Abstract:
:Rheumatoid arthritis (RA), a chronic inflammatory disease usually occurring in synovial tissues and joints, is highly associated with genetic and environmental factors. ORAI1, a gene related to cellular immune system, has been shown to be involved in the pathogenesis of chronic inflammatory diseases and immune diseases. To identify whether ORAI1 gene contributes to RA susceptibility, we enrolled 400 patients with RA and 621 healthy individuals for a case-control genetic association study. Five tagging single nucleotides polymorphisms (tSPNs) within ORAI1 gene were selected for genotyping. An SNP, rs7135617, showed a significant correlation with the risk of RA. Our results indicated that genetic polymorphism of ORAI1 gene is involved in the susceptibility of RA in a Taiwanese population.
journal_name
Mediators Inflammjournal_title
Mediators of inflammationauthors
Yen JH,Chang CM,Hsu YW,Lee CH,Wu MS,Hwang DY,Chen BK,Liao HT,Wu MT,Chang WCdoi
10.1155/2014/834831subject
Has Abstractpub_date
2014-01-01 00:00:00pages
834831eissn
0962-9351issn
1466-1861journal_volume
2014pub_type
杂志文章abstract::Scorpion venoms consist of a complex of several toxins that exhibit a wide range of biological properties and actions, as well as chemical compositions, toxicity, and pharmacokinetic and pharmacodynamic characteristics. These venoms are associated with high morbility and mortality, especially among children. Victims o...
journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
doi:10.1155/2010/903295
更新日期:2010-01-01 00:00:00
abstract:Background:Acute lung injury (ALI) and subsequent pulmonary infection are the most severe and usually fatal complications for elderly hip fracture patients. It is necessary to find some biomarkers for early diagnosis and prognosis of it. Objective:This study is aimed at examining the differential expression of miR-146...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2018/8101359
更新日期:2018-10-28 00:00:00
abstract::Tantalum (Ta) is gaining attention as a biomaterial in bone tissue engineering. Although the clinical advantage of Ta-based implants for primary and revision total joint replacement (TJA) has been well documented, few studies investigated the effect of wear products of Ta implants on peri-implant cells, and their pote...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2020/3824593
更新日期:2020-12-03 00:00:00
abstract::Inflammation is considered to be one of the most critical factors involved in the development of complex metabolic diseases such as type 2 diabetes, cancer, and cardiovascular disease. A few decades ago, the discovery of mitochondria-associated endoplasmic reticulum (ER) membrane (MAM) was followed by the identificati...
journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
doi:10.1155/2016/1851420
更新日期:2016-01-01 00:00:00
abstract:Background:Endothelial dysfunction and apoptosis resulting from oxidative stress can lead to the development of atherosclerosis. Our group has previously showed that CD137 signaling contributes to the progression of atherosclerosis and the vulnerability of plaques. The aim of this study is to investigate the effects of...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2020/4321912
更新日期:2020-06-06 00:00:00
abstract::Maresin1 (MaR1), a new anti-inflammatory and proresolving lipid mediator, has been proven to exert organ-protective effects in septic animal models. However, the potential mechanisms are still not fully elucidated. In this study, we sought to explore the impact of MaR1 on metabolic dysfunction in cecal ligation and pu...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2019/2309175
更新日期:2019-01-16 00:00:00
abstract::Since iron can contribute to detrimental radical generating processes through the Fenton and Haber-Weiss reactions, it seems to be a reasonable approach to modulate iron-related pathways in inflammation. In the human organism a counterregulatory reduction in iron availability is observed during inflammatory diseases. ...
journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
doi:10.1155/2015/516740
更新日期:2015-01-01 00:00:00
abstract::Chronic kidney disease (CKD) patients, characterized by traditional and nontraditional risk factors, are prone to develop atheromatosis and thus cardiovascular events and mortality. The angiogenesis of the adventitial vasa vasorum (aVV) surrounding the carotid has been described as the atheromatosis initiator. Therefo...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2017/3795142
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND:This study aims to investigate the effect of feeding low-fat diet (LFD) to diet-induced obesity (DIO) mice lacking TLR5 (TLR5(-/-)), which have a tendency to develop glucose intolerance with increased adiposity, compared to that in C57BL/6 mice. RESULTS:TLR5(-/-) and C57BL/6 male mice were divided into thre...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2015/852126
更新日期:2015-01-01 00:00:00
abstract::The mixed leukocyte population obtained from the peritoneum of the August rat is a potentially important experimental model of inherent eosinophilia that has not been well characterized. In the present study, isolated cell preparations generated a concentration-dependent release of leukotriene (LT) C(4) when exposed t...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/S0962935196000610
更新日期:1996-01-01 00:00:00
abstract::Accumulated studies have implicated microRNAs (miRNAs) exert modifying effects on colorectal cancer (CRC). Protein tyrosine phosphatase, receptor type O (PTPRO) has been identified as a tumor suppressor in several kinds of cancer, including CRC. Previously, we have found that exosome-encapsulated miR-6803-5p is increa...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2019/8128501
更新日期:2019-11-20 00:00:00
abstract::TLRs recognize a broad spectrum of microorganism molecules, triggering a variety of cellular responses. Among them, phagocytosis is a critical process for host defense. Leukotrienes (LTs), lipid mediators produced from 5-lipoxygenase (5-LO) enzyme, increase FcγR-mediated phagocytosis. Here, we evaluated the participat...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2017/2086840
更新日期:2017-01-01 00:00:00
abstract:Objective:Neuropeptide Y (NPY), an orexigenic peptide known to cause hyperphagia, has been involved in the occurrence and development of obesity. However, differences in the distribution of serum NPY levels in obese phenotypes (including metabolically unhealthy obesity (MUO) phenotype and metabolically healthy obesity ...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2020/7903140
更新日期:2020-08-04 00:00:00
abstract::Tumor necrosis factor alpha (TNF-α) is a cytokine which plays opposing roles in the context of infectious disease pathogenesis. TNF-α is essential for the development of a protective immune response to some pathogens, for example, Mycobacterium tuberculosis, by synergizing with other cytokines. However, exorbitant or ...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2015/619480
更新日期:2015-01-01 00:00:00
abstract::We investigated the serum concentrations of interleukin-6 (IL-6) and two IL-6 family of cytokines (leukaemia inhibitory factor (LIF) and ciliary neurotrophic factor (CNTF) as well as IL-6 soluble receptor (sIL-6R) using an enzyme-linked immunosorbent assay (ELISA) in 66 patients with rheumatoid arthritis (RA) and 24 h...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1080/09629359890875
更新日期:1998-01-01 00:00:00
abstract::We previously demonstrated that Bothrops jararaca venom (BjV) has an antitumor effect on Ehrlich ascites tumor (EAT) cells and induces an increase of polymorphonuclear leukocytes in early stages of tumor growth. It has been reported that this venom presents an important inflammatory effect when inoculated in animal mo...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1080/0962935029000041
更新日期:2002-08-01 00:00:00
abstract:Background:Inflammation plays a pivotal role in the pathogenesis of chronic obstructive pulmonary disease (COPD). We evaluated the lncRNA and mRNA expression profile of peripheral blood mononuclear cells (PBMCs) from healthy nonsmokers, smokers without airflow limitation, and COPD patients. Methods:lncRNA and mRNA pro...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2018/7501851
更新日期:2018-03-13 00:00:00
abstract::Inflammatory bowel disease (IBD) is a group of inflammatory conditions of the gastrointestinal tract of unclear aetiology of which two major forms are Crohn's disease (CD) and ulcerative colitis (UC). CD and UC are immunologically distinct, although they both result from hyperactivation of proinflammatory pathways in ...
journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
doi:10.1155/2014/325129
更新日期:2014-01-01 00:00:00
abstract::The production of nitric oxide (NO) was measured in cultures of spleen cells stimulated by lipopolysaccharide (LPS), IL-2 or LPS + IL-2. We observed that NO synthesis is increased by IFN-gamma but inhibited by IFN-alpha/beta. This is not the case when IL-2 is present in the cultures, since interferons play a minor rol...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/S0962935196000117
更新日期:1996-01-01 00:00:00
abstract::Thousands of people suffer from severe malaria every year. The innate immune response plays a determinant role in host's defence to malaria. Transient receptor potential vanilloid 1 (TRPV1) modulates macrophage-mediated responses in sepsis, but its role in other pathogenic diseases has never been addressed. We investi...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2014/506450
更新日期:2014-01-01 00:00:00
abstract::With the development of culture-independent techniques, numerous studies have demonstrated that the lower airway is not sterile in health and harbors diverse microbial communities. Furthermore, new evidence suggests that there is a distinct lower airway microbiome in those with chronic respiratory disease. To understa...
journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
doi:10.1155/2017/3890601
更新日期:2017-01-01 00:00:00
abstract::Microscopic colitis (MC), comprising collagenous colitis (CC) and lymphocytic colitis (LC), is a common cause of chronic diarrhea. Various immune cell infiltrations in the epithelium and lamina propria are seen in MC immunopathology. We compared gene and protein expressions of different immune cell attracting chemokin...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2015/132458
更新日期:2015-01-01 00:00:00
abstract:OBJECTIVE:Individuals with inflammation have a myriad of pregnancy aberrations including increasing their preterm birth risk. Toll-like receptors (TLRs) and receptor for advanced glycation end products (RAGE) and their ligands were all found to play a key role in inflammation. In the present study, we reviewed TLR and ...
journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
doi:10.1155/2010/490406
更新日期:2010-01-01 00:00:00
abstract::In this study, we investigated in groups of female BALB/c mice injected with Crotalus durissus terrificus venom (Cdt) the renal function based on creatinine clearance, percentage of fractional excretion cytokines and histological examination of renal tissue. Cdt caused renal alterations that induced proteinuria during...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2011/103193
更新日期:2011-01-01 00:00:00
abstract::Collagen triple helix repeat containing-1 (CTHRC1) has been identified as cancer-related protein. CTHRC1 expresses mainly in adventitial fibroblasts and neointimal smooth muscle cells of balloon-injured vessels and promotes cell migration and tissue repair in response to injury. CTHRC1 plays a pivotal role in some pat...
journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
doi:10.1155/2020/9578701
更新日期:2020-08-12 00:00:00
abstract:BACKGROUND:In aromatherapy, essential oils are used as anti-inflammatory remedies, but experimental studies on their action mechanisms are very limited. AIMS OF THE STUDY:To assess their anti-inflammatory activities, the effects of essential oils on neutrophil recruitment in mice were examined in vivo. METHOD:The eff...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1080/09629350410001664798
更新日期:2004-02-01 00:00:00
abstract::Despite early recanalization of an occluded infarct artery, tissue reperfusion remains impaired in more than one-third of the acute myocardial infarction (AMI) patients owing to a process of reperfusion injury. The role of systemic inflammation in triggering this phenomenon is unknown. Proinflammatory factors (hs-CRP,...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/MI.2005.385
更新日期:2005-12-14 00:00:00
abstract::Tuberculosis is characterized by the presence of activated mononuclear cells both in the peripheral circulation and in pleural fluid. Expression and up-regulation of adhesion molecules is the basis of cell-cell adhesion in granuloma formation and in leukocyte migration to the inflammatory site. Soluble isoforms of adh...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/S0962935196000403
更新日期:1996-01-01 00:00:00
abstract:Objectives:To investigate the protective effect of ginsenoside Rg1 on relieving sepsis-induced lung inflammation and injury in vivo and in vitro. Methods:Cultured human pulmonary epithelial cell line A549 was challenged with LPS to induce cell injury, and CLP mouse model was generated to mimic clinical condition of sy...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2019/6453296
更新日期:2019-02-24 00:00:00
abstract::Modification of endogenous eicosanoid synthesis by dietary n-3 fatty acid supplementation reduces febrile responses, but the mechanisms underlying these effects in vivo have not been determined. In the present study, local inflammation was induced by intramuscular injection ofturpentine in rats fed control or n-3 supp...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/S0962935194000499
更新日期:1994-01-01 00:00:00