_title：Mediators of inflammation

authors： Stefanutti C,Mazza F,Steiner M,Watts GF,De Nève J,Pasqualetti D,Paal J

更新日期：2016-01-01 00:00:00

abstract：:To elucidate the modulatory role of histamine-degrading enzymes in airway constrictor responses, human bronchial strips were studied under isometric conditions in vitro. Pretreatment of tissues with the histamine N-methyltransferase (HMT) inhibitor SKF 91488 specifically potentiated the contractile responses to histam...

journal_title：Mediators of inflammation

authors： Tamaoki J,Chiyotani A,Tagaya E,Isono K,Konno K

更新日期：1994-01-01 00:00:00

abstract：:This study was designated to evaluate the influence of behavioral depression on the airway leukocyte recruitment in allergic animals. To achieve this, total and differential cell counts in bronchoalveolar (BAL) fluid of ovalbumin (OVA)-sensitized and depressed rats was evaluated. Inescapable electric footshock, applie...

journal_title：Mediators of inflammation

authors： Varriano MA,Varriano AA,Datti F,Datti M,Antunes E,Teixeira NA

更新日期：2001-08-01 00:00:00

abstract：:Stimulation of phosphoinositide hydrolysis in myocardium from autoimmune myocarditis mice by ThEA and histamine was assayed. Myocardium from autoimmune heart, but not the normal forms, specifically increased phosphoinositide turnover in the presence of histaminergic agonists. This increment was blocked by a specific H...

journal_title：Mediators of inflammation

authors： Goren N,Leiros CP,Sterin-Borda L,Borda ES

更新日期：1993-01-01 00:00:00

abstract：BACKGROUND:Growth arrest specific gene 6 (Gas6) protein enhances survival of oligodendrocytes and neurons, and it is involved in autoimmunity. Therefore, we aimed to verify whether cerebrospinal-fluid (CSF) Gas6 concentration may represent a biomarker of disease activity in multiple sclerosis. METHODS:Sixty-five patie...

journal_title：Mediators of inflammation

authors： Sainaghi PP,Collimedaglia L,Alciato F,Molinari R,Sola D,Ranza E,Naldi P,Monaco F,Leone M,Pirisi M,Avanzi GC

更新日期：2013-01-01 00:00:00

abstract：:Sestrin2 (sesn2) is an endogenous antioxidant protein that has recently gained attention for its potential to treat various inflammatory diseases. However, the relationship of sesn2 with cardiomyopathy is still unclear. In H9c2 cells, sesn2 knockdown reduced the level of 5' adenosine monophosphate-activated protein ki...

journal_title：Mediators of inflammation

authors： Hwang HJ,Kim JW,Chung HS,Seo JA,Kim SG,Kim NH,Choi KM,Baik SH,Yoo HJ

更新日期：2018-07-05 00:00:00

abstract：:Background. Growth arrest-specific (Gas) 6 is one of the endogenous ligands of TAM receptors (Tyro3, Axl, and Mertk), and its role as an immune modulator has been recently emphasized. Naturally occurring CD4+CD25+ regulatory T cells (Tregs) are essential for the active suppression of autoimmunity. The present study wa...

journal_title：Mediators of inflammation

authors： Zhao GJ,Zheng JY,Bian JL,Chen LW,Dong N,Yu Y,Hong GL,Chandoo A,Yao YM,Lu ZQ

更新日期：2017-01-01 00:00:00

abstract：:Cysteinyl leukotrienes (CysLTs) are potent lipid inflammatory mediators synthesized from arachidonic acid, through the 5-lipoxygenase (5-LO) pathway. Owing to their properties, CysLTs play a crucial role in the pathogenesis of inflammation; therefore, CysLT modifiers as synthesis inhibitors or receptor antagonists, ce...

journal_title：Mediators of inflammation

authors： Colazzo F,Gelosa P,Tremoli E,Sironi L,Castiglioni L

更新日期：2017-01-01 00:00:00

abstract：:OKT3 , a murine monoclonal antibody specific to the human CD3 complex, induces immunosuppression by depletion of T cells. Administration of OKT3 results in significant release of proinflammatory cytokines, such as TNFalpha and IL1beta. Liver recipients who experience rejection within 3 weeks after transplantation with...

journal_title：Mediators of inflammation

authors： Roayaie S,Sheiner PA,Emre S,Guy S,Schwartz ME,Boros P,Miller CM

更新日期：2000-01-01 00:00:00

abstract：:Inflammatory bowel disease (IBD) is a group of inflammatory conditions of the gastrointestinal tract of unclear aetiology of which two major forms are Crohn's disease (CD) and ulcerative colitis (UC). CD and UC are immunologically distinct, although they both result from hyperactivation of proinflammatory pathways in ...

journal_title：Mediators of inflammation

authors： Ślebioda TJ,Kmieć Z

更新日期：2014-01-01 00:00:00

abstract：:Group A streptococcus (GAS) imposes a great burden on humans. Efforts to minimize the associated morbidity and mortality represent a critical issue. Glycogen synthase kinase-3 β (GSK-3 β) is known to regulate inflammatory response in infectious diseases. However, the regulation of GSK-3 β in GAS infection is still unk...

journal_title：Mediators of inflammation

authors： Chang YT,Chen CL,Lin CF,Lu SL,Cheng MH,Kuo CF,Lin YS

更新日期：2013-01-01 00:00:00

abstract：:Thymosin beta(4) is a polypeptide isolated from thymosin fraction 5. This peptide exhibits important activities in the regulation and differentiation of thymus-dependent lymphocytes. An analogue of thymosin beta(4), [Phe(4F)(12)] deacetyl- thymosin beta(4), was synthesized by a solution method, followed by deprotectio...

journal_title：Mediators of inflammation

authors： Abiko T,Sekino H

更新日期：1992-01-01 00:00:00

abstract：:Angiostrongylus cantonensis (A. cantonensis) is an important food-borne parasitic disease. Previous study showed that A. cantonensis infection can cause demyelination in the central nerve system, but the mechanism of action has not been understood. To explore the mechanism and to look for effective therapeutic methods...

journal_title：Mediators of inflammation

authors： Ying F,Cunjing Z,Feng F,Shuo W,Xin Z,Fukang X,Zhongdao W

更新日期：2017-01-01 00:00:00

abstract：:The present study investigated the association between the rs12979860 polymorphism in the IL-28B gene and HTLV-1 infection as well as the development of HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). HTLV-1-infected patients (26 HAM/TSP symptomatic and 53 asymptomatic) and 300 seronegative health...

journal_title：Mediators of inflammation

authors： Vallinoto AC,Santana BB,Sá KS,Ferreira TC,Sousa RC,Azevedo VN,Feitosa RN,Machado LF,Ishak MO,Ishak R

更新日期：2015-01-01 00:00:00

abstract：:Cytokine-induced endothelial dysfunction leads to inflammation and vascular adhesion molecule production in retinal pigment epithelium (RPE) cells. Inflammation is a critical mediator in retinal degeneration (RD) diseases, including age-related macular degeneration (AMD), and RD progression may be prevented through an...

journal_title：Mediators of inflammation

authors： Huang WC,Liou CJ,Shen SC,Hu S,Hsiao CY,Wu SJ

更新日期：2020-10-16 00:00:00

abstract：BACKGROUND:Empirical observations have shown that ozonated autohemotherapy markedly improves the symptoms of chronic limb ischemia (muscular pain at rest, intermittent claudication, etc) in atherosclerotic patients, but mechanisms of action remain unclear. AIMS:Human endothelial cells (HUVECs) are known to release nit...

journal_title：Mediators of inflammation

authors： Valacchi G,Bocci V

更新日期：2000-01-01 00:00:00

abstract：:The mechanism of pain reduction involves bidirectional processes of pain blocking (nociception) and reductions in the levels of proinflammatory cytokines in the blood. Does transcutaneous electrical nerve stimulation (TENS) reduce blood levels of proinflammatory cytokines? For this systematic review, we searched in si...

journal_title：Mediators of inflammation

authors： do Carmo Almeida TC,Dos Santos Figueiredo FW,Barbosa Filho VC,de Abreu LC,Fonseca FLA,Adami F

更新日期：2018-04-02 00:00:00

abstract：:Rheumatoid arthritis (RA), a chronic inflammatory disease usually occurring in synovial tissues and joints, is highly associated with genetic and environmental factors. ORAI1, a gene related to cellular immune system, has been shown to be involved in the pathogenesis of chronic inflammatory diseases and immune disease...

journal_title：Mediators of inflammation

authors： Yen JH,Chang CM,Hsu YW,Lee CH,Wu MS,Hwang DY,Chen BK,Liao HT,Wu MT,Chang WC

更新日期：2014-01-01 00:00:00

abstract：:Tuberculosis is characterized by the presence of activated mononuclear cells both in the peripheral circulation and in pleural fluid. Expression and up-regulation of adhesion molecules is the basis of cell-cell adhesion in granuloma formation and in leukocyte migration to the inflammatory site. Soluble isoforms of adh...

journal_title：Mediators of inflammation

authors： Hamzaoui A,Hamzaoui K,Kahan A,Chabbou A

更新日期：1996-01-01 00:00:00

abstract：:This study investigated the protective effects of intravitreal Resolvin D1 (RvD1) against LPS-induced rat endotoxic uveitis (EIU). RvD1 was administered into the right eye at a single injection of 5 μL volume containing 10-100-1000 ng/kg RvD1 1 h post-LPS injection (200 μg, Salmonella minnesota) into thefootpad of Spr...

journal_title：Mediators of inflammation

authors： Rossi S,Di Filippo C,Gesualdo C,Potenza N,Russo A,Trotta MC,Zippo MV,Maisto R,Ferraraccio F,Simonelli F,D'Amico M

更新日期：2015-01-01 00:00:00

abstract：:Peptide 204-212 of lipocortin (LC) 5 inhibited porcine pancreatic phospholipase A(2) (PLA(2)) induced rat stomach strip contractions and ADP induced rabbit platelet aggregation in a concentration dependent manner (IC(30) of 10 muM and 400 muM, respectively). The first two amino acids are not necessary since the eptape...

journal_title：Mediators of inflammation

authors： Mugridge KG,Becherucci C,Parente L,Perretti M

更新日期：1993-01-01 00:00:00

abstract：:Human Vγ9Vδ2 T cells recognise pyrophosphate-based antigens (phosphoantigens) and have multiple functions in innate and adaptive immunity, including a unique ability to activate other cells of the immune system. We used flow cytometry and ELISA to define the early cytokine profiles of Vγ9Vδ2 T cells stimulated in vitr...

journal_title：Mediators of inflammation

authors： Dunne MR,Mangan BA,Madrigal-Estebas L,Doherty DG

更新日期：2010-01-01 00:00:00

abstract：:Nitric oxide has enigmatic qualities in inflammation. In order to appreciate the precise contributions of nitric oxide to a pathophysiological process, one must account for enzyme source, coproduction of oxidants and antioxidant defences, time, rate of nitric oxide production, cellular source, peroxynitrite formation ...

journal_title：Mediators of inflammation

authors： Miller MJ,Grisham MB

更新日期：1995-01-01 00:00:00

abstract：INTRODUCTION:Impaired maternal immune tolerance resulting in systemic inflammation plays a pivotal role in the pathogenesis of preeclampsia. Phenotypical changes of monocytes and neutrophil granulocytes have already been studied in preeclampsia, and some studies also included T lymphocyte activation markers; however, t...

journal_title：Mediators of inflammation

authors： Bajnok A,Ivanova M,Rigó J Jr,Toldi G

更新日期：2017-01-01 00:00:00

abstract：:Shinbaro3, a formulation derived from the hydrolysed roots of Harpagophytum procumbens var. sublobatum (Engl.) Stapf, has been clinically used in the pharamacopuncture treatment of arthritis in Korea. In the present study, Shinbaro3 inhibited NO generation in LPS-induced RAW 264.7 cells in a dose-dependent manner. Shi...

journal_title：Mediators of inflammation

authors： Chung HJ,Koh W,Kim WK,Shin JS,Lee J,Lee SK,Ha IH

更新日期：2018-04-05 00:00:00

abstract：:Chronic kidney disease (CKD) patients, characterized by traditional and nontraditional risk factors, are prone to develop atheromatosis and thus cardiovascular events and mortality. The angiogenesis of the adventitial vasa vasorum (aVV) surrounding the carotid has been described as the atheromatosis initiator. Therefo...

journal_title：Mediators of inflammation

authors： Arcidiacono MV,Martinez-Alonso M,Belart M,Vilar A,Martín M,Craver L,Betriu À,Mauricio D,Valdivielso JM,Fernández E,Borràs M

更新日期：2017-01-01 00:00:00

abstract：:Rheumatoid arthritis (RA) is characterized by an abnormal cellular and cytokine infiltration of inflamed joints. This study addresses a previously unrecognized interaction between neutrophilic-myeloperoxidase (MPO) and macrophages (Mphi) which could explain the perpetuation of inflammation associated with RA. A monoar...

journal_title：Mediators of inflammation

authors： Gelderman MP,Stuart R,Vigerust D,Fuhrmann S,Lefkowitz DL,Allen RC,Lefkowitz SS,Graham S

更新日期：1998-01-01 00:00:00

abstract：:This study tested the hypothesis that shock wave therapy (SW) enhances mitochondrial uptake into the lung epithelial and parenchymal cells to attenuate lung injury from acute respiratory distress syndrome (ARDS). ARDS was induced in rats through continuous inhalation of 100% oxygen for 48 h, while SW entailed applicat...

journal_title：Mediators of inflammation

authors： Lin KC,Wallace CG,Yin TC,Sung PH,Chen KH,Lu HI,Chai HT,Chen CH,Chen YL,Li YC,Shao PL,Lee MS,Sheu JJ,Yip HK

更新日期：2018-10-21 00:00:00

abstract：BACKGROUND:The cyclooxygenase- (COX-) 2/microsomal PGE-synthase- (mPGES-) 1/PGE-receptor- (EP-) 4 axis could play a key role in the physiopathology of abdominal aortic aneurysm (AAA) in humans. In this study, we investigated the influence of cardiovascular risk factors on the expression of the PGE2 pathway in human AAA...

journal_title：Mediators of inflammation

authors： Dilmé JF,Solà-Villà D,Bellmunt S,Romero JM,Escudero JR,Camacho M,Vila L

更新日期：2014-01-01 00:00:00