Abstract:
:We investigated the influence of 2-chlorodeoxyadenosine (2-CdA) in combination with tumour necrosis factor-alpha (TNFalpha) or its mutein VI, which differs from the native molecule by N-terminal amino acid composition, on the survival time of mice inoculated with leukaemia L1210 or P388. Groups of mice with leukaemia L1210 and P388 receiving 2-CdA combined with TNFalpha had shorter survival times than animals treated with these agents separately. In contrast, the administration of 2-CdA in conjunction with mutein VI, prolonged the survival of mice inoculated with these leukaemias as compared with animals receiving these agents separately. The results of the present study emphasize the importance of the biological activity of the TNFalpha molecule N-terminus.
journal_name
Mediators Inflammjournal_title
Mediators of inflammationauthors
Góra-Tybor J,Warzocha K,Robak Tdoi
10.1155/S0962935195000330subject
Has Abstractpub_date
1995-01-01 00:00:00pages
205-8issue
3eissn
0962-9351issn
1466-1861journal_volume
4pub_type
杂志文章abstract::The aim of the study was to evaluate the role of Smad3, Smad7, and TGF-β1 in intrauterine adhesion (IUA) patients and experimental rabbit models. 60 IUA patients, 30 control participants, and 18 female rabbits were enrolled in this study. We found that the plasma concentrations and protein expressions of TGF-β1 were s...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2016/4158287
更新日期:2016-01-01 00:00:00
abstract:Background:Acute lung injury (ALI) and subsequent pulmonary infection are the most severe and usually fatal complications for elderly hip fracture patients. It is necessary to find some biomarkers for early diagnosis and prognosis of it. Objective:This study is aimed at examining the differential expression of miR-146...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2018/8101359
更新日期:2018-10-28 00:00:00
abstract::A TP II analogue, [1-Nal3] TP II, was synthesized by a conventional solution method, followed by deprotection with 1M TFMSA-thioanisole (molar ratio 1:1) in TFA in the presence of Me2Se and m-cresol as scavengers. The synthetic [1-Nal3] TP II, TP II and [Phe (4 F)3] TP II were tested for comparative effect on the impa...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1080/09629350020002930
更新日期:2000-01-01 00:00:00
abstract::The expression of cytochrome P4501A1 (CYP1A1) enzyme is changed in various organs during the host response to inflammation or infection, leading to alterations in the metabolism of endogenous and exogenous compounds. Results of this study showed that CYP1A1 expression was significantly downregulated in the mammary tis...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2018/4093285
更新日期:2018-02-28 00:00:00
abstract::Human respiratory syncytial virus (RSV) sometimes causes acute and severe lower respiratory tract illness in infants and young children. RSV strongly upregulates proinflammatory cytokines and the platelet-activating factor (PAF) receptor, which is a receptor for Streptococcus pneumoniae, in the pulmonary epithelial ce...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2012/528568
更新日期:2012-01-01 00:00:00
abstract::Inflammatory mediators play a critical role in ulcerative colitis immune and inflammatory processes. The aim of the study was to investigate the effects of Ginkgo biloba extract on inflammatory mediators (SOD, MDA, TNF-alpha, NF-kappaBp65, IL-6) in TNBS-induced colitis in rats. Colitis in rats was induced by colonic a...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/MI/2006/92642
更新日期:2006-01-01 00:00:00
abstract:OBJECTIVES:Obesity and related diseases are dramatically increasing problems, particularly in children and adolescents. We determined circulating levels of different interleukin (IL)-1 family members in normal weight and overweight adolescents. METHODS:Seventy male, Caucasian adolescents (13-17 years) were recruited. ...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2010/958403
更新日期:2010-01-01 00:00:00
abstract::Procalcitonin (PCT) is one of the best diagnostic and prognostic markers in clinical practice, widely used to evaluate the evolution of bacterial infections. Although it is mainly produced by thyroid, during sepsis almost all the peripheral tissues are involved in PCT production. Parenchymal cells have been suggested ...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2014/248963
更新日期:2014-01-01 00:00:00
abstract::Surgery induces release of neuroendocrine hormones (cortisol), cytokines (interleukin-6: IL-6, tumour necrosis factor-alpha: TNF-alpha), acute phase proteins (C-reactive protein: CRP, leptin). We studied the effects of general and spinal anaesthesia on stress response to haemorrhoidectomy. Patients were assigned to ge...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/MI/2006/97257
更新日期:2006-01-01 00:00:00
abstract::The purpose of this paper is to evaluate the chronic effect of sitagliptin on metabolic profile, inflammation, and redox status in the Zucker Diabetic Fatty (ZDF) rat, an animal model of obese type 2 diabetes. Diabetic and obese ZDF (fa/fa) rats and their controls (ZDF +/+) were treated during 6 weeks with vehicle (co...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2010/592760
更新日期:2010-01-01 00:00:00
abstract::Chronic kidney disease (CKD) patients, characterized by traditional and nontraditional risk factors, are prone to develop atheromatosis and thus cardiovascular events and mortality. The angiogenesis of the adventitial vasa vasorum (aVV) surrounding the carotid has been described as the atheromatosis initiator. Therefo...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2017/3795142
更新日期:2017-01-01 00:00:00
abstract::High levels of serum long chain saturated fatty acids (LCSFAs) have been associated with inflammation in type 2 diabetes. Dietary SFAs can promote inflammation, the secretion of IgG antibodies, and secretion of the proinflammatory cytokine IL-1β. This study characterizes anti-LCSFA IgG antibodies from patients with ty...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2015/196297
更新日期:2015-01-01 00:00:00
abstract::Inflammatory mediators, including cytokines, histamine, bradykinin, prostaglandins, and leukotrienes, impact the immune system, usually as proinflammatory factors. Other mediators act as regulatory components to establish homeostasis after injury or prevent the inflammatory process. Histamine, a biogenic vasoactive am...
journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
doi:10.1155/2018/9524075
更新日期:2018-08-27 00:00:00
abstract:BACKGROUND:Exhaled nitric oxide (FeNO) has been reported to be elevated in the oxidative stress involved in asthmatic patients, and the reaction of nitric oxide (NO) with superoxide anions results in the formation of nitrotyrosine. The purpose of this study was to investigate the effect of inhaled steroid treatment on ...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/MI/2006/31919
更新日期:2006-01-01 00:00:00
abstract::A family of eleven proteins comprises the Janus kinases (JAK) and signal transducers and activators of transcription (STAT) signaling pathway, which enables transduction of signal from cytokine receptor to the nucleus and activation of transcription of target genes. Irregular functioning of the cascade may contribute ...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2017/6716419
更新日期:2017-01-01 00:00:00
abstract::Peritoneal dialysis therapy has increased in popularity since the end of the 1970s. This method provides a patient survival rate equivalent to hemodialysis and better preservation of residual renal function. However, technique failure by peritonitis, and ultrafiltration failure, which is a multifactorial complication ...
journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
doi:10.1155/2012/912595
更新日期:2012-01-01 00:00:00
abstract::B-1a cells are distinguishable from conventional B cells, which are designated B-2 cells, on the basis of their developmental origin, surface marker expression, and functions. In addition to the unique expression of the CD5 antigen, B-1a cells are characterized by the expression level of CD23. Although B-1a cells are ...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2018/9289417
更新日期:2018-12-23 00:00:00
abstract::Abnormal angiogenesis and vascular remodeling contribute to pathogenesis of a number of disorders such as tumor, arthritis, atherosclerosis, restenosis, hypertension, and neurodegeneration. During angiogenesis and vascular remodeling, behaviors of stem/progenitor cells, endothelial cells (ECs), and vascular smooth mus...
journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
doi:10.1155/2013/928315
更新日期:2013-01-01 00:00:00
abstract::The present study investigated the frequencies of rs1800450 (MBL ⁎B, G>A), rs1800451 (MBL ⁎C, G>A), and rs5030737 (MBL ⁎D, C>T) polymorphisms in exon 1 of the MBL2 gene among patients with chronic viral hepatitis. Blood samples from patients infected with hepatitis B virus (HBV; n = 65), hepatitis C virus (HCV; n = 92...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2017/3718451
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND AND AIM:Immunization with live virus vaccines may cause an immunosuppression with lymphopaenia, impaired cytokine production and defective lymphocyte response to mitogenes. These abnormalities were described in subjects vaccinated against measles. This study was performed to analyse the host immune response ...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1080/09629350310001599639
更新日期:2003-08-01 00:00:00
abstract:BACKGROUND:Airway smooth muscle (ASM) is considered to be a target for mediators released during airway inflammation. AIMS:To investigate the expression of c-fos, a constituent of the transcription factor activator protein-1, in human ASM cells. In addition, to measure the release of interleukin (IL)-6 into the condit...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1080/09629350124155
更新日期:2001-06-01 00:00:00
abstract::Although the initiating events of Crohn's disease are unknown, models of experimental colitis have provided new insights in the immunologically mediated pathways of mucosal inflammation. In Crohn's disease activated mucosal T lymphocytes produce proinflammatory cytokines within the mucosal compartment. With this under...
journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
doi:10.1080/09629359891063
更新日期:1998-01-01 00:00:00
abstract::Periodontitis is an inflammatory disease caused by pathogenic microorganisms and characterized by the destruction of the periodontium. Obese individuals have an increased risk of periodontitis, and elevated circulating levels of adipokines, such as nicotinamide phosphoribosyltransferase (NAMPT), may be a pathomechanis...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2013/437123
更新日期:2013-01-01 00:00:00
abstract::Endothelial dysfunction is regarded as an important factor in the pathogenesis of vascular disease in obesity-related type 2 diabetes. The imbalance in repair and injury (hyperglycemia, hypertension, dyslipidemia) results in microvascular changes, including apoptosis of microvascular cells, ultimately leading to diabe...
journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
doi:10.1155/2010/792393
更新日期:2010-01-01 00:00:00
abstract::miRNA-10a is rhythmically expressed and regulates genes involved in lipid and glucose metabolism. However, the effects of miRNA-10a on obesity and glucose intolerance, as well as on the diurnal pattern of expression of circadian clock genes, remain unknown. We explored the effects of miRNA-10a-5p on insulin resistance...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2020/8192187
更新日期:2020-08-17 00:00:00
abstract::The aim of our work was to find if MCP-1 -2518 (A/G) single nucleotide polymorphism (SNP) influences somehow the serum concentrations of high-sensitive CRP (hsCRP) both in patients suffering from ischemic heart disease (IHD), myocardial infarction (MI), angina pectoris (AP), and hypertension (HT) and in control group ...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2009/390951
更新日期:2009-01-01 00:00:00
abstract::Prevalence of thyroid dysfunction and its impact on cognition in older people has been demonstrated, but many points remain unclarified. In order to study the effect of aging on the thyroid gland, we compared the thyroid gland of very old mice with that of younger ones. We have first investigated the changes of thyroi...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2017/8102170
更新日期:2017-01-01 00:00:00
abstract::Exosomes are nanosized vesicles released from every cell in the body including those in the respiratory tract and lungs. They are found in most body fluids and contain a number of different biomolecules including proteins, lipids, and both mRNA and noncoding RNAs. Since they can release their contents, particularly mi...
journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
doi:10.1155/2016/5628404
更新日期:2016-01-01 00:00:00
abstract::In recent years, many researchers are focusing their attention on the link between inflammation and cancer. The inflammation is involved in the tumor development and suppression, by stimulating the immune response. In particular, the transition from chronic inflammation to cancer produces angiogenic and growth factors...
journal_title:Mediators of inflammation
pub_type: 杂志文章,评审
doi:10.1155/2016/3064643
更新日期:2016-01-01 00:00:00
abstract:AIM:The aim of this study was to evaluate the presence of the cytokines tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) in human periapical lesions. SUBJECTS AND METHODS:Samples were obtained from three groups of teeth: symptomatic teeth, asymptomatic lesions, and uninflamed periradicular tissues as a...
journal_title:Mediators of inflammation
pub_type: 杂志文章
doi:10.1155/2007/38210
更新日期:2007-01-01 00:00:00