Abstract:
OBJECTIVES:In the present study, the ability of magnolol, a hydroxylated biphenyl compound isolated from Magnolia officinalis, to stimulate osteoblast function and inhibit the release of bone-resorbing mediators was investigated in osteoblastic MC3T3-E1 cells. METHODS:Osteoblast function was measured by cell growth, alkaline phosphatase activity, collagen synthesis, and mineralization. Glutathione content was also measured in the cells. Bone-resorbing cytokines, receptor activator of nuclear factor-κB ligand (RANKL), TNF-α, and IL-6 were measured with an enzyme immunoassay system. RESULTS:Magnolol caused a significant elevation of cell growth, alkaline phosphatase activity, collagen synthesis, mineralization, and glutathione content in the cells (P < 0.05). Skeletal turnover is orchestrated by a complex network of regulatory factors. Among cytokines, RANKL, TNF-α, and IL-6 were found to be key osteoclastogenetic molecules produced by osteoblasts. Magnolol significantly (P < 0.05) decreased the production of osteoclast differentiation inducing factors such as RANKL, TNF-α, and IL-6 in the presence of antimycin A, which inhibits mitochondrial electron transport and has been used as an ROS generator. CONCLUSION:Magnolol might be a candidate as an agent for the prevention of bone disorders such as osteoporosis.
journal_name
Mediators Inflammjournal_title
Mediators of inflammationauthors
Kwak EJ,Lee YS,Choi EMdoi
10.1155/2012/829650subject
Has Abstractpub_date
2012-01-01 00:00:00pages
829650eissn
0962-9351issn
1466-1861journal_volume
2012pub_type
杂志文章abstract::Thiopurines are extensively used immunosuppressants for the treatment of inflammatory bowel disease (IBD). The polymorphism of thiopurine S-methyltransferase (TPMT) influences thiopurine metabolism and therapy outcome. We used a TPMT knockdown (kd) model of human Jurkat T-lymphocytes cells to study the effects of trea...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2015/434825
更新日期:2015-01-01 00:00:00
abstract::Chronic inflammation is a hallmark of HIV infection. Eicosanoids reflect inflammation, oxidant stress, and vascular health and vary by sex and metabolic parameters. Raltegravir (RAL) is an HIV-1 integrase inhibitor that may have limited metabolic effects. We assessed urinary F2-isoprostanes (F2-IsoPs), prostaglandin E...
journal_title:Mediators of inflammation
pub_type: 杂志文章,随机对照试验
doi:10.1155/2014/803095
更新日期:2014-01-01 00:00:00
abstract::Background and Objectives. Malaria infection, caused by Plasmodium falciparum, is the most lethal and frequently culminates in severe clinical complications. Interleukin-22 (IL-22) has been implicated in several diseases including malaria. The objective of this study was to investigate the role of IL-22 gene polymorph...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2020/5193723
更新日期:2020-02-19 00:00:00
abstract:INTRODUCTION:Proliferative vitreoretinopathy (PVR) is a severe inflammatory complication of retinal detachment. Pathological epiretinal membranes grow on the retina surface leading to contraction, and surgery fails in 5% to 10% of the cases. We evaluated the expression of VEGF-A, Otx1, Otx2, Otx3, and p53 family member...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2013/857380
更新日期:2013-01-01 00:00:00
abstract:Background:Sphingosine-1-phosphate (S1P) is a biologically active lysophospholipid mediator involved in modulating inflammatory process. We investigated the effects of FTY720, a structural analogue of S1P after phosphorylation, on lung injury induced by hindlimb ischemia reperfusion (IR) in rats. Methods:Fifty Sprague...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2017/5301312
更新日期:2017-01-01 00:00:00
abstract::The inflammatory process has direct effects on normal and abnormal wound healing. Hypertrophic scar formation is an aberrant form of wound healing and is an indication of an exaggerated function of fibroblasts and excess accumulation of extracellular matrix during wound healing. Two cytokines--transforming growth fact...
journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
doi:10.1155/2010/413238
更新日期:2010-01-01 00:00:00
abstract::Delayed rectifier K(+)-channels (Kv1.3) are predominantly expressed in T lymphocytes. Based on patch-clamp studies, the channels play crucial roles in facilitating the calcium influx necessary to trigger lymphocyte activation and proliferation. Using selective channel inhibitors in experimental animal models, in vivo ...
journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
doi:10.1155/2015/436572
更新日期:2015-01-01 00:00:00
abstract:OBJECTIVE:Acute ST-segment elevation myocardial infarction (ASTEMI) is accompanied by increased expression of inflammation and decreased expression of anti-inflammation. IL-37 was found to be involved in the atherosclerosis-related diseases and increased in acute coronary syndrome. However, the level of IL-37 in blood ...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2015/626934
更新日期:2015-01-01 00:00:00
abstract::Human respiratory syncytial virus (RSV) sometimes causes acute and severe lower respiratory tract illness in infants and young children. RSV strongly upregulates proinflammatory cytokines and the platelet-activating factor (PAF) receptor, which is a receptor for Streptococcus pneumoniae, in the pulmonary epithelial ce...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2012/528568
更新日期:2012-01-01 00:00:00
abstract::Acute lung injury (ALI) is characterized by alveolar edema and uncontrolled neutrophil migration to the lung, and no specific therapy is still available. Ellagic acid, a compound present in several fruits and medicinal plants, has shown anti-inflammatory activity in several experimental disease models. We used the non...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2013/164202
更新日期:2013-01-01 00:00:00
abstract::Nitric oxide has enigmatic qualities in inflammation. In order to appreciate the precise contributions of nitric oxide to a pathophysiological process, one must account for enzyme source, coproduction of oxidants and antioxidant defences, time, rate of nitric oxide production, cellular source, peroxynitrite formation ...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/S0962935195000639
更新日期:1995-01-01 00:00:00
abstract::Modification of endogenous eicosanoid synthesis by dietary n-3 fatty acid supplementation reduces febrile responses, but the mechanisms underlying these effects in vivo have not been determined. In the present study, local inflammation was induced by intramuscular injection ofturpentine in rats fed control or n-3 supp...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/S0962935194000499
更新日期:1994-01-01 00:00:00
abstract:Objectives:To investigate the protective effect of ginsenoside Rg1 on relieving sepsis-induced lung inflammation and injury in vivo and in vitro. Methods:Cultured human pulmonary epithelial cell line A549 was challenged with LPS to induce cell injury, and CLP mouse model was generated to mimic clinical condition of sy...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2019/6453296
更新日期:2019-02-24 00:00:00
abstract::Vascular complications of diabetes mellitus represent a major public health problem. Although many steps forward have been made to define the causes and to find the best possible therapies, the problem remains crucial. In recent years, more and more evidences have defined a link between microbiota and the initiation, ...
journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
doi:10.1155/2019/4128682
更新日期:2019-05-08 00:00:00
abstract::Mechanical ventilation (MV) is a major life support technique for the management of trauma-associated hemorrhagic shock (HS). Ventilator-induced diaphragm dysfunction (VIDD), one of the most common complications of MV, has been well demonstrated in animal and human studies. However, few data are available concerning t...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2019/3738409
更新日期:2019-11-14 00:00:00
abstract::The aim of the study was to evaluate the role of Smad3, Smad7, and TGF-β1 in intrauterine adhesion (IUA) patients and experimental rabbit models. 60 IUA patients, 30 control participants, and 18 female rabbits were enrolled in this study. We found that the plasma concentrations and protein expressions of TGF-β1 were s...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2016/4158287
更新日期:2016-01-01 00:00:00
abstract::Tantalum (Ta) is gaining attention as a biomaterial in bone tissue engineering. Although the clinical advantage of Ta-based implants for primary and revision total joint replacement (TJA) has been well documented, few studies investigated the effect of wear products of Ta implants on peri-implant cells, and their pote...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2020/3824593
更新日期:2020-12-03 00:00:00
abstract::Gout is a common inflammatory disease characterized by acute arthritis and hyperuricemia. A number of epidemiological studies have suggested the critical role of gout in carcinogenesis. The aim of this study was to estimate the association between gout and cancer risk by meta-analysis of all relevant studies published...
journal_title:Mediators of inflammation
pub_type: 杂志文章,meta分析,评审
doi:10.1155/2015/680853
更新日期:2015-01-01 00:00:00
abstract::Innate lymphoid cells (ILCs) are a group of hematopoietic cells devoid of antigen receptors that have important functions in lymphoid organogenesis, in the defense against extracellular pathogens, and in the maintenance of the epithelial barrier. Three distinct groups of ILCs have been identified on the basis of pheno...
journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
doi:10.1155/2014/235460
更新日期:2014-01-01 00:00:00
abstract::Cardiovascular (CV) disease is the most common cause of premature mortality in patients with rheumatoid arthritis (RA). It is the result of an accelerated atherosclerotic process. Both RA and atherosclerosis are complex polygenic diseases. Besides traditional CV risk factors and chronic inflammation, a number of studi...
journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
doi:10.1155/2012/574817
更新日期:2012-01-01 00:00:00
abstract::Pulmonary fibrosis is a progressive and fatal fibrotic disease of the lungs with unclear etiology. Recent insight has suggested that early injury/inflammation of alveolar epithelial cells could lead to dysregulation of tissue repair driven by multiple cytokines. Although dysregulation of interleukin- (IL-) 22 is invol...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2013/209179
更新日期:2013-01-01 00:00:00
abstract::The pivotal role of epithelial cells is to secrete and absorb ions and water in order to allow the formation of a luminal fluid compartment that is fundamental for the epithelial function as a barrier against environmental factors. Importantly, epithelial cells also take part in the innate immune system. As a first li...
journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
doi:10.1155/2016/7596531
更新日期:2016-01-01 00:00:00
abstract::The present study investigated the association between the rs12979860 polymorphism in the IL-28B gene and HTLV-1 infection as well as the development of HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). HTLV-1-infected patients (26 HAM/TSP symptomatic and 53 asymptomatic) and 300 seronegative health...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2015/804167
更新日期:2015-01-01 00:00:00
abstract::Inflammatory mediators, including cytokines, histamine, bradykinin, prostaglandins, and leukotrienes, impact the immune system, usually as proinflammatory factors. Other mediators act as regulatory components to establish homeostasis after injury or prevent the inflammatory process. Histamine, a biogenic vasoactive am...
journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
doi:10.1155/2018/9524075
更新日期:2018-08-27 00:00:00
abstract::As one of the ligands of aryl hydrocarbon receptor (AhR), baicalein, isolated from Scutellaria baicalensis Georgi, has been proved to exert potential therapeutic effects on ulcerative colitis (UC), but its therapeutic mechanism remains obscure. Authentically, ulcerative colitis can be alleviated by regulating the diff...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2020/5918587
更新日期:2020-10-05 00:00:00
abstract:BACKGROUND:Hepatic ischemia-reperfusion (I/R) injury is a pivotal clinical problem occurring in many clinical conditions such as transplantation, trauma, and hepatic failure after hemorrhagic shock. Apoptosis and autophagy have been shown to contribute to cell death in hepatic I/R injury. Ethyl pyruvate, a stable and s...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2013/461536
更新日期:2013-01-01 00:00:00
abstract::Neuropathic pain is a serious clinical problem to be solved. This study is aimed at investigating protein kinase A (PKA) expression in neuropathic pain and its possible mechanisms of involvement. A neuropathic pain-related gene expression dataset was downloaded from Gene Expression Omnibus, and differentially expresse...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2020/6420425
更新日期:2020-03-23 00:00:00
abstract::The most frequent pathogen that causes bacterial meningitis is the Gram-positive bacterium Streptococcus pneumoniae. By entering the brain, host cells will be activated and proinflammatory cytokines like interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) are released. The goal of the current study was to examine...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2016/7678542
更新日期:2016-01-01 00:00:00
abstract::Scorpion venoms consist of a complex of several toxins that exhibit a wide range of biological properties and actions, as well as chemical compositions, toxicity, and pharmacokinetic and pharmacodynamic characteristics. These venoms are associated with high morbility and mortality, especially among children. Victims o...
journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
doi:10.1155/2010/903295
更新日期:2010-01-01 00:00:00
abstract:BACKGROUND:Asthma is characterized by airway remodeling. Follistatin-like protein 1 (FSTL1) is an extracellular glycoprotein. Recent studies suggest that FSTL1 may participate in the pathogenesis of asthma. OBJECTIVES:To analyze the association between FSTL1 and some parameters and inspect the role of FSTL1 in asthma....
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2017/7918472
更新日期:2017-01-01 00:00:00