Abstract:
:Observation of the microcirculation of the hamster cheek pouch by intravital microscopy revealed five steps of neutrophil migration from the venules after topical application of leukotriene B(4) to the microvasculature: rolling along the venular wall (Step 1), adhesion to it (Step 2), disappearance from the vascular lumen (Step 3), presence between the endothelial cells and the subendothelial basement membrane (Step 4) and passage through the basement membrane (Step 5). The present study was performed to examine whether a metalloproteinase inhibitor inhibits neutrophil migration at any of the above five steps. Chymostatin and leupeptin did not inhibit any of these five steps. In contrast, FN-439, a selective inhibitor of matrix metalloproteinase, reduced the number of neutrophils in the perivascular space without affecting Steps 1 to 3. It was concluded that neutrophils may use metalloproteinase (collagenase/gelatinase) to penetrate the subendothelial basement membrane.
journal_name
Mediators Inflammjournal_title
Mediators of inflammationauthors
Oda T,Katori M,Hatanaka K,Nagai Ydoi
10.1155/S0962935195000238subject
Has Abstractpub_date
1995-01-01 00:00:00pages
133-7issue
2eissn
0962-9351issn
1466-1861journal_volume
4pub_type
杂志文章abstract::Human respiratory syncytial virus (RSV) sometimes causes acute and severe lower respiratory tract illness in infants and young children. RSV strongly upregulates proinflammatory cytokines and the platelet-activating factor (PAF) receptor, which is a receptor for Streptococcus pneumoniae, in the pulmonary epithelial ce...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2012/528568
更新日期:2012-01-01 00:00:00
abstract::The present study investigated the association between the rs12979860 polymorphism in the IL-28B gene and HTLV-1 infection as well as the development of HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). HTLV-1-infected patients (26 HAM/TSP symptomatic and 53 asymptomatic) and 300 seronegative health...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2015/804167
更新日期:2015-01-01 00:00:00
abstract::We investigated the serum concentrations of interleukin-6 (IL-6) and two IL-6 family of cytokines (leukaemia inhibitory factor (LIF) and ciliary neurotrophic factor (CNTF) as well as IL-6 soluble receptor (sIL-6R) using an enzyme-linked immunosorbent assay (ELISA) in 66 patients with rheumatoid arthritis (RA) and 24 h...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1080/09629359890875
更新日期:1998-01-01 00:00:00
abstract::The therapeutic strategies used in the treatment of hepatitis C are essentially based on the combination of direct-acting antiviral agents (DAAs). This therapy has been shown to be very effective in relation to patient adherence to treatment and has shown high rates of sustained virological response (SVR). However, th...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2019/4738237
更新日期:2019-11-04 00:00:00
abstract::Since iron can contribute to detrimental radical generating processes through the Fenton and Haber-Weiss reactions, it seems to be a reasonable approach to modulate iron-related pathways in inflammation. In the human organism a counterregulatory reduction in iron availability is observed during inflammatory diseases. ...
journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
doi:10.1155/2015/516740
更新日期:2015-01-01 00:00:00
abstract::Modification of endogenous eicosanoid synthesis by dietary n-3 fatty acid supplementation reduces febrile responses, but the mechanisms underlying these effects in vivo have not been determined. In the present study, local inflammation was induced by intramuscular injection ofturpentine in rats fed control or n-3 supp...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/S0962935194000499
更新日期:1994-01-01 00:00:00
abstract::The observed effects after ozone exposure strongly depend on ozone concentration and exposure time. We hypothesized that depending on the O3 exposure protocol, mainly either an oxidant damage or an inflammation will determine the O3 toxicity. We compared two different ozone exposure protocols: an acute exposure (3 ppm...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1080/09629359791497
更新日期:1997-01-01 00:00:00
abstract::A TP II analogue, [1-Nal3] TP II, was synthesized by a conventional solution method, followed by deprotection with 1M TFMSA-thioanisole (molar ratio 1:1) in TFA in the presence of Me2Se and m-cresol as scavengers. The synthetic [1-Nal3] TP II, TP II and [Phe (4 F)3] TP II were tested for comparative effect on the impa...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1080/09629350020002930
更新日期:2000-01-01 00:00:00
abstract::Lactobacillus species can exert health promoting effects in the gastrointestinal tract (GIT) through many mechanisms, which include pathogen inhibition, maintenance of microbial balance, immunomodulation, and enhancement of the epithelial barrier function. Different species of the genus Lactobacillus can evoke differe...
journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
doi:10.1155/2013/237921
更新日期:2013-01-01 00:00:00
abstract::Keloids are characterized by excessive collagen deposition and growth beyond the edges of the initial injury, and cytokines may be related to their formation. The objective of this study was to evaluate the collagen fibers, analyze in situ expression of cytokines in keloid lesions, and compare to the control group. Re...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2017/6573802
更新日期:2017-01-01 00:00:00
abstract::Background. Inflammation mediators related to radiation proctitis are partially elucidated, and neovascularization is thought to play a key role. Objectives. To investigate the expression of vascular endothelial growth factor (VEGF) and CD31 as angiogenetic markers in postradiation rectal tissue. Methods. Rectal mucos...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2013/515048
更新日期:2013-01-01 00:00:00
abstract::It was recently demonstrated that TLR4 activation via dietary lipids triggers inflammatory pathway and alters insulin responsiveness in the fat tissue during obesity. Here, we question whether other TLR family members could participate in the TLR-mediated inflammatory processes occurring in the obese adipose tissue. W...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2010/823486
更新日期:2010-01-01 00:00:00
abstract::Matrix metalloproteinase-14 (MMP-14) promotes vulnerable plaque morphology in mice, whereas tissue inhibitor of metalloproteinases-3 (TIMP-3) overexpression is protective. MMP-14(hi) TIMP-3(lo) rabbit foam cells are more invasive and more prone to apoptosis than MMP-14(lo) TIMP-3(hi) cells. We investigated the implica...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2014/276457
更新日期:2014-01-01 00:00:00
abstract::The pathogenesis of brain inflammation and damage by human immunodeficiency virus (HIV) infection is unclear. Because blood-brain barrier damage and impaired cerebral perfusion are common features of HIV-1 infection, we evaluated the role of tumour necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) in ...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/S0962935192000292
更新日期:1992-01-01 00:00:00
abstract::The mechanisms underlying the recurrence of atrial fibrillation (AF) after radiofrequency catheter ablation (RFCA) are not well concerned. The study sought to explore the association between growth differentiation factor-15 (GDF-15) and the incidence of recurrent events among AF patients after the ablation procedure. ...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2020/8360936
更新日期:2020-08-21 00:00:00
abstract:Background:Sphingosine-1-phosphate (S1P) is a biologically active lysophospholipid mediator involved in modulating inflammatory process. We investigated the effects of FTY720, a structural analogue of S1P after phosphorylation, on lung injury induced by hindlimb ischemia reperfusion (IR) in rats. Methods:Fifty Sprague...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2017/5301312
更新日期:2017-01-01 00:00:00
abstract::Postoperative cognitive dysfunction (POCD) increases morbidity and mortality after surgery. But the underlying mechanism is not clear yet. While age is now accepted as the top one risk factor for POCD, results from studies investigating postoperative cognitive functions in adults have been controversial, and data abou...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2016/3271579
更新日期:2016-01-01 00:00:00
abstract::The effects of anti-inflammatory plant extracts, such as black tea extract (BTE) and resveratrol (RSV) could modulate cell activation leading to atherosclerosis, however there is little comparative information about how different endothelial cell types are affected by these compounds. In order to compare human endothe...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2009/146872
更新日期:2009-01-01 00:00:00
abstract::The serum concentration of two pro-angiogenic cytokines: basic fibroblast growth factor (bFGF) and transforming growth factor beta1 (TGF-beta1), and anti-angiogenic factor endostatin in the serum of 80 never treated B-cell chronic lymphocytic leukemia (CLL) patients and 27 healthy volunteers was measured using an enzy...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1080/0962935031000134888
更新日期:2003-06-01 00:00:00
abstract::Peritoneal dialysis therapy has increased in popularity since the end of the 1970s. This method provides a patient survival rate equivalent to hemodialysis and better preservation of residual renal function. However, technique failure by peritonitis, and ultrafiltration failure, which is a multifactorial complication ...
journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
doi:10.1155/2012/912595
更新日期:2012-01-01 00:00:00
abstract::Ventilator-induced lung injury (VILI) is one of the most common complications of mechanical ventilation (MV), which strongly impacts the outcome of ventilated patients. Current evidences indicated that inflammation is a major contributor to the pathogenesis of VILI. Our results showed that MV induced excessive proinfl...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2020/7650978
更新日期:2020-07-23 00:00:00
abstract::Group A streptococcus (GAS) imposes a great burden on humans. Efforts to minimize the associated morbidity and mortality represent a critical issue. Glycogen synthase kinase-3 β (GSK-3 β) is known to regulate inflammatory response in infectious diseases. However, the regulation of GSK-3 β in GAS infection is still unk...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2013/720689
更新日期:2013-01-01 00:00:00
abstract::Diabetic retinopathy is considered a neurovascular disorder, hyperglycemia being considered the main risk factor for this pathology. Diabetic retinopathy also presents features of a low-grade chronic inflammatory disease, including increased levels of cytokines in the retina, such as interleukin-1 beta (IL-1β). Howeve...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2017/4316316
更新日期:2017-01-01 00:00:00
abstract::Peripheral artery disease (PAD) is a common disease affecting 20-25% of population over 60 years old. Early diagnosis is difficult because symptoms only become evident in advanced stages of the disease. Inflammation, impaired metabolism, and mitochondrial dysfunction predispose to PAD, which is normally associated wit...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2018/2760272
更新日期:2018-09-20 00:00:00
abstract:BACKGROUND:Infection in the neonatal period is an extremely serious condition and diagnosis is difficult. C-reactive protein (CRP) is widely used as a marker of infection; however, its usefulness is limited in the early phase. The role of soluble intracellular adhesion molecule-1 (sICAM-1), an adhesion molecule, has be...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1080/09629350220131944
更新日期:2002-04-01 00:00:00
abstract::A marked proliferation of synovial fibroblasts in joints leads to pannus formation in rheumatoid arthritis (RA). Various kinds of cytokines are produced in the pannus. The purpose of this study is to elucidate the effects of phosphodiesterase 4 (PDE4) inhibitors in a new animal model for the evaluation of pannus forma...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2007/58901
更新日期:2007-01-01 00:00:00
abstract:Aims:To assess the maresin 1 (MaR1) contents in type 2 diabetic patients with or without diabetic foot ulcer and to analyze the association of MaR1 concentrations with several metabolism-related parameters. Methods:Plasma MaR1 concentrations were analyzed in 96 subjects with normal glucose tolerant (NC, n = 43), type ...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2020/4539035
更新日期:2020-04-16 00:00:00
abstract::Multiple sclerosis (MS) is a chronic demyelinating disease of the human central nervous system (CNS). The condition predominantly affects young adults and is characterised by immunological and inflammatory changes in the periphery and CNS that contribute to neurovascular disruption, haemopoietic cell invasion of targe...
journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
doi:10.1155/MI/2006/93684
更新日期:2006-01-01 00:00:00
abstract::Sanguisorbae Radix (SR) is well known as herbal medicine named "Zi-Yu" in Korea, which is the dried roots of Sanguisorba officinalis L. (Rosacease). We investigated the underlying mechanism on the inhibition of atopic dermatitis (AD) of an ethanol extract of SR (ESR) using 2,4-dinitrochlorobenzene- (DNCB-) induced AD ...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2016/2947390
更新日期:2016-01-01 00:00:00
abstract::H. pylori induces a complicated local and systematic immune response and contributes to the carcinogenesis of gastric cancer. A primary type 1 immune response is evoked by H. pylori since its occurrence. However, it is not unusual that an inhibitory immunity is dominant in H. pylori-associated diseases, which are prom...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2017/4927964
更新日期:2017-01-01 00:00:00