当前位置： SCI文献检索 > MEDIATORS OF INFLAMMATION期刊下所有文献 > Levels of soluble ICAM-1 in premature and full-term neonates with infection.

Levels of soluble ICAM-1 in premature and full-term neonates with infection.

Abstract：

BACKGROUND:Infection in the neonatal period is an extremely serious condition and diagnosis is difficult. C-reactive protein (CRP) is widely used as a marker of infection; however, its usefulness is limited in the early phase. The role of soluble intracellular adhesion molecule-1 (sICAM-1), an adhesion molecule, has been examined in recent studies as an early marker of neonatal infection with controversial results. AIM:Assessment of sICAM-1 concentrations and correlation with CRP, which is the currently used marker of infection, in order to use sICAM as an early diagnostic tool in neonates suspected for infection METHODS:Blood samples and blood cultures were obtained from two groups of pre-term and full-term neonates with clinical suspicion of infection prior to the initiation of antibiotics. The sICAM-1 and CRP values were compared with the corresponding noninfected ones (n = 10 each). RESULTS:The sICAM-1 levels were found increased in the group of both premature and term neonates with infection compared with the corresponding healthy ones (P < 0.0001). Prematurity combined with infection resulted in excessive increase of the levels of sICAM-1 in comparison with full-term infected newborns (p < 0.001). CRP values were normal in all samples except one in both full-term and premature infected neonates on day 1 of clinically suspected infection. Serial detection of CRP values on days 2 and 4 of infection revealed a pattern according to which CRP values in premature neonates continued rising, while in the group of full terms these values, after rising on the second day, lowered on day 4. CONCLUSIONS:Increased sICAM-1 levels can be detected early in both full-term and premature neonates with sepsis while CRP levels are within normal range at the same time. Assessment of sICAM-1 concentrations may be used as a diagnostic tool in neonates suspected for infection, resulting in earlier initiation of antibiotic therapy and therefore improving their outcome.

journal_name

Mediators Inflamm

journal_title

Mediators of inflammation

authors

Apostolou M,Dimitriou H,Kaleyias J,Perdikogianni C,Stiakaki E,Costalos C,Kalmanti MC

doi

10.1080/09629350220131944

subject

Has Abstract

pub_date

2002-04-01 00:00:00

pages

95-8

issue

eissn

0962-9351

issn

1466-1861

journal_volume

pub_type

杂志文章

在线工具

Levels of soluble ICAM-1 in premature and full-term neonates with infection.