Anti-inflammatory effects of ellagic acid on acute lung injury induced by acid in mice.

abstract：:To elucidate the role of (1-->3)-beta-D-glucan in pulmonary aspergilloma, serum concentrations of (1-->3)-beta-D-glucan were measured repeatedly for as long as 10 months in eight patients. In four patients with inactive disease, concentrations of (1-->3)-beta-D-glucan were in the normal range.The concentrations of (1-...

journal_title：Mediators of inflammation

authors： Yuasa K,Goto H

更新日期：1997-01-01 00:00:00

abstract：:The effect of exogenous RNA on many cellular functions has been studied in a variety of eukaryotic cells but there are few reports on macrophages. In the present study, it is demonstrated that cytoplasmatic RNA extracted from rat macrophages stimulated with Escherichia coli lipopolysaccharide (LPS), referred to as L-R...

journal_title：Mediators of inflammation

authors： Ribeiro RA,Lucca FL,Flores CA,Cunha FQ,Ferreira SH

更新日期：1993-01-01 00:00:00

abstract：:Extracellular superoxide dismutase (SOD3), an enzyme mediating dismutation of superoxide into hydrogen peroxide, has been shown to reduce inflammation by inhibiting macrophage migration into injured tissues. In inflamed tissues, superoxide is produced by the phagocytic NOX2 complex, which consists of the catalytic sub...

journal_title：Mediators of inflammation

authors： Kelkka T,Laurila JP,Sareila O,Olofsson P,Laukkanen MO,Holmdahl R

更新日期：2012-01-01 00:00:00

abstract：Background:Sepsis-induced myocardial dysfunction is a severe clinical problem. Recent studies have indicated that autophagy and myocardial energy depletion play a major role in myocardial dysfunction during sepsis, a mechanistic target of rapamycin (mTOR) as a master sensor of energy status and autophagy mediator; howe...

journal_title：Mediators of inflammation

authors： Han W,Wang H,Su L,Long Y,Cui N,Liu D

更新日期：2018-06-28 00:00:00

abstract：:Previous studies showed little CD137 expressed in normal vascular smooth muscle cells (VSMCs) and it is important to find a valid way to elevate it before studying its function. The level of CD137 was detected by RT-PCR, western blot, and flow cytometry, respectively. CD137 signaling activation was activated by agonis...

journal_title：Mediators of inflammation

authors： Zhong W,Li B,Li XY,Wang ZQ,Shao C,Wang CP,Chen R,Yan JC

更新日期：2017-01-01 00:00:00

abstract：:Leptin participates in the inflammatory responses in multiple cell types and animal models. Chronic cerebral hypoperfusion (CCH) induces inflammation in the central nervous system (CNS), which acts as one of the main reasons for CCH-induced white matter lesions (WMLs). But whether leptin participates in the pathogenes...

journal_title：Mediators of inflammation

authors： Du Y,Song Y,Zhang X,Luo Y,Zou W,Zhang J,Fu J

更新日期：2020-12-18 00:00:00

abstract：:Multiple sclerosis is an autoimmune disease with classical traits of demyelination, axonal damage, and neurodegeneration. The migration of autoimmune T cells and macrophages from blood to central nervous system as well as the destruction of blood brain barrier are thought to be the major processes in the development o...

journal_title：Mediators of inflammation

authors： Cheng W,Chen G

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:Production of antibodies that are specific for allergens is an important pathological process in inflammatory allergic diseases. These contain the antibodies against antigens of Candida albicans, one of the normal microbial flora in an intestinal tract. We studied the effects of the prednisolone administrati...

journal_title：Mediators of inflammation

authors： Tansho S,Abe S,Ishibashi H,Mitsuya M,Wada K,Ikeda T,Suegara N,Koshio O,Ono Y,Yamaguchi H

更新日期：2004-06-01 00:00:00

abstract：:Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized by chronic inflammation of multiple joints. The central pathogenesis of RA is the proliferation of synovial fibroblasts in response to inflammatory cytokines. However, some of the targeted therapies for inflammation reactions do not display signi...

journal_title：Mediators of inflammation

authors： Yin G,Wang Y,Cen XM,Yang M,Liang Y,Xie QB

更新日期：2015-01-01 00:00:00

abstract：:The purpose of this study is to assess the role of nitric oxide (NO) in the intestinal lesions of passive anaphylaxis, since this experimental model resembles necrotizing enterocolitis. Sprague-Dawley rats were sensitized with IgE anti-dinitrophenol monoclonal antibody. Extravasation of protein-rich plasma and haemorr...

journal_title：Mediators of inflammation

authors： Tavares JC,Moreno A,Crespo MS

更新日期：1997-01-01 00:00:00

abstract：:We investigated the influence of 2-chlorodeoxyadenosine (2-CdA) in combination with tumour necrosis factor-alpha (TNFalpha) or its mutein VI, which differs from the native molecule by N-terminal amino acid composition, on the survival time of mice inoculated with leukaemia L1210 or P388. Groups of mice with leukaemia ...

journal_title：Mediators of inflammation

authors： Góra-Tybor J,Warzocha K,Robak T

更新日期：1995-01-01 00:00:00

abstract：:Vascular adhesion protein-1 (VAP-1) is an ectoenzyme that functions as a copper-containing amine oxidase and is involved in leukocyte adhesion at sites of inflammation. Inhibition of VAP-1 oxidative deamination has become an attractive target for anti-inflammatory therapy with demonstrated efficacy in rodent models of...

journal_title：Mediators of inflammation

authors： Kubota R,Reid MJ,Lieu KL,Orme M,Diamond C,Tulberg N,Henry SH

更新日期：2020-01-20 00:00:00

abstract：:Collagen triple helix repeat containing-1 (CTHRC1) has been identified as cancer-related protein. CTHRC1 expresses mainly in adventitial fibroblasts and neointimal smooth muscle cells of balloon-injured vessels and promotes cell migration and tissue repair in response to injury. CTHRC1 plays a pivotal role in some pat...

journal_title：Mediators of inflammation

authors： Mei D,Zhu Y,Zhang L,Wei W

更新日期：2020-08-12 00:00:00

abstract：BACKGROUND:Rodent models suggest that follistatin-like 3 (fstl3) is associated with diabetes and obesity. In humans, plasma fstl3 is reduced with gestational diabetes. In vitro, TNF-α induces fstl3 secretion, which suggests a link to inflammation. OBJECTIVE:To elucidate the association between plasma fstl3 and obesity...

journal_title：Mediators of inflammation

authors： Brandt C,Pedersen M,Rinnov A,Andreasen AS,Møller K,Hojman P,Pedersen BK,Plomgaard P

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:Studies on peripheral benzodiazepine receptor function have yielded a diverse list of activities of which the anti-inflammatory effects need to be further examined. AIMS:To evaluate the role of steroids, nitric oxide and adenosine-deaminase in the anti-inflammatory effect of PK11195. METHODS:Pleurisy was i...

journal_title：Mediators of inflammation

authors： da Silva MB,Farges RC,Fröde TS

更新日期：2004-04-01 00:00:00

abstract：:Antimicrobial peptides (AMPs) are usually small molecule peptides, which display broad-spectrum antimicrobial activity, high efficiency, and stability. For the multiple-antibiotic-resistant strains, AMPs play a significant role in the development of novel antibiotics because of their broad-spectrum antimicrobial activ...

journal_title：Mediators of inflammation

authors： Sun Y,Shang D

更新日期：2015-01-01 00:00:00

abstract：:Observation of the microcirculation of the hamster cheek pouch by intravital microscopy revealed five steps of neutrophil migration from the venules after topical application of leukotriene B(4) to the microvasculature: rolling along the venular wall (Step 1), adhesion to it (Step 2), disappearance from the vascular l...

journal_title：Mediators of inflammation

authors： Oda T,Katori M,Hatanaka K,Nagai Y

更新日期：1995-01-01 00:00:00

abstract：:Endoglin is a coreceptor of the TGF-β superfamily predominantly expressed on the vascular endothelium and selective subsets of immune cells. We previously demonstrated that Endoglin heterozygous (Eng (+/-)) mice subjected to dextran sulfate sodium (DSS) developed persistent gut inflammation and pathological angiogenes...

journal_title：Mediators of inflammation

authors： Peter MR,Jerkic M,Sotov V,Douda DN,Ardelean DS,Ghamami N,Lakschevitz F,Khan MA,Robertson SJ,Glogauer M,Philpott DJ,Palaniyar N,Letarte M

更新日期：2014-01-01 00:00:00

abstract：:Inflammatory mediators play a critical role in ulcerative colitis immune and inflammatory processes. The aim of the study was to investigate the effects of Ginkgo biloba extract on inflammatory mediators (SOD, MDA, TNF-alpha, NF-kappaBp65, IL-6) in TNBS-induced colitis in rats. Colitis in rats was induced by colonic a...

journal_title：Mediators of inflammation

authors： Zhou YH,Yu JP,Liu YF,Teng XJ,Ming M,Lv P,An P,Liu SQ,Yu HG

更新日期：2006-01-01 00:00:00

abstract：:Galectin-1 (Gal-1), an evolutionarily conserved β-galactoside-binding lectin, controls immune cell homeostasis and tempers acute and chronic inflammation by blunting proinflammatory cytokine synthesis, engaging T-cell apoptotic programs, promoting expansion of T regulatory (Treg) cells, and deactivating antigen-presen...

journal_title：Mediators of inflammation

authors： Seropian IM,González GE,Maller SM,Berrocal DH,Abbate A,Rabinovich GA

更新日期：2018-11-05 00:00:00

abstract：:The aim of the present study was to compare serum levels of soluble forms of interleukin-2 receptor, CD4 and CD8, released by lymphocytes during activation of the immune system, in patients with allergic bronchial asthma, with those in healthy subjects. Significantly higher levels of soluble IL-2R and soluble CD4 were...

journal_title：Mediators of inflammation

authors： Lorenzo GD,Mansueto P,Melluso M,Morici G,Norrito F,Cigna D,Candore G,Caruso C

更新日期：1995-01-01 00:00:00

abstract：:Fibroblasts are important to host defence and immunity, can also as initiators of inflammation as well. As the endogenous "braking signal", Lipoxins can regulate anti-inflammation and the resolution of inflammation. We investigated the effect of lipoxinA(4) on the expression of cyclooxygenase-2 in lipopolysaccharide-s...

journal_title：Mediators of inflammation

authors： Zheng S,Wang Q,He Q,Song X,Ye D,Gao F,Jin S,Lian Q

更新日期：2011-01-01 00:00:00

abstract：:Fasting insulin, adiponectin, high-sensitivity C-reactive protein (hs-CRP), and interleukin-1 receptor antagonist (IL-1Ra) were determined in 278 men and 273 women with blood pressure > or = 130 and/or > or = 85 mmHg and/or with antihypertensive medication. Metabolic syndrome (MetS) with the National Cholesterol Educa...

journal_title：Mediators of inflammation

authors： Ahonen T,Saltevo J,Laakso M,Kautiainen H,Kumpusalo E,Vanhala M

更新日期：2009-01-01 00:00:00

abstract：:To evaluate the impact of low levels of high density lipoprotein cholesterol (HDL-c) on patients with LDL-c average levels, focusing on oxidative, lipidic, and inflammatory profiles. Patients with cardiovascular risk factors (n = 169) and control subjects (n = 73) were divided into 2 subgroups, one of normal HDL-c and...

journal_title：Mediators of inflammation

authors： Mascarenhas-Melo F,Sereno J,Teixeira-Lemos E,Marado D,Palavra F,Pinto R,Rocha-Pereira P,Teixeira F,Reis F

更新日期：2013-01-01 00:00:00

abstract：:The apoptosis-associated speck-like protein containing a caspase recruit domain (ASC) is involved in apoptosis and innate immunity and is a major adaptor molecule responsible for procaspase-1 activation. ASC mRNA is encoded by three exons: exons 1 and 3 encode a pyrin domain (PYD) and caspase recruit domain (CARD), re...

journal_title：Mediators of inflammation

authors： Matsushita K,Takeoka M,Sagara J,Itano N,Kurose Y,Nakamura A,Taniguchi S

更新日期：2009-01-01 00:00:00

abstract：:The human virome comprises viruses that infect host cells, virus-derived elements in our chromosomes, and viruses that infect other organisms, including bacteriophages and plant viruses. The development of high-throughput sequencing techniques has shown that the human gut microbiome is a complex community in which the...

journal_title：Mediators of inflammation

authors： Focà A,Liberto MC,Quirino A,Marascio N,Zicca E,Pavia G

更新日期：2015-01-01 00:00:00

abstract：:Rheumatoid arthritis (RA) is characterized by an abnormal cellular and cytokine infiltration of inflamed joints. This study addresses a previously unrecognized interaction between neutrophilic-myeloperoxidase (MPO) and macrophages (Mphi) which could explain the perpetuation of inflammation associated with RA. A monoar...

journal_title：Mediators of inflammation

authors： Gelderman MP,Stuart R,Vigerust D,Fuhrmann S,Lefkowitz DL,Allen RC,Lefkowitz SS,Graham S

更新日期：1998-01-01 00:00:00

abstract：:Activation of macrophages is one of the key processes in generating the immune response against pathogens or misfolded/aggregated otherwise unharmful host's proteins. Antigens and their immune complexes (IC) may shape macrophage phenotype in various directions. Data on the impact of protein structure during inflammati...

journal_title：Mediators of inflammation

authors： Dalgėdienė I,Lučiūnaitė A,Žvirblienė A

更新日期：2018-11-18 00:00:00

abstract：BACKGROUND:Platelet-activating factor (PAF) seems to be implicated in systemic lupus erythematosus (SLE) patients with associated renal diseases. AIMS:In this study, we ensured the role of PAF in SLE patients without renal complications. METHODS:Blood PAF and acetylhydrolase activity, plasma soluble phospholipase A(2...

journal_title：Mediators of inflammation

authors： Denizot Y,Liozon E,Guglielmi L,Ly K,Soria P,Loustaud V,Vidal E,Jauberteau MO

更新日期：2003-04-01 00:00:00

abstract：:Peritoneal dialysis therapy has increased in popularity since the end of the 1970s. This method provides a patient survival rate equivalent to hemodialysis and better preservation of residual renal function. However, technique failure by peritonitis, and ultrafiltration failure, which is a multifactorial complication ...

journal_title：Mediators of inflammation

authors： Baroni G,Schuinski A,de Moraes TP,Meyer F,Pecoits-Filho R

更新日期：2012-01-01 00:00:00